CN110269749B - Directional drainage dressing for maintaining proper moisture of wound and preparation method thereof - Google Patents
Directional drainage dressing for maintaining proper moisture of wound and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0223—Adhesive bandages or dressings with fluid retention members characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an oriented drainage dressing for maintaining proper moisture of a wound and a preparation method thereof, wherein the oriented drainage dressing for maintaining proper moisture of the wound has a composite layer structure and comprises a hydrophilic layer, a moisture retention layer and an evaporation layer which are adjacent, the hydrophilic layer, the moisture retention layer and the evaporation layer are all provided with porous structures, the pore size is gradually reduced, the hydrophilic layer is made of a material with hydrophilicity and the moisture regain being less than or equal to 5%, and the moisture retention layer is made of a material with hydrophilicity and the moisture regain being more than or equal to 100%; the preparation method comprises the following steps: and forming a polysaccharide B nanofiber membrane and a hydrophobic layer on the surfaces of the two sides of the polysaccharide A non-woven fabric respectively, and forming a bacterial cellulose ultrafine mesh fiber membrane on the surface of the polysaccharide B nanofiber membrane to prepare the directional drainage dressing for maintaining the proper moisture of the wound. The directional drainage dressing for maintaining the proper moisture of the wound can maintain the proper moisture of the wound for a long time, and has excellent antibacterial effect; the preparation method of the directional drainage dressing for maintaining the proper moisture of the wound has the advantages of low cost and good application prospect.
Description
Technical Field
The invention belongs to the technical field of dressings, and relates to a directional drainage dressing for maintaining proper moisture of a wound and a preparation method thereof.
Background
Wounds on the skin surface, including burns, physical and chemical injuries, produce high levels of wound exudate during wound repair, excess fluid can over-hydrate the wound and irritate the surrounding normal skin, causing skin infections and allergic reactions that prevent self-repair of the wound. Conventional hydrophilic dressings absorb some of the wound exudate, but because of their uniform wetting properties, the dressing often retains some of the exudate on the side in contact with the wound, preventing wound recovery. The ideal wound dressing should keep the wound in a moderately moist environment all the time, not only can timely suck the exudate on the surface of the wound away without forming effusion, but also can maintain part of the exudate of the wound in the dressing, and avoid the wound from being too dry and scab.
Research finds that when the material has asymmetric lyophilic and lyophobic wettability in the thickness direction of the material, liquid can conduct directionally along two sides of the material, namely the liquid can be spontaneously conveyed to the lyophilic surface from the lyophobic surface, the problem that the exudate is remained on the side close to the skin in the liquid suction process of the traditional dressing can be improved, and how to keep the wound to be moderately moist still needs to be solved.
In addition, the conventional dressing has limited inhibition effect on bacteria in the process of absorbing wound exudate, and cannot prevent the growth of bacteria on the surface of a wound and the penetration of external microorganisms.
Therefore, there is a need to develop a multifunctional wound dressing that can spontaneously absorb exudate from the surface of a wound, maintain the wound to be moderately moist, and have a good bacteriostatic effect.
Disclosure of Invention
The invention aims to solve the problems that the wound dressing in the prior art is difficult to maintain the proper moisture of the wound and has limited bacteriostatic action, and provides a directional drainage dressing for maintaining the proper moisture of the wound and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following scheme:
a directional drainage dressing for maintaining proper moisture of a wound has a composite layer structure and comprises a hydrophilic layer, a moisture retention layer and an evaporation layer which are adjacent, wherein the hydrophilic layer, the moisture retention layer and the evaporation layer are all provided with porous structures, the pore diameter is gradually reduced, the hydrophilic layer is made of a material with hydrophilicity and the moisture regain being less than or equal to 5%, and the moisture retention layer is made of a material with hydrophilicity and the moisture regain being more than or equal to 100%;
one of the technical problems to be solved by the invention is to maintain the proper wetness of the wound, and to achieve the purpose of maintaining the proper wetness of the wound due to the fact that the body surface exudate at the wound is more and is in an over-moist state, not only is the body surface exudate at the wound ensured to be timely discharged to avoid hydrops, but also the dressing is ensured to be capable of properly absorbing moisture to avoid over-drying; the invention generates differential capillary effect by controlling the aperture degression of the hydrophilic layer, the moisture-preserving layer and the evaporation layer, so that the accumulated liquid at the wound can be guided out directionally, and the dressing can absorb moisture properly by reasonably selecting the materials of the hydrophilic layer and the moisture-preserving layer; the hydrophilic layer is made of hydrophilic materials with the moisture regain less than or equal to 5%, and the hydrophilic layer is in direct contact with the skin, so that the moisture absorption amount is too high, the layer has residual effusion and cannot be absorbed by the moisture retention layer, and the skin can still be in direct contact with liquid moisture; the moisture-keeping layer is made of hydrophilic material with moisture regain not less than 100%, has good hydrophilicity, can quickly absorb exudate and discharge the exudate through evaporation, has certain moisture absorption capacity, cannot be excessively dried, and can ensure moisture but not wet; it should be noted that the moisture absorption of the present invention is not stored in the dressing, and the moisture generally has two forms, liquid water and gaseous water, the liquid water is mostly stored in the pores of the fiber diameter, the gaseous water is in the fiber interior and in the pores, the present invention does not want to store a large amount of moisture (mainly liquid state) in the pores of the fiber diameter in the dressing, the skin is softened by a large amount of moisture residue to cause inflammation, and the wound healing is hindered, so the moisture is sucked away and evaporated out through the pore diameter change of the layers, but the present invention does not want to over dry the skin, the over dry skin causes scabbing and discomfort, so the moisture retention layer is needed to still store a certain amount of moisture, the moisture content of the part is moderate, the dressing in the prior art only can realize directional liquid guiding, which often causes over-drying of the wound, the present invention provides a solution-by reasonably designing the structure of the dressing and selecting specific materials, properly absorb moisture while directionally draining the liquid, and effectively avoid the excessive dryness of the wound.
