CN112168494A - 3D spacer fabric-aerogel composite medical dressing and preparation method thereof - Google Patents
3D spacer fabric-aerogel composite medical dressing and preparation method thereof Download PDFInfo
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- CN112168494A CN112168494A CN202011034294.1A CN202011034294A CN112168494A CN 112168494 A CN112168494 A CN 112168494A CN 202011034294 A CN202011034294 A CN 202011034294A CN 112168494 A CN112168494 A CN 112168494A
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- spacer fabric
- aerogel
- medical dressing
- composite medical
- aerogel composite
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- 125000006850 spacer group Chemical group 0.000 title claims abstract description 74
- 239000004964 aerogel Substances 0.000 title claims abstract description 61
- 239000002131 composite material Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000004744 fabric Substances 0.000 claims abstract description 50
- 239000011159 matrix material Substances 0.000 claims abstract description 19
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 17
- 239000002344 surface layer Substances 0.000 claims abstract description 13
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 15
- 235000010413 sodium alginate Nutrition 0.000 claims description 15
- 229940005550 sodium alginate Drugs 0.000 claims description 15
- 239000000661 sodium alginate Substances 0.000 claims description 15
- 239000000835 fiber Substances 0.000 claims description 12
- 238000003780 insertion Methods 0.000 claims description 10
- 230000037431 insertion Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000003760 magnetic stirring Methods 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 15
- 208000027418 Wounds and injury Diseases 0.000 abstract description 15
- 208000004210 Pressure Ulcer Diseases 0.000 abstract description 8
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 8
- 230000035699 permeability Effects 0.000 abstract description 4
- 238000005086 pumping Methods 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 2
- 238000010008 shearing Methods 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 23
- 239000000243 solution Substances 0.000 description 9
- 239000000416 hydrocolloid Substances 0.000 description 8
- 238000009940 knitting Methods 0.000 description 8
- 206010011985 Decubitus ulcer Diseases 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 5
- 239000002250 absorbent Substances 0.000 description 5
- 230000003139 buffering effect Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000006260 foam Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 238000009941 weaving Methods 0.000 description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000002640 oxygen therapy Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
Classifications
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- A61F13/01029—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00604—Multilayer
- A61F2013/00612—Multilayer with different thickness
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00748—Plasters means for wound humidity control with hydrocolloids or superabsorbers
Abstract
The invention discloses a 3D spacer fabric-aerogel composite medical dressing and a preparation method thereof, and belongs to the technical field of medical dressings. The hydrophilic aerogel matrix is filled between the upper surface layer and the lower surface layer of the hydrophobic 3D spacer fabric in a composite mode to form a self-pumping structure, excessive exudates can be absorbed quickly, and a relatively humid environment is provided for wounds. The aerogel is reinforced by the 3D spacer fabric, so that the aerogel has a dressing function and also has a function of a supporting surface. The pressure is redistributed while the wound exudate is rapidly absorbed, so that the shearing force is reduced. In addition, the air flow can flow through the 3D spacer fabric, improve the microclimate of the supporting surface, have good air permeability, promote the healing of wound. The structure is reasonable in design, can be widely applied to wound treatment, particularly bedsore wounds, and has good application prospect.
Description
Technical Field
The invention belongs to the technical field of medical dressings, and particularly relates to a 3D spacer fabric-aerogel composite medical dressing and a preparation method thereof.
Background
The water absorption capacity and the water vapor transmission rate of the dressing of the hydrocolloid are improved by the characteristics of hydrophobicity, and an air channel is formed between the hydrocolloid and the aerogel by matching the hydrophobic performance of the aerogel material and the water absorption performance of the hydrocolloid, so that the water vapor transmission capacity of the dressing can be effectively improved. The invention relates to an aerogel composite biological dressing and a preparation method thereof, the preparation process is complex, and the aerogel composite biological dressing is designed only aiming at the water absorption capacity and the water vapor permeability and is not designed aiming at the buffering performance.
