CN114470295A - Preparation method of drug-loaded hydrogel composite fabric for wound dressing - Google Patents
Preparation method of drug-loaded hydrogel composite fabric for wound dressing Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
- A61F7/034—Flameless
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0268—Compresses or poultices for effecting heating or cooling having a plurality of compartments being filled with a heat carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a preparation method of a drug-loaded hydrogel composite fabric for a wound dressing, which comprises the following steps: step one, adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 25-30 minutes to swell the materials in cold water, heating to 90-95 ℃, and stirring for 120-150 minutes to generate a mixed substance A; step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 10-15 minutes at a speed of 60-120 r/min, and then stirring for 15-20 minutes at a speed of 200-300 r/min to generate a mixed substance B; adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring for 2-5 minutes at 300-500 r/min, then stirring for 10-15 minutes at 50-100 r/min, heating the solution to 50-60 ℃ after uniformly mixing, and thus obtaining the sodium alginate hydrogel; the hydrogel can realize hot compress on the wound, so that the drug effect of the hydrogel can be better exerted, and the wound healing is accelerated by utilizing the hot compress.
Description
Technical Field
The invention relates to the technical field of functional medical dressings, in particular to a preparation method of a drug-loaded hydrogel composite fabric for a wound dressing.
Background
Wound healing is an extremely complex physiological process, and the physical quality of a patient is an internal factor determining wound healing, but the role of medical dressings is more than negligible. Medical dressings are a very important class of medical textiles, and with the progress of science and technology and various requirements in the medical field, novel medical dressings with certain functions are receiving more and more attention. The functional medical dressing can provide special functions for the healing of wounds according to the actual conditions of the wounds.
The early stage of wound treatment is generally to use cold compress to reduce swelling and stop bleeding, but the stage of healing after injury is to use hot compress means to accelerate tissue vasodilatation, increase blood flow, increase nutrient substances and oxygen supply, increase raw materials for wound regeneration, and further accelerate wound healing.
However, many existing wound dressings cannot provide hot compress effect to the wound, and the structural layers of the composite fabric are not buffered, so that the external pressure applied to the wound is not buffered, and the wound is slowly healed.
Disclosure of Invention
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide a preparation method of a drug-loaded hydrogel composite fabric for a wound dressing, which can realize hot compress on a wound, so that the drug effect of the hydrogel can be better exerted, meanwhile, the wound healing is accelerated by utilizing the hot compress, and the external pressure on the wound is reduced by utilizing a 3D buffer fabric, so that the wound healing is quicker.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
A preparation method of a drug-loaded hydrogel composite fabric for a wound dressing comprises the following steps:
step one, adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 25-30 minutes to swell the materials in cold water, heating to 90-95 ℃, and stirring for 120-150 minutes to generate a mixed substance A;
step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 10-15 minutes at a speed of 60-120 r/min, and then stirring for 15-20 minutes at a speed of 200-300 r/min to generate a mixed substance B;
adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring for 2-5 minutes at 300-500 r/min, then stirring for 10-15 minutes at 50-100 r/min, heating the solution to 50-60 ℃ after uniformly mixing, and thus obtaining the sodium alginate hydrogel;
pouring the sodium alginate hydrogel obtained in the step three into a mould, and putting the cut composite fabric into the mould;
and step five, freezing the mould in the step four for 1-2 hours at the temperature of-10 ℃, then carrying out vacuum freeze drying, and finally drying to obtain the dressing.
Further, compound fabric in step four comprises the triplex from top to bottom, is extexine, 3D buffer layer and skin-friendly layer in proper order, the inside packing of 3D buffer layer has hydrogel layer, the hydrogel layer top surface with still be provided with the air bed between the extexine bottom surface, the extexine top surface still is provided with the zone of heating.
Furthermore, the outer surface layer is a knitted fabric formed by a chain knitting structure, the chain knitting yarn of the outer surface layer chain knitting structure is hydrophobic fiber, and the hydrophobic fiber is one of terylene, chinlon, spandex, polypropylene fiber or polyvinyl chloride.
