CN110252034B - Biological 3D prints toilet's fungus degree control and monitoring system - Google Patents
Biological 3D prints toilet's fungus degree control and monitoring system Download PDFInfo
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- 238000012544 monitoring process Methods 0.000 title claims abstract description 27
- 241000233866 Fungi Species 0.000 title description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 45
- 230000001954 sterilising effect Effects 0.000 claims abstract description 38
- 238000007789 sealing Methods 0.000 claims abstract description 32
- 239000002245 particle Substances 0.000 claims abstract description 28
- 241000894006 Bacteria Species 0.000 claims abstract description 24
- 238000012706 support-vector machine Methods 0.000 claims abstract description 24
- 238000001914 filtration Methods 0.000 claims abstract description 21
- 238000010146 3D printing Methods 0.000 claims abstract description 20
- 238000012549 training Methods 0.000 claims description 20
- 230000000694 effects Effects 0.000 claims description 19
- 238000001816 cooling Methods 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- 230000004083 survival effect Effects 0.000 claims description 5
- 230000009290 primary effect Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000013461 design Methods 0.000 description 6
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- 230000000977 initiatory effect Effects 0.000 description 3
- 238000003303 reheating Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000606161 Chlamydia Species 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
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- 238000003379 elimination reaction Methods 0.000 description 2
- 230000030279 gene silencing Effects 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
- A61L9/18—Radiation
- A61L9/20—Ultraviolet radiation
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- G06F18/2411—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on the proximity to a decision surface, e.g. support vector machines
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Abstract
The invention discloses a biological 3D printing clean room bacteria degree control and monitoring system which can solve the problem that the existing biological 3D printing clean room is poor in sealing capability, get rid of dependence on a biological safety cabinet and monitor and evaluate the bacteria degree in the clean room. The method is realized by adopting the following technical scheme: the biological 3D printing clean room bacteria degree control and monitoring system comprises a sterilization system, a monitoring system and a sealing system, wherein the sterilization system is arranged in a clean room, the sealing system is arranged at a clean room door, and the sterilization system comprises an air filtering device and a disinfection and sterilization device; the air filtering device adopts an FFU fan filter unit, the disinfection and sterilization device adopts a C-wave ultraviolet sterilization lamp with the wavelength range of 200-275nm, the monitoring system comprises a laser suspended particle counter and a support vector machine, and the sealing system is an inflatable sealing system.
Description
Technical Field
The invention relates to a biological 3D printing clean room bacteria degree control and monitoring system, and belongs to the technical field of biological 3D printing equipment.
Background
Biological 3D printing is the application of 3D printing technology in the biomedical field, combining 3D printing technology with medical, biological and computer technologies to create 3D models for patient specific anatomy, physiology. The biological 3D printer is a device which can position and assemble biological materials or cell units according to the additive manufacturing principle under the drive of a digital three-dimensional model, manufacture products such as medical instruments, tissue engineering scaffolds, tissue organs and the like, disperse the model into a plurality of layers by reading in the three-dimensional model reconstructed or designed by medical image data, and control a printing nozzle to print the biological materials or cells layer by a computer until the printing is finished.
Because biological 3D prints the particularity, need clean aseptic printing environment, however optimization to biological 3D printer environment at present, mostly all only to inside filtration of toilet and atmospheric control, only realize through the sealing strip only to the sealed work of toilet, be difficult to reach the sealed effect of ideal, and along with the increase of number of uses, the sealing strip can become flexible gradually, probably leading to the toilet to receive the pollution because the entering of outside air at the printing in-process, can not satisfy the accurate demand to the printing environment when biological 3D printer prints far away.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides a biological 3D printing clean room bacteria degree control and monitoring system, which can solve the problem of poor sealing capability of the existing biological 3D printing clean room, get rid of dependence on a biological safety cabinet and monitor and evaluate the bacteria degree in the clean room.