The Chinese invention patent, publication No. CN108186197A, discloses a composite functional dressing for preventing and treating pressure sores, which comprises an isolation layer, wherein a hydrocolloid layer is arranged on the isolation layer, a foam layer is arranged on the hydrocolloid layer, and a back lining layer is arranged on the foam layer; the raw material of the hydrocolloid layer contains a moistening absorbent which comprises a liquid moistening absorbent and a solid moistening absorbent, and the dosage ratio of the liquid moistening absorbent to the solid moistening absorbent is 1: 0.1-10. The dressing can absorb wound exudate in time, improves the overall liquid absorption amount, and is convenient to observe and replace; the invention also provides a preparation method of the dressing, which comprises the steps of (1) preparing a hydrocolloid layer; (2) preparing a foam layer; (3) compounding the hydrocolloid layer, the foam layer, the back lining layer and the isolating layer, and sterilizing to obtain a finished product; the preparation method is simple and convenient for industrial production. The invention relates to a multi-layer composite functional dressing for preventing and treating pressure sores, which can generate a layering phenomenon in a multi-layer structure, does not relate to the design of a buffering performance structure, and therefore does not have good buffering performance and can not redistribute pressure.
The Chinese invention patent, publication No. CN109549777A, discloses a dressing for preventing and treating pressure sores, which comprises a backing layer, an air cushion layer, a gel layer and an optional medicine layer from outside to inside in sequence, wherein the air cushion layer is preferably an annular air bag, and the pressure of air in the annular air bag is equal to or less than 1 atmosphere; preferably, the annular gas bags are 1 to 10 in number and are arranged separately from each other, more preferably, each annular gas bag is divided into 2 to 5 equal or unequal compartments which are independent from each other, and at least one compartment is filled with 0.01 to 0.1 atmosphere of oxygen or ozone, the compartment filled with 0.01 to 0.1 atmosphere of oxygen or ozone has 1 to 10 gas holes, and the gas holes are preferably uniformly or non-uniformly arranged facing the circle center of the annular gas bag. The invention provides a dressing which has simple structure and low cost and can provide oxygen therapy for pressure sore patients. The invention relates to a dressing for preventing and treating pressure sores, which is designed only for the buffering performance and is not designed for the liquid suction capacity and the liquid suction amount.
Disclosure of Invention
In order to solve the problems in the prior art, the invention discloses a 3D spacer fabric-aerogel composite medical dressing and a preparation method thereof, the structural design is reasonable, the manufacturing process is simple, the capability of the medical dressing for absorbing redundant exudates is improved, the wound can be kept moist, the proper buffering performance is provided, and the wound healing is promoted.
The invention is realized by the following technical scheme:
the invention discloses a 3D spacer fabric-aerogel composite medical dressing which comprises a hydrophobic 3D spacer fabric and a hydrophilic aerogel matrix, wherein the aerogel matrix is filled between an upper surface layer and a lower surface layer of the 3D spacer fabric in a composite mode.
Preferably, the surface layer of the 3D spacer fabric is a knitted fabric formed by combining a chaining structure and a weft insertion structure.
Preferably, the chain yarns of the chain stitch are hydrophobic fibers, and the weft insertion yarns of the weft insertion stitch are hydrophobic fibers.
Preferably, the aerogel matrix is sodium alginate-based aerogel, and the mass fraction of sodium alginate in the aerogel matrix is 2% -10%.
Preferably, the thickness of the 3D interval fabric is 7-12 mm, and the aerogel matrix is arranged at the 3D intervalThe filling coefficient of the fabric is 60-90%, and the density of the 3D spacer fabric-aerogel composite medical dressing is 0.85-1.25 g/cm3。
The invention discloses a preparation method of the 3D spacer fabric-aerogel composite medical dressing, which comprises the following steps:
step 1: dissolving sodium alginate in distilled water, preparing a sodium alginate solution with the mass fraction of 5-10%, and fully stirring to form a uniform solution;
step 2: standing the uniform solution prepared in the step 1, pouring the solution into a mold, and putting the cut 3D spacer fabric into the mold;
and step 3: pre-freezing for 4-6 h at-60 ℃, and then carrying out vacuum freeze drying;
and 4, step 4: and drying the product after vacuum freeze drying to obtain the 3D spacer fabric-aerogel composite medical dressing.
Preferably, in the step 1, magnetic stirring is adopted for 3-6 hours.
