CN110302105A - For facial fat degradation and compact technology and its application - Google Patents
For facial fat degradation and compact technology and its application Download PDFInfo
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- CN110302105A CN110302105A CN201810258330.9A CN201810258330A CN110302105A CN 110302105 A CN110302105 A CN 110302105A CN 201810258330 A CN201810258330 A CN 201810258330A CN 110302105 A CN110302105 A CN 110302105A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Abstract
The present invention relates to cosmetic technical fields, it is specifically a kind of to degrade and the compact cosmetic complex containing tea extract and its application for facial fat, the cosmetic complex containing tea extract includes the following parts by weight: 1-200 parts of tea extract, 1-200 parts of L-carnitine, 1-200 parts of lipid metaboli relevant enzyme；The invention has the advantages that: the cosmetic complex of the invention containing tea extract has the function of that good fat reducing, elimination eye pouch and skin of face are compact, and has without intrusive injection, small, the long advantage of holding time of rebound.
Description
Technical field
The present invention relates to cosmetic technical fields, specifically, being to contain tealeaves with compact for facial fat degradation
The cosmetic complex of extract and its application.
Background technique
Fat reducing is always the target that numerous women pursue, one of the risk factor of obesity not only health, while also shadow
Ring the beauty of appearance, especially facial fat deposition.The injection melted on the market for facial fat at present, due to being intrusion
Formula has certain side effect and infection chance.And the compound with certain fat reducing effect is smeared for external application, often go out
It now holds time short, is easy to the disadvantages of rebounding.Therefore addition multiple compounds improve the action potency of composition, play collaboration effect
It answers, extends fat reducing effect, be very valuable.
Chinese patent literature CN104906028 (application number 201510381658.6) discloses one kind, and there is improvement skin to ask
The fermentation composition of topic and its application, and cosmetics and its application based on the fermented product composition contain in raw material
CFTE (fruit, tealeaves, edible mushroom that Chinese herbal medicine contains polyphenol) culture medium and ETS (edible mushroom, tealeaves, soybean) fermentation species
Sub- liquid.
Chinese patent literature CN105434209 (application number 201510298514.4) discloses a kind of beautifying wrinkle-removing line tightening
Composition of plastotype and preparation method thereof, the composition is by green-tea extract, lotus leaf extract, A. gigas extract, gold
Thread plum extracting solution, Purslane extract, yeast extract, belamcanda chinensis extract, peony root extract, oenothera seed oil, seven leaves
Tree saponin, asiaticoside, hydrolysis fibroin, elastin, soy bean protein hydrolysate, collagen, Alpha-lipoic acid,
Co-Q10, chlorella, polyglutamic acid, natto gum, Cer NP, jojoba ester, saualane, hyaluronic acid hydrogenate poly- certain herbaceous plants with big flowers alkene,
D-lactic acid sodium, Vitamin C Ethyl Ether, 1.3 butanediols, the raw materials such as water are made.Can skin nutrition, promote face's blood follow
Ring prevents moisture of skin to scatter and disappear, and long-time service can be generated and be smoothed away wrinkles, the effect of fading melanin.
It is of the present invention at present to degrade and the compact cosmetic complex containing tea extract for facial fat
And its application has no document report.
Summary of the invention
The purpose of the present invention is to provide a kind of for facial fat degradation and the compact makeup containing tea extract
Product compound and its preparation and application.
The first aspect of the present invention provides a kind of cosmetic complex containing tea extract, including following parts by weight
Component: 1-200 parts of tea extract, 1-200 parts of L-carnitine, 1-200 parts of lipid metaboli relevant enzyme；The tealeaves extracts
Object, wherein the mass percentage content of tea polyphenols is not less than 3% not less than the mass percentage content of 10%, caffeine.Wherein
The mass percentage content of tea polyphenols is lower than 20%, the mass percentage content of caffeine will affect fat melting effect lower than 3% and
Tightening effect.
Preferably, the cosmetic complex containing tea extract, comprise the following components in parts by weight: tealeaves mentions
50-100 parts of object are taken, 50-100 parts of L-carnitine, 80-100 parts of lipid metaboli relevant enzyme.
Preferably, the tea extract, wherein the mass percentage contents of tea polyphenols is 10-20%, caffeine
Mass percentage content is 3-10%.
Further, the preparation method of the tea extract, comprising the following steps:
Tealeaves processed product is taken, after 1-2 hours dry at 30-50 DEG C in baking oven (more excellent is convection oven), is crushed；Use 3-
5 times of volume 50-80% ethyl alcohol extract 1-3 times at 30-60 DEG C, 1-2 hours each, combined extract, and being concentrated into no alcohol must flow
Medicinal extract adds 1-2 times of volume of water to mix, and is extracted 1-3 times with 1-3 times of volume of ethylacetate, combining extraction liquid is concentrated to dryness to obtain tealeaves
Extract.