The invention is realized by adopting the following technical scheme:
the biological 3D printing clean room bacteria degree control and monitoring system comprises a sterilization system, a monitoring system and a sealing system, wherein the sterilization system is arranged in a clean room, the sealing system is arranged at a clean room door, and the sterilization system comprises an air filtering device and a disinfection and sterilization device;
the air filtering device adopts an FFU fan filter unit, the FFU fan filter unit adopts an outer rotor centrifugal fan, and a primary and high-efficiency two-stage fan filter is arranged. The fan sucks air from the top of the fan filter unit and filters the air through the primary and high-efficiency fan filters. An air outlet of the FFU fan filter unit is communicated with an air inlet of the clean room, and an air inlet of the filter unit is communicated with an air outlet of the clean room, so that the effect of internal circulation is achieved, and the air in the clean room is filtered; the disinfection and sterilization device is arranged above the clean room;
the disinfection and sterilization device selects a C-wave ultraviolet sterilization lamp with the wavelength range of 200-275nm, is arranged above the clean room and is used for comprehensively disinfecting and sterilizing the interior of the clean room; wherein, the wave band with the strongest bactericidal effect is 250-270nm, so that the C-wave ultraviolet sterilizing lamp can effectively and simply kill microorganisms including bacterial propagules, spores, mycobacteria, coronaviruses, fungi, rickettsiae, chlamydia and the like;
the monitoring system comprises a laser suspended particle counter and a support vector machine, wherein the laser suspended particle counter and the support vector machine are installed on the wall of the clean room box, and the support vector machine classifies the values of the air suspended particles collected by the laser suspended particle counter;
sealing system is inflatable sealing system, including frame, door plant and gasbag, set up the door plant in the frame, the door plant passes through hinged joint with the frame, the frame corner is slick and sly, and the inboard is provided with U type groove, the embedding of U type inslot sets up the gasbag, the gasbag is located between frame and the door plant, the gasbag passes through the breather pipe and connects the air pump, still be provided with discharge valve on the gasbag.
Specifically, the FFU fan filter unit comprises a group section which comprises an initial effect filtering section, a warm and humid control section, a fan section, a silencing section, a reservation section, a high-efficiency filtering section and an air supply section, wherein the initial effect filtering section, the warm and humid control section, the fan section, the silencing section, the reservation section, the high-efficiency filtering section and the air supply section are sequentially connected, the warm and humid control section comprises a preheating section, a precooling section, a humidifying section, a precooling section and a reheating section, the fan section adopts an outer rotor centrifugal fan, and the initial effect filtering section and the high-efficiency filtering.
The cost function J (theta) of the support vector machine is as follows:
wherein C is a regularization constant, i is the ith training sample, m is the number of training samples, n is the number of features, θ is the training weight, x is the sample input, y is the sample output, x is the regularization constant(i)For the ith sample input, y(i)Output for the ith sample; thetaTIs a transpose of the theta matrix, cost1Is a cost function evolved by the logistic algorithm when y is 1; cost0Is a cost function evolved by the logistic algorithm when y is 0; j is the jth characteristic value of the j,
is a regular term;
the gaussian RBF kernel function is as follows:
wherein, l is a defined new feature, σ is a parameter of a Gaussian kernel function, x is a sample input, f is a prediction output of an input sample, and when the input training sample x is close to the defined new feature l, | | x-l | | survival2Is close to 0 and σ is a gaussian kernel parameter, is a definite value, so the value of f is close to 1, the predicted output y is 1; when the distance between the input training sample x and the new feature l is far, | x-l | survival2And as a result, f approaches 0, and the predicted output y is 0.
Compared with the prior art, the invention has the beneficial effects that:
the clean room of the invention is as follows: 1) the air filtering structure adopts an internal circulation structure, and is free from the interference of outside air.
2) The sterilization structure adopts a C-wave ultraviolet sterilization lamp with the wavelength range of 200-275nm, and can effectively and simply kill microorganisms such as bacteria.
