CN110302288A - A kind of clearing heat, relieving sore-throat, Chinese medicine composition of healing sore and relieving pain and preparation method thereof - Google Patents

A kind of clearing heat, relieving sore-throat, Chinese medicine composition of healing sore and relieving pain and preparation method thereof Download PDF

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CN110302288A
CN110302288A CN201910686784.0A CN201910686784A CN110302288A CN 110302288 A CN110302288 A CN 110302288A CN 201910686784 A CN201910686784 A CN 201910686784A CN 110302288 A CN110302288 A CN 110302288A
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sore
weight
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relieving
throat
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李建军
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Abstract

The present invention relates to a kind of clearing heat, relieving sore-throat, the Chinese medicine composition of healing sore and relieving pain and preparation method thereof, the raw material components of the Chinese medicine composition include borax, licorice, subprostrate sophora, Radix Isatidis, campanulaceae, indigo naturalis, radix scrophulariae, calamitas urinae hominis, raddle, blackberry lily and borneol.Each raw material are subjected to appropriate weight proportion, the Chinese medicine composition with clearing heat, relieving sore-throat, healing sore and relieving pain is finally prepared.The traditional chinese medicine composition of the invention is able to solve because excessive internal heat causes to have sore throat, cough, canker sore, tonsillitis and the problems such as acute herpetic angina.Chinese medicine composition compatibility of the present invention is scientific, it is significant in efficacy, take effect rapidly, and have no toxic side effect, preparation method is simple and easy, mild condition and stability is good, easy to spread.

Description

A kind of clearing heat, relieving sore-throat, Chinese medicine composition of healing sore and relieving pain and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicine composition and Preparation method.
Background technique
Sore-throat is a kind of most common illness, it is mainly in the cold season in 1 year, flu, tonsillitis, nasal sinus Inflammation, pertussis, sphagitis and virus infection.Canker sore is commonly called as " aphtha ", is a kind of common to betide mucous membrane of mouth Ulcerative damages illness is more common in the positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions Lack keratinization layer or angling is poor.Tongue ulcer refers to the canker sore for betiding tongue, tongue abdomen position.When canker sore is broken out Sharp ache, local cusalgia is obvious, and serious person also will affect diet, speak, and causes very big inconvenience to daily life；It can concurrent mouth The constitutional symptoms such as smelly, chronic pharyngitis, constipation, headache, dizziness, nausea, out of strength, irritated, fever, enlargement of lymph nodes.Tonsillitis Acute tonsillitis and chronic tonsillitis can be divided into, it, can after suffering from acute infectious disease (such as scarlet fever, morbilli, influenza, diphtheria) Cause chronic tonsillitis, nasal cavity has sinus infection can also be associated with the disease, pathogeny bacterium streptococcus and staphylococcus etc are most common, Clinical manifestation is frequent pharyngeal discomfort, foreign body sensation, dry, itch, irritable cough, the symptoms such as halitosis.Herpangina be by Acute infective angina caused by enterovirus characterized by febris acuta and isthmus faucium portion bleb ulcer, with excrement-mouth or is exhaled Suction road is major transmission path, and infectiousness is very strong, propagates fast, various regions all over the world, and in distributing or popular, summer and autumn is high-incidence season Section, clinic is to generate heat, pharyngalgia, isthmus faucium portion mucous membrane exanthema vesiculosum and superficial ulcer are main performance.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides it is a kind of it is significant in efficacy, take effect it is rapidly clear Hot relieving sore-throat, Chinese medicine composition of healing sore and relieving pain and preparation method thereof, the clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicine composition can It solves to cause to have sore throat because of excessive internal heat, cough, canker sore, tonsillitis and the problems such as acute herpetic angina.
The technical scheme adopted by the invention is as follows:
The Chinese medicine composition of a kind of clearing heat, relieving sore-throat, healing sore and relieving pain, raw material components include:
Borax 5-10 parts by weight, licorice 5-10 parts by weight, subprostrate sophora 5-10 parts by weight, Radix Isatidis 5-10 parts by weight, tangerine Obstruct 5-10 parts by weight, indigo naturalis 5-10 parts by weight, radix scrophulariae 5-10 parts by weight, calamitas urinae hominis 5-10 parts by weight, raddle 5-10 parts by weight, Blackberry lily 5-10 parts by weight, borneol 2-5 parts by weight.