Preferably, the lipid metaboli relevant enzyme is selected from: glycerokinase, glycerol-3-phosphate dehydrogenase, fatty acid α-hydroxylation
Enzyme, hepatic lipase, acylcoenzyme a synthase, fatty acyl-CoA dehydrogenase, enoyl-CoA hydratase, carnitine-acyltransferase I, hormone
One or more of sensitive lipase, Hydroxymethylglutaryl monoacyl coacetylase, thiolase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of citric acid.Citric acid category
In one kind of tartaric acid, main function is to speed up cutin update, is usually used in lotion, creams, shampoo, whitening articles, anti-aging use
Product, Acne etc..The update of cutin facilitates the peeling of the middle melanin of skin, and the receipts of pore are thin, the dissolution etc. of blackhead.
It is further preferred that 5-8 parts of citric acid.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of Herba Lysimachiae extract；Institute
The Herba Lysimachiae extract stated, wherein flavonoids mass percentage content is 20-30%, choline mass percentage content is 5-
10%, cAMP mass percentage content is 5-10%.
Further, the preparation method of the Herba Lysimachiae extract, comprising the following steps:
Herba lysimachiae is taken, the 70--95% ethanol water of 3-5 times of volume is added, is heated to reflux 1-3 times, it is 1-2 hours each,
Filtering, merging filtrate, filtrate recycling ethanol, concentration, it is dry to get.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of extract of soybean；It is described
Extract of soybean, wherein the mass percentage content of phosphatidyl choline be not less than 20%.The more preferably extract of soybean,
The wherein mass percentage content 25-30% of phosphatidyl choline.
Further, the preparation method of the extract of soybean, comprising the following steps:
Soybean dry powder is taken, 30-90% ethyl alcohol heat mentions 1-2 hours at 30-90 DEG C, pours out extracting solution, and the dregs of a decoction extract again
1-2 hours；Merge concentrated extracting solution to no alcohol, obtains extract of soybean；Extract of soybean adds suitable quantity of water, uses 5- after resin adsorption
The elution of 20 times of volume pure water, then with 5-10 times of volume 45-80% ethanol elution, collect ethanol eluate, be concentrated to dryness to obtain soybean
Extract.Preferably, the resin adsorption is that upper AB-8 resin column does Dynamic Adsorption, and flow velocity slows down as far as possible, and what is flow down is molten
Liquid is still added on column and is adsorbed, and carries out 1-4 hour.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of deoxycholic aicd.Deoxygenate gallbladder
Acid is a kind of promotion bile (liquid-like constituents) secretion, eliminates bile retardance, helps fat digestion and absorption.It is further preferred that
5-8 parts of deoxycholic aicd.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of ferulic acid.Ferulic acid energy
Free radical is removed, promotes the generation for removing the enzyme of free radical, increases the activity of Glutathione S transferase and quinone reductase, and inhibit
Tyrosinase activity, to adjust human physiological functions.It can play the role of bodybuilding and protection skin in human body simultaneously.Further
Preferably, ferulic acid 5-8 parts.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of vitamin E.Vitamin
E, which has, to delay senescence, and reduces the generation of wrinkle, reduces cell oxygen demand, poison of the anti-oxidation protection body cell from free radical
Evil, improves the effect of lipid-metabolism.It is further preferred that 5-8 parts of vitamin E.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of albumin.People may be selected
Blood albumin, ovalbumin, seralbumin, bovine serum albumin(BSA), dog albumin etc..Albumin can maintain plasma colloid osmotic
That presses is constant；The small organic molecule and inorganic ions that can promote slightly solubility reversibly combine the compound for forming ease of solubility,
As types of transportation of these substances in blood circulation；With stickiness, collagenous, removing toxic substances can be played the role of.Albumin
It is the carrier of albumen and compound transport, the transport of fat degradation products can be promoted, fat degradation products is promoted to reach target
Tissue is degraded, it is further preferred that 5-8 parts of seralbumin.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of coacetylase.Coacetylase
(CoA, CoASH or HSCoA) is primarily involved in the metabolism of fatty acid and pyruvic acid.It is further preferred that 3-5 parts of coacetylase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of glutathione reductase.
Glutathione reductase (glutathione reductase) be it is a kind of using reduced-NAD (P) by oxidized form of glutathione
(GS-SG) the enzyme EC.1.6.4.2 at reduced form (GSH) is reacted in catalysis.Glutathione is a kind of important cellular antioxidants.
It is further preferred that 5-6 parts of glutathione reductase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of citrate synthase.Lemon
The enzyme that acetyl-CoA of the acid synthase catalysis from glycolysis or other catabolic reactions is reacted with oxaloacetic acid condensation synthesizing citric acid.