3) The dependence on the biological safety cabinet is eliminated.
4) The bacteria degree monitoring system is added, and the effect of monitoring the bacteria degree in the clean room in real time can be achieved through the cooperation of the suspended particle counter and the support vector machine.
5) The device adopts inflatable gasbag sealing strip, replaces former ordinary sealing strip, has improved sealed effect, also can not reduce sealing performance along with the increase of number of times of use.
6) Through the control of air pump and exhaust valve, both guaranteed the sealed effect when printing, can not cause the door plant to block or the gasbag damages when opening the hatch door yet.
7) The smooth design of four corners of the clean room outer frame and the door frame and the design of the U-shaped groove of the clean room outer frame are beneficial to the sealing effect after the air bag is inflated.
8) The hinge assembly is used for replacing the hinge connection between the cabin door and the outer frame, and the hinge assembly is used for connecting the cabin door and the outer frame, so that the sealing effect cannot be reduced due to a gap formed by the connection of the cabin door and the outer frame.
Drawings
FIG. 1 is a schematic view of a closed cleanroom door (internal components not shown);
FIG. 2 is a side cross-sectional view of a clean room door closed;
FIG. 3 is a top sectional view of a clean room door closed;
fig. 4 is a top sectional view of a clean room door open.
FIG. 5 is a schematic view of the segments of an FFU fan filter unit;
FIG. 6 is a schematic view of an FFU fan filter set and clean room air circulation;
fig. 7 is a schematic view of a connection structure of the FFU fan filter unit and the fresh air system.
The meaning of the reference numerals: 1-outer frame, 2-door panel, 3-hinge, 4-exhaust valve, 5-air bag, 6-door handle, 7-air pump, 8-vent pipe, 9-C wave ultraviolet sterilization lamp, 10-FFU fan filter unit, 11-laser suspended particle counter, 12-primary effect filter section, 13-temperature and humidity control section, 14-fan section, 15-noise elimination section, 16-reservation section, 17-high efficiency filter section, 19-waffle slab, 20-air return vertical shaft, 21-fresh air unit, 22-air blower chamber, 23-perforated raised floor, 24-ceiling static pressure box, 25-air outlet, 26-air inlet and 30-clean room.
Detailed Description
The invention is further illustrated by the following examples and figures:
the biological 3D printing clean room bacteria degree control and monitoring system comprises a sterilization system, a monitoring system and a sealing system, wherein the sterilization system is arranged in a clean room, the sealing system is arranged at a clean room door, and the sterilization system comprises an air filtering device and a disinfection and sterilization device;
the air filtering device adopts an FFU fan filter unit, an air outlet of the filter unit is communicated with an air inlet of the clean room through an air duct, and an air inlet of the filter unit is communicated with an air outlet of the clean room, so that an internal circulation effect is achieved, the air in the clean room is filtered, and the air is prevented from being interfered by external air;
the air outlet 25 of the FFU fan filter unit is communicated with the air inlet of the clean room, and the air inlet 26 of the fan filter unit is communicated with the air outlet of the clean room, so that the effect of internal circulation is achieved. As shown in fig. 6.
The fan of the FFU fan filter unit adopts an outer rotor centrifugal fan and is provided with a primary fan filter and a high-efficiency fan filter. The fan sucks air from the top of the fan filter unit and filters the air through the primary and high-efficiency fan filters. The centrifugal fan with the outer rotor has the characteristics of stable performance, long service life, low noise, no maintenance, small vibration, stepless speed regulation and the like, and is suitable for obtaining higher-level clean environments in various environments.
