CN110286119B - TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer - Google Patents
TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer Download PDFInfo
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- CN110286119B CN110286119B CN201910576804.9A CN201910576804A CN110286119B CN 110286119 B CN110286119 B CN 110286119B CN 201910576804 A CN201910576804 A CN 201910576804A CN 110286119 B CN110286119 B CN 110286119B
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- 238000001514 detection method Methods 0.000 title claims abstract description 62
- 238000003018 immunoassay Methods 0.000 title claims abstract description 8
- 238000005192 partition Methods 0.000 claims abstract description 32
- 230000000149 penetrating effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 2
- 238000009434 installation Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 238000005452 bending Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Abstract
The invention provides a TIP head detection frame which comprises a detection frame body, a partition plate and a positioning mechanism, wherein the detection frame body is provided with a cavity, the cavity is provided with a first side wall and a second side wall which are oppositely arranged, at least one light inlet hole is formed in the first side wall, at least one light outlet hole is formed in the second side wall corresponding to the at least one light inlet hole, at least one light transmitting hole is formed in the partition plate correspondingly, and the partition plate is detachably arranged in the cavity through the positioning mechanism so that at least one light transmitting hole is positioned on the central axis of the corresponding light inlet hole and the corresponding light outlet hole. The technical problem that after the detection frame body and the partition plate are integrally formed or welded and formed, the partition plate and the hole site on the detection frame body are easy to misplace, so that the measurement result is misaligned in the prior art is solved; meanwhile, the invention also provides a module assembly for sample type detection with the TIP head detection frame and a chemiluminescent immunoassay analyzer comprising the module assembly.
Description
Technical Field
The invention relates to the field of sample type detection, in particular to a TIP head detection frame, a sample type detection module assembly and a chemiluminescent immunoassay analyzer.
Background
The light beam emitted by the sample type detection needs to reach the receiving end after passing through the partition plate positioned in the TIP head detection frame, the partition plate is formed by bending after being integrally formed with the detection frame body in the prior art, or is formed by welding after bending by adopting metal plates, after bending and welding, the centers of square holes on the partition plate and light passing holes on two sides of the detection frame body are easy to misplace due to the limitation of the prior process technology, so that the initial numerical value difference is larger when the sample is detected, the sample is detected after the TIP head is inhaled, misjudgment easily occurs as a result, the accuracy of a blood detection result is influenced, and medical accidents can be possibly caused when the sample is serious.
Disclosure of Invention
The invention provides a TIP head detection frame which aims at solving the technical problem that after a detection frame body and a baffle plate are integrally formed or welded and formed, the baffle plate and a hole site on the detection frame body are easy to be misplaced, so that a measurement result is misaligned; meanwhile, the invention also provides a module assembly for detecting the chemiluminescent sample type with the TIP head detection frame.
The scheme for solving the technical problems is as follows: the utility model provides a TIP head detection frame, includes detects framework, baffle and positioning mechanism, a cavity is seted up to the detection framework, the cavity has relative first lateral wall and the second lateral wall that sets up, be formed with at least one light inlet on the first lateral wall, correspond on the second lateral wall at least one light inlet is formed with at least one coaxial light outlet, correspond on the baffle and be formed with at least one light trap, the baffle passes through positioning mechanism detachably install in the cavity, so that at least one the light trap is located corresponding light inlet with corresponding on the central axis of light outlet.
According to the TIP head detection frame provided by the invention, the partition board is detachably connected with the detection frame body, and the partition board is arranged in the interval cavity through the positioning mechanism, so that the light holes are ensured to be positioned on the central axes of the corresponding light inlet holes and the corresponding light outlet holes, and the problem that the hole positions on the partition board and the hole positions on the detection frame body are misplaced can be effectively avoided; the invention also provides a chemiluminescent immunoassay analyzer with the sample type detection module assembly.
