CN110302065A - A kind of whitening strips and its preparation process containing photocatalyst - Google Patents
A kind of whitening strips and its preparation process containing photocatalyst Download PDFInfo
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- CN110302065A CN110302065A CN201910763871.1A CN201910763871A CN110302065A CN 110302065 A CN110302065 A CN 110302065A CN 201910763871 A CN201910763871 A CN 201910763871A CN 110302065 A CN110302065 A CN 110302065A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to a kind of whitening strips and its preparation process containing photocatalyst, belong to oral care product technical field.For solve the problems, such as existing whitening strips using peroxide easily cause sensitivity of tooth, whitening effect are uneven, persistence is poor, it is inconvenient to use and packaging not environmentally, the present invention provides a kind of whitening strips containing photocatalyst, component includes nano-titanium dioxide, bioactivity glass, -20 octadecyl alcolol ether methacrylate ester copolymer of acrylate/polyoxyethylene, gelling agent and moisturizer.The present invention plays whitening function by photocatalyst of nano-titanium dioxide；Bioactivity glass plays a part of to highlight creamy white；Nano-titanium dioxide can be adsorbed in dental surface with bioactivity glass, generate and continue whitening effect；The two is dispersed in gel-type vehicle, reaches uniform whitening effect.Whitening strips are prepared into web-like by the present invention, and when use can arbitrarily cut, and packed using reusable Self-enclosing zippered bag, reduce packing cost, more environmentally friendly.
Description
Technical field
The invention belongs to oral care product technical field more particularly to a kind of whitening strips and its preparation containing photocatalyst
Technique.
Background technique
With the improvement of people ' s living standards with the popularization of mouth disease precautionary measures, modern oral care is more and more
It is related to the dental requirements of aesthetics, especially tooth whitening has obtained widely available at home.
The method of tooth whitening essentially only there are two types of, one is chemical bleaching, another kind be cover whitening.Chemistry drift
It is white mainly include cold light whitening, the whitening of denture fixing device formula, tooth T-me it is white, containing gargling whitening, seal the side such as medicine whitening, ultrasonic wave toothwash in tooth
Formula.Wherein, the whitening of denture fixing device formula and tooth T-me it is white be current most popular family's whitening mode, tooth T-me is white more convenient, more
Generally, and price is compared for the whitening of denture fixing device formula, also considerably cheaper.
The whitening agent in whitening strips is mainly peroxide at present, and such as hydrogen peroxide, urea peroxide, other compositions include
Gelatinizing agent, moisturizer, desensitizer, sweetener, aromatic, pH adjusting agent etc..Its application method is to remove anti-stick layer, will contain beauty
White dose of gel layer is attached at facing -2 hours 0.5 hour, 1-2 times daily, is used continuously one week.
The existing generally existing following problem of whitening strips: 1, often there is sensitivity of tooth, tooth in high concentration peroxide
Tooth embrittlement, gum pain or has a hickie, the symptoms such as mucous membrane discoloration, though low concentration of peroxide safety coefficient increases, the whitening time
Long and effect is bad；2, when tooth is attached at facing, due to tooth patch size and Tooth Size mismatches or compactness problem, causes
Facing whitening is uneven；3, inconvenient to use, it needs to take back sheet off after use, and cleaning of brushing teeth is adhered to the surplus of facing or gum
Remaining gel；4, peroxide is unstable, easily decomposes and is lost, just obvious using rear effect, but lasting effects are poor；5, due to peroxidating
Each patch or upper lower tooth are usually used independent sealed package to patch, cause packaging material mistake by the unstability of object, whitening strips
More, production cost is expensive, and not environmentally.
Summary of the invention
For solve existing whitening strips using peroxide easily cause sensitivity of tooth, whitening effect are uneven, persistence is poor,
It is inconvenient to use and packaging not environmentally the problem of, the present invention provides a kind of whitening strips and its preparation process containing photocatalyst.