This enzyme controls the entrance of tricarboxylic acid cycle, by a variety of regulations.It is allosteric enzymes, is pressed down by NADH, ATP and the other structure of α-ketoglutaric acid
System, succinyl-coenzyme A and acetyl coenzyme A Competitive assays, AMP can fight the inhibition of ATP, play activation.It is further preferred that
8-10 parts of citrate synthase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of aconitase.Aconitic acid
Enzyme is the enzyme mutually converted between catalytic citric acid and isocitric acid in tricarboxylic acid cycle.It is further preferred that aconitase
5-6 parts.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of isocitric dehydrogenase.
Isocitric dehydrogenase (IDH) is one and is responsible for the enzyme that catalysis isocitric acid (ICT) oxidative deamination generates α-ketoglutaric acid (α KG)
Family.Its anti-oxidative damage, movable to the synthesis of the removing toxic substances of reactive oxygen species and fatty acid and cholesterol etc. for participating in cell,
Important function is played in tricarboxylic acid cycle.It is further preferred that 3-5 parts of isocitric dehydrogenase.
Preferably, the cosmetic complex containing tea extract further includes succinic thiokinase 2-10
Part.Succinyl-coenzyme A is one of integral link of tricarboxylic acid cycle.Succinyl-coenzyme A is high under the action of succinic thiokinase
Energy thioester bond hydrolysis, energy transfer generate GTP and succinic acid to GDP.The GTP of generation can be utilized directly, can also be by its high energy phosphorus
Acid groups are transferred to ADP and generate ATP it is further preferred that 5-6 parts of succinic thiokinase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of succinate dehydrogenase.Amber
Amber acidohydrogenase (Succinatedehydrogenase, abbreviation SDH), flavine enzyme belong to cytochrome oxidase, are TCA
Only one is integrated in the multi-subunit enzyme on film and is incorporated into mitochondrial inner membrane in eucaryote in circulation, in prokaryotes
It is integrated on cell membrane, is connection one of oxidative phosphorylation and the hinge of electron transmission, can be eukaryocyte mitochondria and more
The aerobic respiratory chain with production capacity of kind prokaryotic cell provides electronics, is a kind of marker enzyme of mitochondria.It is further preferred that succinic acid
5-8 parts of dehydrogenase.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of fumarase.Prolong recklessly
Rope acid enzyme (fumarase) fumarase formal name is fumarate hydrase (fumaratehydra-tase), is
It is catalyzed fumaric acid+H2The reversible enzyme for carrying out mutual transformation reaction of O → L MALIC ACID.It is further preferred that fumarase 6-8
Part.
Preferably, the cosmetic complex containing tea extract further includes 2-10 parts of malic dehydrogenase.Apple
Tartaric acid dehydrogenase is one of tricarboxylic acid cycle enzyme.Catalysis L MALIC ACID dehydrogenation becomes the enzyme of oxaloacetic acid.It is widely present in
It is one of tricarboxylic acid cycle enzyme on mitochondria, bacterial cell membrane.It is further preferred that 5-6 parts of malic dehydrogenase.
The second aspect of the present invention provides a kind of with as above any cosmetic complex containing tea extract
Face as active constituent imports preparation.
The cosmetic complex accounts for quality of the pharmaceutical preparations percentage 0.01-99.9% as sole active agent, preferably
0.1-10%.
Preferably, it is liniment, paint, liniment, gelling agent, freeze dried injection etc. that the face, which imports preparation,.
Preferably, the face, which imports solvent in preparation, can be used physiological saline, deionized water or seasoning liquid, seasoning liquid
Formula are as follows: water, mannitol, 1,2- hexylene glycol, hyaluronic acid.
The third aspect of the present invention provides a kind of as above any cosmetic complex containing tea extract and exists
Preparation reduces the application in the cosmetics of facial fat deposition.
The fourth aspect of the present invention provides a kind of as above described in any item cosmetic complexes containing tea extract
Application in the cosmetics that eye pouch is eliminated in preparation.
The fifth aspect of the present invention provides a kind of as above described in any item cosmetic complexes containing tea extract
Preparing the application in the compact cosmetics of skin of face.
The invention has the advantages that:
1, of the invention be used for facial fat degradation and the compact cosmetic complex containing tea extract have very
Good fat reducing effect.
2, the cosmetic complex of the invention containing tea extract also has the function of eliminating eye pouch.
3, the cosmetic complex of the invention containing tea extract can also play the compact effect of skin of face.
4, the cosmetic complex of the invention containing tea extract has without intrusive injection, rebounds small, maintains
The advantage of time length.