The further preferred clearing heat, relieving sore-throat, healing sore and relieving pain the raw material components of Chinese medicine composition include:
7.5 parts by weight of borax, 7 parts by weight of licorice, 8 parts by weight of subprostrate sophora, 7 parts by weight of Radix Isatidis, 8 parts by weight of campanulaceae, 7.5 parts by weight of indigo naturalis, 7 parts by weight of radix scrophulariae, 7.5 parts by weight of calamitas urinae hominis, 8 parts by weight of raddle, 7.5 parts by weight of blackberry lily, borneol 3.5 Parts by weight.
Further, the dosage form of described pharmaceutical composition is powder or paste.
The clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, comprising the following steps:
(1) licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis successively cleaned respectively, cleaned, dried, are mixed, Obtain raw materials treated；
(2) it is boiled by fire after being soaked in water in Xiang Suoshu raw materials treated, then turns to be cooked by slow fire, be added after cooling prebiotic Bacterium is fermented, and is then filtered, is concentrated, is dried, obtains fermentation material；
(3) radix scrophulariae, calamitas urinae hominis and blackberry lily are successively cleaned, cleaned, dried, mixed, soak in water rear high fire It boils, turns to be cooked by slow fire, be then successively filtered, be concentrated, dry, obtain decoction material, obtain decoction material；
(4) decoction material, borax, raddle, borneol crushed after mixing with the fermentation material, are dried, Obtain the traditional Chinese powder medicine of the clearing heat, relieving sore-throat, healing sore and relieving pain.
Further, in step (2), the mass ratio of the raw materials treated and water is 1:(4-6), soaking time 1- 3h；It is described to be cooked by slow fire the time as 40-140min.
Further, in step (2), the mass ratio of the licorice and probiotics is (20-30): 1；The probiotics is Any one in lactobacillus acidophilus, bifidobacterium lactis or Lactobacillus rhamnosus；The temperature of the fermentation is 45-55 DEG C, described The time of fermentation is 5-7 months.
Further, in step (3), in step (3), radix scrophulariae after the mixing, calamitas urinae hominis and blackberry lily quality and addition The mass ratio of water is 1:(4-6), soaking time 1-3h；It is described to be cooked by slow fire the time as 40-140min.
Further, in step (4), the partial size of smashed traditional Chinese powder medicine is 800-1000 mesh；The drying temperature is 45-50 DEG C, the drying time is 40-80min.
Further, application method is adult 3-4 times daily, and each 7-8g is sucked by atomizer, and children's dosage subtracts Partly, for treating abscess of throat, cough, canker sore, tonsillitis and acute herpetic angina the problems such as.
The clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, comprising the following steps:
(1) each raw material in addition to borax, raddle and borneol cleaned, cleaned, crushed, be uniformly mixed, added It filters, steam after soaking in Chinese liquor, distiller's yeast is then added and ferments, obtains fermentation material；
(2) borax, raddle and borneol are ground respectively, obtains borax smalls, raddle smalls and borneol smalls；
(3) fermentation material is distilled, distillating extracting liquid is condensed into cream, borax smalls, raddle smalls is added It is stirred evenly with borneol smalls, obtains the Chinese medicinal ointment of the clearing heat, relieving sore-throat, healing sore and relieving pain.
Further, in step (1), it is 80-120 mesh that each raw material, which is crushed to partial size, and the temperature of the immersion is 25- 28 DEG C, the time of the immersion is 6-8 days, and the Alcohol degree of the white wine is 50-65 degree.
Further, in step (1), the temperature steamed is 120-200 DEG C, and the time steamed is 60-90 points Clock, the additive amount of the distiller's yeast are the 1-3wt% of the raw material gross weight, and the fermentation time is 30-60 days, the temperature of the fermentation Degree is 25-28 DEG C.
Further, in step (2), the partial size of borax smalls, raddle smalls and borneol smalls is 500-800 mesh.
Further, in step (3), by distillating extracting liquid mild fire infusion 1-2h after being boiled by fire.
