CN109674574A - A kind of hot compress sticking dressing and preparation method thereof - Google Patents

A kind of hot compress sticking dressing and preparation method thereof Download PDF

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Publication number
CN109674574A
CN109674574A CN201910038616.0A CN201910038616A CN109674574A CN 109674574 A CN109674574 A CN 109674574A CN 201910038616 A CN201910038616 A CN 201910038616A CN 109674574 A CN109674574 A CN 109674574A
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China
Prior art keywords
parts
dressing
sodium chloride
hot compress
chloride solution
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Pending
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CN201910038616.0A
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Chinese (zh)
Inventor
罗岗
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Shanxi Kangning Medicine And Technology Co Ltd
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Shanxi Kangning Medicine And Technology Co Ltd
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Priority to CN201910038616.0A priority Critical patent/CN109674574A/en
Publication of CN109674574A publication Critical patent/CN109674574A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F7/03Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A61F7/032Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
    • A61F7/034Flameless
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F7/0241Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0203Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
    • A61F2007/0204Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing clay, mud, fango, sand, kaolin clay, volcanic or other inorganic granular solids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0225Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F7/03Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A61F7/032Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
    • A61F7/034Flameless
    • A61F2007/036Fuels
    • A61F2007/038Carbon or charcoal, e.g. active

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Thermal Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

The invention discloses a kind of hot compress sticking dressing and preparation method thereof, which includes that following parts by weight raw material are prepared: 2-4 parts of vermiculite, 2-3 parts of active carbon, 1-2 parts of sodium chloride, 45-48 parts of iron powder, 22-28 parts of water;The dressing adjusts raw material composition and ratio by specific aim, makes dressing electrothermal calefactive rate faster, and fever time is longer, the effect of hot compress is more preferable;Meanwhile the method also by sodium chloride solution being added several times in mixture keeps dressing fever time longer to inhibit oxidation reaction speed in dressing, fomentation effect is more preferable, and will not generate high temperature and cause to scald, and use is safer.