As a preferable scheme:
the directional drainage dressing for maintaining the proper moisture of the wound is characterized in that the hydrophilic layer and the moisture retention layer are both made of polysaccharide.
The directional drainage dressing for maintaining the proper moisture of the wound is characterized in that the hydrophilic layer and the moisture retention layer are respectively made of polysaccharide A and polysaccharide B, the polysaccharide A is chitosan, the polysaccharide B is pectin, dialdehyde pectin, konjac glucomannan or pullulan, the polysaccharides are generally hydrophilic, the water absorption performance of each polysaccharide is different, and the chitosan theoretically absorbs water but in a small amount; the water absorption capacity of pectin, dialdehyde pectin, konjac glucomannan, pullulan and the like is large, so the invention selects chitosan as the material of the hydrophilic layer, and selects pectin, dialdehyde pectin, konjac glucomannan or pullulan as the material of the moisturizing layer.
The directional drainage dressing for maintaining the proper moisture of the wound is characterized in that the hydrophilic layer and the moisture retention layer are respectively a polysaccharide A non-woven fabric with the thickness of 50-100 mu m and a polysaccharide B nanofiber membrane with the thickness of 50-100 mu m; the polysaccharide B nanofiber membrane is a fiber aggregate, a large number of pores are formed in the polysaccharide B nanofiber membrane, and the final effect to be achieved by the method is that water in the pores is evaporated, and water in the fibers is reserved; the polysaccharide A non-woven fabric is too thick, so that the nano-fiber film is difficult to completely absorb liquid and has residues on the other surface, and the thin non-woven fabric has poor formability, which is a problem of the preparation process per se; the same problem exists when the polysaccharide B nanofiber membrane is too thick, and moisture cannot be transferred into the next layer in time and remains on the other side when the polysaccharide B nanofiber membrane is too thick.
The directional drainage dressing for maintaining the proper moisture of the wound is characterized in that the evaporation layer is a bacterial cellulose superfine reticular fiber membrane with the thickness of 1 mu m, and the porous pore diameters of the polysaccharide A non-woven fabric, the polysaccharide B nano fiber membrane and the bacterial cellulose superfine reticular fiber membrane are respectively 50-100 mu m, 1-6 mu m and 100-500 nm;
the pore diameter of 50-100 mu m is equivalent to that of a large pore, and the large-scale pore diameter range of the large pore-micron-scale pore-nano-scale pore is changed, so that the differential capillary effect is more obvious, the directional liquid guiding speed is higher, and in-vitro exudate at a wound can be timely drained and evaporated on the surface of the bacterial cellulose ultrafine mesh fibrous membrane.
According to the directional drainage dressing for maintaining the proper moisture of the wound, the surface, away from the moisture retention layer, of the hydrophilic layer is embedded with the hydrophobic layer, the thickness of the hydrophobic layer is about 10-20 microns, the directional drainage dressing mainly comprises the hydrophobic nano coating and the antibacterial agent dispersed in the hydrophobic nano coating, the hydrophilic layer and the hydrophobic layer are matched with each other to generate a hydrophilic-hydrophobic wettability gradient difference, so that the directional drainage is facilitated, and the directional drainage speed of the dressing is higher due to the fact that the hydrophilic-hydrophobic wettability gradient difference is matched with a differential capillary effect;
when the directional liquid guiding dressing simultaneously contains the polysaccharide A non-woven fabric, the polysaccharide B nano fiber film, the bacterial cellulose ultrafine net fiber film and the hydrophobic layer, the comprehensive performance of the product is excellent, and the directional liquid guiding dressing can not only guide liquid quickly, but also maintain the proper moisture of wounds and resist bacteria. Each layer in the directional drainage dressing has own function, and the layers are finally overlapped to endow the dressing with good performance, the hydrophobic layer is tightly attached to the skin when in use and is used for killing bacteria on the surface of a wound, and is also used for being matched with the polysaccharide A non-woven fabric to generate wettability gradient difference, and the directional drainage is realized.
The directional drainage dressing for maintaining the proper moisture of the wound is characterized in that the hydrophobic nano coating is made of hydrophobic polymers, the hydrophobic polymers are fluorine-containing polyurethane, polystyrene, polyvinylidene fluoride-hexafluoropropylene or polyvinylidene fluoride-chlorotrifluoroethylene, and the antibacterial agent is Ag with the particle size of 20-50 nm;
the invention solves another technical problem of improving the antibacterial performance of the dressing, the conventional dressing has limited inhibition effect on bacteria in the process of absorbing wound exudate, and cannot prevent the growth of bacteria on the surface of a wound and the permeation of external microorganisms.