Detailed description of the invention
Fig. 1 is that obesity mice uses the changes of weight ratio after cosmetic complex of the present invention, same kind of products at abroad fat melting needle
Compared with；After 24 raising weight gain 45g of NOD obesity mice, random point 3 groups, administration application: 1, French import fat melting needle group (dosage
0.1ml/ times), brand Cellulyse, specification 10ml/ branch.2, Switzerland's import fat melting needle brand SWISS HEHL group (dosage
0.1ml/ times), specification 10ml/ branch, 3,1 cosmetic complex group (dosage 0.1mg/ times) of embodiment, every 10ml/ branch.First
After secondary injection, interval second of continuous injection for 24 hours, interval injects third time, completes to inject three times in one week after 48 hours.Daily
Changes of weight is observed and recorded, every group of mouse weight average value mapping (p < 0.05) is taken.
Fig. 2 is that experiment in vitro detects cosmetic complex of the present invention to fat melting activity fatty in fat cell；
Experimental group: 1640 groups of 1.RPMI of group；Group 2. same kind of products at abroad groups (French import fat melting needle (dosage 0.1ml/
It is secondary), brand Cellulyse, specification 10ml/ branch, solvent is physiological saline)；Group 3. same kind of products at abroad groups (Switzerland's import fat melting
Needle (dosage 0.1ml/ times), brand SWISS HEHL group, specification 10ml/ branch, solvent is physiological saline)；4. solvent group (solvents of group
For physiological saline)；5. example 1 groups of group close object group.
The density bed board that people's Primary adipocyte is pressed to about 8500/ hole, after 12 hours it is adherent securely after, by dividing 5 above
Group is loaded, every group of 3 multiple holes, after culture 48 hours, carries out oil red O stain to cell, observation cellular morphology changes, and use is different
Cell after propyl alcohol processing dyeing, absorbance (A) value is measured under 490nm wavelength, will organize 1 (A) value as a control group, is calculated
Opposite fat content in fat cell.
Fig. 3 is cosmetic complex of the present invention to normal cell toxicity assessment result.
The primary skin epithelial cell bed board of people and 96 orifice plates, 8000, every hole cell are respectively after culture adherent 12 hours
Control group and addition 1 cosmetic composition of embodiment (1) concentration gradient are 2,4,10,40mg/ml, while being added isometric
RMPI1640 culture solution is as blank control group, after culture 48 hours, using CCK8 kit, measures cell Proliferation and growth is lived
Property, blank control group is set as 1, embodiment 1 is set as group 1, calculates survival rate.
Fig. 4 is the cosmetic complex of the present invention experimental result compact for skin of face.
Specific embodiment
It elaborates below with reference to embodiment to specific embodiment provided by the invention.Product used in embodiment
It is marketable material.
Embodiment 1
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 1 part of tea extract,
5 parts of L-carnitine, 3 parts of glycerokinase；
The preparation method of the tea extract, comprising the following steps:
Tealeaves processed product is taken, after 1-2 hours dry at 30-50 DEG C in baking oven (more excellent is convection oven), is crushed；Use 3-
5 times of volume 50-80% ethyl alcohol extract 1-3 times at 30-60 DEG C, 1-2 hours each, combined extract, and being concentrated into no alcohol must flow
Medicinal extract adds 1-2 times of volume of water to mix, and is extracted 1-3 times with 1-3 times of volume of ethylacetate, combining extraction liquid is concentrated to dryness to obtain tealeaves
Extract, wherein the mass percentage content of tea polyphenols is not less than 3% not less than the mass percentage content of 10%, caffeine.
Embodiment 2
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 5 parts of tea extract,
1 part of L-carnitine, 1 part of glycerol-3-phosphate dehydrogenase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 3
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 20 parts of tea extract,
30 parts of L-carnitine, fatty acid α -20 parts of hydroxylase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 4
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 40 parts of tea extract,
60 parts of L-carnitine, 80 parts of hepatic lipase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 5
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 60 parts of tea extract,
50 parts of L-carnitine, 50 parts of acylcoenzyme a synthase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 6
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 80 parts of tea extract,
90 parts of L-carnitine, 120 parts of fatty acyl-CoA dehydrogenase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 7
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 100
Part, 110 parts of L-carnitine, 140 parts of enoyl-CoA hydratase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 8
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 120
Part, 130 parts of L-carnitine, carnitine -160 parts of acyltransferase I；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 9
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 140
Part, 150 parts of L-carnitine, 180 parts of hormone-sensitive lipase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 10
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 160
Part, 180 parts of L-carnitine, 200 parts of Hydroxymethylglutaryl monoacyl coacetylase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 11
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 180
Part, 200 parts of L-carnitine, 100 parts of thiolase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 12
A kind of cosmetic complex containing tea extract, includes the following parts by weight: tea extract 200
Part, 150 parts of L-carnitine, 110 parts of hepatic lipase, 10 parts of citric acid；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 13
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 3 parts of tea extract,
4 parts of L-carnitine, 3 parts of glycerokinase, 2 parts of Herba Lysimachiae extract；The Herba Lysimachiae extract, wherein flavonoids quality percentage
It is 20-30% than content, choline mass percentage content is that 5-10%, cAMP mass percentage content are 5-10%.