Further, external application method is that this cream is applied directly to affected part, can be relieved pain within 1 hour or so, for treating oral cavity Ulcer.
It underdraws below to effect caused by raw material in the present invention.
Borax, it is sweet in flavor, salty, it is cold in nature；It attaches to the lung and stomach meridians.Effect: heat-clearing and phlegm-dissolving, detoxifying and anticorrosive.Cure mainly phlegm-heat cough, Sore throat, thrush, dysphagic accumulation, all bone sticking larynxs, cataract, pterygium, pudendal ulcer.
Licorice, it is sweet in flavor, it is mild-natured；Thoughts of returning home warp, stomach meridian, the spleen channel, lung channel.Effect: it invigorates the spleen and benefits qi, cough-relieving apophlegmatic, delay Anxious analgesic therapy, mediation property of medicine, treatment is weakness of the spleen and the stomach, contraction suddenly has a pain, mitigates drug in the deficiency of qi in middle-jiao, cough and asthma, skin sore, abdomen Strong, solution poisoning of drug.
Subprostrate sophora, bitter are cold in nature；It attaches to the lung and stomach meridians.Effect: clearing heat and detoxicating, detumescence relieving sore-throat.It pents up, swallow for fire toxin Larynx swelling and pain, gingivitis.
Radix Isatidis, bitter are cold in nature；Return heart, stomach meridian.Effect: clearing heat and detoxicating, cool blood relieving sore-throat.For febrile virulent maculae, tongue Dark reddish purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
Campanulaceae, bitter are mild-natured；It is distributed in lung channel.Effect: clearing lung and eliminating the phlegm, relieving sore throat and evacuating pus.It is full to treat coughing with a lot of sputum, chest diaphragm Bored, pharyngalgia hoarse voice, lung subcutaneous ulcer pyemesis.
Indigo naturalis, taste is salty, cold in nature；Return liver warp.Effect: clearing heat and cooling blood, arresting convulsion.With control epidemic heat syndrome, macular eruption, blood-head tells nosebleed, Pectoralgia hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared etc..
Radix scrophulariae, sweet in flavor, bitter, salty, cold nature；Distributed in lung channel, stomach meridian, kidney channel.Effect: cool blood enriching yin, purging fire for removing toxin.It controls Treat consumption of YIN caused by febrile disease, tongue drop polydipsia, febrile virulent maculae, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus, Hypertension.
Calamitas urinae hominis, taste is salty, cold in nature；Return liver, three burnt, bladder meridians.Effect: clearing heat and detoxicating, dissolving stasis and hemostasis.For throat The diseases such as swelling and pain, noma aphtha, hemoptysis, bleeding from five sense organs or subcutaneous tissue.
Raddle, bitter are cold in nature；Return liver, stomach, heart born of the same parents warp.Effect: calming the liver town is inverse, cooling blood and hemostasis.Gas is controlled to vomit Inverse, dysphagia and regurgitation, asthma, frightened epilepsy, haematemesis, nosebleed epistaxis, intestines wind, hemorrhoid complicated by anal fistula, metrorrhagia and metrostaxis leukorrhagia.
Blackberry lily, bitter are cold in nature；It is distributed in lung channel.Effect: clearing heat and detoxicating, dissolving phlegm, relieving sore-throat.With control the pent-up of heat toxin convulsive seizure due to phlegm-fire, pharynx Larynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.Have antibacterial, antiviral, antiinflammation, have great significance to viral sphagitis is treated, It is preferable to be particularly useful for the treatment of laryngospasm oedema effect.
Borneol, acrid flavour, hardship are cold in nature；Thoughts of returning home warp, the spleen channel, lung channel.Effect: inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.With controlling heat Close coma, close in phlegm heat, hot summer weather soldier faints, child convulsion and various sore, carbuncle and painful swellings, burst after do not hold back, burn and scald, abscess of throat, larynx Numbness, red eye, swell pain, aphthae etc..