The directional liquid guiding dressing for maintaining the proper wetness of the wound is characterized in that the unidirectional moisture guiding index of the directional liquid guiding dressing for maintaining the proper wetness of the wound from the innermost layer to the outermost layer is 1000-1400%, and the water pressure resistance is 0mmH2O; the unidirectional moisture permeability index from the outermost layer to the innermost layer is-300-0%, and the waterproof property is realizedThe pressure is 20-80 mmH2O。
The invention also provides a method for preparing the directional drainage dressing for maintaining the proper moisture of the wound, which comprises the steps of respectively forming a polysaccharide B nanofiber membrane and a hydrophobic layer on the surfaces of two sides of the polysaccharide A non-woven fabric, and forming a bacterial cellulose ultrafine mesh fiber membrane on the surface of the polysaccharide B nanofiber membrane to prepare the directional drainage dressing for maintaining the proper moisture of the wound;
polysaccharide A is chitosan, polysaccharide B is pectin, dialdehyde pectin, konjac glucomannan or pullulan, and the porous aperture in the polysaccharide A non-woven fabric, the polysaccharide B nano-fiber membrane and the bacterial cellulose superfine mesh fiber membrane is decreased progressively;
the polysaccharide B nanofiber membrane, the hydrophobic layer, and the bacterial cellulose ultrafine mesh fiber membrane may be formed by various processes, for example, by an electrostatic spinning process in which a raw material of the membrane is dissolved to prepare a spinning solution and then subjected to electrostatic spinning, or by a coating process in which a raw material of the membrane is prepared to a dispersion solution and then subjected to coating, or by an electrostatic spraying process in which a raw material of the membrane is prepared to a dispersion solution and then subjected to electrostatic spraying, as long as a membrane having a pore size within a specific range can be formed, and may be applied to the present invention.
The method comprises the following specific steps:
(1) taking one side surface of the polysaccharide A non-woven fabric as a receiving surface, and carrying out electrostatic spinning on the polysaccharide B solution to form a polysaccharide B nanofiber membrane, wherein the concentration of a polysaccharide B spinning solution is 5-15 wt%, the voltage of electrostatic spinning is 10-50 kV, the receiving distance is 10-30 cm, the filling speed of the spinning solution is 0.2-5 mL/h, the diameter of the obtained fiber is 200 nm-2 mu m, the average pore diameter of the fiber membrane is 1-6 mu m, and the thickness of the fiber membrane is 50-100 mu m;
(2) immersing a composite fiber membrane consisting of the polysaccharide A non-woven fabric and the polysaccharide B nano-fiber into a cross-linking agent solution for cross-linking reaction, wherein the temperature of the cross-linking reaction is normal temperature, and the time is 10-60 min, and the cross-linking reaction is mainly used for improving the stability of the polysaccharide B nano-fiber membrane; the cross-linking agent solution corresponding to different polysaccharides B is different, and when the polysaccharide B is pectin, the cross-linking agent solution corresponding to the polysaccharide B is saturated calcium chloride ethanol solution, and multivalent cation Ca2+With polysaccharidesThe combination of the uronic acid unit can reduce the water solubility of the uronic acid unit, improve the stability of the uronic acid unit in an aqueous environment and prevent the uronic acid unit from being dissolved in water; when the polysaccharide is dialdehyde pectin, konjac glucomannan or pullulan, the corresponding cross-linking agent solution is adipic dihydrazide ethanol solution with the concentration of 1-5 wt%, aldehyde groups on the dialdehyde pectin, the konjac glucomannan or the pullulan can react with amino groups on the adipic dihydrazide to generate cross-linking, and the stability of the polysaccharide can be improved as well;
(3) coating a dispersion liquid I of the bacterial cellulose on the surface of the polysaccharide B nanofiber membrane to form a bacterial cellulose ultrafine mesh fiber membrane, and adopting a dipping coating process, wherein the dispersion liquid I is prepared by uniformly dispersing the bacterial cellulose in deionized water or ultrapure water, and the concentration of the dispersion liquid is 0.1-1 wt%;
(4) and (2) with the other side surface of the polysaccharide A non-woven fabric as a receiving surface, carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving hydrophobic polymer in solvent, adding AgNO3And stirring in a constant-temperature water bath after adding a reducing agent, wherein the mass ratio of the hydrophobic polymer to the solvent is 1-5: 100, and AgNO3The mass ratio of the reducing agent to the hydrophobic polymer is 1-10: 100, and the reducing agent and AgNO are3The mass ratio of the components is 1-20: 100, the reducing agent is tea polyphenol, the solvent is acetone, tetrahydrofuran, N-dimethylformamide or N, N-dimethylacetamide, the constant temperature is 50-100 ℃, the stirring time is 1h, the electrostatic spraying voltage is 5-30 kV, the receiving distance is 5-20 cm, the filling speed of the spinning solution is 0.2-2 mL/h, the electric spraying depth/thickness is 10-20 mu m, and Ag is+The degree of conversion to the simple substance Ag is more than 90%.