Preferably, in the step 2, the standing is carried out for 20-24 hours under the conditions that the relative humidity is 60% -65% and the temperature is 22-28 ℃.
Preferably, in the step 3, the vacuum freeze drying is carried out under the conditions of the pressure of-200 Pa and the temperature of-100 ℃, and the time is 36-48 h.
Preferably, in step 4, the drying temperature is 60 ℃ and the drying time is 90 min.
Compared with the prior art, the invention has the following beneficial technical effects:
the 3D spacer fabric-aerogel composite medical dressing disclosed by the invention is characterized in that a hydrophobic 3D spacer fabric and a hydrophilic aerogel are compounded to form a self-pumping structure, so that excessive exudates can be quickly absorbed, and a relatively humid environment is provided for wounds. The aerogel is reinforced by the 3D spacer fabric, so that the aerogel has a dressing function and also has a function of a supporting surface. The pressure is redistributed while the wound exudate is rapidly absorbed, so that the shearing force is reduced. In addition, the air flow can flow through the 3D spacer fabric, improve the microclimate of the supporting surface, have good air permeability, promote the healing of wound. The structure is reasonable in design, can be widely applied to wound treatment, particularly bedsore wounds, and has good application prospect.
Furthermore, the surface layer of the 3D spacer fabric is a knitted fabric formed by compounding the chain knitting tissue and the weft insertion tissue, the structure is compact, the effective contact area of the hydrophobic surface layer and the skin wound surface is enlarged, and the absorption of exudate of the wound is facilitated.
Furthermore, the surface layer chain knitting yarns and the weft insertion yarns adopt hydrophobic fibers, and can form a self-pumping structure with hydrophilic aerogel, so that the liquid absorption capacity is improved.
Furthermore, sodium alginate is used as a matrix, so that the preparation is safe and non-toxic and has good biocompatibility; and the raw material source is wide, and the manufacturing cost is low.
Furthermore, the 3D spacer fabric is 7-12 mm thick, has a large structural thickness and can bear more exudates; the filling coefficient of the aerogel matrix in the 3D spacer fabric is 60-90%, the aerogel matrix is not completely filled in the spacer fabric, and airflow can flow along the spacer fabric, so that the microclimate of the supporting surface is improved, and the aerogel matrix has good air permeability; the density of the composite medical dressing is 0.85-1.25 g/cm3Light weight, and is favorable for the recovery of the wound surface.
The preparation method of the 3D spacer fabric-aerogel composite medical dressing disclosed by the invention is simple in process, mild in reaction condition, short in preparation period, suitable for industrial production and good in market prospect.
Drawings
Fig. 1 is a schematic structural view of a 3D spacer fabric-aerogel composite medical dressing of the present invention;
in the figure: 1 is a 3D spacer fabric, 2 is an aerogel matrix, and 3 is an air layer.
Detailed Description
The invention is described in further detail below with reference to the accompanying drawings:
referring to fig. 1, the 3D spacer fabric-aerogel composite medical dressing of the present invention comprises a 3D spacer fabric 1 and an aerogel matrix 2; the surface layer of the 3D spacer fabric 1 is a knitted fabric formed by combining a chaining structure and a weft insertion structure. The 3D spacer fabric 1 is compounded with the aerogel matrix 2, the filling coefficient of the aerogel matrix 2 in the 3D spacer fabric 1 is 60% -90%, and an air layer 3 is left. The chain knitting yarns of the chain knitting structure adopt hydrophobic fibers, and the weft insertion yarns of the weft insertion structure also adopt hydrophobic fibers.
The 3D spacer fabric-aerogel composite medical dressing is usually prepared to be 7-12 mm in thickness and 0.85-1.25 g/cm in density3The specification of (1).
The 3D spacer fabric-aerogel composite medical dressing can be used as a wound care material, particularly a pressure sore care material, and is applied to the field of medical care.