The invention has the benefit that
The Chinese medicine composition of clearing heat, relieving sore-throat of the present invention, healing sore and relieving pain, by using borax, licorice, subprostrate sophora, plate Lan Gen, campanulaceae, indigo naturalis, radix scrophulariae, calamitas urinae hominis, raddle, blackberry lily and borneol are raw material and carry out appropriate weight proportion, final to prepare Obtain the Chinese medicine composition with clearing heat, relieving sore-throat, healing sore and relieving pain.The present invention is played using borax, calamitas urinae hominis and borneol as monarch drug in a prescription The effect of clearing heat and detoxicating, relieving sore throat and acesodyne, expelling pus and promoting granulation；Use subprostrate sophora, indigo naturalis, blackberry lily, Radix Isatidis, raddle, campanulaceae for minister The effect of medicine, auxiliary monarch drug in a prescription, and the fire of lung-fire, irascibility, internal heat, stomach fire and three cokes drops；Using radix scrophulariae as adjutant, except auxiliary monarch drug in a prescription and Outside the drug effect of ministerial drug, also have effects that cool blood enriching yin, purging fire for removing toxin；It is to make medicine with licorice, plays the role of coordinating the drug actions of a prescription, And enhance and accelerate the performance of drug effect.The traditional chinese medicine composition of the invention is able to solve because excessive internal heat causes to have sore throat, canker sore, flat The problems such as peach body inflammation and acute herpetic angina.Chinese medicine composition compatibility of the present invention is scientific, each component collaboration works, and treats Effect is significant, takes effect rapidly, and has no toxic side effect.Of the present invention preparation method is simple, mild condition and stability is good, easily In popularization, fermentation process technology is used to Part of Chinese Medicinal, can by the intermediate material of the macromolecular in Chinese medicine, decomposition and inversion at For the effective small-molecule substance that can be directly absorbed, the Chinese medicinal component curative effect through everfermentation is fast, definite effect, and drug effect is promoted 20-30 times, the curative effect for each component Chinese medicine that effectively raises speed, attenuation synergistic improves mouthfeel.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below Detailed description.Obviously, described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments. Based on the embodiments of the present invention, those of ordinary skill in the art obtained institute without making creative work There is other embodiment, belongs to the range that the present invention is protected.
1g is represented in following example with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of clearing heat, relieving sore-throat, the traditional Chinese powder medicine of healing sore and relieving pain, raw material components include:
5 parts by weight of borax, 5 parts by weight of licorice, 5 parts by weight of subprostrate sophora, 5 parts by weight of Radix Isatidis, 5 parts by weight of campanulaceae, blueness 5 parts by weight of black pigment used by women in ancient times to paint their eyebrows, 5 parts by weight of radix scrophulariae, 5 parts by weight of calamitas urinae hominis, 5 parts by weight of raddle, 5 parts by weight of blackberry lily, 2 parts by weight of borneol.
The clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, comprising the following steps:
(1) licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis successively cleaned respectively, cleaned, dried, are mixed, Obtain raw materials treated；
(2) water that 4 times of quality are added in Xiang Suoshu raw materials treated impregnates 1h, is boiled by fire, and then turns to be cooked by slow fire 40min is added 2g lactobacillus acidophilus after cooling, ferments 5 months at 45 DEG C, be then filtered, be concentrated, dry, sent out Ferment material；
(3) radix scrophulariae, calamitas urinae hominis and blackberry lily are successively cleaned, cleaned, dried, mixed, the water of 4 times of quality is added 1h is impregnated, is boiled by fire, turns to be cooked by slow fire 40min, is then successively filtered, is concentrated, dries, obtain decoction material；
(4) decoction material, borax, raddle, borneol and the fermentation material are crushed to partial size after mixing is 800 Mesh, 45 DEG C of dry 40min are to get the traditional Chinese powder medicine for arriving the clearing heat, relieving sore-throat, healing sore and relieving pain.
Embodiment 2
The present embodiment provides a kind of clearing heat, relieving sore-throat, the traditional Chinese powder medicine of healing sore and relieving pain, raw material components include:
10 parts by weight of borax, 10 parts by weight of licorice, 10 parts by weight of subprostrate sophora, 10 parts by weight of Radix Isatidis, 10 weight of campanulaceae Part, 10 parts by weight of indigo naturalis, 10 parts by weight of radix scrophulariae, 10 parts by weight of calamitas urinae hominis, 10 parts by weight of raddle, 10 parts by weight of blackberry lily, borneol 5 Parts by weight.
The clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, comprising the following steps:
(1) licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis successively cleaned respectively, cleaned, dried, are mixed, Obtain raw materials treated；
(2) water that 6 times of quality are added in Xiang Suoshu raw materials treated impregnates 3h, is boiled by fire, and then turns to be cooked by slow fire 140min is added 9g bifidobacterium lactis after cooling, ferments 7 months at 55 DEG C, be then filtered, be concentrated, dry, sent out Ferment material；
(3) radix scrophulariae, calamitas urinae hominis and blackberry lily are successively cleaned, cleaned, dried, mixed, the water of 6 times of quality is added 3h is impregnated, is boiled by fire, turns to be cooked by slow fire 140min, is then filtered, is concentrated, dries, obtain decoction material；
(4) decoction material, borax, raddle, borneol are crushed to partial size with the fermentation material after mixing is 1000 mesh, 50 DEG C of dry 80min are to get the traditional Chinese powder medicine for arriving the clearing heat, relieving sore-throat, healing sore and relieving pain.
Embodiment 3
The present embodiment provides a kind of clearing heat, relieving sore-throat, the traditional Chinese powder medicine of healing sore and relieving pain, raw material components include:
7.5 parts by weight of borax, 7 parts by weight of licorice, 8 parts by weight of subprostrate sophora, 7 parts by weight of Radix Isatidis, 8 parts by weight of campanulaceae, 7.5 parts by weight of indigo naturalis, 7 parts by weight of radix scrophulariae, 7.5 parts by weight of calamitas urinae hominis, 8 parts by weight of raddle, 7.5 parts by weight of blackberry lily, borneol 3.5 Parts by weight.
The clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, comprising the following steps:
(1) licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis successively cleaned respectively, cleaned, dried, are mixed, Obtain raw materials treated；
(2) water that 5 times of quality are added in Xiang Suoshu raw materials treated impregnates 2h, is boiled by fire, and then turns to be cooked by slow fire 90min is added 5g Lactobacillus rhamnosus after cooling, ferments 6 months at 50 DEG C, be then filtered, be concentrated, dry, obtain Fermentation material；
(3) radix scrophulariae, calamitas urinae hominis and blackberry lily are successively cleaned, cleaned, dried, mixed, the water of 5 times of quality is added 2h is impregnated, is boiled by fire, turns to be cooked by slow fire 90min, is then successively filtered, is concentrated, dries, obtain decoction material；
(4) decoction material, borax, raddle, borneol and the fermentation material are crushed to partial size after mixing is 900 Mesh, 48 DEG C of dry 1h are to get the traditional Chinese powder medicine for arriving the clearing heat, relieving sore-throat, healing sore and relieving pain.
Embodiment 4
The present embodiment provides a kind of clearing heat, relieving sore-throat, the Chinese medicinal ointment of healing sore and relieving pain, raw material components include:
5 parts by weight of borax, 5 parts by weight of licorice, 5 parts by weight of subprostrate sophora, 5 parts by weight of Radix Isatidis, 5 parts by weight of campanulaceae, blueness 5 parts by weight of black pigment used by women in ancient times to paint their eyebrows, 5 parts by weight of radix scrophulariae, 5 parts by weight of calamitas urinae hominis, 5 parts by weight of raddle, 5 parts by weight of blackberry lily, 2 parts by weight of borneol.
The clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, comprising the following steps:
(1) each raw material in addition to borax, raddle and borneol cleaned, cleaned, being crushed to partial size is 80 mesh, It is uniformly mixed, filters, steamed at 120 DEG C 60 minutes after adding 50 degree of white wine to impregnate 6 days at 25 DEG C, raw material gross weight is then added The distiller's yeast of 1wt% ferments 30 days, and the temperature of fermentation is 25 DEG C, obtains fermentation material；
(2) borax, raddle and borneol are ground respectively, obtains the grain of borax smalls, raddle smalls and borneol smalls Diameter is 500 mesh；
(3) fermentation material is distilled, mild fire infusion 1h after distillating extracting liquid is boiled by fire is condensed into cream, adds Enter borax smalls, raddle smalls and borneol smalls to stir evenly, obtains the Chinese medicinal ointment of the clearing heat, relieving sore-throat, healing sore and relieving pain.
