CN113893090A - Medical composite self-pumping dressing with multilayer structure and preparation method and application thereof - Google Patents
Medical composite self-pumping dressing with multilayer structure and preparation method and application thereof Download PDFInfo
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- CN113893090A CN113893090A CN202111230018.7A CN202111230018A CN113893090A CN 113893090 A CN113893090 A CN 113893090A CN 202111230018 A CN202111230018 A CN 202111230018A CN 113893090 A CN113893090 A CN 113893090A
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- 239000002131 composite material Substances 0.000 title claims abstract description 42
- 238000005086 pumping Methods 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000004744 fabric Substances 0.000 claims abstract description 92
- 125000006850 spacer group Chemical group 0.000 claims abstract description 65
- 239000004964 aerogel Substances 0.000 claims abstract description 50
- 239000010410 layer Substances 0.000 claims abstract description 43
- 239000002344 surface layer Substances 0.000 claims abstract description 37
- 239000012528 membrane Substances 0.000 claims abstract description 20
- 239000002121 nanofiber Substances 0.000 claims abstract description 20
- 238000009940 knitting Methods 0.000 claims description 22
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 15
- 235000010413 sodium alginate Nutrition 0.000 claims description 15
- 229940005550 sodium alginate Drugs 0.000 claims description 15
- 239000000661 sodium alginate Substances 0.000 claims description 15
- 239000000835 fiber Substances 0.000 claims description 13
- 238000003780 insertion Methods 0.000 claims description 13
- 230000037431 insertion Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000004814 polyurethane Substances 0.000 claims description 12
- 229920002635 polyurethane Polymers 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 11
- 238000004108 freeze drying Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000002243 precursor Substances 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 7
- 238000013329 compounding Methods 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- 238000010041 electrostatic spinning Methods 0.000 claims description 5
- 230000029663 wound healing Effects 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 3
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 10
- 230000035876 healing Effects 0.000 abstract description 8
- 238000013461 design Methods 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000008204 material by function Substances 0.000 abstract description 2
- 239000013543 active substance Substances 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 19
- 208000027418 Wounds and injury Diseases 0.000 description 19
- 239000000243 solution Substances 0.000 description 19
- 230000002209 hydrophobic effect Effects 0.000 description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- 239000013060 biological fluid Substances 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001523 electrospinning Methods 0.000 description 4
- 229920000049 Carbon (fiber) Polymers 0.000 description 3
- 239000004917 carbon fiber Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000009941 weaving Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
- D01D5/0084—Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B1/00—Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B1/14—Other fabrics or articles characterised primarily by the use of particular thread materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Textile Engineering (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical composite self-pumping dressing with a multilayer structure, a preparation method and application thereof, and relates to the technical field of functional materials. The composite self-pumping dressing comprises a three-dimensional spacing fabric, a nanofiber membrane arranged on the top surface layer of the three-dimensional spacing fabric and an aerogel layer filled in the three-dimensional spacing fabric; the three-dimensional spacer fabric is hydrophilic three-dimensional spacer fabric; the aerogel layer is a hydrophilic aerogel layer. The dressing provided by the invention has reasonable structural design and simple manufacturing process, improves the capability of the medical dressing to absorb redundant exudate, releases active substances to promote the growth of wound tissues, can keep the wound moist, provides proper buffer performance and promotes the healing of the wound.
Description
Technical Field
The invention relates to the technical field of functional materials, in particular to a medical composite self-pumping dressing with a multilayer structure, and a preparation method and application thereof.
Background
The management of biological fluids around wounds is a prerequisite for wound healing, including the control of bleeding and the removal of excess biological fluids. Excessive biological fluids tend to over-moisturize the wound, which is an overlooked but ubiquitous problem that impedes the wound healing process. Conventional hydrophilic dressings typically absorb some of the biological fluid, but due to their hydrophilic nature, inevitably leave biological fluid at the interface of the wound and the dressing. The remaining biological fluid continually moisturizes the wound, complicating the healing process.
Disclosure of Invention
The invention aims to solve the defects in the background technology, and provides a medical composite self-pumping dressing with a multilayer structure and a preparation method and application thereof.