Specifically, as shown in fig. 5, the FFU fan filter unit includes a primary filter section 12, a temperature and humidity control section 13, a fan section 14, an acoustic elimination section 15, a reservation section 16, a high efficiency filter section 17, and an air supply section, which are connected in sequence, the temperature and humidity control section 13 includes a preheating section, a pre-cooling section, a humidification section, a re-cooling section, and a re-heating section, the fan section employs an external rotor centrifugal fan, the primary filter section 12 and the high efficiency filter section 17 are respectively provided with a primary fan filter and a high efficiency fan filter, and air is filtered by the high efficiency fan filter of the FFU fan filter unit to reach a clean requirement and then is sent into a clean room.
The air supply section comprises a waffle slab 19, a return air vertical shaft 20, a fresh air unit 21, a blower chamber 22, a perforated raised floor 23 and a ceiling static pressure box 24, an air inlet of the FFU fan filter unit passes through the waffle slab 19 and the return air vertical shafts 20 on two sides, is mixed with fresh air processed by the fresh air unit 21, and returns to the ceiling static pressure box 24 after being subjected to anti-static processing through the blower chamber 22 and the perforated raised floor 23, and the ceiling static pressure box is connected with the primary effect filter section 12.
Because the pressure in the clean room is higher than the pressure in the plenum chamber, the possibility that dust particles permeate the clean room from the suspended ceiling plenum chamber does not exist, and the problem that suspended particles permeate the clean room is fundamentally solved. The specific structure diagram is shown in fig. 7.
Wherein, precooling section, cold section, preheating section, reheat section are all realized through the coil pipe heat transfer, and the confession return water temperature of precooling section, cold section, preheating section, reheat section is as shown in Table 1:
TABLE 1
| Pre-cooling section | Recooling section | Preheating section | Reheating section | |
| Temperature of water supply | 10-20℃ | 4-10℃ | 80-100℃ | 80-100℃ |
| Temperature of return water | 16-26℃ | 10-15℃ | 50-70℃ | 60-80℃ |
Preferably, the temperature of water supply and return of the precooling coil is 13 ℃/19 ℃, the temperature of water supply and return of the recooling coil is 5 ℃/10.6 ℃, the temperature of water supply and return of the preheating coil is 90 ℃/60 ℃, and the temperature of water supply and return of the reheating coil is 90 ℃/70 ℃.
The disinfection and sterilization device selects a C-wave ultraviolet sterilization lamp with the wavelength ranging from 200 nm to 275nm, is arranged above the clean room, and is used for comprehensively disinfecting and sterilizing the interior of the clean room; wherein, the wave band with the strongest bactericidal action is 250-270nm, so that the C-wave ultraviolet sterilizing lamp can effectively, simply and conveniently kill microorganisms including bacterial propagules, spores, mycobacteria, coronaviruses, fungi, rickettsiae, chlamydia and the like;
the monitoring system comprises a laser suspended particle counter and a support vector machine, wherein the laser suspended particle counter and the support vector machine are installed on the wall of the clean room box, and the support vector machine classifies the values of the air suspended particles collected by the laser suspended particle counter;
the sealing system is an inflatable sealing system and comprises an outer frame 1, a door plate 2 and an air bag 5, wherein the door plate 2 is arranged in the outer frame 1, the door plate 2 is connected with the outer frame 1 through a hinge 3, one end of the hinge 3 is fixedly connected with the door plate 2 of the clean room, and the other end of the hinge is hinged with the outer frame 1 of the clean room.
Four corners of frame 1 are all slick and sly, and the inboard is provided with U type groove, the embedding in U type groove sets up gasbag 5, gasbag 5 is located between frame and the door plant, gasbag 5 passes through breather pipe 8 and connects air pump 7, still be provided with discharge valve 4 on the gasbag 5. After the door panel 2 is closed, the air bag 5 is inflated to seal the gap between the door panel and the door frame, thereby improving the sealing problem of the clean room.
The smooth design of four corners of the clean room door frame and the design of the U-shaped groove of the clean room outer frame are beneficial to the sealing effect after the air bag is inflated.