Description

A kind of hot compress sticking dressing and preparation method thereof
Technical field
The present invention relates to health care product fields, and in particular to a kind of hot compress sticking dressing and preparation method thereof.
Background technique
Hot compress is a kind of common method of health-care hospital, and internal disease, internal injury have good medical health effect.Existing skill Articles in art for hot compress mainly have hot water hot compress bag, electric heating deposited bag, variable phase hot compress bag and hot compress paste etc. several.Wherein hot water Hot compress bag, soaking time is short, needs to be replaced frequently hot water, and user's trip is not convenient enough;Electric heating deposited bag can only have electricity It is used under occasion, is not easy to trip and carries hot compress;Although variable phase hot compress bag carrying is more convenient, soaking time also compares Long, but after its cooling, the umklapp transformation of certain time is needed heat, when trip, does not often have the condition that phase transformation is heated, Chang Wu Method carries out hot compress use;Hot compress paste provides heat source using dressing, and light, soaking time is long, is a kind of convenient for carrying hot compress Most widely used hot compress articles.Electrothermal calefactive rate, fever time and the maximum temperature of dressing are by oxidation reaction speed therein With time effects, and the speed of oxidation reaction is determined by reactant concentration, and the reaction time is determined by reaction-ure mixture, because This, reactant concentration and reaction-ure mixture during adjustment dressing fever, just can control the fever time of dressing, electrothermal calefactive rate and Maximum temperature.But dressing used in existing hot compress paste, it is unreasonable due to its raw material and proportion, lead to dressing fever speed Degree is slow, fever time is short, maximum temperature is high, has seriously affected the fomentation effect of hot compress paste.
Summary of the invention
It is an object of the invention to overcome the shortcomings of that dressing electrothermal calefactive rate is slow in existing hot compress paste, fever time is short, provide A kind of hot compress sticking dressing and preparation method thereof;The dressing adjusts raw material composition and ratio by specific aim, makes dressing fever speed It spends faster, and fever time is longer, the effect of hot compress is more preferable, is imitated using the hot compress paste of the dressing with better health care Fruit.
In order to achieve the above-mentioned object of the invention, the present invention provides a kind of hot compress sticking dressings, including following parts by weight raw material It is prepared: 2-4 parts of vermiculite, 2-3 parts of active carbon, 1-2 parts of sodium chloride, 45-48 parts of iron powder, 22-28 parts of water.
Wherein, it is preferred that the hot compress sticking dressing is prepared including following parts by weight raw material: 3 parts of vermiculite, 2.25 parts of active carbon, 1 part of sodium chloride, 46.875 parts of iron powder, 25 parts of water.
Wherein, it is preferred that the partial size of the vermiculite is 0.1-1.0mm;Preferred vermiculite partial size has preferably water suction, protects Wet, heat insulation function keeps the heating continuing time of dressing longer.
Wherein, it is preferred that the partial size of the active carbon is 0.5-2.0mm;Preferred activated carbon particle size, which has, preferably to be inhaled Water, moisture-keeping functions keep the heating continuing time of dressing longer.
Wherein, it is preferred that the partial size of the iron powder is 0.5-1.0mm;Preferred iron powder partial size has oxidation speed faster Degree, makes the electrothermal calefactive rate of dressing faster.
In order to achieve the above-mentioned object of the invention, further, the present invention provides a kind of preparation method of hot compress sticking dressing, packets Include following steps:
(1) it is uniformly mixed vermiculite, active carbon and iron powder to obtain mixture according to the ratio;Sodium chloride is dissolved with water, is obtained Sodium chloride solution;
(2) it by 2-5 addition mixture of sodium chloride solution average mark, requires to be stirred after sodium chloride solution is added every time Mixing obtains hot compress sticking dressing after the completion of mixing.
Sodium chloride solution point is added in mixture several times for a kind of preparation method of above-mentioned hot compress sticking dressing, this method, and It is absorbed by active carbon and vermiculite, so that during dressing fever intermittent the chlorination absorbed can be discharged in active carbon and vermiculite Sodium solution is suppressed oxidation reaction speed in dressing, keeps dressing fever time longer, and fomentation effect is more preferable, and will not produce Raw high temperature causes to scald, and use is safer.
Wherein, it is preferred that in step (2), sodium chloride solution is equally divided into 3 addition mixtures.
Wherein, it is preferred that the speed stirred in step (2) is 100-300r/min, time 2-5mn;It is deposited by preferred More evenly, active carbon and vermiculite are more preferable to the assimilation effect of sodium chloride solution, and the heating property of dressing is more preferable for material mixing.
Compared with prior art, beneficial effects of the present invention:
1, dressing of the present invention adjusts raw material composition and ratio by specific aim, makes dressing electrothermal calefactive rate faster, and fever time Longer, the effect of hot compress is more preferable.
2, the dressing that preparation method of the present invention is prepared can be such that oxidation reaction speed is controlled, and make dressing fever time Longer, fomentation effect is more preferable, and will not generate high temperature and cause to scald, and use is safer.
3, preparation method of the present invention is simple, reliable, is suitble to the large-scale production of dressing.
Specific embodiment
Below with reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood It is all that this is belonged to based on the technology that the content of present invention is realized for the scope of the above subject matter of the present invention is limited to the following embodiments The range of invention.
Embodiment 1
(1) it is uniformly mixed 3 parts of vermiculite, 2.25 parts of active carbon and 46.875 parts of iron powder to obtain mixture;By 1 part Sodium chloride dissolved with 25 parts of water, obtain sodium chloride solution;
(2) sodium chloride solution is averagely added three times in mixture, is added after sodium chloride solution all in the speed of 200r/min every time Mixing 3min is stirred under degree, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Embodiment 2
(1) it is uniformly mixed 2 parts of vermiculite, 3 parts of active carbon and 45 parts of iron powder to obtain mixture;By 2 parts of chlorination Sodium is dissolved with 28 parts of water, obtains sodium chloride solution;
(2) it by 2 addition mixtures of sodium chloride solution average mark, is added after sodium chloride solution all 100r/min's every time Mixing 5min is stirred under speed, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Embodiment 3
(1) it is uniformly mixed 4 parts of vermiculite, 2 parts of active carbon and 48 parts of iron powder to obtain mixture;By 1 part of chlorination Sodium is dissolved with 22 parts of water, obtains sodium chloride solution;
(2) it by 5 addition mixtures of sodium chloride solution average mark, is added after sodium chloride solution all 300r/min's every time Mixing 2min is stirred under speed, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Comparative example 1
(1) it is uniformly mixed 3 parts of vermiculite, 4 parts of active carbon and 46.875 parts of iron powder to obtain mixture;By 1 part Sodium chloride is dissolved with 25 parts of water, obtains sodium chloride solution;
(2) sodium chloride solution is averagely added three times in mixture, is added after sodium chloride solution all in the speed of 200r/min every time Mixing 3min is stirred under degree, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Comparative example 2
(1) it is uniformly mixed 3 parts of vermiculite, 1 part of active carbon and 46.875 parts of iron powder to obtain mixture;By 1 part Sodium chloride is dissolved with 25 parts of water, obtains sodium chloride solution;
(2) sodium chloride solution is averagely added three times in mixture, is added after sodium chloride solution all in the speed of 200r/min every time Mixing 3min is stirred under degree, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Comparative example 3
(1) it is uniformly mixed 3 parts of vermiculite, 2.25 parts of active carbon and 46.875 parts of iron powder to obtain mixture;By 1 part Sodium chloride dissolved with 25 parts of water, obtain sodium chloride solution;
(2) sodium chloride solution is added at one time in mixture, is carried out under the speed of 200r/min after sodium chloride solution is added It is stirred 3min, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Comparative example 4
(1) it is uniformly mixed 3 parts of vermiculite, 2.25 parts of active carbon and 46.875 parts of iron powder to obtain mixture;By 1 part Sodium chloride dissolved with 25 parts of water, obtain sodium chloride solution;
(2) it by 6 addition mixtures of sodium chloride solution average mark, is added after sodium chloride solution all in the speed of 200r/min every time Mixing 3min is stirred under degree, sodium chloride solution obtains hot compress sticking dressing after the completion of mixing with mixture.
Comparative example 5
Existing hot compress sticking dressing: mixed by following composition: iron powder 55%, vermiculite 10%, active carbon 5%, natural mineral salt 4%, Drinking water 20%.
Identical hot compress paste is made in above-described embodiment 1-3 and comparative example the 1-5 dressing being prepared, in identical experiment item Performance detection is carried out under part (temperature is 25 DEG C) (when hot compress paste temperature is greater than 35 DEG C, to be denoted as and start to generate heat;When temperature is lower than 35 DEG C, being denoted as fever terminates;When temperature is more than 47 DEG C, human body will generate cusalgia sense), record experimental result is as follows:
Serial number Start fever time (s) Heating continuing time (h) It generates heat maximum temperature (DEG C)
Embodiment 1 187 14.5 43.6
Embodiment 2 196 14.3 44.2
Embodiment 3 203 14.2 43.4
Comparative example 1 286 16.4 39.8
Comparative example 2 153 11.7 51.3
Comparative example 3 178 12.5 48.1
Comparative example 4 237 15.8 38.9
Comparative example 5 216 10.8 53.7
According to above-mentioned experimental result: dressing of the present invention is fast with electrothermal calefactive rate in embodiment 1-3, and fever time is long, fever The advantages of moderate temperature, can significantly improve the effect of hot compress;In the raw material ratio of comparative example 1, the dosage of active carbon is more than this The regulation of invention, causes oxidation reaction to slow, although extending heating continuing time, starts fever time and significantly prolongs Long, fever maximum temperature is significantly low, and the effect of hot compress is deteriorated;In the raw material ratio of comparative example 2, the dosage of active carbon is less than this The regulation of invention causes oxidation reaction speed to be accelerated, and shortens although starting fever time, and heating continuing time significantly shortens, Fever maximum temperature significantly improves, and may cause burning for human skin;In the preparation method of comparative example 3, sodium chloride solution one Secondary property is added, and causes the speed of oxidation reaction during generating heat in dressing that cannot inhibit, to cause heating continuing time aobvious It writes and shortens, fever maximum temperature significantly improves;In the preparation method of comparative example 4, the number that sodium chloride solution is added is more than this hair Bright regulation causes to inhibit excessively the oxidation reaction speed during generating heat in dressing, although extending heating continuing time, But start fever time significantly to extend, fever maximum temperature is significantly low, and the effect of hot compress is deteriorated;Embodiment 4 is existing dressing, Its heating effect is significantly worse than the dressing in 1-3 of the embodiment of the present invention, i.e., dressing of the present invention, heating property is significantly better than existing Casting product.