The preparation method of the Herba Lysimachiae extract, comprising the following steps:
Herba lysimachiae is taken, the 70--95% ethanol water of 3-5 times of volume is added, is heated to reflux 1-3 times, it is 1-2 hours each,
Filtering, merging filtrate, filtrate recycling ethanol, concentration, it is dry to get.
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 14
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 5 parts of tea extract,
2 parts of L-carnitine, 5 parts of glycerol-3-phosphate dehydrogenase, 4 parts of extract of soybean；The extract of soybean, wherein phosphatidyl gallbladder
The mass percentage content of alkali is not less than 20%.
The preparation method of the extract of soybean, comprising the following steps:
Soybean dry powder is taken, 30-90% ethyl alcohol heat mentions 1-2 hours at 30-90 DEG C, pours out extracting solution, and the dregs of a decoction extract again
1-2 hours；Merge concentrated extracting solution to no alcohol, obtains extract of soybean；Extract of soybean adds suitable quantity of water, uses 5- after resin adsorption
The elution of 20 times of volume pure water, then with 5-10 times of volume 45-80% ethanol elution, collect ethanol eluate, be concentrated to dryness to obtain soybean
Extract.Preferably, the resin adsorption is that upper AB-8 resin column does Dynamic Adsorption, and flow velocity slows down as far as possible, and what is flow down is molten
Liquid is still added on column and is adsorbed, and carries out 1-4 hour.
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 15
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 8 parts of tea extract,
1 part of L-carnitine, fatty acid α -8 parts of hydroxylase, 2 parts of deoxycholic aicd；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 16
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 10 parts of tea extract,
7 parts of L-carnitine, 10 parts of acylcoenzyme a synthase, 2 parts of ferulic acid；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 17
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 12 parts of tea extract,
9 parts of L-carnitine, 12 parts of fatty acyl-CoA dehydrogenase, 2 parts of vitamin E；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 18
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 14 parts of tea extract,
10 parts of L-carnitine, 14 parts of enoyl-CoA hydratase, 5 parts of albumin；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 19
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 16 parts of tea extract,
12 parts of L-carnitine, carnitine -16 parts of acyltransferase I, 10 parts of coacetylase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 20
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 18 parts of tea extract,
15 parts of L-carnitine, 18 parts of hormone-sensitive lipase, 10 parts of glutathione reductase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 21
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 20 parts of tea extract,
18 parts of L-carnitine, 20 parts of Hydroxymethylglutaryl monoacyl coacetylase, 10 parts of citrate synthase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 22
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 10 parts of tea extract,
20 parts of L-carnitine, 10 parts of thiolase, 10 parts of aconitase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 23
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 8 parts of tea extract,
1 part of L-carnitine, fatty acid α -8 parts of hydroxylase, 2 parts of isocitric dehydrogenase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 24
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 10 parts of tea extract,
7 parts of L-carnitine, 10 parts of acylcoenzyme a synthase, 2 parts of succinic thiokinase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 25
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 12 parts of tea extract,
9 parts of L-carnitine, 12 parts of fatty acyl-CoA dehydrogenase, 2 parts of succinate dehydrogenase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 26
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 14 parts of tea extract,
10 parts of L-carnitine, 14 parts of enoyl-CoA hydratase, 5 parts of fumarase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 27
A kind of cosmetic complex containing tea extract, includes the following parts by weight: 14 parts of tea extract,
10 parts of L-carnitine, 14 parts of enoyl-CoA hydratase, 5 parts of malic dehydrogenase；
The preparation method is the same as that of Example 1 for the tea extract, and wherein the mass percentage content of tea polyphenols is not less than
10%, the mass percentage content of caffeine is not less than 3%.
Embodiment 28: cosmetic complex of the invention tests the influence that mouse weight changes
Experimental method
1.1 animal
NOD obesity mice 24 (Nanjing model animal center), female, weight 35-40g.
1.2 zooperies grouping
45g is increased to mouse weight, random point 3 groups, administration application:
1, French import fat melting needle group (dosage 0.1ml/ times), brand Cellulyse, specification 10ml/ branch.
2, Switzerland's import fat melting needle brand SWISS HEHL group (dosage 0.1ml/ times), specification 10ml/ branch.
3,1 compound group (dosage 0.1mg/ times) of embodiment, every 10ml/ branch.It is all made of subcutaneous layer of fat to inject, first
After secondary injection, interval second of continuous injection for 24 hours, interval injects third time, completes to inject three times in one week after 48 hours.Daily
Changes of weight is observed and recorded, every group of mouse weight average value mapping (p < 0.05) is taken.