The invention provides a medical composite self-pumping dressing with a multilayer structure, which comprises a three-dimensional spacing fabric, a nanofiber membrane arranged on the top surface layer of the three-dimensional spacing fabric and an aerogel layer filled in the three-dimensional spacing fabric;
the three-dimensional spacer fabric is hydrophilic three-dimensional spacer fabric; the aerogel layer is a hydrophilic aerogel layer.
Preferably, the thickness of the three-dimensional interval fabric is 7-12 mm, and the filling coefficient of the aerogel layer in the three-dimensional interval fabric is 60-90%; the density of the composite self-pumping dressing is 0.85-1.25 g/cm3。
Preferably, the aerogel layer is arranged on the bottom surface layer of the three-dimensional space fabric, and an air layer is arranged between the aerogel layer and the top surface layer of the three-dimensional space fabric.
Preferably, the nanofiber membrane is made of polyurethane;
the aerogel layer is sodium alginate-based aerogel, and the mass fraction of sodium alginate in the aerogel layer is 2-10%.
Preferably, the top surface layer and the bottom surface layer of the three-dimensional spacing fabric are both knitted fabrics formed by compounding of chain knitting tissues and weft insertion tissues; the top surface layer and the bottom surface layer of the three-dimensional spacer fabric are connected through a plurality of continuous spacer wires;
the chain knitting yarns of the chain knitting structure are hydrophilic fibers; the weft insertion yarns of the weft insertion tissues are hydrophilic fibers.
The second purpose of the invention is to provide a preparation method of the medical composite self-pumping dressing with the multilayer structure, which comprises the following steps:
immersing the bottom surface layer of the three-dimensional spacer fabric into aerogel with a certain liquid level height, pre-freezing, and then freeze-drying to obtain the freeze-dried three-dimensional spacer fabric;
and then, laying a nanofiber membrane on the top surface layer of the three-dimensional space fabric subjected to freeze drying by adopting an electrostatic spinning process to obtain the medical composite self-pump dressing with the multilayer structure.
Preferably, in the process of laying the nanofiber membrane, the adopted precursor solution is prepared by dissolving polyurethane in an organic solvent; wherein the weight ratio of the polyurethane to the organic solvent is 1: 5; the organic solvent is N, N-dimethyl formyl.
Preferably, the pre-freezing temperature is-60 ℃ and the time is 4-6 h.
Preferably, in the freeze drying process, the temperature is-80 ℃, the time is 36-48 h, and the vacuum degree is 0.1 MPa.
The third purpose of the invention is to provide the application of the medical composite self-pumping dressing with a multilayer structure in wound healing.
Compared with the prior art, the invention has the beneficial effects that:
the medical composite self-pumping dressing with the multilayer structure is a medical dressing formed by compounding a three-dimensional spacer fabric, aerogel and a nanofiber membrane, and particularly, the hydrophobic nanofiber membrane, the hydrophilic three-dimensional spacer fabric and the hydrophilic aerogel are compounded to form a self-pumping structure, so that excessive exudates can be quickly absorbed, and a relatively humid environment is provided for a wound. The aerogel is reinforced by the three-dimensional spacing fabric, so that the aerogel has a dressing function and a supporting surface function. The pressure is redistributed while the wound exudate is rapidly absorbed, so that the shearing force is reduced. In addition, the airflow can flow through the three-dimensional spacing fabric, the microclimate of the supporting surface is improved, the air permeability is good, and the healing of the wound is promoted. The structure is reasonable in design, can be widely applied to wound treatment, especially to the aspect of accelerating the healing of chronic wounds, and has good application prospect. The electrospinning hydrophobic nanofiber membrane provided by the invention is combined with the hydrophilic upper layer fabric of the three-dimensional spacer fabric to form a hydrophobic-hydrophilic unidirectional moisture-conducting structure, and the effect of hydrostatic pressure and Laplace force provided by the structure can be utilized to effectively absorb exudates. Meanwhile, due to the hydrophobic characteristic, a lower humid environment on the surface of the skin side can be maintained, and the phenomenon that the wound overhydrates to influence healing is avoided.