Technical solution of the present invention:
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%-
20%, bioactivity glass 1%-10%, -20 octadecyl alcolol ether methacrylate ester copolymer 1%- of acrylate/polyoxyethylene
10%, gelling agent 45%-85% and moisturizer 5%~20%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%~
15%, bioactivity glass 3%~8%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene~
8%, gelling agent 55%~75% and moisturizer 10%~18%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%-
12%, bioactivity glass 5%-7%, -20 octadecyl alcolol ether methacrylate ester copolymer 5%- of acrylate/polyoxyethylene
7%, gelling agent 60%-70% and moisturizer 12%~15%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 10%, life
Object activity glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, 72% and of gelling agent
Moisturizer 8%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%-
20%, bioactivity glass 1%-10%, -20 octadecyl alcolol ether methacrylate ester copolymer 1%- of acrylate/polyoxyethylene
10%, gelling agent 45%-85%, moisturizer 5%~20% and aromatic 0.1%~2%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%~
15%, bioactivity glass 3%~8%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene~
8%, gelling agent 55%~75%, moisturizer 10%~18% and aromatic 0.5%~1.5%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%-
12%, bioactivity glass 5%-7%, -20 octadecyl alcolol ether methacrylate ester copolymer 5%- of acrylate/polyoxyethylene
7%, gelling agent 60%-70%, moisturizer 12%~15% and aromatic 0.8%~1.2%.
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 10%, life
Object activity glass 5%, gelling agent 71%, is protected -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene
Humectant 8% and aromatic 1%.
Further, the nano-titanium dioxide is anatase crystal nano titanium dioxide powder, and titanium dioxide partial size is
15~30nm.
Further, the bioactivity glass the preparation method comprises the following steps: by SiO2、CaO、K2O、P2O5、CaF2And Na2O is pressed
Weight ratio be 42:21:14:3:12:15 be uniformly mixed be placed at 1550 DEG C melt 50min obtain uniform mixture, by institute
Stating mixture and being placed in room temperature water-bath makes its quenching, and it is bioactivity that the particle that partial size is 50~100nm is ground to after drying
Glass.
Further, the gelling agent is polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethoxy
The combination of one or more of cellulose, carbomer or carmethose.
Further, the moisturizer is the combination of one or more of glycerol, propylene glycol or polyethylene glycol.
Further, the aromatic is green lemon Mint Essence, Chinese ilex Mint Essence, Green tea essence, milk flavour, green apple
The combination of fruity essence or one or more of strawberry essence.
A kind of preparation method of the whitening strips provided by the invention containing photocatalyst, includes the following steps:
Step 1: gelling agent is dissolved in solvent, -20 octadecyl alcolol ether methacrylate of acrylate/polyoxyethylene is added
Ester copolymer is stirred to the gel at homogeneous transparent, is sequentially added remaining components and is stirred evenly, and obtains whitening after draining bubble
Gel is stand-by；
Step 2: pasting back sheet by tooth of polyolefin material, the one side of polyolefin backing carries out release treatment, and another side applies
Cloth whitening gelatin；Using roll-to-roll coating machine, whitening gelatin obtained by step 1 is uniformly coated on coiled without anti-sticking function
On polyolefin backing surface layer, the solvent in whitening gelatin is volatilized by dry track, the coating machine other end be recycled to get
Whitening strips containing photocatalyst.
Further, solvent described in step 1 is the ethyl alcohol of pure water or any mass percentage；The speed of agitator is
50 revs/min.
Further, the long 0.5~5m of dry track described in step 2, drying temperature are 20~70 DEG C, and gained contains photocatalyst
Whitening strips wide 0.5~2cm, the long 0.5~2m of every volume, tooth stick whitening gelatin with a thickness of 100-300 μm.
The application method of whitening strips provided by the invention containing photocatalyst are as follows: according to Tooth Size from coiled tooth when use
The tooth patch for cutting out suitable size is sticked, whitening gelatin is pasted on dental surface on one side, is sticked whitening tooth after 0.5~1h every time
Patch is removed.
Beneficial effects of the present invention:
Whitening strips provided by the invention pass through the freedom of photocatalyst effect generation using Nano titanium dioxide as photocatalyst
Hydroxy and active oxygen are attached to the various coloring materials of dental surface to decompose, remove, and reach whitening effect.The present invention uses
Photocatalyst beautifying and whitening agent not damage tooth, stimulation gum, safe without toxic side effect during tooth-whitening.Whitening strips simultaneously
In bioactivity glass and enamel have good biocompatibility, the fine cracks of dental surface can be repaired, played
The effect for highlighting creamy white, makes tooth have more gloss.Nano-titanium dioxide in tooth patch can be adsorbed in tooth with bioactivity glass
Tooth surface generates the effect for continuing whitening.