Has the advantages that:
(1) according to the directional drainage dressing for maintaining the proper moisture of the wound, the differential capillary effect is generated by controlling the pore diameters of the hydrophilic layer, the moisture retention layer and the evaporation layer to be gradually reduced, so that the accumulated liquid at the wound can be directionally led out, and the dressing can properly absorb moisture by reasonably selecting the materials of the hydrophilic layer and the moisture retention layer, so that the wound can be maintained to be properly moist for a long time;
(2) according to the directional drainage dressing for maintaining the proper moisture of the wound, the directional drainage speed is obviously improved by combining the hydrophilic-hydrophobic wettability gradient difference with the differential capillary effect;
(3) the directional drainage dressing for maintaining the proper moisture of the wound has excellent antibacterial effect;
(4) the preparation method of the directional drainage dressing for maintaining the proper moisture of the wound has low cost and good application prospect.
Drawings
FIG. 1 is an SEM image (500 magnification) of an oriented drainage dressing prepared in example 1 and used for maintaining a wound moderately moist; wherein, the coating comprises 1-an evaporation layer, 2-a moisture retention layer, 3-a hydrophilic layer and 4-a hydrophobic layer.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of chitosan non-woven fabric with the thickness of 50 microns as a receiving surface, and carrying out electrostatic spinning on a pectin solution with the concentration of 5 wt% to form a pectin nanofiber membrane with the thickness of 50 microns, wherein the voltage of the electrostatic spinning is 10kV, the receiving distance is 10cm, and the pouring speed of the spinning solution is 0.2 mL/h;
(2) immersing a composite membrane formed by the chitosan non-woven fabric and the pectin nano-fiber membrane into a saturated calcium chloride ethanol solution for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 10 min;
(3) coating the dispersion solution I of the bacterial cellulose on the surface of the pectin nanofiber membrane by adopting a dip coating process to form a bacterial cellulose ultrafine mesh fiber membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 0.1 wt%;
(4) and (2) carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer by taking the other side surface of the chitosan non-woven fabric as a receiving surface, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving fluorine-containing polyurethane in acetone, adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath with the mass ratio of fluorinated polyurethane to acetone of 1:100, AgNO3The mass ratio of the tea polyphenol to the fluorine-containing polyurethane is 5:100, and the tea polyphenol and AgNO are3The mass ratio of the AgNO is 3:100, the constant temperature is 50 ℃, the stirring time is 1h, and tests show that the AgNO is3Degree of conversion to elemental Ag, i.e. Ag+The conversion degree to Ag simple substance is 99%, the voltage of electrostatic spraying is 5kV, the receiving distance is 5cm, the perfusion speed of the spinning solution is 0.2mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, as shown in fig. 1, the directional drainage dressing comprises a hydrophilic layer 3 (namely chitosan non-woven fabric), a moisture retention layer 2 (namely pectin nanofiber membrane) and an evaporation layer 1 (namely bacterial cellulose ultrafine net fiber membrane) which are adjacent, the hydrophilic layer 3, the moisture retention layer 2 and the evaporation layer 1 all have porous structures, the pore diameters of the porous structures are respectively 50 microns, 1 micron and 100nm, the pore diameters are gradually reduced, a hydrophobic layer 4 is embedded on the surface of the hydrophilic layer 3, far away from the moisture retention layer 2, the thickness of the hydrophobic layer 4 is 20 microns, and the directional drainage dressing mainly comprises a fluorinated polyurethane nano coating and Ag with the particle diameter of 20nm dispersed in the fluorinated polyurethane nano coating;
the directional liquid-guiding dressing for maintaining proper moisture of wound has a unidirectional moisture-guiding index of 1300% from the innermost layer to the outermost layer, and a water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is-300%, and the water pressure resistance is 70mmH2O; the moisture regain of the dressing is 350 percent; the bacteriostatic circle and the antibacterial rate of the dressing to staphylococcus aureus are respectively 6mm and 99.9 percent; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Comparative example 1
A method for preparing a directional drainage dressing for keeping a wound moderately moist, which comprises the steps substantially the same as those of example 1, except that AgNO is adopted in step (4)3With fluorinated polyurethanesThe quantity ratio is 15:100, and the test shows that Ag in the step (4)+The conversion degree to Ag simple substance is 92%, and the bacteriostatic circle and the antibacterial rate to staphylococcus aureus of the finally prepared directional drainage dressing for maintaining proper moisture of the wound are respectively 3.5mm and 98%.
Comparative example 2
A method for preparing directional drainage dressing for keeping wound properly moist, the steps are basically the same as example 1, except that in step (4), tea polyphenol and AgNO are used3Is 0.5:100, the test shows that Ag in the step (4)+The conversion degree to Ag simple substance is 85%, and the bacteriostatic circle and the antibacterial rate to staphylococcus aureus of the finally prepared directional drainage dressing for maintaining proper moisture of the wound are respectively 3mm and 96%.