1.3 observation indexs: changes of weight is observed in weighing
As a result as shown in Figure 1, after this cosmetics of obesity mice, compared with fat melting needle group 1, example 1 group closes object group body
It significantly reduces again, and fall is faster (p < 0.05).Even if weight loss amplitude and rebound are strong compared with fat melting needle group 2
There were significant differences (p < 0.05) for degree, shows that example 1 group closes object and can obtain the effect of clearly fat reducing.
Embodiment 29: the fat melting activity of cosmetic complex of the invention
Experimental method
1.1 cell
People's Primary adipocyte
The grouping of 1.2 cell experiments
1640 groups of 1.RPMI of group
Group 2. same kind of products at abroad groups (French import fat melting needle (dosage 0.1ml/ times), brand Cellulyse, specification
10ml/ branch, solvent are physiological saline)
Group 3. same kind of products at abroad groups (Switzerland's import fat melting needle (dosage 0.1ml/ times), brand SWISSHEHL group, specification
10ml/ branch, solvent are physiological saline)
Group 4. solvent groups (solvent is physiological saline)
5. example 1 groups of group close object group
The density bed board that people's Primary adipocyte is pressed to about 8500/ hole, after 12 hours it is adherent securely after, by dividing 5 above
Group is loaded, every group of 3 multiple holes, after culture 48 hours, carries out oil red O stain to cell, observation cellular morphology changes, and use is different
Cell after propyl alcohol processing dyeing, absorbance (A) value is measured under 490nm wavelength, will organize 1 (A) value as a control group, is calculated
Opposite fat content in fat cell.
1.3 experiment in vitro detect 1 compound of embodiment to fat melting effect fatty in fat cell.
As a result as shown in Fig. 2, example 1 group is closed after object group makees employment Primary adipocyte 48h, with fat melting needle (France into
Mouth fat melting needle (dosage 0.1ml/ times), brand Cellulyse, specification 10ml/ branch) compare, fat cell is obviously reduced, and fat contains
Amount significantly reduces, and fall is faster (p < 0.05).Even if with same kind of products at abroad group (Switzerland's import fat melting needle brand
SWISS HEHL group (dosage 0.1ml/ times), specification 10ml/ branch) compare, fatty fall has significance difference in fat cell
Different (p < 0.05) shows that example 1 group closes object group in vitro to fat cell obviously fat melting effect.
Embodiment 30: the toxicity test of cosmetic complex of the invention to normal cell
Experimental method
1.1 cell
The primary skin epithelial cell of people
1.2 we by example 1 group close object be added in vitro culture primary skin epithelial cell, culture 48 hours after, use
CCK8 method detects the vigor of cell, and group 1 is culture medium RPMI1640 control group；Group 2 is 1 compound group of embodiment.
As a result as shown in figure 3, example 1 group closes the cell survival rate of object group compared with the control group, cell there are no bright
Aobvious toxicity (p > 0.05)；The component for illustrating cosmetic composition of the invention is safely and effectively.
Embodiment 31: cosmetic complex of the invention eliminates the clinical test of eye pouch
30 subjects are randomly selected, are taken pictures before experience by claimed below, it is multiple then to smear cosmetics of the invention
Object is closed at face and eye pouch, probe is imported using corresponding ultrasound, acts on 30-60min near face and eye pouch, each two
It is primary, totally 3 times it is as a treatment course, a course for the treatment of is taken pictures in 3 days by claimed below after terminating, while being carried out profession and being commented
Estimate (appraisal procedure is as follows).
Eye pouch evaluation method: being practised physiognomy data using the face that plane photographing method obtains subject first, is tracked follow-up 1 year,
A photograph acquisition is carried out at quarterly intervals, seeks subject A, the average value of B and C line respectively every time.