Further, the skin-friendly layer is made of perforated non-woven fabric, the perforated non-woven fabric is made of one or more of polylactic acid, polypropylene, polycaprolactone, polyethylene terephthalate, polybutylene terephthalate, polytrimethylene terephthalate, polyethylene-vinyl acetate copolymer, polyolefin copolymer or thermo-acid elastomer Vistamaxx, the aperture of the perforated non-woven fabric is 0.5-1 mm, and the perforated non-woven fabric has uniformly dispersed round, rhombic, regular hexagonal or cross-shaped holes.
Further, the 3D buffer layer is that hydrophilic fiber and polyester fiber are S type symmetric interval circulation array along weaving the direction and weave and form, hydrophilic fiber is silk, wool, rabbit hair, camel hair or cotton wherein one.
Further, the hydrogel layer is the sodium alginate hydrogel in the third step.
Further, the sodium alginate hydrogel comprises the following components in percentage by mass: 0.1 to 10 percent of gelatin, 0.1 to 10 percent of gellan gum, 0.1 to 10 percent of sodium alginate, 1 to 20 percent of polyvinyl alcohol, 0.01 to 0.05 percent of transforming growth factor TGF-beta and the balance of distilled water.
Further, the heating layer is sequentially provided with a heating filler, a non-woven fabric wrapping layer and a top sealing pasting layer from inside to outside, and the heating filler is a mixed substance of iron powder, activated carbon, sodium chloride and vermiculite.
Furthermore, the heating layer is connected with the top surface of the outer surface layer in a later stage attaching mode.
Furthermore, the stirring modes of the vacuum stirrer in the first step, the second step and the third step all adopt magnetic stirring.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
(1) this scheme is provided with the zone of heating, can open the packing when posting the device, tears the sealed layer of pasting in top of zone of heating top surface, and then makes oxygen can enter into the zone of heating inside and carry out oxidation reaction with the iron powder, produces the heat, and then can carry out the hot compress to the wound, improves the absorption efficiency of wound to the aquogel drug effect, and then can improve the healing efficiency of wound.
(2) This scheme is provided with extexine, 3D buffer layer and close skin layer and cooperatees, forms 3D elasticity buffering space, can cushion it when external pressure contacts the device, and then reduces oppression and the damage that causes the wound to improve the healing efficiency of wound, improve the device's use reliability and validity.
Drawings
FIG. 1 is a schematic view of a dressing of the present invention;
FIG. 2 is a schematic representation of a composite fabric structure of the present invention;
FIG. 3 is a schematic view of the structure of the hydrogel layer of the present invention;
fig. 4 is a schematic view of the heating layer structure of the present invention.
The reference numbers in the figures illustrate:
1. an outer skin layer; 2. a skin-friendly layer; 3. a 3D buffer layer; 4. a hydrogel layer; 5. an air layer; 6. and heating the layer.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
Example 1:
referring to fig. 1 to 4, a method for preparing a drug-loaded hydrogel composite fabric for a wound dressing includes the following steps:
adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 30 minutes to enable the materials to swell in cold water, heating to 90 ℃, and stirring for 120 minutes to generate a mixed substance A;
step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 12 minutes at 100r/min, and then stirring for 18 minutes at 260r/min to generate a mixed substance B;
adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring for 3 minutes at a speed of 400r/min, then stirring for 13 minutes at a speed of 80r/min, heating the solution to 55 ℃ after uniformly mixing, and thus, generating the sodium alginate hydrogel;
pouring the sodium alginate hydrogel obtained in the step three into a mould, and putting the cut composite fabric into the mould;
and step five, freezing the mould in the step four for 1.5 hours at the temperature of minus 10 ℃, then carrying out vacuum freeze drying, and finally drying to obtain the dressing.