Present invention thickener used in tooth patch is -20 octadecyl alcolol ether methacrylate ester of acrylate/polyoxyethylene
Copolymer, the substance can make tooth patch have stronger adhesiveness, can keep the state for being attached at dental surface for a long time,
To ensure that photocatalyst and bioactivity glass preferably act on tooth.- 20 octadecyl alcolol ether methyl-prop of acrylate/polyoxyethylene
Diluted acid ester copolymer and nano-titanium dioxide are able to extend nano-titanium dioxide in tooth by Covalent bonding together formation compound
The residence time on surface, and there is very high suspension stability, nano-titanium dioxide and bioactivity glass can be made uniformly to divide
It dissipates in gel-type vehicle, achievees the effect that uniform whitening.
Web-like is made in whitening strips by the present invention, can arbitrarily be cut when in use, particular for the non-uniform crowd of creamy white,
It can be cut into required shape as needed and carry out local whitening, from when dental surface removal after use, be not easy to remain gel, use
It is convenient.A roll of tooth patch uses for 1 people or more people, is packed using reusable Self-enclosing zippered bag, reduces packing cost,
It is more environmentally friendly.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%-
20%, bioactivity glass 1%-10%, -20 octadecyl alcolol ether methacrylate ester copolymer 1%- of acrylate/polyoxyethylene
10%, gelling agent 45%-85% and moisturizer 5%~20%.
Embodiment 2
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%~
15%, bioactivity glass 3%~8%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene~
8%, gelling agent 55%~75% and moisturizer 10%~18%.
Embodiment 3
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%-
12%, bioactivity glass 5%-7%, -20 octadecyl alcolol ether methacrylate ester copolymer 5%- of acrylate/polyoxyethylene
7%, gelling agent 60%-70% and moisturizer 12%~15%.
Embodiment 4
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 10%, life
Object activity glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, 72% and of gelling agent
Moisturizer 8%.
Embodiment 5
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%-
20%, bioactivity glass 1%-10%, -20 octadecyl alcolol ether methacrylate ester copolymer 1%- of acrylate/polyoxyethylene
10%, gelling agent 45%-85%, moisturizer 5%~20% and aromatic 0.1%~2%.
Embodiment 6
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%~
15%, bioactivity glass 3%~8%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene~
8%, gelling agent 55%~75%, moisturizer 10%~18% and aromatic 0.5%~1.5%.
Embodiment 7
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%-
12%, bioactivity glass 5%-7%, -20 octadecyl alcolol ether methacrylate ester copolymer 5%- of acrylate/polyoxyethylene
7%, gelling agent 60%-70%, moisturizer 12%~15% and aromatic 0.8%~1.2%.
Embodiment 8
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 10%, life
Object activity glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, polyvinylpyrrolidine
Ketone 71%, glycerol 8% and green apple essence 1%.
Embodiment 9
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%, life
Object activity glass 1%, -20 octadecyl alcolol ether methacrylate ester copolymer 1% of acrylate/polyoxyethylene, polyvinylpyrrolidine
Ketone 85% and glycerol 12%.
Embodiment 10
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 1%, life
Object activity glass 1%, -20 octadecyl alcolol ether methacrylate ester copolymer 1% of acrylate/polyoxyethylene, polyvinylpyrrolidine
Ketone 84.9%, glycerol 12% and green lemon Mint Essence 0.1%.
Embodiment 11
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 4%, life
Object activity glass 2%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene, polyvinylpyrrolidine
Ketone 85% and glycerol 6%.
Embodiment 12
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 4%, life
Object activity glass 2%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene, polyvinylpyrrolidine
Ketone 84.9%, glycerol 6% and green lemon Mint Essence 0.1%.
Embodiment 13
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%, life
Object activity glass 3%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene, hydroxypropyl methylcellulose
71% and propylene glycol 18%.