The foregoing description is only an overview of the present invention, and is intended to provide a better understanding of the present invention, as it is embodied in the following description, with reference to the preferred embodiments of the present invention and the accompanying drawings. Specific embodiments of the present invention are given in detail by the following examples and the accompanying drawings.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute a limitation on the application. In the drawings:
FIG. 1 is a schematic diagram of an explosion structure of a TIP head detection frame according to embodiment 1 of the present invention;
FIG. 2 is a schematic view of an exploded view of a TIP head detection frame at another angle relative to FIG. 1;
FIG. 3 is a schematic perspective view of a chemiluminescent sample type detection module assembly according to embodiment 2 of the present invention;
FIG. 4 is a schematic diagram of an exploded view of a chemiluminescent sample type detection module assembly according to embodiment 2 of the present invention;
FIG. 5 is a schematic view of an exploded view of a chemiluminescent sample type detection module assembly at another angle relative to FIG. 4;
Fig. 6 is a schematic diagram of a three-dimensional structure of a chemiluminescent immunoassay analyzer according to embodiment 3 of the present invention.
Detailed Description
The principles and features of the present invention are described below with reference to the drawings, the examples are illustrated for the purpose of illustrating the invention and are not to be construed as limiting the scope of the invention. The invention is more particularly described by way of example in the following paragraphs with reference to the drawings. Advantages and features of the invention will become more apparent from the following description and from the claims. It should be noted that the drawings are in a very simplified form and are all to a non-precise scale, merely for convenience and clarity in aiding in the description of embodiments of the invention.
Example 1
As shown in fig. 1 and 2, the present invention provides a TIP head detection frame 10, which includes a detection frame 11, a partition 12, and a positioning mechanism, where the detection frame 11 is provided with a cavity 11a, the cavity 11a has an opening 11b, a first side wall 111 and a second side wall 112 that are disposed opposite to each other, and a third side wall 113 and a fourth side wall 114 that are disposed opposite to each other, at least one light entrance hole 111a is formed on the first side wall 111, and at least one coaxial light exit hole 112a is formed on the second side wall 112 corresponding to the at least one light entrance hole 111a, that is, the light entrance hole 111a is on a straight line with a central axis O1 of the corresponding light exit hole 112 a. At least one light hole 12a is correspondingly formed in the partition plate 12, and the partition plate 12 is detachably mounted on the first side wall 111 and the second side wall 112 in the cavity 11a through a positioning mechanism, so that at least one light hole 12a is located on the central axis of the corresponding light inlet hole 111a and light outlet hole 112 a.
In this embodiment, the number of the light holes, the light entrance holes and the light exit holes is six, wherein the light holes 12a are rectangular holes, the light entrance holes 111a and the light exit holes 112a are round holes, and it can be understood that the shapes of the light holes 12a, the light entrance holes 111a and the light exit holes 112a can be set according to the needs, for example, the light holes 12a are elongated elliptical holes, and the light entrance holes 111a and the light exit holes 112a are square holes.
The central symmetry axis O2 of the light hole 12a in the length direction needs to intersect with the central axes O1 of the corresponding light entrance hole 111a and light exit hole 112a, that is, the central symmetry axis O2 of the light hole 12a in the length direction cannot be staggered with the connecting line of the central axes O1 of the light entrance hole 111a and the light exit hole 112 a. Preferably, the central symmetry axis O2 of the light-transmitting hole 12a perpendicularly intersects the central axis O1. In the present embodiment, the central axis O3 of the light transmitting hole 12a, the axis of the corresponding light entering hole 111a, and the central axis of the corresponding light exiting hole 112a are positioned on the same straight line.
In order to ensure that the partition plate 12 is mounted in the cavity 11a without deflection, the third side wall 113 and the fourth side wall 114 of the detection frame 11 are correspondingly provided with clamping grooves 113a and 114a respectively, and two ends of the partition plate 12 are correspondingly and detachably inserted into the clamping grooves 113a and 114a respectively for fixation.
It will be appreciated that, to facilitate the installation of the partition 12, the upper and lower ends of the clamping grooves 113a, 114a penetrate the detection frame body, so that the partition 12 can be inserted from the upper ends of the clamping grooves 113a, 114a or from the lower ends when the partition 12 is installed. In the present embodiment, the card slots 113a and 114a are slotted by wire cutting. It can be understood that the clamping grooves 113a, 114a may be opened to a suitable position to enable the partition board 12 to be inserted into the clamping grooves 113a, 114a for installation and fixation, and then the light inlet holes 111a are located on the central axes of the corresponding light transmission holes 12a and the corresponding light outlet holes 112 a.