Referring to fig. 1, the composite fabric in step four is composed of three parts from top to bottom, namely an outer surface layer 1, a 3D buffer layer 3 and a skin-friendly layer 2 in sequence, wherein a hydrogel layer 4 is filled in the 3D buffer layer 3, an air layer 5 is further arranged between the top surface of the hydrogel layer 4 and the bottom surface of the outer surface layer 1, and a heating layer 6 is further arranged on the top surface of the outer surface layer 1.
Referring to fig. 2, the outer surface layer 1 is a knitted fabric formed by a chain knitting structure, and the chain knitting yarn of the chain knitting structure of the outer surface layer 1 is polyester.
Referring to fig. 2, the skin-friendly layer 2 is made of perforated non-woven fabric, the perforated non-woven fabric is made of polylactic acid, and the aperture of the perforated non-woven fabric is 0.5mm and is a circular hole.
Referring to fig. 2, the 3D buffer layer 3 is formed by weaving silk fibers and polyester fibers in an S-shaped symmetric interval circular array along the weaving direction.
Referring to fig. 3, the hydrogel layer 4 is a sodium alginate hydrogel.
Referring to fig. 3, the mass percentages of the sodium alginate hydrogel are as follows: 5% of gelatin, 5% of gellan gum, 5% of sodium alginate, 10% of polyvinyl alcohol, 0.025% of transforming growth factor TGF-beta and the balance of distilled water.
Refer to fig. 4, zone of heating 6 from interior to exterior is the filler that generates heat in proper order, non-woven fabrics parcel layer, the sealed layer of pasting in top, the filler that generates heat is the iron powder, activated carbon, sodium chloride and vermiculite mixed material, can put up the device when opening the packing, through tearing the sealed layer of pasting in top of 6 top surfaces of zone of heating, make oxygen can enter into 6 insides of zone of heating and carry out oxidation reaction with the iron powder, generate heat, and then can carry out the hot compress to the wound, improve the absorption efficiency of wound to the aquogel drug effect, and then can improve the healing efficiency of wound.
Referring to fig. 1, the heating layer 6 is connected to the top surface of the outer surface layer 1 by post-attaching.
Referring to fig. 1, the stirring manner of the vacuum stirrer in the first step, the second step and the third step is magnetic stirring, so that the damage to the raw material can be reduced.
Example 2:
the mass percentages of the sodium alginate hydrogel in this example are as follows: 10% of gelatin, 10% of gellan gum, 10% of sodium alginate, 20% of polyvinyl alcohol, 0.05% of transforming growth factor TGF-beta and the balance of distilled water.
The preparation method of the dressing comprises the following steps:
adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 25 minutes to enable the materials to swell in cold water, heating to 95 ℃, and stirring for 150 minutes to generate a mixed substance A;
step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 15 minutes at 120r/min, and then stirring for 20 minutes at 300r/min to generate a mixed substance B;
adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring at 500r/min for 5 minutes, then stirring at 100r/min for 15 minutes, and heating the solution to 60 ℃ after uniform mixing to obtain the sodium alginate hydrogel;
pouring the sodium alginate hydrogel obtained in the step three into a mould, and putting the cut composite fabric into the mould;
and step five, freezing the mould in the step four for 2 hours at the temperature of minus 10 ℃, then carrying out vacuum freeze drying, and finally drying to obtain the dressing.
Example 3:
the mass percentages of the sodium alginate hydrogel in this example are as follows: 1% of gelatin, 1% of gellan gum, 5% of sodium alginate, 1% of polyvinyl alcohol, 0.01% of transforming growth factor TGF-beta and the balance of distilled water.
The preparation method of the dressing comprises the following steps:
adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 25 minutes to enable the materials to swell in cold water, heating to 90 ℃, and stirring for 120 minutes to generate a mixed substance A;
step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 10 minutes at a speed of 60r/min, and then stirring for 20 minutes at a speed of 200r/min to generate a mixed substance B;
step three, adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring at 300r/min for 5 minutes, then stirring at 50r/min for 15 minutes, heating the solution to 50 ℃ after uniform mixing, and thus obtaining the sodium alginate hydrogel;
pouring the sodium alginate hydrogel obtained in the step three into a mould, and putting the cut composite fabric into the mould;
and step five, freezing the mould in the step four for 2 hours at the temperature of minus 10 ℃, then carrying out vacuum freeze drying, and finally drying to obtain the dressing.