The invention adopts aerogel with stronger hydrophilicity as the liquid storage layer, so that the exudate finally enters and is stored in the aerogel layer through the one-way moisture-conducting effect, and the liquid absorption capacity is improved. Sodium alginate is particularly adopted as a matrix, so that the preparation is safe and non-toxic and has good biocompatibility; and the raw material source is wide, and the manufacturing cost is low.
The 3-dimensional spacing fabric adopted by the invention has the thickness of 7-12 mm, and the structure has larger thickness, so that more exudates can be borne; the filling coefficient of the aerogel matrix in the three-dimensional space fabric is 60-90%, the aerogel matrix is not completely filled in the space fabric, and airflow can flow along the space fabric, so that the microclimate of the supporting surface is improved, and the aerogel matrix has good air permeability; the density of the composite medical dressing is 0.85-1.25 g/cm3Light weight, and is favorable for the recovery of the wound surface.
The surface layer of the three-dimensional spacing fabric adopted by the invention is a knitted fabric formed by compounding the chaining tissue and the weft insertion tissue, the structure is compact, the number of typical contact points of the hydrophilic surface layer and the hydrophobic nanofiber membrane is increased, and an effective power source is provided for pumping liquid.
The preparation method of the composite medical dressing provided by the invention has the advantages of simple process, mild reaction conditions, short preparation period, suitability for industrial production and good market prospect.
Drawings
Fig. 1 is a schematic structural diagram of a medical composite self-pumping dressing with a multilayer structure provided by the invention.
Detailed Description
In order to make the technical solutions of the present invention better understood and implemented by those skilled in the art, the present invention is further described below with reference to the following specific embodiments and the accompanying drawings, but the embodiments are not meant to limit the present invention.
It should be noted that the experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials used are commercially available, unless otherwise specified.
The medical composite self-pumping dressing with the multilayer structure can be used as a wound care material, particularly a pressure sore care material, and is applied to the field of medical care.
The medical composite self-pumping dressing with the multilayer structure, disclosed by the invention, is shown in figure 1 and comprises a three-dimensional spacing fabric 1, a nanofiber membrane 4 arranged on the top surface layer of the three-dimensional spacing fabric 1 and an aerogel layer 2 filled in the three-dimensional spacing fabric 1;
the three-dimensional spacer fabric 1 is a hydrophilic three-dimensional spacer fabric; the aerogel layer 2 is a hydrophilic aerogel layer.
As shown in fig. 1, the aerogel layer 2 is disposed on the bottom surface layer of the three-dimensional spacer fabric 1, and an air layer 2 is disposed between the aerogel layer 2 and the top surface layer of the three-dimensional spacer fabric 1.
The top surface layer and the bottom surface layer of the three-dimensional spacing fabric adopted in the following embodiments are both knitted fabrics formed by compounding a chain knitting tissue and a weft insertion tissue; the top surface layer and the bottom surface layer of the three-dimensional spacer fabric are connected through a plurality of continuous spacer wires;
the chain knitting yarns of the chain knitting structure are hydrophilic polyester fibers;
the weft insertion yarns of the weft insertion tissues are hydrophilic polyester fibers;
the spacing filaments are hydrophobic fiber monofilaments with the diameter of 0.2 mm.
The three-dimensional spacer fabric used in the following examples was woven using a double needle bed raschel warp knitting machine.
The following examples illustrate the preparation of a medical composite self-pumping dressing using the provided multilayer structure.