Embodiment 14
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 5%, life
Object activity glass 3%, -20 octadecyl alcolol ether methacrylate ester copolymer 3% of acrylate/polyoxyethylene, hydroxypropyl methylcellulose
70.5%, propylene glycol 18% and Chinese ilex Mint Essence 0.5%.
Embodiment 15
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 8%, life
Object activity glass 4%, -20 octadecyl alcolol ether methacrylate ester copolymer 4% of acrylate/polyoxyethylene, hydroxypropyl methylcellulose
79% and propylene glycol 5%.
Embodiment 16
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 8%, life
Object activity glass 4%, -20 octadecyl alcolol ether methacrylate ester copolymer 4% of acrylate/polyoxyethylene, hydroxypropyl methylcellulose
78.5%, propylene glycol 5% and Chinese ilex Mint Essence 0.5%.
Embodiment 17
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%, life
Object activity glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, hydroxypropyl cellulose
73% and polyethylene glycol 10%.
Embodiment 18
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 7%, life
Object activity glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, hydroxypropyl cellulose
72%, polyethylene glycol 10% and Green tea essence 1%.
Embodiment 19
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 12%, life
Object activity glass 7%, -20 octadecyl alcolol ether methacrylate ester copolymer 7% of acrylate/polyoxyethylene, hydroxypropyl cellulose
59% and polyethylene glycol 15%.
Embodiment 20
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 12%, life
Object activity glass 7%, -20 octadecyl alcolol ether methacrylate ester copolymer 7% of acrylate/polyoxyethylene, hydroxypropyl cellulose
58%, polyethylene glycol 15% and Green tea essence 1%.
Embodiment 21
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 15%, life
Object activity glass 9%, -20 octadecyl alcolol ether methacrylate ester copolymer 9% of acrylate/polyoxyethylene, hydroxyethyl cellulose
47%, glycerol 10% and propylene glycol 10%.
Embodiment 22
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 15%, life
Object activity glass 9%, -20 octadecyl alcolol ether methacrylate ester copolymer 9% of acrylate/polyoxyethylene, hydroxyethyl cellulose
45.5%, glycerol 10%, propylene glycol 10% and milk flavour 1.5%.
Embodiment 23
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 16%, life
Object activity glass 8%, -20 octadecyl alcolol ether methacrylate ester copolymer 8% of acrylate/polyoxyethylene, hydroxyethyl cellulose
53%, glycerol 10% and propylene glycol 5%.
Embodiment 24
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 16%, life
Object activity glass 8%, -20 octadecyl alcolol ether methacrylate ester copolymer 8% of acrylate/polyoxyethylene, hydroxyethyl cellulose
51.5%, glycerol 10%, propylene glycol 5% and milk flavour 1.5%.
Embodiment 25
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 18%, life
Object activity glass 6%, carbomer 58%, gathers -20 octadecyl alcolol ether methacrylate ester copolymer 6% of acrylate/polyoxyethylene
Ethylene glycol 6% and propylene glycol 6%.
Embodiment 26
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 18%, life
Object activity glass 6%, carbomer 56%, gathers -20 octadecyl alcolol ether methacrylate ester copolymer 6% of acrylate/polyoxyethylene
Ethylene glycol 6%, propylene glycol 6% and green apple essence 2%.
Embodiment 27
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 20%, life
Object activity glass 10%, -20 octadecyl alcolol ether methacrylate ester copolymer 10% of acrylate/polyoxyethylene, carbomer 52%,
Polyethylene glycol 4% and propylene glycol 4%.
Embodiment 28
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 20%, life
Object activity glass 10%, -20 octadecyl alcolol ether methacrylate ester copolymer 10% of acrylate/polyoxyethylene, carbomer 50%,
Polyethylene glycol 4%, propylene glycol 4% and green apple essence 2%.
Embodiment 29
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 11%, life
Object activity glass 8%, -20 octadecyl alcolol ether methacrylate ester copolymer 8% of acrylate/polyoxyethylene, carmethose
62%, glycerol 3%, polyethylene glycol 4% and propylene glycol 4%.