Specifically, the positioning mechanism includes at least one positioning pin 131 and a fastener 132, the first side wall 111, the second side wall 112 and the partition 12 are correspondingly provided with mounting holes, and the positioning pin 131 sequentially penetrates through the mounting holes of the first side wall 111 and the second side wall 112 of the partition 12 and is matched and fixed with the positioning pin 131 on the outer side surface of the first side wall 111 or the second side wall 112 through the fastener 132. In a preferred embodiment of the present invention, a screw is provided at an end of the positioning pin 131, the fastening member 132 is a screw, and the screw end of the positioning pin 131 extends from the outer side 111b of the first side wall 111 after the positioning pin 131 sequentially passes through the positioning holes of the first side wall 111, the partition 12 and the second side wall 112, and the screw is used for fastening the positioning pin 131 by screwing with the end of the positioning pin 131.
It can be appreciated that the number of the positioning pins can be determined according to practical situations, in this embodiment, the number of the positioning pins is two, and the positioning holes formed in the partition 12 are symmetrically arranged, which is more beneficial to the position stability of the partition 12 after being installed.
The following describes the mounting process of the TIP head detection frame in this embodiment:
after the partition plate 12 is inserted from the upper end or the lower end of the clamping grooves 113a and 114a, the positioning pins 131 are inserted along the positioning holes on the first side wall 111, extend out of the corresponding positioning holes on the second side wall 112 after passing through the positioning holes of the partition plate 12, and then the two ends of the positioning pins 131 are fixed by the screws 132, namely the assembly is successful.
The baffle 12 is detachably arranged in the cavity 11a and is fixedly connected with the first side wall 111 and the second side wall 112 respectively through the cooperation of the positioning pin 131, the clamping grooves 113a and 114a and the fastening piece 132, and meanwhile, the central axes of the light inlet hole 111a, the light transmitting hole 12a and the light outlet hole 112a are ensured to be positioned on the same straight line, so that the problem that the position of the baffle 12 is misplaced with the position of the detection frame 11 can be effectively avoided.
Example 2
As shown in fig. 3 to 5 in combination with fig. 2, this embodiment discloses a sample type detection module assembly 100 having the above-described TIP head detection frame 10, and further includes a TIP slot 20, a transmitting plate 30, and a receiving plate 40. Wherein TIP slot 20 is mounted at opening 11 b.
The transmitting plate 30 has a transmitting surface 31, the receiving plate 40 has a receiving surface 41, the transmitting plate 30 is mounted on the outer side of the first side wall 111, the outer side surface of the first side wall 111 is opposite to the transmitting surface 31, the receiving plate 40 is mounted on the outer side of the second side wall 112, and the outer side surface of the second side wall 112 is opposite to the receiving surface 41.
At least one light emitting end 32 is mounted on the emitting surface 31, the light receiving end 42 corresponding to the light emitting end 32 one by one is arranged on the receiving surface 41 and is used for receiving light emitted by the light emitting end 32, a corresponding group of light emitting ends 32 and light receiving ends 42 respectively correspond to a corresponding group of light inlet holes 111a and light outlet holes 112a, central axis connecting lines of the light inlet holes 111a and the corresponding light outlet holes 112a coincide with light paths of the corresponding light emitting ends 32 and the light receiving ends 42, TIP placing holes 20a are formed on the TIP groove 20, and the central line of the TIP placing holes 20a perpendicularly intersects with the light path connecting lines of the corresponding light emitting ends 32 and the corresponding light receiving ends 42.
Wherein, TIP groove 20 includes a mounting portion 21 at both ends and a placement portion 22 between both ends, TIP placement hole 20a is located at placement portion 22 for placing a TIP head for holding a test sample, mounting portion 21 is matched with cavity 11a, specifically, the outer contour of the lower end of placement portion 22 is matched with opening 11b, and the lower end of placement portion 22 extends into cavity 11a through opening 11 b.
It can be understood that the mounting portion 21 is fixed to the upper ends of the third side wall 113 and the fourth side wall 114 by the pins 150, and then fixed to the screw holes 160a by the screws 160, or may be fixed in other manners, so as to ensure that the TIP placement hole is stable after the TIP slot is mounted.