Example 1
A preparation method of a medical composite self-pumping dressing with a multilayer structure comprises the following steps:
step 1: dissolving 2g of sodium alginate in 100ml of distilled water to prepare a sodium alginate water solution with the mass fraction of 2%;
step 2: magnetically stirring for 3 hours to form a uniform solution;
and step 3: standing for 24h under the conditions of relative humidity of 60% and temperature of 25 ℃;
and 4, step 4: weaving a warp-knitted three-dimensional spacer fabric with a surface layer of a chaining and a weft insertion on a double-needle bar Raschel warp knitting machine; the three-dimensional spacer fabric is woven by a double needle bed Raschel warp knitting machine with 6 guide bars in total of GB 1-GB 6, yarns carried on GB2 and GB5 are hydrophobic fiber multifilaments, yarns carried on GB1 and GB6 are carbon fiber tows, and hydrophobic fiber monofilaments with the diameter of 0.2mm are carried on GB3 and GB 4; GB1 and GB2 two guide bars weave three-dimensional on front needle bedThe top layer of the spacer fabric, the bottom layer of the fabric knitted by the back needle bed and the bottom layer of the fabric knitted by the GB5 and the GB6, the spacer filaments carried by the GB3 and the GB4, the top and bottom layers of the spacer fabric are connected by the spacer filaments by alternately knitting the front and back needle beds to form the three-dimensional spacer fabric, the thickness of the fabric is 10mm, and the surface density is 925g/m2；
And 5: pouring a sodium alginate solution with the height of about 80% of the thickness of the spacer fabric into the mold;
step 6: cutting the three-dimensional spacer fabric according to the shape of the die and putting the three-dimensional spacer fabric into the die;
and 7: pre-freezing at-60 deg.C for 5h, transferring to a freeze-drying machine, and freeze-drying at-100 deg.C under-200 Pa for 48 h; obtaining a three-dimensional spacer fabric-aerogel composite;
and 8: dissolving polyurethane in N, N-dimethyl formyl solution, and fully stirring to form uniform precursor solution; wherein, polyurethane/dimethylformamide is 20 wt%;
loading the precursor solution into a syringe by adopting an electrostatic spinning process, and electro-spinning a nanofiber membrane on the surface of the upper layer of the three-dimensional spacer fabric-aerogel composite obtained in the step 7 to obtain the medical composite self-pump dressing with a multilayer structure, wherein the thickness of the dressing is 7mm, and the density of the dressing is 0.92g/cm3The specification of (1).
Example 2
A preparation method of a medical composite self-pumping dressing with a multilayer structure comprises the following steps:
step 1: dissolving 5g of sodium alginate in distilled water to prepare a sodium alginate water solution with the mass fraction of 5%;
step 2: magnetically stirring for 6 hours to form a uniform solution;
and step 3: standing for 20h under the conditions that the relative humidity is 65% and the temperature is 28 ℃;
and 4, step 4: weaving a warp-knitted three-dimensional spacer fabric with a surface layer of a chaining and a weft insertion on a double-needle bar Raschel warp knitting machine; the three-dimensional spacer fabric is woven by a double needle bed Raschel warp knitting machine with 6 guide bars in total of GB 1-GB 6, yarns carried on GB2 and GB5 are hydrophobic fiber multifilaments, yarns carried on GB1 and GB6 are carbon fiber tows, and yarns carried on GB3 and GB4 are hydrophobic fiber monofilaments; the three-dimensional spacer fabric is formed by knitting the top surface layers of the three-dimensional spacer fabric on a front needle bed by two guide bars GB1 and GB2, knitting the bottom surface layers of the three-dimensional spacer fabric on a rear needle bed by two guide bars GB5 and GB6, carrying spacer filaments on the two guide bars GB3 and GB4, and alternately knitting the two guide bars on the front needle bed and the rear needle bed to connect the top surface layers and the bottom surface layers of the spacer fabric by the spacer filaments;
and 5: pouring a sodium alginate solution with the height of about 60% of the thickness of the spacer fabric into the mold;
step 6: cutting the three-dimensional spacer fabric according to the shape of the die and putting the three-dimensional spacer fabric into the die;
and 7: pre-freezing for 4h at-60 ℃, then transferring to a freeze dryer, and carrying out freeze drying for 36h under the conditions that the pressure is-200 Pa and the temperature is-100 ℃ to obtain a three-dimensional space fabric-aerogel compound;
and 8: dissolving polyurethane in N, N-dimethyl formyl solution, and fully stirring to form uniform precursor solution; wherein, polyurethane/dimethylformamide is 20 wt%;
loading the precursor solution into an injector by adopting an electrostatic spinning process, and electro-spinning a nanofiber membrane on the surface of the upper layer of the three-dimensional spacer fabric-aerogel compound obtained in the step 7 to obtain the medical composite self-pump dressing with a multilayer structure, wherein the thickness of the dressing is 7mm, and the density of the dressing is 0.92cm3The specification of (1).