Claims (8)

1. a kind of hot compress sticking dressing, which is characterized in that be prepared including following parts by weight raw material: 2-4 parts of vermiculite, 2-3 Active carbon, 1-2 parts of the sodium chloride, 45-48 parts of iron powder, 22-28 parts of water of part.
2. dressing according to claim 1, which is characterized in that be prepared including following parts by weight raw material: 3 parts of leech Stone, 2.25 parts of active carbon, 1 part of sodium chloride, 46.875 parts of iron powder, 25 parts of water.
3. dressing according to claim 1, which is characterized in that the partial size of the vermiculite is 0.1-1.0mm.
4. dressing according to claim 1, which is characterized in that the partial size of the active carbon is 0.5-2.0mm.
5. dressing according to claim 1, which is characterized in that the partial size of the iron powder is 0.5-1.0mm.
6. a kind of preparation method of hot compress sticking dressing, which comprises the following steps:
(1) it is uniformly mixed vermiculite, active carbon and iron powder to obtain mixture according to the ratio;Sodium chloride is dissolved with water, is obtained Sodium chloride solution;
(2) it by 2-5 addition mixture of sodium chloride solution average mark, requires to be stirred after sodium chloride solution is added every time Mixing obtains hot compress sticking dressing after the completion of mixing.
7. preparation method according to claim 6, which is characterized in that sodium chloride solution is equally divided into 3 addition mixtures In.
8. preparation method according to claim 6, which is characterized in that the speed stirred in step (2) is 100-300r/ Min, time 2-5min.
CN201910038616.0A 2019-01-16 2019-01-16 A kind of hot compress sticking dressing and preparation method thereof Pending CN109674574A (en)