When in use: selecting the sodium alginate hydrogel according to the mass percentage: the optimal mixture ratio of gelatin 5%, gellan gum 5%, sodium alginate 5%, polyvinyl alcohol 10%, transforming growth factor TGF-beta 0.025%, and the balance of distilled water, and the dressing obtained by the preparation steps in example 1 is selected to have the best effect.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.
Claims (10)
1. A preparation method of a drug-loaded hydrogel composite fabric for a wound dressing is characterized by comprising the following steps:
step one, adding gelatin, gellan gum, polyvinyl alcohol and distilled water into a vacuum stirrer, stirring for 25-30 minutes to swell the materials in cold water, heating to 90-95 ℃, and stirring for 120-150 minutes to generate a mixed substance A;
step two, adding sodium alginate, transforming growth factor TGF-beta and distilled water into a vacuum stirrer, stirring for 10-15 minutes at a speed of 60-120 r/min, and then stirring for 15-20 minutes at a speed of 200-300 r/min to generate a mixed substance B;
adding the mixed substance B into a vacuum stirrer containing the mixed substance A, mixing the mixed substance B with the substance A, stirring for 2-5 minutes at 300-500 r/min, then stirring for 10-15 minutes at 50-100 r/min, heating the solution to 50-60 ℃ after uniformly mixing, and thus obtaining the sodium alginate hydrogel;
pouring the sodium alginate hydrogel obtained in the step three into a mould, and putting the cut composite fabric into the mould;
and step five, freezing the mould in the step four for 1-2 hours at the temperature of-10 ℃, then carrying out vacuum freeze drying, and finally drying to obtain the dressing.
2. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 1, wherein the method comprises the following steps: composite fabric in step four comprises triplex from top to bottom, is extexine (1), 3D buffer layer (3) and close skin layer (2) in proper order, 3D buffer layer (3) inside packing has hydrogel layer (4), hydrogel layer (4) top surface with still be provided with air bed (5) between extexine (1) bottom surface, extexine (1) top surface still is provided with zone of heating (6).
3. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 2, wherein the method comprises the following steps: the outer surface layer (1) is a knitted fabric formed by a chain knitting tissue, the chain knitting yarn of the chain knitting tissue of the outer surface layer (1) is hydrophobic fiber, and the hydrophobic fiber is one of terylene, chinlon, spandex, polypropylene or polyvinyl chloride.
4. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 2, wherein the method comprises the following steps: close skin layer (2) and make for the non-woven fabrics material that punches, the material of the non-woven fabrics that punches is in polylactic acid, polypropylene, polycaprolactone, polyethylene terephthalate, polybutylene terephthalate, poly propylene glycol terephthalate, polyethylene-vinyl acetate copolymer, polyolefin copolymer or heat in the sour elastomer Vistamaxx or more than two kinds, the aperture of the non-woven fabrics that punches is 0.5 ~ 1mm, circular, rhombus, regular hexagon or the cross shape hole that has homodisperse.
5. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 2, wherein the method comprises the following steps: the 3D buffer layer (3) is that hydrophilic fiber and polyester fiber are S type symmetric spacing circulation array along weaving the direction and weave and form, hydrophilic fiber is silk, wool, rabbit hair, camel hair or cotton one of them.
6. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 2, wherein the method comprises the following steps: the hydrogel layer (4) is the sodium alginate hydrogel in the third step.
7. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 1, wherein the method comprises the following steps: the sodium alginate hydrogel comprises the following components in percentage by mass: 0.1 to 10 percent of gelatin, 0.1 to 10 percent of gellan gum, 0.1 to 10 percent of sodium alginate, 1 to 20 percent of polyvinyl alcohol, 0.01 to 0.05 percent of transforming growth factor TGF-beta and the balance of distilled water.
8. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to claim 2, wherein the method comprises the following steps: the heating layer (6) is sequentially provided with a heating filler, a non-woven fabric wrapping layer and a top sealing pasting layer from inside to outside, and the heating filler is a mixed substance of iron powder, activated carbon, sodium chloride and vermiculite.
9. The method for preparing the drug-loaded hydrogel composite fabric for the wound dressing according to any one of claims 2, which is characterized in that: the heating layer (6) is connected with the top surface of the outer surface layer (1) in a later stage attaching mode.
10. The preparation method of the drug-loaded hydrogel composite fabric for the wound dressing according to claim 1, which is characterized in that: and the stirring modes of the vacuum stirrer in the first step, the second step and the third step are magnetic stirring.
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|---|---|---|---|---|
| CN116650544A (en) * | 2023-06-30 | 2023-08-29 | 东悦医疗器械(武汉)有限公司 | A pharmaceutical composition and hot compress patch containing folium Ginkgo extract, and its preparation method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008048327A1 (en) * | 2008-09-15 | 2010-04-15 | Beiersdorf Ag | heating plaster |
| CN105327385A (en) * | 2014-08-06 | 2016-02-17 | 上海威尔医疗保健厂 | Preparation method of functional hydrogel medical dressing |
| CN109674574A (en) * | 2019-01-16 | 2019-04-26 | 山西康宁医药科技有限公司 | A kind of hot compress sticking dressing and preparation method thereof |
| CN109938920A (en) * | 2019-04-29 | 2019-06-28 | 振德医疗用品股份有限公司 | A kind of tiny structure foam dressing and its manufacturing method |
| KR20200068801A (en) * | 2018-12-05 | 2020-06-16 | (주) 삼보첨단소재 | Support-natural polymer hydrogel composite, method for preparing the same and apparatus for continuous process |
| CN211409697U (en) * | 2019-07-30 | 2020-09-04 | 江苏苏云医疗器材有限公司 | Composite medical elastic bandage |
| CN112168494A (en) * | 2020-09-27 | 2021-01-05 | 西安工程大学 | 3D spacer fabric-aerogel composite medical dressing and preparation method thereof |
-
2021
- 2021-12-28 CN CN202111623283.1A patent/CN114470295B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008048327A1 (en) * | 2008-09-15 | 2010-04-15 | Beiersdorf Ag | heating plaster |
| CN105327385A (en) * | 2014-08-06 | 2016-02-17 | 上海威尔医疗保健厂 | Preparation method of functional hydrogel medical dressing |
| KR20200068801A (en) * | 2018-12-05 | 2020-06-16 | (주) 삼보첨단소재 | Support-natural polymer hydrogel composite, method for preparing the same and apparatus for continuous process |
| CN109674574A (en) * | 2019-01-16 | 2019-04-26 | 山西康宁医药科技有限公司 | A kind of hot compress sticking dressing and preparation method thereof |
| CN109938920A (en) * | 2019-04-29 | 2019-06-28 | 振德医疗用品股份有限公司 | A kind of tiny structure foam dressing and its manufacturing method |
| CN211409697U (en) * | 2019-07-30 | 2020-09-04 | 江苏苏云医疗器材有限公司 | Composite medical elastic bandage |
| CN112168494A (en) * | 2020-09-27 | 2021-01-05 | 西安工程大学 | 3D spacer fabric-aerogel composite medical dressing and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116650544A (en) * | 2023-06-30 | 2023-08-29 | 东悦医疗器械(武汉)有限公司 | A pharmaceutical composition and hot compress patch containing folium Ginkgo extract, and its preparation method |
| CN116650544B (en) * | 2023-06-30 | 2024-03-15 | 东悦医疗器械(武汉)有限公司 | A hot compress patch containing folium Ginkgo extract for promoting blood circulation for removing blood stasis and treating burn, and its preparation method |
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| CN114470295B (en) | 2023-05-30 |
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