When the printing is to be carried out, the clean room cabin door is closed, the air bag in the U-shaped groove of the outer frame is externally connected with the air pump, the air bag is inflated through the air pump, the door plate and the door frame are thoroughly sealed, and then the preparation work of internal air filtration, sterilization and the like is carried out.
After complete sealing, the inside air of toilet is inhaled FFU fan filter unit 10 by the fan through the air inlet, filters through high efficiency fan filter, and the clean air after filtering is evenly sent out, and C ripples ultraviolet sterilamp 9 carries out the virus killing and sterilizes, gets into the wind channel once more, and the fan through the air inlet inhales the air in the clean room, forms the clean air inner loop among the printing environment.
The laser suspended particle counter 11 collects suspended particles in the clean room in real time, and inputs the collected values of the suspended particles into a support vector machine trained to perfect fitting, so that whether the concentration of air bacteria in the clean room meets the biological 3D printing standard or not can be judged, and online real-time monitoring is realized.
After printing is finished, the exhaust valve 4 is opened to exhaust the gas in the air bag 5, a proper gap is reserved for overturning the clean room cabin door 2, and jamming of the clean room cabin door 2 or damage to the air bag 5 cannot be caused.
When the air bag is in an inflated state, the whole U-shaped groove is just filled in the U-shaped groove of the outer frame of the clean room, and the air bag and the door of the clean room are thoroughly sealed. When the air bag exhausts, the air in the air bag is completely extracted by the exhaust valve, and the air bag is in a minimum state and is embedded in the U-shaped groove, so that a proper gap is reserved for the overturning of the clean room cabin door.
Compared with the traditional clean room sterilization technology, the method has the following advantages:
1) the air filtering structure adopts an internal circulation structure, and is free from the interference of outside air.
2) The sterilization structure adopts a C-wave ultraviolet sterilization lamp with the wavelength range of 200-275nm, and can effectively and simply kill microorganisms such as bacteria.
3) The dependence on the biological safety cabinet is eliminated.
4) The bacteria degree monitoring system is added, and the effect of monitoring the bacteria degree in the clean room in real time can be achieved through the cooperation of the suspended particle counter and the support vector machine.
5) The device adopts inflatable gasbag sealing strip, replaces former ordinary sealing strip, has improved sealed effect, also can not reduce sealing performance along with the increase of number of times of use.
6) Through the control of air pump and exhaust valve, both guaranteed the sealed effect when printing, can not cause the door plant to block or the gasbag damages when opening the hatch door yet.
7) The smooth design of four corners of the clean room outer frame and the door frame and the design of the U-shaped groove of the clean room outer frame are beneficial to the sealing effect after the air bag is inflated.
8) The hinge assembly is used for replacing the hinge connection between the cabin door and the outer frame, and the hinge assembly is used for connecting the cabin door and the outer frame, so that the sealing effect cannot be reduced due to a gap formed by the connection of the cabin door and the outer frame.
The cost function J (theta) of the support vector machine is as follows:
wherein C is a regularization constant, i is the ith training sample, m is the number of training samples, n is the number of features, θ is the training weight, x is the sample input, y is the sample output, x is the regularization constant(i)For the ith sample input, y(i)Output for the ith sample; thetaTIs a transpose of the theta matrix, cost1Is a cost function evolved by the logistic algorithm when y is 1; cost0Is a cost function evolved by the logistic algorithm when y is 0; j is the jth characteristic value of the j,
the fitting method is a regular term, so that the condition of high deviation or high variance can be prevented from occurring in the fitting process;
the gaussian RBF kernel function is as follows:
wherein l is definedFeatures, sigma is a parameter of the gaussian kernel function, x is a sample input, f is a prediction output of the input sample, and | x-l | y is zero when the input training sample x is close to the new feature l defined2Is close to 0 and σ is a gaussian kernel parameter, is a definite value, so the value of f is close to 1, the predicted output y is 1; when the distance between the input training sample x and the new feature l is far, | x-l | survival2And as a result, f approaches 0, and the predicted output y is 0.