Embodiment 30
A kind of whitening strips containing photocatalyst, the component including following mass percentage: nano-titanium dioxide 11%, life
Object activity glass 8%, -20 octadecyl alcolol ether methacrylate ester copolymer 8% of acrylate/polyoxyethylene, carmethose
60.8%, glycerol 3%, polyethylene glycol 4%, propylene glycol 4% and strawberry essence 1.2%.
Embodiment 31
The preparation method for present embodiments providing a kind of whitening strips containing photocatalyst, includes the following steps:
Step 1: gelling agent is dissolved in solvent, -20 octadecyl alcolol ether methacrylate of acrylate/polyoxyethylene is added
Ester copolymer is stirred to the gel at homogeneous transparent, is sequentially added remaining components and is stirred evenly, and obtains whitening after draining bubble
Gel is stand-by；
Step 2: whitening gelatin obtained by step 1 is uniformly coated on coiled without anti-sticking function using roll-to-roll coating machine
On the polyolefin backing surface layer of energy, the solvent in whitening gelatin is volatilized by dry track, is recycled in the coating machine other end,
Up to the whitening strips containing photocatalyst.
Embodiment 32
The present embodiment is the preparation method for the whitening strips containing photocatalyst that embodiment 1- embodiment 30 provides, including as follows
Step:
Step 1: gelling agent is dissolved in the ethyl alcohol of pure water or any mass percentage, acrylate/polyoxy second is added
- 20 octadecyl alcolol ether methacrylate ester copolymer of alkene is stirred to the gel at homogeneous transparent, sequentially adds remaining components and to turn
50 revs/min of speed stirs evenly, and drains that obtain whitening gelatin after bubble stand-by；
Step 2: whitening gelatin obtained by step 1 is uniformly coated on coiled without anti-sticking function using roll-to-roll coating machine
On the polyolefin backing surface layer of energy, the dry track that by track length be 0.5~5m, drying temperature is 20~70 DEG C volatilizes beauty
Pure water or ethyl alcohol in white gel are recycled in the coating machine other end to get the whitening strips containing photocatalyst, and gained is touched containing light
The whitening strips of matchmaker wide 0.5~2cm, the long 0.5~2m of every volume, tooth stick whitening gelatin with a thickness of 100-300 μm.
Comparative example 1
This comparative example provides a kind of tooth patch without photocatalyst, and the component including following mass percentage: biology is living
Property glass 5%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, polyvinylpyrrolidone
81%, glycerol 8% and green apple essence 1%.
The preparation method comprises the following steps: polyvinylpyrrolidone is dissolved in pure water, -20 octadecyl alcolol of acrylate/polyoxyethylene is added
Ether methacrylate ester copolymer is stirred to the gel for being in homogeneous transparent；Sequentially add glycerol, bioactivity glass and green apple
Essence stirs evenly, and drains that obtain gel after bubble stand-by；Using roll-to-roll coating machine, gained gel is uniformly coated on into
On the polyolefin backing surface layer without anti-sticking function of volume, waved by 0.5~5m long, the dry track that drying temperature is 20~70 DEG C
Water in xerogel is recycled in the coating machine other end, obtains tooth patch.
Comparative example 2
This comparative example provides a kind of tooth patch without bioactivity glass, the component including following mass percentage:
Nano-titanium dioxide 10%, -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, polyvinyl pyrrole
Alkanone 75%, glycerol 9% and green apple essence 1%.
The preparation method comprises the following steps: polyvinylpyrrolidone is dissolved in pure water, -20 octadecyl alcolol of acrylate/polyoxyethylene is added
Ether methacrylate ester copolymer is stirred to the gel for being in homogeneous transparent；Sequentially add glycerol, nano-titanium dioxide and green apple
Essence stirs evenly, and drains that obtain gel after bubble stand-by；Using roll-to-roll coating machine, gained gel is uniformly coated on into
On the polyolefin backing surface layer without anti-sticking function of volume, waved by 0.5~5m long, the dry track that drying temperature is 20~70 DEG C
Water in xerogel is recycled in the coating machine other end, obtains tooth patch.
Comparative example 3
This comparative example provides a kind of without the tooth of photocatalyst and bioactivity glass patch, including following mass percentage
Component: -20 octadecyl alcolol ether methacrylate ester copolymer 5% of acrylate/polyoxyethylene, polyvinylpyrrolidone 85%,
Glycerol 9% and green apple essence 1%.