As can be seen by comparing example 1 with comparative examples 1 and 2, Ag in example 1+The degree of conversion to elemental Ag is higher than in comparative examples 1 and 2, and the antibacterial performance of the product of example 1 is better than in comparative examples 1 and 2 because of the polymer/AgNO3Ratio and AgNO3The ratio of reducing agent can influence the degree of reduction reaction, and the invention reasonably controls the polymer/AgNO3Ratio and AgNO3In a ratio of reducing agent such that AgNO3Fully converted into Ag simple substance nano particles, thereby improving the antibacterial effect of the fibrous membrane and reducing the cytotoxicity of the fibrous membrane.
Comparative example 3
The steps of a preparation method of the directional liquid guiding dressing are basically the same as those of the example 1, the difference is that the moisture retention layer is made of cellulose acetate, the moisture regain of the finally prepared directional liquid guiding dressing is 12%, and the comparison between the comparative example 3 and the example 1 shows that the dressing in the example 1 can better maintain the proper moist state of a wound, while the dressing in the comparative example 3 cannot maintain the proper moist state of the wound, because the pectin nanofiber membrane is insoluble in water after being crosslinked, but the moisture regain can still reach 350%, a certain amount of moisture can be stored in the fiber, the dry state of the wound surface is maintained, and the moisture is ensured but not wet, while the cellulose acetate nanofiber membrane is insoluble in water, and the moisture regain is only 12%, so that the wound surface is excessively dry.
Comparative example 4
A method for preparing a directional drainage dressing for maintaining proper moisture of a wound basically comprises the same steps as example 1, except that the step (4) is omitted, the unidirectional drainage index of the obtained directional drainage dressing from the innermost layer to the outermost layer is 1000%, and the water pressure resistance is 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is-130%, and the water pressure resistance is 20mmH2O; comparing comparative example 4 with example 1, it can be seen that the dressing in example 1 has better directional drainage performance, because step (4) forms a hydrophobic layer on the non-woven surface through the electrostatic spraying process, a hydrophobic-hydrophilic wettability gradient is formed, and the liquid can spontaneously move from the hydrophobic side to the hydrophilic side under the driving of the gradient, so the directional drainage performance is correspondingly enhanced.
Example 2
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of chitosan non-woven fabric with the thickness of 60 mu m as a receiving surface, and carrying out electrostatic spinning on 10 wt% dialdehyde pectin solution to form a dialdehyde pectin nanofiber membrane with the thickness of 60 mu m, wherein the voltage of the electrostatic spinning is 20kV, the receiving distance is 20cm, and the perfusion speed of the spinning solution is 2 mL/h;
(2) immersing a composite membrane formed by the chitosan non-woven fabric and the dialdehyde pectin nano-fiber membrane into 1 wt% of adipic dihydrazide ethanol solution for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 20 min;
(3) coating the dispersion solution I of the bacterial cellulose on the surface of a dialdehyde pectin nanofiber membrane by adopting a dip coating process to form a bacterial cellulose ultrafine mesh fiber membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 0.5 wt%;
(4) and (2) carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer by taking the other side surface of the chitosan non-woven fabric as a receiving surface, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving fluorine-containing polyurethane in tetrahydrofuran, and adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath to obtain fluorinated polyurethaneThe mass ratio of the active ingredient to tetrahydrofuran is 2:100, AgNO3The mass ratio of the tea polyphenol to the fluorine-containing polyurethane is 2:100, and the tea polyphenol and AgNO are3The mass ratio of (A) to (B) is 5:100, the constant temperature is 80 ℃, the stirring time is 1h, the electrostatic spraying voltage is 10kV, the receiving distance is 10cm, the perfusion speed of the spinning solution is 1mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, and comprises adjacent hydrophilic layers (namely chitosan non-woven fabric), moisture-preserving layers (namely dialdehyde pectin nanofiber membrane) and evaporation layers (namely bacterial cellulose superfine reticular fiber membrane), wherein the hydrophilic layers, the moisture-preserving layers and the evaporation layers are all provided with porous structures, the pore diameters of the porous structures are 60 mu m, 2 mu m and 200nm respectively, the pore diameters are gradually reduced, the surface of the hydrophilic layer, far away from the moisture-preserving layer, is embedded with a hydrophobic layer, the thickness of the hydrophobic layer is 10 mu m, and the directional drainage dressing mainly comprises a fluorinated polyurethane nano coating and Ag with the particle size of 30nm dispersed in the fluorinated polyurethane nano coating;
the directional liquid-guiding dressing for maintaining proper moisture of wound has unidirectional moisture-guiding index of 1100% from innermost layer to outermost layer, and water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is-100%, and the water pressure resistance is 40mmH2O; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Example 3
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of the chitosan non-woven fabric with the thickness of 100 mu m as a receiving surface, and carrying out electrostatic spinning on the konjac glucomannan solution with the concentration of 15 wt% to form a konjac glucomannan nanofiber membrane with the thickness of 80 mu m, wherein the voltage of the electrostatic spinning is 50kV, the receiving distance is 30cm, and the filling speed of the spinning solution is 5 mL/h;