In the specific implementation process, before training, a large number of air suspended particle value samples need to be collected, and the air suspended particle value samples which meet the standard of the bacteria degree in a clean room and the air suspended particle value samples which do not meet the standard also need to be obtained. The method comprises the steps of dividing the test set into a training set, a verification set and a test set, inputting the test set into a support vector machine for training, and fitting a matrix of theta values when a cost function J (theta) is reduced to the minimum. Training is carried out through a support vector machine, the decision boundary of the number of the air suspended particles with the bacteria degree reaching the standard and not reaching the standard is found out, and the bacteria degree in the clean room can be monitored and evaluated after fitting.
Since the cost function of the support vector machine is a convex function and the condition of local optimum is not required to be considered, a theta matrix which can minimize J (theta) is directly found and then substituted into the Gaussian kernel function.
The Gaussian kernel function is used for solving the problem that the fitted assumed function has a high-order polynomial and cannot be fitted to a training sample best; meanwhile, in order to accelerate the operation rate, before the gaussian kernel function runs, a new characteristic value l needs to be defined, and if three points are defined, one point x is aimed atiTo l1、l2、l3Distance of three points, if1、l2Is a positive sample, then xiThe closer to these two points, the higher the probability that the final y is 1 should be; conversely, if the two points are far away, the probability that y is 0 should be higher. Then inputting the value of the air suspended particles newly acquired by us into a Gaussian kernel function, and judging thetaTf value if θTIf f is greater than 0, then y is predicted to be equal to1, namely the value of the air suspended particles reaches the standard; otherwise, predicting that y is 0, namely the value of the aerosol particles does not reach the standard.
In the application of biological 3D printing, because the feature vector is very small, the kernel function of the support vector machine selects a Gaussian (RBF) kernel function, and the best fitting effect can be achieved. Meanwhile, the Support Vector Machine (SVM) is used for processing the classification problem, and the method has the following advantages:
1) and sparsity, namely, a good classification effect can be obtained by a small amount of samples.
2) The theory is perfect, and a set of nearly perfect theory can explain the principle.
3) The best decision boundary is always selected.
4) And the output has no probability value, and only 0 and 1 are output, so that the method is simple and clear.
5) The operation speed is high.
While the foregoing shows and describes the principles of the invention, together with the general features and advantages thereof, the same is to be understood more fully and specifically as a prelude to the more detailed description that is presented later, and not as a limitation on the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (6)
1. The biological 3D printing clean room bacteria degree control and monitoring system is characterized by comprising a sterilization system and a monitoring system which are arranged in a clean room, and a sealing system arranged at a clean room door, wherein the sterilization system comprises an air filtering device and a disinfection and sterilization device;
the air filtering device adopts an FFU fan filter unit, the FFU fan filter unit adopts an outer rotor centrifugal fan, and a primary and high-efficiency two-stage fan filter is arranged; the fan sucks air from the top of the fan filter unit and filters the air through the primary fan filter and the high-efficiency fan filter, an air outlet of the FFU fan filter unit is communicated with an air inlet of the clean room, and an air inlet of the filter unit is communicated with an air outlet of the clean room, so that the effect of internal circulation is achieved, and the air in the clean room is filtered;
the disinfection and sterilization device is arranged above the clean room;
the monitoring system comprises a laser suspended particle counter and a support vector machine, wherein the laser suspended particle counter and the support vector machine are installed on the wall of the clean room box, and the support vector machine classifies the values of the air suspended particles collected by the laser suspended particle counter;
sealing system is inflatable sealing system, including frame, door plant and gasbag, set up the door plant in the frame, the door plant passes through hinged joint with the frame, the frame corner is slick and sly, and the inboard is provided with U type groove, the embedding of U type inslot sets up the gasbag, the gasbag is located between frame and the door plant, the gasbag passes through the breather pipe and connects the air pump, still be provided with discharge valve on the gasbag.