The preparation method comprises the following steps: polyvinylpyrrolidone is dissolved in pure water, -20 octadecyl alcolol of acrylate/polyoxyethylene is added
Ether methacrylate ester copolymer is stirred to the gel for being in homogeneous transparent；Glycerol and green apple essence is added, stirs evenly, drains
It is stand-by that gel is obtained after bubble；Using roll-to-roll coating machine, gained gel is uniformly coated on coiled poly- without anti-sticking function
On alkene backing surface layer, the water in gel is volatilized by 0.5~5m long, the dry track that drying temperature is 20~70 DEG C, is being applied
The cloth machine other end is recycled, and obtains tooth patch.
Comparative example 4
This comparative example provides a kind of without -20 octadecyl alcolol ether methacrylate ester copolymer of acrylate/polyoxyethylene
Tooth patch, the component including following mass percentage: nano-titanium dioxide 10%, bioactivity glass 5%, polyvinyl pyrrole
Alkanone 76%, glycerol 8% and green apple essence 1%.
It stirs the preparation method comprises the following steps: polyvinylpyrrolidone is dissolved in pure water to the gel for being in homogeneous transparent；It sequentially adds
Glycerol, nano-titanium dioxide, bioactivity glass and green apple essence, stir evenly, and drain that obtain gel after bubble stand-by；It adopts
With roll-to-roll coating machine, gained gel is uniformly coated on the coiled polyolefin backing surface layer without anti-sticking function, passes through 0.5
~5m long, the dry track that drying temperature is 20~70 DEG C volatilize the water in gel, are recycled, obtain in the coating machine other end
Tooth patch.
Comparative example 5
This comparative example method according to disclosed in 103826595 B embodiment 1 of Chinese patent CN is prepared for a kind of urea peroxide
Whitening strips include the component of following mass percentage: hydroxypropyl methyl cellulose (HPMC) 59%, polyvinyl acetate in film
Ester (PVAc) 30%, carbomer (971) 5%, propylene glycol 5%, titanium dioxide 1% amount to 100%.Bleaching
Ingredient in particle be urea peroxide 100%,
The whitening effect verification test of whitening strips provided by the invention containing photocatalyst is as follows:
(1) test method:
Subject 300, male 98, women 202, the age 18-55 years old, health, at least 8 natural incisors,
There is exogenous tooth staining, no intrinsic discolored tooth tooth, all patients are without the diseases such as serious periodontal and canker sore, anodontia
The hypoplasia of enamel, no related drugs allergies, women non-pregnancy or nursing period.
Be randomly divided into 10 groups, every group 30, this 10 groups of subjects use respectively embodiment 8, embodiment 10, embodiment 14,
Embodiment 22, embodiment 28, the tooth patch of comparative example 1-5 preparation, subject use tooth to paste daily 1 hour, are used continuously 7 days, the
It is normally brushed teeth with ordinary toothpaste daily within 0-30 days, in the 0th day, the 7th day, the 30th day inspection tooth color number.
Using itself cross-reference, the VITA Toothguide 3D-Master tooth general according to the domestic and international department of stomatology
Standard of the color board as tooth color selects subject upper left central incisor and upper right central incisor to carry out creamy white inspection.
(2) evaluation criteria:
Subject using tooth color is carried out before and after toothpaste, improve coloration reach 3 colorations be it is effective, 1~2 coloration is
Effectively, coloration is invalid without raising or coloration reduction person.Obvious effective rate=effective number/number of subjects × 100%；It is efficient=(aobvious
Imitate number+significant figure)/number of subjects × 100%；Obvious effective rate and effective percentage are calculated, the results are shown in Table 1.
Table 1
From the data in table 1, it can be seen that the whitening that the whitening strips provided by the invention containing photocatalyst are used continuously 7 days is efficient
It is 100%, i.e., tooth can be improved into 1~2 coloration；And the whitening strips that embodiment 8,10,14,22 and 28 provides are continuous
Reach 57%-60% using 7 days obvious effective rates, that is, has subject's tooth of 57%-60% that 3 colorations or more can be improved.It is right
The whitening effective percentage that the tooth patch containing photocatalyst that ratio 2 provides is used continuously 7 days is 100%.And comparative example 1, comparative example 3 are not
The whitening effective percentage that tooth patch containing photocatalyst is used continuously 7 days is only 53% and 7%, and obvious effective rate is 0.