A first gap is left between the outer side surface of the first side wall 111 and the emitting surface 31, and a second gap is left between the outer side surface of the second side wall 112 and the receiving surface 42. In this embodiment, the method for presetting the first gap and the second gap is as follows: at least one first mounting column 1111 having a height equal to the first gap is provided on an outer side surface of the first sidewall 111, one end of the first mounting column 1111 is fixedly connected to the outer side surface of the first sidewall 111, and the emission plate 30 is mounted on the other end of the first mounting column 1111; the outer side surface of the second side wall 112 has at least one second mounting post 1121 having a height equal to the size of the second gap, one end of the second mounting post 1121 is fixedly connected to the outer side surface of the second side wall 112, and the receiving plate 40 is mounted to the other end of the second mounting post 1121.
When the heights of the first mounting post 1111 and the second mounting post 1121 are set, it is guaranteed that when the empty tip is placed in the tip slot, the light value received by the light receiving end 42 through the light emitting end 32 by the light of the empty tip can meet a preset light value, and it is understood that the preset light value is related to the light emitting intensity of the light emitting end 32 and the material of the tip, and the preset light value can be set according to the actual test requirement. In order to ensure the accuracy of experimental data in practical application, the size range of the first gap is 6.5mm-7.5mm, and the size range of the second gap is 2.5mm-3.5mm.
In this embodiment, in order to ensure the installation stability of the transmitting plate, the number of the first installation columns 1111 is three, and the three first installation columns are not located on a straight line, so that the transmitting plate can be completely fixed according to the principle of three-point surface formation; also, in order to secure mounting stability of the receiving plate, the number of the second mounting posts 1121 is three, and the three second mounting posts 1121 are not located on a straight line.
In addition, in order to ensure that the position of the light receiving end 42 corresponds to a preset position when the receiving plate is mounted, at least two second positioning posts 1122 are mounted on the outer side surface of the second side wall 112, and second positioning holes 40b adapted to the second positioning posts 1122 are formed in the receiving plate 40.
The following describes the installation and use process of the sample type detection module assembly in this embodiment:
Mounting a TIP groove 20 on the upper end of the assembled TIP head detection frame 10, inserting the lower end of the placement part 22 along the opening 11b, positioning and fixing the detection frame 11 and the TIP groove 20 by using a pin 150, and locking and fixing the detection frame 11 and the TIP groove 20 by using a screw 160; the transmitting plate 30 is mounted on the first mounting column 1111; in a state where the second positioning holes 40b of the receiving plate 40 correspond to the second positioning columns 1122, the receiving plate 40 is mounted on the second mounting column 1121, i.e., the sample type detection module assembly is completed.
In use, a TIP head with a sample is placed in the TIP placement hole 20a of the TIP slot 20, the light emitting end 32 of the emitting plate 30 is electrically connected to emit light, and the light passes through the light inlet hole 111a, the light transmitting hole 12a, the sample and the light outlet hole 112a to reach the corresponding light receiving end, and a detector analyzes the type of the sample according to the light signal received by the light receiving end.
Example 3
As shown in fig. 6, the present embodiment provides a chemiluminescent immunoassay analyzer 200 comprising a housing 201, the housing 201 having two lumens 201a spaced apart from each other, each of which houses two sample type detection module assemblies 100 as provided in example 2.
The above description is only of the preferred embodiments of the present invention, and is not intended to limit the present invention in any way; those skilled in the art will readily appreciate that the present invention may be implemented as shown in the drawings and described above; however, those skilled in the art will appreciate that many modifications, adaptations, and variations of the present invention are possible in light of the above teachings, without departing from the scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the present invention.
