CN110278711B - 作为RORγ调节剂的三环砜 - Google Patents

作为RORγ调节剂的三环砜 Download PDF

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CN110278711B
CN110278711B CN201780082664.9A CN201780082664A CN110278711B CN 110278711 B CN110278711 B CN 110278711B CN 201780082664 A CN201780082664 A CN 201780082664A CN 110278711 B CN110278711 B CN 110278711B
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fluorophenyl
sulfonyl
cyclopenta
hexahydro
perfluoropropan
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CN110278711A (zh
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D·马库斯
M·博登·伯特兰
T.G.M·迪哈尔
M·G·杨
Z·萧
H·Y·萧
Y·朱
C·A·魏格尔特
D·G·巴特
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084595A2 (en) * 2006-01-20 2007-07-26 Schering Corporation Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
WO2009008980A2 (en) * 2007-07-05 2009-01-15 Schering Corporation Tetrahydropyranochromene gamma secretase inhibitors
WO2009011851A1 (en) * 2007-07-17 2009-01-22 Schering Corporation Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
WO2015103507A1 (en) * 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Cyclohexyl sulfone rorϒ modulators
WO2015103510A1 (en) * 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Heterocyclic sulfone as ror-gamma modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464103B2 (en) * 2012-11-29 2016-10-11 Merck Sharp & Dohme Corp. Spirocyclic sulfones as gamma secretase inhibitors
US9771320B2 (en) 2014-01-06 2017-09-26 Bristol-Myers Squibb Company Carbocyclic sulfone RORγ modulators
CA2936116A1 (en) * 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084595A2 (en) * 2006-01-20 2007-07-26 Schering Corporation Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
WO2009008980A2 (en) * 2007-07-05 2009-01-15 Schering Corporation Tetrahydropyranochromene gamma secretase inhibitors
WO2009011851A1 (en) * 2007-07-17 2009-01-22 Schering Corporation Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
WO2015103507A1 (en) * 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Cyclohexyl sulfone rorϒ modulators
WO2015103510A1 (en) * 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Heterocyclic sulfone as ror-gamma modulators

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Aromatization of Tetrahydrocyclopropa[a]naphthalenes:an Alternative Synthesis of 1H-Cyclopropa[a]naphthalene;Paul Müller et al.;《Helvetica Chimica Acta》;19891231;第72卷(第7期);第1627-1638页 *
Cyclization of Ylidenemalononitriles. X. Synthesis of Benzazapropellane Derivatives from α-Cyano-β-chloroalkylcinnamonitriles;E. Campaigne et al.;《Journal of Heterocyclic Chemistry》;19771231;第14卷(第8期);第1337-1345页 *
Decomposition Products of Pyrazolines formed from 3-Alkylthioinden-1-ones and Diazomethane;Katherine Buggle et al.;《Journal of the Chemical Society Perkin Transactions I》;19750101(第6期);第572-575页 *
Intramolecular Capture of a Cyclobutylthionium Ion for the Synthesis of New Strained Heterocycles and Carbocycles: A Rapid Assembly of the BCD Ring Sequence of Penitrems;Guido Alberti et al.;《Synlett》;20060824(第14期);第2241-2245页 *
Ring-expansion of 3-Arylinden-1-ones with Lithium Methylsulphinylmethanide;Katherine Buggle et al.;《Journal of the Chemical Society Perkin Transactions I》;19830101;第2075-2076页 *
SAR of tricyclic sulfones as γ-secretase inhibitors;Xu Ruo et al.;《Science China Chemistry》;20111011;第54卷(第11期);第1688-1701页 *
Synthesis of New Heterocycles through a Cation-Driven Tandem Ring-Enlargement-Annulation Reaction;Angela M. Bernard et al.;《Organic Letters》;20020627;第4卷(第15期);第2565-2567页 *
Synthesis of Tribenzotriquinacene by Stereocontrolled Cyclization of Phenyl-Substituted Cs-Diindans(4bo1,9,9aa,lO-Tetrahydroindeno[1,2-a]indenes);Dietmar Kuck et al.;《Chemische Berichte》;19941231;第151-164页 *

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