(2) immersing a composite membrane formed by the chitosan non-woven fabric and the konjac glucomannan nano-fiber membrane into 5 wt% adipic acid dihydrazide ethanol solution for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 60 min;
(3) coating the dispersion solution I of the bacterial cellulose on the surface of the konjac glucomannan nanofiber membrane by adopting a dip coating process to form a bacterial cellulose ultrafine mesh fiber membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 1 wt%;
(4) and (2) carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer by taking the other side surface of the chitosan non-woven fabric as a receiving surface, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving polystyrene in N, N-dimethyl formamide, adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath with polystyrene and N, N-dimethylformamide at a mass ratio of 5:100, AgNO3The mass ratio of the tea polyphenol to the polystyrene is 10:100, and the tea polyphenol and the AgNO are3The mass ratio of (A) to (B) is 20:100, the constant temperature is 100 ℃, the stirring time is 1h, the electrostatic spraying voltage is 30kV, the receiving distance is 20cm, the perfusion speed of the spinning solution is 2mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, and comprises adjacent hydrophilic layers (namely chitosan non-woven fabric), moisture-preserving layers (namely konjac glucomannan nanofiber membrane) and evaporation layers (namely bacterial cellulose ultrafine net-shaped fiber membrane), wherein the hydrophilic layers, the moisture-preserving layers and the evaporation layers are all provided with porous structures, the pore diameters of the porous layers are respectively 100 micrometers, 5 micrometers and 500nm, the pore diameters are gradually reduced, the surface of the hydrophilic layer, far away from the moisture-preserving layer, is embedded with a hydrophobic layer, the thickness of the hydrophobic layer is 20 micrometers, and the directional drainage dressing mainly comprises a polystyrene nano coating and Ag with the particle size of 50nm dispersed in the polystyrene nano coating;
the directional liquid-guiding dressing for maintaining proper moisture of wound has one-way moisture-guiding index of 1400% from innermost layer to outermost layer, and water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is 0%, and the water pressure resistance is 80mmH2O; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Example 4
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of a chitosan non-woven fabric with the thickness of 100 mu m as a receiving surface, and carrying out electrostatic spinning on a pullulan solution with the concentration of 10 wt% to form a pullulan nano-fiber membrane with the thickness of 100 mu m, wherein the voltage of the electrostatic spinning is 50kV, the receiving distance is 30cm, the perfusion speed of the spinning solution is 3mL/h, the diameter of the obtained fiber is 1 mu m, the average pore diameter of the fiber membrane is 4 mu m, and the thickness of the fiber membrane is 80 mu m.
(2) Immersing a composite membrane formed by the chitosan non-woven fabric and the pullulan nano-fiber membrane into an adipic acid dihydrazide ethanol solution with the concentration of 2 wt% for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 30 min;
(3) coating the bacterial cellulose dispersion solution I on the surface of the pullulan nano fibrous membrane by adopting a dip coating process to form a bacterial cellulose superfine reticular fibrous membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 0.5 wt%;
(4) and (2) carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer by taking the other side surface of the chitosan non-woven fabric as a receiving surface, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving polyvinylidene fluoride in N, N-dimethylacetamide, and adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath with mass ratio of polyvinylidene fluoride to N, N-dimethylacetamide (AgNO) of 3:1003The mass ratio of the tea polyphenol to the polyvinylidene fluoride is 5:100, and the tea polyphenol and AgNO are3The mass ratio of (A) to (B) is 10:100, the constant temperature is 100 ℃, the stirring time is 1h, the electrostatic spraying voltage is 30kV, the receiving distance is 20cm, the perfusion speed of the spinning solution is 2mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, and comprises adjacent hydrophilic layers (namely chitosan non-woven fabric), moisture-preserving layers (namely pullulan nano fibrous membrane) and evaporating layers (namely bacterial cellulose ultrafine net fibrous membrane), wherein the hydrophilic layers, the moisture-preserving layers and the evaporating layers are all provided with porous structures, the pore diameters of the porous layers are respectively 100 mu m, 6 mu m and 500nm, the pore diameters are gradually reduced, the surface of the hydrophilic layer, far away from the moisture-preserving layer, is embedded with a hydrophobic layer, the thickness of the hydrophobic layer is 20 mu m, and the directional drainage dressing mainly comprises a polyvinylidene fluoride nano coating and Ag with the particle size of 50nm dispersed in the polyvinylidene fluoride nano coating;
the directional liquid-guiding dressing for maintaining proper moisture of wound has one-way moisture-guiding index of 1400% from innermost layer to outermost layer, and water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is 0%, and the water pressure resistance is 80mmH2O; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Example 5
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of chitosan non-woven fabric with the thickness of 80 microns as a receiving surface, carrying out electrostatic spinning on a pectin solution with the concentration of 15 wt% to form a pectin nanofiber membrane with the thickness of 80 microns, wherein the voltage of the electrostatic spinning is 50kV, the receiving distance is 30cm, the perfusion speed of the spinning solution is 5mL/h, the diameter of the obtained fiber is 2 microns, the average pore diameter of the fiber membrane is 6 microns, and the thickness is 100 microns.