The first, plane photographing method obtains client's face picture information
(1) measuring tool: stainless steel graduated scale (accuracy 1mm), digital camera (Canon) commanding lens select camera lens EF-
S18-135mm Macro 0.45m/1.5ft；
(2) plane photographing mensuration: the fixed stool in selection position, liftoff 40cm, using green cotton as background.It advises tested
Person sits up straight, and loosens limbs, guarantees that eye-ear plane is parallel to the ground.Tripod is fixed, and camera is fixed on tripod, adjusts cloud
Object distance is fixed as 180cm to level by platform, and the pupil middle line of camera lens center alignment people is hung down sagittal line intersection point in, root
According to the sitting height swinging handle up and down adjustment camera of people, guarantee that optical center and bilateral interpupillary line are located at sustained height, at this time institute
The photograph obtained is in Frankfurt plane, and (the holographic scraping cooperation of Liu Tao face can adopt Chinese herb medicine eye pad pasting treatment eye pouch clinical observation
Master's thesis .2010.4).Focal length is fixed as 135mm, assistant is smooth in measured's forehead by a stainless steel graduated scale, makes
Its with people --- camera lens straight line is vertical.Everything in readiness advises measurement object to earn camera lens at eye level naturally forward, continuously takes pictures 2
?.Verification photo quality at once, if it find that following situations: 1) head is shaken, and mirror image is fuzzy；2) interpupillary line is not located at level
On line or line midpoint is not overlapped with radiography center；3) eyes do not look squarely front, and the mimetic muscles such as orbicularis are shunk, and influence lower eyelid survey
Measure data；4) other possible unsatisfied situations, (Xie Juan is used under esthetic analysis software evaluation with Communication with Customer retake immediately
Jaw angle osteotomy face plastic operation effect [J] Medical University Of Anhui journal, 2006, (5) 576-578)；
After the completion of all photograph, with Image-Pro Plus 7.0, (U.S. Media Cybernetics is public for qualified photograph
Department)) it measures, using the calibration function carry out activity calibration of software, (every photograph is with background high scale ruler visual
50.0mm is a unit carry out activity calibration), mark each measurement point, connection measurement line.Each index is surveyed twice, because of scale
Minimum scale be 1mm, according to surveying principle, software measurement result reading be accurate to 0.1mm.
The second, measurement result is analyzed, and obtains A, B and C line number value (Wu Xiaoshan Normal Occlusion of Han People Young Adults lower eyelid soft tissue
Measuring study [D] the Central South University of normal anatomical structures, 2008)
Using three data below measuring as efficacy determination:
A. pupil center's point to eye pouch minimum point vertical range；B. pupil adjoins line midpoint hanging down to eye pouch edge to intraocular
Straight distance；C. adjoin the vertical range at line midpoint to eye pouch edge outside pupil to eye.
It is invalid: before and after treatment, with experience before photograph comparison indifference and through test, A, B, tri- value of C≤2mm；
Improve: before and after treatment, with experience before photograph comparison slight difference and through test, A, B, tri- value of C be all satisfied 2mm≤
A, B, C≤4mm；
It is effective: before and after treatment, to have more significant difference with photograph comparison before experience and pass through and test, A, B, tri- value of C are all satisfied
Tri- value of 4mm≤A, B, C≤6mm；
It fully recovers: before and after treatment, having marked difference with photograph comparison before experience and pass through and test, A, B, tri- value of C are all satisfied 6mm
≤ A, B, C, eye pouch disappear substantially.
Third, result
It is shown in Table 1, table 1 is 1 year by a definite date clinical testing data of the present invention.
Table 1
A, B or C value in table is average value of 30 subjects in same time period.
Cosmetic complex of the invention has the function of significantly eliminating eye pouch it can be seen from 1 data of table.
Embodiment 32: the cosmetic complex of the invention clinical test compact for skin of face
One exists for 30 tested experiencers's (smearing cosmetic composition of the invention in face, every three days once)
Random, the compact moulding effect stability Journal of Sex Research experiment of double blind being unfolded in 1 year follow-up period:
Referring to the appraisal procedure that " Chinese aesthetic medicine " is set is published within 2000, (Yang Ping thanks to the red thin face of channels and collaterals weight reducing apparatus
220 clinical observation " Chinese aesthetic medicine " the 5th phase of volume 9,339) facial 2 line lengths: A line, are measured: from auris dextra exterior feature with
The highest point of face connection crosses minimum point in the middle part of lower jaw through mandibular edge, is symmetric to the degree of enclosing of left auricle highest point；B line: from
Auris dextra exterior feature and the minimum point of face connection are symmetric to the degree of enclosing of left auricle minimum point across the midpoint of nasolabial groove；With A, B two
The compact moulding effect variation of face is measured in the variation of line length summation.
Experimental result is as shown in figure 4, illustrate the work that cosmetic composition of the invention has significant skin of face compact
With.
The preferred embodiment of the present invention has been described in detail above, but the invention be not limited to it is described
Embodiment, those skilled in the art can also make various equivalent on the premise of not violating the inventive spirit of the present invention
Variation or replacement, these equivalent variation or replacement are all included in the scope defined by the claims of the present application.
Claims (24)
1. a kind of cosmetic complex containing tea extract, which is characterized in that comprise the following components in parts by weight: tealeaves mentions
1-200 parts of object are taken, 1-200 parts of L-carnitine, 1-200 parts of lipid metaboli relevant enzyme；The tea extract, wherein tea polyphenols
Mass percentage content is not less than 3% not less than the mass percentage content of 10%, caffeine.
2. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that the tealeaves mentions
Object is taken, wherein the mass percentage content of tea polyphenols is 1-20%, the mass percentage content of caffeine is 1-10%.
3. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that the lipid metaboli
Relevant enzyme is selected from: glycerokinase, glycerol-3-phosphate dehydrogenase, fatty acid α-hydroxylase, hepatic lipase, acylcoenzyme a synthase, rouge
Acyl coenzyme A dehydrogenase, enoyl-CoA hydratase, carnitine-acyltransferase I, hormone-sensitive lipase, Hydroxymethylglutaryl list acyl
One or more of base coacetylase, thiolase.
4. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include citric acid
2-10 parts.
5. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include herba lysimachiae
2-10 parts of extract；The Herba Lysimachiae extract, wherein flavonoids mass percentage content is 20-30%, choline quality hundred
It point be 5-10%, cAMP mass percentage content than content is 5-10%.
6. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include that soybean mentions
Take 2-10 parts of object；The extract of soybean, wherein the mass percentage content of phosphatidyl choline is not less than 20%.
7. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include deoxidation gallbladder
It is 2-10 parts sour.
8. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include ferulic acid
2-10 parts.
9. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include vitamin
2-10 parts of E.
10. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include clear egg
It is 2-10 parts white.
11. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include coenzyme
A2-10 parts.
12. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include paddy Guang
Sweet fabk polypeptide 2-10 parts.
13. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include lemon
2-10 parts of acid synthase.
14. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include the rhizome of Chinese monkshood
Sour enzyme 2-10 parts.
15. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include different lemon
2-10 parts of lemon acidohydrogenase.
16. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include amber
2-10 parts of acyl-CoA synthetase.
17. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include amber
2-10 parts of acidohydrogenase.
18. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include prolonging recklessly
2-10 parts of rope acid enzyme.
19. the cosmetic complex according to claim 1 containing tea extract, which is characterized in that further include apple
2-10 parts of acidohydrogenase.
20. a kind of cosmetic complex for containing tea extract using as described in claim 1-19 is any is as active constituent
Face import preparation.
21. face according to claim 20 imports preparation, which is characterized in that the described face import preparation be liniment,
Paint, liniment, gelling agent, freeze dried injection.
22. a kind of cosmetic complex containing tea extract as described in claim 1-19 is any reduces face in preparation
Application in the cosmetics of fat deposition.
23. a kind of eliminate eye in preparation such as the described in any item cosmetic complexes containing tea extract of claim 1-19
Application in the cosmetics of bag.
24. a kind of as the described in any item cosmetic complexes containing tea extract of claim 1-19 are preparing facial skin
Application in the compact cosmetics of skin.
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| CN201810258330.9A CN110302105A (en) | 2018-03-27 | 2018-03-27 | For facial fat degradation and compact technology and its application |
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ID=68074146
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021056248A1 (en) * | 2019-09-25 | 2021-04-01 | 上海同柏生物科技有限公司 | Technology for facial fat degradation and firming and application of technology |
| CN114404577A (en) * | 2022-03-04 | 2022-04-29 | 北京同柏宸科生物技术开发有限公司 | External composition for promoting degradation of triglyceride in fat cells and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004217583A (en) * | 2003-01-16 | 2004-08-05 | Naris Cosmetics Co Ltd | Skin care preparation for external use for weight reduction |
| CN101904946A (en) * | 2010-07-01 | 2010-12-08 | 成都美羽化妆品有限公司 | Full-effect tea-lavender fat-suppression formulation with natural activity |
| CN104586663A (en) * | 2013-10-31 | 2015-05-06 | 广州市纳爱生物科技有限公司 | Bodybuilding weight-reducing cream |
| CN105997611A (en) * | 2016-05-15 | 2016-10-12 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with bodybuilding and slimmingfunctions |
-
2018
- 2018-03-27 CN CN201810258330.9A patent/CN110302105A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004217583A (en) * | 2003-01-16 | 2004-08-05 | Naris Cosmetics Co Ltd | Skin care preparation for external use for weight reduction |
| CN101904946A (en) * | 2010-07-01 | 2010-12-08 | 成都美羽化妆品有限公司 | Full-effect tea-lavender fat-suppression formulation with natural activity |
| CN104586663A (en) * | 2013-10-31 | 2015-05-06 | 广州市纳爱生物科技有限公司 | Bodybuilding weight-reducing cream |
| CN105997611A (en) * | 2016-05-15 | 2016-10-12 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with bodybuilding and slimmingfunctions |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021056248A1 (en) * | 2019-09-25 | 2021-04-01 | 上海同柏生物科技有限公司 | Technology for facial fat degradation and firming and application of technology |
| CN114404577A (en) * | 2022-03-04 | 2022-04-29 | 北京同柏宸科生物技术开发有限公司 | External composition for promoting degradation of triglyceride in fat cells and preparation method and application thereof |
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