This is because whitening strips provided by the invention are using nano-titanium dioxide as photocatalyst, the partial size of nano-titanium dioxide
For 15~30nm, when ultramicron receives light irradiation, inside due to absorbing luminous energy excite generation electron hole pair, i.e. light
Then raw carrier moves to rapidly its surface and activates the saliva being adsorbed, generate the free hydroxy (OH) of activity and live
Property oxygen (O2), can act on dental surface attachment dna exogenous pigment substance, chain type degradation reaction is brought it about, by pigment
Substance decomposition, removal, to achieve the effect that whitening.
The urea peroxide tooth patch that comparative example 5 uses can also reach 100% effective percentage, but peroxidating after continuous use 7 days
Object easily causes sensitivity of tooth, tooth embritllement, gum pain or has hickie, the symptoms such as mucous membrane discoloration.And the photocatalyst that the present invention uses
Whitening agent not damage tooth, stimulation gum, safe without toxic side effect during tooth-whitening.
Although the whitening effective percentage that the tooth patch that comparative example 2 provides is used continuously 7 days can also reach 100%, its obvious effective rate
Only 27%, hence it is evident that lower than the whitening obvious effective rate that the whitening strips that embodiment 8,10,14,22 and 28 provides are used continuously 7 days
57%-60%, reason are that the bioactivity glass in whitening strips is a kind of bioprosthetic material, the group split-phase of it and tooth
Seemingly, there is good biocompatibility with enamel, compatibility is high, is easily adsorbed by tooth, nanometer level bioactive glass can
The fine cracks for repairing dental surface, play the role of highlighting creamy white, tooth are made to have more gloss, in the base of photocatalyst beautifying and whitening tooth
The lightening effect of dental surface is further increased on plinth.
It is seen within the 30th day after the whitening strips tooth-whitening provided using embodiment 8,10,14,22 and 28 within continuous 7 days in table 1
The whitening effective percentage for the tooth examined still is 70%-80%, obvious effective rate 20%-26%；And what is provided in comparative example 2 contains only
Photocatalyst, tooth patch 7 days whitening effective percentage of continuous use without bioactivity glass can reach 100%, but using after 30 days
Whitening effective percentage only remain 40%, obvious effective rate only remain 7%；It can thus be seen that bioactivity glass and nano-titanium dioxide are multiple
With the effect that can generate lasting whitening.This is because photocatalyst-nano-titanium dioxide in whitening strips can be living with biology
Property glass be adsorbed in dental surface, continuingly act on dental surface attachment dna exogenous pigment substance, remained to after using 30 days
Generate the effect for continuing whitening.
Whitening effective percentage after the tooth that comparative example 4 provides is attached to continuous use 7 days reaches 93%, obvious effective rate 33%；But 30
Whitening effective percentage after it is reduced to 20%, and obvious effective rate is reduced to 3%；The whitening strips phase provided with embodiment 8,10,14,22 and 28
The reason of continuing whitening effect decline than, comparative example 4 be in tooth patch that comparative example 4 provides without containing thickener-acrylate/
- 20 octadecyl alcolol ether methacrylate ester copolymer of polyoxyethylene.- 20 octadecyl alcolol ether methacrylate of acrylate/polyoxyethylene
Ester copolymer and nano-titanium dioxide are able to extend nano-titanium dioxide in dental surface by Covalent bonding together formation compound
Residence time, and have very high suspension stability, nano-titanium dioxide and bioactivity glass can be made to be dispersed in
In gel-type vehicle, achieve the effect that uniform whitening.
Claims (10)
1. a kind of whitening strips containing photocatalyst, which is characterized in that the component including following mass percentage: nanometer titanium dioxide
Titanium 1%-20%, bioactivity glass 1%-10%, the copolymerization of -20 octadecyl alcolol ether methacrylate ester of acrylate/polyoxyethylene
Object 1%-10%, gelling agent 45%-85% and moisturizer 5%~20%.