Embodiment 5
The present embodiment provides a kind of clearing heat, relieving sore-throat, the Chinese medicinal ointment of healing sore and relieving pain, raw material components include:
10 parts by weight of borax, 10 parts by weight of licorice, 10 parts by weight of subprostrate sophora, 10 parts by weight of Radix Isatidis, 10 weight of campanulaceae Part, 10 parts by weight of indigo naturalis, 10 parts by weight of radix scrophulariae, 10 parts by weight of calamitas urinae hominis, 10 parts by weight of raddle, 10 parts by weight of blackberry lily, borneol 5 Parts by weight.
The clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, comprising the following steps:
(1) each raw material in addition to borax, raddle and borneol cleaned, cleaned, being crushed to partial size is 120 Mesh is uniformly mixed, filters, steam at 200 DEG C 90 minutes after adding 65 degree of white wine to impregnate 8 days at 28 DEG C, and it is total that raw material is then added The distiller's yeast of weight 3wt% ferments 60 days, and the temperature of fermentation is 28 DEG C, obtains fermentation material；
(2) borax, raddle and borneol are ground respectively, obtains the grain of borax smalls, raddle smalls and borneol smalls Diameter is 800 mesh；
(3) fermentation material is distilled, mild fire infusion 2h after distillating extracting liquid is boiled by fire is condensed into cream, adds Enter borax smalls, raddle smalls and borneol smalls to stir evenly, obtains the Chinese medicinal ointment of the clearing heat, relieving sore-throat, healing sore and relieving pain.
Embodiment 6
The present embodiment provides a kind of clearing heat, relieving sore-throat, the Chinese medicinal ointment of healing sore and relieving pain, raw material components include:
7.5 parts by weight of borax, 7 parts by weight of licorice, 8 parts by weight of subprostrate sophora, 7 parts by weight of Radix Isatidis, 8 parts by weight of campanulaceae, 7.5 parts by weight of indigo naturalis, 7 parts by weight of radix scrophulariae, 7.5 parts by weight of calamitas urinae hominis, 8 parts by weight of raddle, 7.5 parts by weight of blackberry lily, borneol 3.5 Parts by weight.
The clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, comprising the following steps:
(1) each raw material in addition to borax, raddle and borneol cleaned, cleaned, being crushed to partial size is 80- 120 mesh are uniformly mixed, filter, steam at 160 DEG C 70 minutes after adding 58 degree of white wine to impregnate 7 days at 26.5 DEG C, are then added former Expect that the distiller's yeast of gross weight 2wt% ferments 45 days, the temperature of fermentation is 26.5 DEG C, obtains fermentation material；
(2) borax, raddle and borneol are ground respectively, obtains the grain of borax smalls, raddle smalls and borneol smalls Diameter is 650 mesh；
(3) fermentation material being distilled, mild fire infusion 1.5h after distillating extracting liquid is boiled by fire is condensed into cream, Borax smalls, raddle smalls and borneol smalls is added to stir evenly, obtains the traditional Chinese medicinal ointment of the clearing heat, relieving sore-throat, healing sore and relieving pain Agent.
Comparative example 1
The difference of this comparative example and embodiment 3 is only that the processing side of licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis Method is different, and the above components filter the mixture up to the above component without probiotics fermention after being boiled by fire, other operations It is same as Example 3.
Comparative example 2
The difference of this comparative example and embodiment 3 is only that raw material components, the raw material components of this comparative example do not include indigo naturalis, member Ginseng and raddle, other are same as Example 3.
Experimental example
One, traditional Chinese powder medicine smooth throat to stop cough Contrast on effect obtained by embodiment 1-3 and comparative example 1-2
1, subjects: ICR mouse.
2, it tests process: taking healthy ICR mouse 60, be divided into 6 groups, every group 10；One group is blank group, other are experiment Group；Experimental group is corresponding in a manner of Neulized inhalation to use traditional Chinese powder medicine obtained by embodiment 1-3 and comparative example 1-2, dosage 5g/ kg；Blank group in a manner of Neulized inhalation use equivalent pure water, successive administration five days, twice daily；After last dose 1 hour, Each group mouse is stimulated with ammonium hydroxide, records each experimental mice cough latent period and number of coughing in 3 minutes, and record knot Fruit.