(2) Immersing a composite membrane formed by the chitosan non-woven fabric and the pectin nano-fiber membrane into a saturated calcium chloride ethanol solution for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 60 min;
(3) coating the dispersion solution I of the bacterial cellulose on the surface of the pectin nanofiber membrane by adopting a dip coating process to form a bacterial cellulose ultrafine mesh fiber membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 1 wt%;
(4) and (2) carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer by taking the other side surface of the chitosan non-woven fabric as a receiving surface, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving polyvinylidene fluoride-hexafluoropropylene in tetrahydrofuran, and adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath with mass ratio of polyvinylidene fluoride-hexafluoropropylene to tetrahydrofuran of 5:100, AgNO3The mass ratio of the tea polyphenol to the polyvinylidene fluoride-hexafluoropropylene is 10:100, and the tea polyphenol and AgNO3The mass ratio of (A) to (B) is 20:100, the constant temperature is 100 ℃, the stirring time is 1h, the electrostatic spraying voltage is 30kV, the receiving distance is 20cm, the perfusion speed of the spinning solution is 2mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, and comprises adjacent hydrophilic layers (namely chitosan non-woven fabric), moisture-preserving layers (namely pectin nanofiber membrane) and evaporation layers (namely bacterial cellulose ultrafine reticular fiber membrane), wherein the hydrophilic layers, the moisture-preserving layers and the evaporation layers are all provided with porous structures, the pore diameters of the porous structures are respectively 80 mu m, 5 mu m and 500nm, the pore diameters are gradually reduced, hydrophobic layers are embedded on the surfaces, far away from the moisture-preserving layers, of the hydrophilic layers, the thickness of the hydrophobic layers is 20 mu m, and the directional drainage dressing mainly comprises a vinylidene fluoride-hexafluoropropylene nano coating and Ag with the particle size of 50nm dispersed in the hydrophilic layers;
the directional liquid-guiding dressing for maintaining proper moisture of wound has one-way moisture-guiding index of 1400% from innermost layer to outermost layer, and water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is 0%, and the water pressure resistance is 80mmH2O; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Example 6
A preparation method of a directional drainage dressing for maintaining proper moisture of a wound mainly comprises the following steps:
(1) taking one side surface of chitosan non-woven fabric with the thickness of 100 mu m as a receiving surface, and carrying out electrostatic spinning on dialdehyde pectin solution with the concentration of 15 wt% to form dialdehyde pectin nano-fiber membrane with the thickness of 80 mu m, wherein the voltage of the electrostatic spinning is 30kV, the receiving distance is 30cm, the perfusion speed of the spinning solution is 2mL/h, the diameter of the obtained fiber is 1 mu m, the average pore diameter of the fiber membrane is 3 mu m, and the thickness is 70 mu m.
(2) Immersing a composite membrane formed by the chitosan non-woven fabric and the dialdehyde pectin nano-fiber membrane into an adipic dihydrazide ethanol solution with the concentration of 4 wt% for crosslinking reaction, wherein the temperature of the crosslinking reaction is normal temperature, and the time is 30 min;
(3) coating the dispersion solution I of the bacterial cellulose on the surface of a dialdehyde pectin nanofiber membrane by adopting a dip coating process to form a bacterial cellulose ultrafine mesh fiber membrane with the thickness of 1 mu m, wherein the concentration of the dispersion solution I is 0.5 wt%;
(4) using chitosan non-woven fabricThe other side surface of the dispersion liquid II is a receiving surface, and the dispersion liquid II is subjected to electrostatic spraying to form a hydrophobic layer, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving polyvinylidene fluoride-chlorotrifluoroethylene in N, N-dimethylacetamide, and adding AgNO3Mixing with tea polyphenols, stirring in constant temperature water bath with mass ratio of polyvinylidene fluoride-chlorotrifluoroethylene to N, N-dimethylacetamide (AgNO) of 3:1003The mass ratio of the tea polyphenol to the polyvinylidene fluoride-chlorotrifluoroethylene is 2:100, and the tea polyphenol and AgNO3The mass ratio of (A) to (B) is 10:100, the constant temperature is 100 ℃, the stirring time is 1h, the electrostatic spraying voltage is 30kV, the receiving distance is 20cm, the perfusion speed of the spinning solution is 2mL/h, and the electrospray depth/thickness is 20 μm.
The finally prepared directional drainage dressing for maintaining proper moisture of the wound has a composite layer structure, and comprises a hydrophilic layer (namely chitosan non-woven fabric), a moisture retention layer (namely dialdehyde pectin nanofiber membrane) and an evaporation layer (namely bacterial cellulose superfine reticular fiber membrane) which are adjacent, wherein the hydrophilic layer, the moisture retention layer and the evaporation layer are all provided with porous structures, the pore diameters of the porous structures are respectively 100 mu m, 5 mu m and 500nm, the pore diameters are gradually reduced, a hydrophobic layer is embedded on the surface of the hydrophilic layer, which is far away from the moisture retention layer, the thickness of the hydrophobic layer is 20 mu m, and the directional drainage dressing mainly comprises a polyvinylidene fluoride-chlorotrifluoroethylene nano coating and Ag with the particle diameter of 50nm dispersed in the coating;
the directional liquid-guiding dressing for maintaining proper moisture of wound has one-way moisture-guiding index of 1400% from innermost layer to outermost layer, and water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is 0%, and the water pressure resistance is 80mmH2O; after the dressing of the embodiment is applied to the surface of a wound for 1min, no effusion on the surface of the wound is observed, and the wound can still keep a moist state after 1 day without scab formation on the surface.