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Application Number Priority Date Filing Date Title
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151390A (en) * 2019-05-30 2019-08-23 湖北普爱药业有限公司 A kind of formula of heating paste
CN110484219A (en) * 2019-09-04 2019-11-22 武汉国灸科技开发有限公司 A kind of Portable heating agent and preparation method thereof
CN114015419A (en) * 2021-11-23 2022-02-08 江西艾叶草药业有限责任公司 Manufacturing method of self-heating material of nursing product
CN114045157A (en) * 2021-11-09 2022-02-15 武汉时代珍传医疗器械有限公司 Stone needle powder-containing heating powder and preparation method thereof
CN114470295A (en) * 2021-12-28 2022-05-13 盐城工学院 Preparation method of drug-loaded hydrogel composite fabric for wound dressing
CN116650544A (en) * 2023-06-30 2023-08-29 东悦医疗器械(武汉)有限公司 A pharmaceutical composition and hot compress patch containing folium Ginkgo extract, and its preparation method

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2248550Y (en) * 1996-04-25 1997-03-05 郑宗奇 Hot compressing plaster
US5918590A (en) * 1995-06-29 1999-07-06 The Procter & Gamble Company Heat cells
CN1230670A (en) * 1998-03-26 1999-10-06 李抒 Exothermic agent and warming bag and thermotherapeutic bag with the same
CN1248898A (en) * 1996-12-31 2000-03-29 普罗克特和甘保尔公司 Disposable thermal neck wrap
KR20020038289A (en) * 2000-11-17 2002-05-23 조민호 Method of preparing Sheet-shaped heating element
CN1760310A (en) * 2004-10-13 2006-04-19 上海超迪科技有限公司 Chemic exothermic material and exothermic bag
CN101280177A (en) * 2007-04-04 2008-10-08 中国第一汽车集团公司 Novel spontaneous heating material
CN103876882A (en) * 2014-04-17 2014-06-25 河南羚锐制药股份有限公司 Self-heating-type fragrant hot compress paste
CN205758799U (en) * 2016-03-24 2016-12-07 江苏英科医疗制品有限公司 A kind of spontaneous heating hot compress bag

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5918590A (en) * 1995-06-29 1999-07-06 The Procter & Gamble Company Heat cells
CN2248550Y (en) * 1996-04-25 1997-03-05 郑宗奇 Hot compressing plaster
CN1248898A (en) * 1996-12-31 2000-03-29 普罗克特和甘保尔公司 Disposable thermal neck wrap
CN1230670A (en) * 1998-03-26 1999-10-06 李抒 Exothermic agent and warming bag and thermotherapeutic bag with the same
KR20020038289A (en) * 2000-11-17 2002-05-23 조민호 Method of preparing Sheet-shaped heating element
CN1760310A (en) * 2004-10-13 2006-04-19 上海超迪科技有限公司 Chemic exothermic material and exothermic bag
CN101280177A (en) * 2007-04-04 2008-10-08 中国第一汽车集团公司 Novel spontaneous heating material
CN103876882A (en) * 2014-04-17 2014-06-25 河南羚锐制药股份有限公司 Self-heating-type fragrant hot compress paste
CN205758799U (en) * 2016-03-24 2016-12-07 江苏英科医疗制品有限公司 A kind of spontaneous heating hot compress bag

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151390A (en) * 2019-05-30 2019-08-23 湖北普爱药业有限公司 A kind of formula of heating paste
CN110484219A (en) * 2019-09-04 2019-11-22 武汉国灸科技开发有限公司 A kind of Portable heating agent and preparation method thereof
CN114045157A (en) * 2021-11-09 2022-02-15 武汉时代珍传医疗器械有限公司 Stone needle powder-containing heating powder and preparation method thereof
CN114015419A (en) * 2021-11-23 2022-02-08 江西艾叶草药业有限责任公司 Manufacturing method of self-heating material of nursing product
CN114470295A (en) * 2021-12-28 2022-05-13 盐城工学院 Preparation method of drug-loaded hydrogel composite fabric for wound dressing
CN116650544A (en) * 2023-06-30 2023-08-29 东悦医疗器械(武汉)有限公司 A pharmaceutical composition and hot compress patch containing folium Ginkgo extract, and its preparation method
CN116650544B (en) * 2023-06-30 2024-03-15 东悦医疗器械(武汉)有限公司 A hot compress patch containing folium Ginkgo extract for promoting blood circulation for removing blood stasis and treating burn, and its preparation method

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