Claims (8)
1. The TIP head detection frame is characterized by comprising a detection frame body, a partition plate and a positioning mechanism, wherein the detection frame body is provided with a cavity, the cavity is provided with a first side wall and a second side wall which are oppositely arranged, at least one light inlet hole is formed in the first side wall, at least one coaxial light outlet hole is formed in the second side wall corresponding to the at least one light inlet hole, at least one light transmitting hole is formed in the partition plate correspondingly, and the partition plate is detachably arranged in the cavity through the positioning mechanism so that at least one light transmitting hole is positioned on the central axis of the corresponding light inlet hole and the corresponding light outlet hole;
The detection frame body is also provided with a third side wall and a fourth side wall which are oppositely arranged, clamping grooves are correspondingly formed in the third side wall and the fourth side wall respectively, and two ends of the partition board are detachably inserted into the clamping grooves;
the positioning mechanism comprises at least one positioning pin and a fastening piece, wherein the positioning pin is arranged on the partition board in a penetrating manner, and two ends of the positioning pin are fixedly connected with the first side wall and the second side wall respectively through the fastening piece;
The light hole is a rectangular hole, the light inlet hole and the light outlet hole are round holes, and the central symmetry axis of the light hole in the length direction is intersected with the central connecting line of the corresponding light inlet hole and the corresponding light outlet hole.
2. The sample type detection module assembly is characterized by comprising a TIP groove, a transmitting plate, a receiving plate and the TIP head detection frame as claimed in claim 1, wherein an opening is formed in a cavity of the detection frame body, the TIP groove is installed at the opening, the transmitting plate is provided with a transmitting surface, the receiving plate is provided with a receiving surface, the transmitting plate is installed on the outer side of the first side wall, the outer side surface of the first side wall is opposite to the transmitting surface, the receiving plate is installed on the outer side of the second side wall, the outer side surface of the second side wall is opposite to the receiving surface, at least one light emitting end is installed on the transmitting surface, the receiving surface is provided with a light receiving end corresponding to the light emitting end one by one, a group of corresponding light inlet holes and light outlet holes are respectively corresponding to the light emitting ends, a central axis connecting line of the light inlet holes and the corresponding light outlet holes coincides with a light path connecting line of the corresponding light emitting end and the light receiving end, the light path connecting line of the TIP groove is opposite to the receiving end, and the light path connecting line of the TIP connecting line is formed by intersecting the light emitting end and the light receiving end.
3. The sample type detection module assembly according to claim 2, wherein the TIP groove includes mounting portions at both ends thereof and a placement portion between both ends, the TIP placement hole is located at the placement portion, the mounting portions are fixedly connected with the upper ends of the third and fourth side walls, respectively, an outer contour of a lower end of the placement portion is adapted to the opening, and a lower end of the placement portion extends into the cavity through the opening.
4. The sample type detection module assembly according to claim 3, wherein the mounting portion is fixed to upper ends of the third and fourth side walls by positioning pins, respectively.
5. The sample type detection module assembly of claim 2, wherein a first gap is left between the outer side of the first sidewall and the emitting surface, and a second gap is left between the outer side of the second sidewall and the receiving surface.
6. The sample type detection module assembly of claim 5, wherein the outer side of the first sidewall has at least one first mounting post having a height equal to the size of the first gap, one end of the first mounting post is fixedly connected to the outer side of the first sidewall, and the emitter plate is mounted to the other end of the first mounting post; the lateral surface of second lateral wall have at least one height with the second erection column that the size of second clearance equals, the one end of second erection column with the lateral surface fixed connection of second lateral wall, the receiver plate install in the other end of second erection column.
7. The sample type detection module assembly of claim 5, wherein at least two second positioning posts are mounted on the outer side surface of the second side wall, and the emitter plate is formed with second positioning holes adapted to the second positioning posts.
8. A chemiluminescent immunoassay analyzer comprising a housing having at least one interior cavity, each of said interior cavities having at least one sample type detection module assembly of any one of claims 2-7 mounted therein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910576804.9A CN110286119B (en) | 2019-06-28 | 2019-06-28 | TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910576804.9A CN110286119B (en) | 2019-06-28 | 2019-06-28 | TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer |
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| CN110286119A CN110286119A (en) | 2019-09-27 |
| CN110286119B true CN110286119B (en) | 2024-04-19 |
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| CN113670900A (en) * | 2021-09-07 | 2021-11-19 | 苏州翊讯生物科技有限公司 | Multichannel chemiluminescence immunoassay analyzer |
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| CN110286119A (en) | 2019-09-27 |
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