Example 3
A preparation method of a medical composite self-pumping dressing with a multilayer structure comprises the following steps:
step 1: dissolving 10g of sodium alginate in distilled water to prepare a 10% sodium alginate aqueous solution;
step 2: magnetically stirring for 5 hours to form a uniform solution;
and step 3: standing for 20h under the conditions of relative humidity of 65% and temperature of 22 ℃;
and 4, step 4: weaving a warp-knitted three-dimensional spacer fabric with a surface layer of a chaining and a weft insertion on a double-needle bar Raschel warp knitting machine; the three-dimensional spacer fabric is woven by a double needle bed Raschel warp knitting machine with 6 guide bars in total of GB 1-GB 6, yarns carried on GB2 and GB5 are hydrophobic fiber multifilaments, yarns carried on GB1 and GB6 are carbon fiber tows, and hydrophobic fiber monofilaments with the diameter of 0.2mm are carried on GB3 and GB 4; the three-dimensional spacer fabric is formed by knitting the top surface layers of the three-dimensional spacer fabric on a front needle bed by two guide bars GB1 and GB2, knitting the bottom surface layers of the three-dimensional spacer fabric on a rear needle bed by two guide bars GB5 and GB6, carrying spacer filaments on the two guide bars GB3 and GB4, and alternately knitting the two guide bars on the front needle bed and the rear needle bed to connect the top surface layers and the bottom surface layers of the spacer fabric by the spacer filaments;
and 5: pouring a sodium alginate solution with the height of about 90 percent of the spacer fabric into the mold;
step 6: cutting the three-dimensional spacer fabric according to the shape of the die and putting the three-dimensional spacer fabric into the die;
and 7: pre-freezing for 6h at-60 ℃, then transferring to a freeze dryer, and carrying out freeze drying for 48h under the conditions that the pressure is-200 Pa and the temperature is-100 ℃ to obtain a three-dimensional spacer fabric-aerogel compound;
and 8: dissolving polyurethane in N, N-dimethyl formyl solution, and fully stirring to form uniform precursor solution; wherein, polyurethane/dimethylformamide is 20 wt%;
loading the precursor solution into a syringe by adopting an electrostatic spinning process, and electro-spinning a nanofiber membrane on the surface of the upper layer of the three-dimensional spacer fabric-aerogel composite obtained in the step 7 to obtain the medical composite self-pump dressing with a multilayer structure, wherein the thickness of the dressing is 7mm, and the density of the dressing is 0.92g/cm3The specification of (1).
The medical composite self-pumping dressing with the multilayer structure effectively improves the capability of the medical dressing to absorb excessive exudate, prevents the wound from being overhydrated due to liquid backflow, provides proper buffer performance, and promotes the healing of the wound surface.
The surface of the hydrophobic nanofiber membrane provided by the invention presents a water contact angle of 136 degrees, and liquid drops are quickly diffused and absorbed on the surface of the hydrophilic fabric. The aerogel wetting time of the absorption layer is about 3s, the swelling ratio reaches 710.5%, and the absorption layer has high absorptivity.
Quasi-static compression testing of the composite dressing provided in example 1 showed that it was compressedThe shrinkage modulus is about 2.1GPa, and the yield strength is about 3.2 KPa. The air permeability test shows that the air permeability is about 319.87L/m2And/s 100 Pa. Has good air permeability.
