CN110291060A - 制备取代卟啉药物化合物和组合物的方法 - Google Patents

制备取代卟啉药物化合物和组合物的方法 Download PDF

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Publication number
CN110291060A
CN110291060A CN201780086851.4A CN201780086851A CN110291060A CN 110291060 A CN110291060 A CN 110291060A CN 201780086851 A CN201780086851 A CN 201780086851A CN 110291060 A CN110291060 A CN 110291060A
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CN
China
Prior art keywords
weight
compound
formula
composition
anion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780086851.4A
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English (en)
Chinese (zh)
Inventor
I.巴蒂尼奇-哈伯勒
A.托夫马斯彦
Z.R.措利奇
I.斯帕索杰维奇
C.A.李
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beomi Aesthetic Joint Venture Co Ltd
Duke University
Original Assignee
Beomi Aesthetic Joint Venture Co Ltd
Duke University
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Filing date
Publication date
Application filed by Beomi Aesthetic Joint Venture Co Ltd, Duke University filed Critical Beomi Aesthetic Joint Venture Co Ltd
Publication of CN110291060A publication Critical patent/CN110291060A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B47/00—Formation or introduction of functional groups not provided for in groups C07B39/00 - C07B45/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CN201780086851.4A 2016-12-20 2017-12-19 制备取代卟啉药物化合物和组合物的方法 Pending CN110291060A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662436743P 2016-12-20 2016-12-20
US62/436743 2016-12-20
PCT/US2017/067263 WO2018118891A1 (en) 2016-12-20 2017-12-19 Methods of making substituted porphyrin pharmaceutical compounds and compositions

Publications (1)

Publication Number Publication Date
CN110291060A true CN110291060A (zh) 2019-09-27

Family

ID=62628012

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780086851.4A Pending CN110291060A (zh) 2016-12-20 2017-12-19 制备取代卟啉药物化合物和组合物的方法

Country Status (8)

Country Link
US (1) US20190330220A1 (https=)
EP (1) EP3558902A4 (https=)
JP (1) JP2020502280A (https=)
KR (1) KR20190098211A (https=)
CN (1) CN110291060A (https=)
CA (1) CA3046357A1 (https=)
MX (1) MX2019007301A (https=)
WO (1) WO2018118891A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240116576A (ko) * 2017-04-04 2024-07-29 바이오미매틱스 제이브이, 엘엘씨 방사선 요법 및/또는 화학요법 노출과 연관된 부작용의 치료 및/또는 예방을 위한 방법, 조성물, 및 키트
CN111417400B (zh) * 2017-09-29 2022-12-02 杜克大学 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355802A (zh) * 1999-01-25 2002-06-26 国家犹太医疗及研究中心 取代的卟啉
US6583132B1 (en) * 1993-10-15 2003-06-24 Duke University Oxidant scavengers
WO2005077269A1 (en) * 2004-02-09 2005-08-25 Duke University Substituted porphyrins
WO2010138633A1 (en) * 2009-05-26 2010-12-02 Duke University Method of providing neuroprotection using substituted porphyrins
US20160324868A1 (en) * 2014-01-22 2016-11-10 Duke University Methods of treating pruritus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003237500A1 (en) * 2002-06-07 2003-12-22 Duke University Substituted porphyrins
WO2010080881A1 (en) * 2009-01-07 2010-07-15 Duke University Substituted porphyrins

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583132B1 (en) * 1993-10-15 2003-06-24 Duke University Oxidant scavengers
CN1355802A (zh) * 1999-01-25 2002-06-26 国家犹太医疗及研究中心 取代的卟啉
US20150231150A1 (en) * 1999-01-25 2015-08-20 Aeolus Sciences, Inc. Substituted porphyrins
WO2005077269A1 (en) * 2004-02-09 2005-08-25 Duke University Substituted porphyrins
US20100305083A1 (en) * 2004-02-09 2010-12-02 Ines Batinic-Haberle Substituted porphyrins
WO2010138633A1 (en) * 2009-05-26 2010-12-02 Duke University Method of providing neuroprotection using substituted porphyrins
US20160324868A1 (en) * 2014-01-22 2016-11-10 Duke University Methods of treating pruritus

Also Published As

Publication number Publication date
WO2018118891A1 (en) 2018-06-28
JP2020502280A (ja) 2020-01-23
EP3558902A1 (en) 2019-10-30
US20190330220A1 (en) 2019-10-31
KR20190098211A (ko) 2019-08-21
CA3046357A1 (en) 2018-06-28
MX2019007301A (es) 2019-10-30
EP3558902A4 (en) 2020-06-24

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Application publication date: 20190927