3, test result
Table 1- cough suppressing effect
As can be seen from Table 1, embodiment 1-3 group mouse is after ammonium hydroxide stimulation: cough latent period is considerably longer than 1 group of comparative example With 2 groups of comparative example；Cough number in embodiment 1-3 group mouse 3 minutes is significantly less than 1 group of comparative example and 2 groups of comparative example.Explanation Traditional Chinese powder medicine obtained by embodiment 1-3 can be obviously prolonged the mouse cough incubation period of ammonium hydroxide induction, reduce cough number, and then say Bright powder of the present invention has apparent relieving sore-throat antitussive effect.
Two, traditional Chinese powder medicine obtained by embodiment 1-3 and comparative example 1-2 treats canker sore Contrast on effect
1, subjects: New Zealand White Rabbit, 4 monthly ages, weight 2.5-3kg.
2, it tests process: taking healthy new zealand white rabbit 33, wherein 30 with 3% amobarbital Intravenous Anesthesia, 40% ice On the right side of acetic acid calcination oral cavity, ulcer area is marked with gentian violet after 48 hours, remaining 3 without any processing；Oral cavity will be built up 30 rabbits of Ulcer Models are randomly divided into 6 groups, and every group 5, one group is blank group, other are experimental group；By embodiment 1-3 and Traditional Chinese powder medicine obtained by comparative example 1-2 is spread at each experimental group rabbit canker sore, without any processing at blank group rabbit ulcer, Twice daily；Every rabbit healing fond of food that is not salty is recorded, each group is averaged and records.
3, test result
Table 2- cough suppressing effect
Group It is untreated Blank group Embodiment 1 Embodiment 2 Embodiment 3 Comparative example 1 Comparative example 2
Each group rabbit quantity 3 5 5 5 5 5 5
Healing time (day) — 13.6 5.9 5.6 4.7 8.6 9.1
As can be seen from Table 2, untreated 3 rabbits illustrate rabbit there is no canker sore situation during test Oral problem is not present in health；The healing time of the rabbit canker sore of embodiment 1-3 group is significantly shorter than 1 group of comparative example and right 2 groups of ratio, illustrate that the effect of the treatment canker sore of powder obtained by embodiment 1-3 is substantially better than 1 group of comparative example and 2 groups of comparative example, Also traditional Chinese powder medicine of the present invention is further demonstrated to the validity of canker sore.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.

Claims (10)

1. the Chinese medicine composition of a kind of clearing heat, relieving sore-throat, healing sore and relieving pain, which is characterized in that raw material components include:
Borax 5-10 parts by weight, licorice 5-10 parts by weight, subprostrate sophora 5-10 parts by weight, Radix Isatidis 5-10 parts by weight, campanulaceae 5- 10 parts by weight, indigo naturalis 5-10 parts by weight, radix scrophulariae 5-10 parts by weight, calamitas urinae hominis 5-10 parts by weight, raddle 5-10 parts by weight, blackberry lily 5-10 parts by weight, borneol 2-5 parts by weight.
2. the Chinese medicine composition of clearing heat, relieving sore-throat according to claim 1, healing sore and relieving pain, which is characterized in that raw material components packet It includes:
7.5 parts by weight of borax, 7 parts by weight of licorice, 8 parts by weight of subprostrate sophora, 7 parts by weight of Radix Isatidis, 8 parts by weight of campanulaceae, indigo naturalis 7.5 parts by weight, 7 parts by weight of radix scrophulariae, 7.5 parts by weight of calamitas urinae hominis, 8 parts by weight of raddle, 7.5 parts by weight of blackberry lily, 3.5 weight of borneol Part.
3. the Chinese medicine composition of any one of -2 clearing heat, relieving sore-throats, healing sore and relieving pain according to claim 1, described pharmaceutical composition Dosage form is powder or paste.