The 3D spacer fabric-aerogel composite medical dressing can be prepared by the following method, and is divided into the following steps:
step 1: dissolving a certain amount of sodium alginate in distilled water to prepare a sodium alginate aqueous solution with the mass fraction of 5-10%;
step 2: magnetically stirring for 3-6 hours to form a uniform solution;
and step 3: standing for 20-24 h under the conditions that the relative humidity is 60% -65% and the temperature is 22-28 ℃;
and 4, step 4: weaving a 3D spacer fabric 1; the 3D spacer fabric 1 is woven by a double needle bed Raschel warp knitting machine with 6 guide bars in total of GB 1-GB 6, yarns carried on GB2 and GB5 are hydrophobic fiber multifilaments, yarns carried on GB1 and GB6 are carbon fiber tows, and yarns carried on GB3 and GB4 are hydrophobic fiber monofilaments; the upper surface of the 3D spacer fabric is knitted by two guide bars GB1 and GB2 on a front needle bed, the lower surface of the fabric is knitted by two guide bars GB5 and GB6 on a rear needle bed, and the spacer filaments are carried by the two guide bars GB3 and GB4, and the upper surface and the lower surface of the spacer fabric are connected by the spacer filaments by alternately knitting on the front needle bed and the rear needle bed to form the 3D spacer fabric 1;
and 5: pouring a sodium alginate solution with the height of about 60-90% of the spacer fabric into the mold;
step 6: cutting the 3D spacer fabric 1 according to the shape of a mold and putting the cut spacer fabric into the mold;
and 7: pre-freezing for 4-6 h at-60 ℃, then transferring to a freeze dryer, and carrying out freeze drying for 36-48 h under the conditions that the pressure is-200 Pa and the temperature is-100 ℃.
And 8: and (3) putting the frozen and dried sample into an oven, and drying for 90min at the temperature of 60 ℃ to obtain the 3D spacer fabric-aerogel composite medical dressing.
The preparation method of the 3D spacer fabric-aerogel composite medical dressing of the present invention is further explained below with a specific example:
weighing 5g of sodium alginate powder, measuring 100mL of distilled water, and preparing a sodium alginate aqueous solution with the mass fraction of 5%; stirring the solution by a magnetic stirrer until the sodium alginate is uniformly dispersed without aggregation, wherein the solution is transparent, and then standing for 24 hours under the conditions that the relative humidity is 60% and the temperature is 25 ℃; weaving a warp-knitted spacer fabric with a surface layer of chaining and weft insertion on a double-needle bed Raschel warp knitting machine with the number of E18, wherein the double-needle bed Raschel warp knitting machine is provided with 6 guide bars (GB 1-GB 6), and the two guide bars GB1 and GB2 are used for weaving the upper surface of the 3D spacer fabric on a front needle bed; the two guide bars GB5 and GB6 weave the lower surface of the fabric on the back needle bed; the two guide bars of GB3 and GB4 are alternately knitted with spacer yarns on the front and back needle beds to connect the upper and lower surfaces of the spacer fabric with the spacer yarns, thereby forming the final three-dimensional integral structure. The yarns carried on GB2 and GB5 are hydrophobic fiber multifilament yarns of 300D/96F; the tapes of GB1 and GB6 are hydrophobic fiber multifilament; the filaments of the hydrophobic fibers with the diameter of 0.2mm are carried on GB3 and GB 4. The obtained fabric has a thickness of 10mm and an areal density of 925g/m2. After the fabric is off the machine, cutting the 3D spacer fabric according to the shape of the die; then pouring the solution with the height of 9mm into a mould, and putting the cut spacer fabric into the mould; pre-freezing at-60 deg.C for 5 hr, transferring to freeze dryer, and freeze drying at-100 deg.C under-200 Pa for 48 hr. And (3) putting the frozen and dried sample into an oven, and drying for 90min at the temperature of 60 ℃ to obtain the 3D spacer fabric/aerogel composite medical dressing.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.
Claims (10)
1. The 3D spacer fabric-aerogel composite medical dressing is characterized by comprising a hydrophobic 3D spacer fabric (1) and a hydrophilic aerogel matrix (2), wherein the aerogel matrix (2) is filled between the upper surface layer and the lower surface layer of the 3D spacer fabric (1) in a composite mode.
2. The 3D spacer fabric-aerogel composite medical dressing according to claim 1, wherein the surface layer of the 3D spacer fabric (1) is a knitted fabric formed by combining a chain stitch and a weft insertion stitch.
3. The 3D spacer fabric-aerogel composite medical dressing of claim 2, wherein the pillar stitches of the pillar stitch are hydrophobic fibers and the weft inserted yarns of the weft inserted stitch are hydrophobic fibers.