2. a kind of whitening strips containing photocatalyst, which is characterized in that the component including following mass percentage: nanometer titanium dioxide
Titanium 5%~15%, bioactivity glass 3%~8%, the copolymerization of -20 octadecyl alcolol ether methacrylate ester of acrylate/polyoxyethylene
Object 3%~8%, gelling agent 55%~75% and moisturizer 10%~18%.
3. a kind of whitening strips containing photocatalyst according to claim 1 or claim 2, which is characterized in that further include aromatic 0.1%
~2%.
4. a kind of whitening strips containing photocatalyst according to claim 3, which is characterized in that the nano-titanium dioxide is sharp
Titanium ore crystal type nano TiO 2 powder, partial size are 15~30nm.
5. a kind of whitening strips containing photocatalyst according to claim 4, which is characterized in that the system of the bioactivity glass
Preparation Method are as follows: by SiO2、CaO、K2O、P2O5、CaF2And Na2O is that 42:21:14:3:12:15 is uniformly mixed by weight to be placed on
50min is melted at 1550 DEG C and obtains uniform mixture, and the mixture, which is placed in room temperature water-bath, makes its quenching, grinds after drying
Being milled to the particle that partial size is 50~100nm is bioactivity glass.
6. a kind of whitening strips containing photocatalyst according to claim 5, which is characterized in that the gelling agent is polyethylene pyrrole
One of pyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, carbomer or carmethose or
Several combinations.
7. a kind of whitening strips containing photocatalyst according to claim 6, which is characterized in that the moisturizer is glycerol, third
The combination of one or more of glycol or polyethylene glycol.
8. a kind of preparation method of the whitening strips containing photocatalyst as described in claim 1-7 is any, which is characterized in that including such as
Lower step:
Step 1: gelling agent is dissolved in solvent, it is total that -20 octadecyl alcolol ether methacrylate ester of acrylate/polyoxyethylene is added
Polymers is stirred to the gel at homogeneous transparent, is sequentially added remaining components and is stirred evenly, and obtains whitening gelatin after draining bubble
For use；
Step 2: using roll-to-roll coating machine, whitening gelatin obtained by step 1 is uniformly coated on coiled without anti-sticking function
On polyolefin backing surface layer, the solvent in whitening gelatin is volatilized by dry track, the coating machine other end be recycled to get
Whitening strips containing photocatalyst.
9. a kind of whitening strips containing photocatalyst according to claim 8, which is characterized in that solvent described in step 1 is pure water
Or the ethyl alcohol of any mass percentage；The speed of agitator is 50 revs/min.
10. a kind of whitening strips containing photocatalyst according to claim 9, which is characterized in that dry track described in step 2
Long 0.5~5m, drying temperature are 20~70 DEG C, the wide 0.5~2cm of whitening strips of the gained containing photocatalyst, the long 0.5~2m of every volume,
Tooth stick whitening gelatin it is dry after with a thickness of 100-300 μm.
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| CN113749955A (en) * | 2021-09-28 | 2021-12-07 | 中南大学 | Preparation method of tooth gel, tooth paste and tooth gel with remineralization capability |
| CN115252777A (en) * | 2022-06-09 | 2022-11-01 | 南昌大学 | In-situ whitening and anti-caries gel and preparation method thereof |
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| CN113440424A (en) * | 2021-07-30 | 2021-09-28 | 深圳爱尔创口腔技术有限公司 | Tooth paste capable of simultaneously nursing teeth and gum and preparation method thereof |
| CN113440424B (en) * | 2021-07-30 | 2023-08-08 | 深圳爱尔创口腔技术有限公司 | Tooth paste capable of simultaneously nursing teeth and gums and preparation method thereof |
| CN113749955A (en) * | 2021-09-28 | 2021-12-07 | 中南大学 | Preparation method of tooth gel, tooth paste and tooth gel with remineralization capability |
| CN115252777A (en) * | 2022-06-09 | 2022-11-01 | 南昌大学 | In-situ whitening and anti-caries gel and preparation method thereof |
| CN115252777B (en) * | 2022-06-09 | 2023-08-29 | 南昌大学 | In-situ whitening caries-preventing gel and preparation method thereof |
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Application publication date: 20191008 |