In summary, the medical composite self-pumping dressing with a multilayer structure provided by the invention is a medical dressing formed by compounding a three-dimensional spacer fabric, aerogel and a nanofiber membrane, and particularly, the hydrophobic nanofiber membrane, the hydrophilic three-dimensional spacer fabric and the hydrophilic aerogel are compounded to form a self-pumping structure, so that excessive exudate can be rapidly absorbed, and a relatively humid environment is provided for a wound. The aerogel is reinforced by the three-dimensional spacing fabric, so that the aerogel has a dressing function and a supporting surface function. The pressure is redistributed while the wound exudate is rapidly absorbed, so that the shearing force is reduced. In addition, the airflow can flow through the three-dimensional spacing fabric, the microclimate of the supporting surface is improved, the air permeability is good, and the healing of the wound is promoted. The structure is reasonable in design, can be widely applied to wound treatment, especially to the aspect of accelerating the healing of chronic wounds, and has good application prospect.
The invention adopts aerogel with stronger hydrophilicity as the liquid storage layer, so that the exudate finally enters and is stored in the aerogel layer through the one-way moisture-conducting effect, and the liquid absorption capacity is improved. Sodium alginate is particularly adopted as a matrix, so that the preparation is safe and non-toxic and has good biocompatibility; and the raw material source is wide, and the manufacturing cost is low.
The present invention describes preferred embodiments and effects thereof. Additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The medical composite self-pumping dressing with the multilayer structure is characterized by comprising a three-dimensional spacing fabric, a nanofiber membrane arranged on the top surface layer of the three-dimensional spacing fabric and an aerogel layer filled in the three-dimensional spacing fabric;
the three-dimensional spacer fabric is hydrophilic three-dimensional spacer fabric; the aerogel layer is a hydrophilic aerogel layer.
2. The medical composite self-pump dressing with the multilayer structure according to claim 1, wherein the thickness of the three-dimensional spacing fabric is 7-12 mm, and the filling factor of the aerogel layer in the three-dimensional spacing fabric is 60-90%; the density of the composite self-pumping dressing is 0.85-1.25 g/cm3。
3. The multi-layered medical composite self-pumping dressing according to claim 2, wherein the aerogel layer is disposed on the bottom layer of the three-dimensional spacer fabric, and an air layer is disposed between the aerogel layer and the top layer of the three-dimensional spacer fabric.
4. The medical composite self-pumping dressing of multilayer structure according to claim 1,
the nanofiber membrane is made of polyurethane;
the aerogel layer is sodium alginate-based aerogel, and the mass fraction of sodium alginate in the aerogel layer is 2-10%.
5. The medical composite self-pump dressing with the multilayer structure as claimed in claim 1, wherein the top surface layer and the bottom surface layer of the three-dimensional spacing fabric are both knitted fabrics formed by compounding of chain stitch and weft insertion stitch; the top surface layer and the bottom surface layer of the three-dimensional spacer fabric are connected through a plurality of continuous spacer wires;
the chain knitting yarns of the chain knitting structure are hydrophilic fibers; the weft insertion yarns of the weft insertion tissues are hydrophilic fibers.
6. The preparation method of the medical composite self-pumping dressing with the multilayer structure as claimed in any one of claims 1 to 5, is characterized by comprising the following steps:
immersing the bottom surface layer of the three-dimensional spacer fabric into aerogel with a certain liquid level height, pre-freezing, and then freeze-drying to obtain the freeze-dried three-dimensional spacer fabric;
and then, laying a nanofiber membrane on the top surface layer of the three-dimensional space fabric subjected to freeze drying by adopting an electrostatic spinning process to obtain the medical composite self-pump dressing with the multilayer structure.
7. The method for preparing the medical composite self-pump dressing with the multilayer structure according to claim 6, wherein in the process of laying the nanofiber membrane, a precursor solution is adopted and prepared by dissolving polyurethane in an organic solvent; wherein the weight ratio of the polyurethane to the organic solvent is 1: 5; the organic solvent is N, N-dimethyl formyl.
8. The preparation method of the medical composite self-pump dressing with the multilayer structure as claimed in claim 6, wherein the pre-freezing temperature is-60 ℃ and the time is 4-6 h.
9. The preparation method of the medical composite self-pump dressing with the multilayer structure as claimed in claim 6, wherein in the freeze drying process, the temperature is-80 ℃, the time is 36-48 h, and the vacuum degree is 0.1 MPa.
10. Use of the medical composite self-pumping dressing with a multilayer structure as claimed in any one of claims 1 to 5 in wound healing.
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