4. a kind of preparation method of the traditional Chinese powder medicine of clearing heat, relieving sore-throat, healing sore and relieving pain, which comprises the following steps:
(1) licorice, subprostrate sophora, Radix Isatidis, campanulaceae and indigo naturalis successively cleaned respectively, cleaned, dried, mixed, obtained Raw materials treated；
(2) be boiled by fire after being soaked in water in Xiang Suoshu raw materials treated, then turn to be cooked by slow fire, be added after cooling probiotics into Row fermentation, is then filtered, is concentrated, dries, obtain fermentation material；
(3) radix scrophulariae, calamitas urinae hominis and blackberry lily are successively cleaned, cleaned, dried, mixed, is boiled by fire after soaking in water, Turn to be cooked by slow fire, is then successively filtered, is concentrated, dries, obtain decoction material；
(4) decoction material, borax, raddle, borneol and the fermentation material are crushed after mixing, dry to get To the clearing heat, relieving sore-throat, the traditional Chinese powder medicine of healing sore and relieving pain.
5. according to claim 4 clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, which is characterized in that step (2) in, the mass ratio of the raw materials treated and water is 1:(4-6), soaking time 1-3h；It is described to be cooked by slow fire the time and be 40-140min；The mass ratio of the licorice and probiotics is (20-30): 1；The probiotics is lactobacillus acidophilus, newborn bifid Any one in bacillus or Lactobacillus rhamnosus；The temperature of the fermentation is 45-55 DEG C, and the time of the fermentation is 5-7 Month；
In step (3), the mass ratio of the quality of radix scrophulariae, calamitas urinae hominis and blackberry lily and addition water is 1:(4-6 after the mixing), it impregnates Time is 1-3h；It is described to be cooked by slow fire the time as 40-140min.
6. according to claim 4 clearing heat, relieving sore-throat, healing sore and relieving pain traditional Chinese powder medicine preparation method, which is characterized in that step (4) in, the partial size of smashed traditional Chinese powder medicine is 800-1000 mesh；The drying temperature is 45-50 DEG C, and the drying time is 40-80min。
7. a kind of preparation method of the Chinese medicinal ointment of clearing heat, relieving sore-throat, healing sore and relieving pain, which comprises the following steps:
(1) each raw material in addition to borax, raddle and borneol cleaned, cleaned, crushed, be uniformly mixed, add white wine It filters, steam after immersion, distiller's yeast is then added and ferments, obtains fermentation material；
(2) borax, raddle and borneol are ground respectively, obtains borax smalls, raddle smalls and borneol smalls；
(3) fermentation material is distilled, distillating extracting liquid is condensed into cream, borax smalls, raddle smalls and ice is added Piece smalls stirs evenly, and obtains the Chinese medicinal ointment of the clearing heat, relieving sore-throat, healing sore and relieving pain.
8. according to claim 7 clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, which is characterized in that step (1) in, it is 80-120 mesh that each raw material, which is crushed to partial size, and the temperature of the immersion is 25-28 DEG C, and the time of the immersion is 6-8 days, the Alcohol degree of the white wine was 50-65 degree；The temperature steamed is 120-200 DEG C, and the time steamed is 60-90 minutes, the additive amount of the distiller's yeast was the 1-3wt% of the raw material gross weight, and the fermentation time is 30-60 days, described The temperature of fermentation is 25-28 DEG C.
9. according to claim 7 clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, which is characterized in that step (2) in, the partial size of borax smalls, raddle smalls and borneol smalls is 500-800 mesh.
10. according to claim 7 clearing heat, relieving sore-throat, healing sore and relieving pain Chinese medicinal ointment preparation method, which is characterized in that step (3) in, by distillating extracting liquid mild fire infusion 1-2h after being boiled by fire.
CN201910686784.0A 2019-07-29 2019-07-29 A kind of clearing heat, relieving sore-throat, Chinese medicine composition of healing sore and relieving pain and preparation method thereof Pending CN110302288A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129598A (en) * 2007-08-16 2008-02-27 李鹏 Medicament for treating chronic pharyngitis
CN104189243A (en) * 2014-07-31 2014-12-10 烟台恒迪克能源科技有限公司 Radix scrophulariae granules for treating pharyngitis and preparation method of radix scrophulariae granules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129598A (en) * 2007-08-16 2008-02-27 李鹏 Medicament for treating chronic pharyngitis
CN104189243A (en) * 2014-07-31 2014-12-10 烟台恒迪克能源科技有限公司 Radix scrophulariae granules for treating pharyngitis and preparation method of radix scrophulariae granules

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