Claims (6)
1. An oriented drainage dressing for maintaining proper moisture of a wound, which has a composite layer structure and is characterized in that: the water-absorbing material comprises a hydrophilic layer, a moisture-preserving layer and an evaporation layer which are adjacent, wherein the hydrophilic layer, the moisture-preserving layer and the evaporation layer are all provided with porous structures, the pore diameter is gradually reduced, the hydrophilic layer is made of a material which is hydrophilic and has the moisture regain of less than or equal to 5%, and the moisture-preserving layer is made of a material which is hydrophilic and has the moisture regain of more than or equal to 100%;
the hydrophilic layer and the moisture-keeping layer are respectively made of polysaccharide A and polysaccharide B, the polysaccharide A is chitosan, and the polysaccharide B is pectin, konjac glucomannan or pullulan;
the hydrophilic layer and the moisture retention layer are respectively a polysaccharide A non-woven fabric with the thickness of 50-100 mu m and a polysaccharide B nano-fiber film with the thickness of 50-100 mu m;
the evaporation layer is a bacterial cellulose superfine reticular fiber membrane with the thickness of 1 mu m, and the porous apertures in the polysaccharide A non-woven fabric, the polysaccharide B nano-fiber membrane and the bacterial cellulose superfine reticular fiber membrane are respectively 50-100 mu m, 1-6 mu m and 100-500 nm.
2. The directional drainage dressing for maintaining proper wound moistening according to claim 1, wherein a hydrophobic layer is embedded on the surface of the hydrophilic layer far from the moisture retention layer, the thickness of the hydrophobic layer is 10-20 μm, and the hydrophobic layer mainly comprises a hydrophobic nano-coating and an antibacterial agent dispersed in the hydrophobic nano-coating.
3. The directional drainage dressing for maintaining proper wound moistening as claimed in claim 2, wherein the hydrophobic nano-coating is made of hydrophobic polymer, the hydrophobic polymer is fluorinated polyurethane, polystyrene, polyvinylidene fluoride-hexafluoropropylene or polyvinylidene fluoride-chlorotrifluoroethylene, and the antibacterial agent is Ag with particle size of 20-50 nm.
4. The directional drainage dressing for maintaining proper moisture of wound according to any one of claims 1 to 3, wherein the directional drainage dressing for maintaining proper moisture of wound has a unidirectional moisture permeability index of 1000 to 1400% from the innermost layer to the outermost layer, and a water pressure resistance of 0mmH2O; the one-way moisture permeability index from the outermost layer to the innermost layer is-300-0%, and the water pressure resistance is 20-80 mmH2O。
5. A method for preparing the directional drainage dressing for maintaining the proper moisture of the wound as claimed in any one of claims 1 to 4, which is characterized in that: forming a polysaccharide B nanofiber membrane and a hydrophobic layer on the surfaces of the two sides of the polysaccharide A non-woven fabric respectively, and forming a bacterial cellulose ultrafine mesh fiber membrane on the surface of the polysaccharide B nanofiber membrane to prepare the directional drainage dressing for maintaining the proper moisture of the wound;
the polysaccharide A is chitosan, the polysaccharide B is pectin, konjac glucomannan or pullulan, and the porous pore diameters in the polysaccharide A non-woven fabric, the polysaccharide B nano-fiber membrane and the bacterial cellulose superfine mesh fiber membrane are decreased progressively.
6. The method according to claim 5, characterized by the following specific steps:
(1) taking one side surface of the polysaccharide A non-woven fabric as a receiving surface, and performing electrostatic spinning on the polysaccharide B solution to form a polysaccharide B nanofiber membrane;
(2) immersing a composite membrane formed by the polysaccharide A non-woven fabric and the polysaccharide B nano-fiber membrane into a cross-linking agent solution for cross-linking reaction, wherein the temperature of the cross-linking reaction is normal temperature, and the time is 10-60 min;
(3) coating the dispersion liquid I of the bacterial cellulose on the surface of the polysaccharide B nanofiber membrane to form a bacterial cellulose ultrafine mesh fiber membrane;
(4) and (2) with the other side surface of the polysaccharide A non-woven fabric as a receiving surface, carrying out electrostatic spraying on the dispersion liquid II to form a hydrophobic layer, wherein the preparation process of the dispersion liquid II comprises the following steps: dissolving hydrophobic polymer in solvent, adding AgNO3And stirring in a constant-temperature water bath after adding a reducing agent, wherein the mass ratio of the hydrophobic polymer to the solvent is 1-5: 100, and AgNO3The mass ratio of the reducing agent to the hydrophobic polymer is 1-10: 100, and the reducing agent and AgNO are3The mass ratio of the components is 1-20: 100, the reducing agent is tea polyphenol, the solvent is acetone, tetrahydrofuran, N-dimethylformamide or N, N-dimethylacetamide, the constant temperature is 50-100 ℃, and the stirring time is 1 h.
Priority Applications (1)
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| CN115463622A (en) * | 2022-08-03 | 2022-12-13 | 广东纤友朵美生物科技有限公司 | Gel based on oxidized pectin and preparation method thereof |
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