4. The 3D spacer fabric-aerogel composite medical dressing according to claim 1, wherein the aerogel matrix (2) is sodium alginate based aerogel, and the mass fraction of sodium alginate in the aerogel matrix (2) is 2-10%.
5. The 3D spacer fabric-aerogel composite medical dressing as claimed in claim 1, wherein the thickness of the 3D spacer fabric (1) is 7-12 mm, the filling factor of the aerogel matrix (2) in the 3D spacer fabric (1) is 60-90%, and the density of the 3D spacer fabric-aerogel composite medical dressing is 0.85-1.25 g/cm3。
6. The preparation method of the 3D spacer fabric-aerogel composite medical dressing as claimed in any one of claims 1 to 5, characterized by comprising the following steps:
step 1: dissolving sodium alginate in distilled water, preparing a sodium alginate solution with the mass fraction of 5-10%, and fully stirring to form a uniform solution;
step 2: standing the uniform solution prepared in the step (1), pouring the solution into a mold, and putting the cut 3D spacer fabric (1) into the mold;
and step 3: pre-freezing for 4-6 h at-60 ℃, and then carrying out vacuum freeze drying;
and 4, step 4: and drying the product after vacuum freeze drying to obtain the 3D spacer fabric-aerogel composite medical dressing.
7. The preparation method of the 3D spacer fabric-aerogel composite medical dressing as claimed in claim 6, wherein in step 1, magnetic stirring is adopted for 3-6 hours.
8. The preparation method of the 3D spacer fabric-aerogel composite medical dressing as claimed in claim 6, wherein in the step 2, the standing is performed for 20-24 hours under the conditions of relative humidity of 60% -65% and temperature of 22-28 ℃.
9. The preparation method of the 3D spacer fabric-aerogel composite medical dressing as claimed in claim 6, wherein in step 3, the vacuum freeze-drying is performed under the conditions of-200 Pa pressure and-100 ℃ temperature for 36-48 h.
10. The method for preparing a 3D spacer fabric-aerogel composite medical dressing according to claim 6, wherein in the step 4, the drying temperature is 60 ℃ and the drying time is 90 min.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011034294.1A CN112168494B (en) | 2020-09-27 | 2020-09-27 | 3D spacer fabric-aerogel composite medical dressing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011034294.1A CN112168494B (en) | 2020-09-27 | 2020-09-27 | 3D spacer fabric-aerogel composite medical dressing and preparation method thereof |
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| CN112168494A true CN112168494A (en) | 2021-01-05 |
| CN112168494B CN112168494B (en) | 2022-04-29 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113089336A (en) * | 2021-03-26 | 2021-07-09 | 大华(银川)医疗科技有限公司 | 3D spacer fabric composite material with temperature-sensitive shape memory function and application thereof |
| CN113893090A (en) * | 2021-10-20 | 2022-01-07 | 西安工程大学 | Medical composite self-pumping dressing with multilayer structure and preparation method and application thereof |
| CN114053034A (en) * | 2021-11-19 | 2022-02-18 | 青岛大学 | Expansion pressurization band-aid/application and preparation method |
| CN114470295A (en) * | 2021-12-28 | 2022-05-13 | 盐城工学院 | Preparation method of drug-loaded hydrogel composite fabric for wound dressing |
| WO2022188861A1 (en) * | 2021-03-12 | 2022-09-15 | 上海创始医疗科技(集团)股份有限公司 | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof |
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| WO2022188861A1 (en) * | 2021-03-12 | 2022-09-15 | 上海创始医疗科技(集团)股份有限公司 | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof |
| CN113089336A (en) * | 2021-03-26 | 2021-07-09 | 大华(银川)医疗科技有限公司 | 3D spacer fabric composite material with temperature-sensitive shape memory function and application thereof |
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| CN114053034A (en) * | 2021-11-19 | 2022-02-18 | 青岛大学 | Expansion pressurization band-aid/application and preparation method |
| CN114470295A (en) * | 2021-12-28 | 2022-05-13 | 盐城工学院 | Preparation method of drug-loaded hydrogel composite fabric for wound dressing |
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