2. The biological 3D printing clean room bacteria degree control and monitoring system according to claim 1, wherein the FFU fan filter unit comprises a group section comprising a primary filter section, a temperature and humidity control section, a fan section, a sound eliminating section, a reservation section, a high efficiency filter section and an air supply section which are connected in sequence.
3. The biological 3D printing clean room bacteria degree control and monitoring system according to claim 2, wherein the temperature and humidity control section comprises a preheating section, a pre-cooling section, a humidifying section, a re-cooling section and a re-heating section, the fan section adopts an outer rotor centrifugal fan, and the primary effect filtering section and the high efficiency filtering section are respectively provided with a primary effect fan filter and a high efficiency fan filter.
4. The biological 3D printing clean room bacteria degree control and monitoring system according to claim 1, wherein the disinfection and sterilization device is a C-wave ultraviolet sterilization lamp with a wavelength range of 200-275 nm.
5. The biological 3D printing clean room bacteria degree control and monitoring system according to claim 4, wherein the disinfection and sterilization device is a C-wave ultraviolet sterilization lamp with a wavelength range of 250-270 nm.
6. The biological 3D printing clean room bacteria degree control and monitoring system according to claim 1, wherein the cost function J (θ) of the support vector machine is:
wherein C is a regularization constant, i is the ith training sample, m is the number of training samples, n is the number of features, θ is the training weight, x is the sample input, y is the sample output, x is the regularization constant(i)For the ith sample input, y(i)Output for the ith sample; thetaTIs the transpose of the theta matrix; cost1Is a cost function evolved by the logistic algorithm when y is 1; cost0Is a cost function evolved by the logistic algorithm when y is 0; j is the jth characteristic value of the j,
is a regular term;
the gaussian RBF kernel function is as follows:
wherein, l is a defined new feature, σ is a parameter of a Gaussian kernel function, x is a sample input, f is a prediction output of an input sample, and when the input training sample x is close to the defined new feature l, | | x-l | | survival2The value of (a) is close to 0, and σ is a gaussian kernel function parameter, which is a determined value, so that the value of f is close to 1, and under the condition that the value of f is close to 1, the prediction output y of the support vector machine is set to be 1; when the distance between the input training sample x and the new feature l is far, | x-l | survival2Therefore, the value of f is close to 0, and when the value of f is close to 0, the prediction output y of the support vector machine is set to 0.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012206080A (en) * | 2011-03-30 | 2012-10-25 | Ngk Insulators Ltd | Honeycomb filter |
| CN106408031A (en) * | 2016-09-29 | 2017-02-15 | 南京航空航天大学 | Super parameter optimization method of least squares support vector machine |
| CN107427835A (en) * | 2015-02-17 | 2017-12-01 | 西门子医疗保健诊断公司 | The classification of bar-code label situation from the top view sample cell image for laboratory automation |
| EP3016864B1 (en) * | 2013-07-01 | 2018-02-14 | Telespazio S.p.A. | A group for allowing free orientation of a sphere with respect to outside force fields |
| CN108973154A (en) * | 2018-08-13 | 2018-12-11 | 哈尔滨汇恒科技有限公司 | Air based on biological 3D printing equipment compresses temperature control device |
Family Cites Families (1)
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012206080A (en) * | 2011-03-30 | 2012-10-25 | Ngk Insulators Ltd | Honeycomb filter |
| EP3016864B1 (en) * | 2013-07-01 | 2018-02-14 | Telespazio S.p.A. | A group for allowing free orientation of a sphere with respect to outside force fields |
| CN107427835A (en) * | 2015-02-17 | 2017-12-01 | 西门子医疗保健诊断公司 | The classification of bar-code label situation from the top view sample cell image for laboratory automation |
| CN106408031A (en) * | 2016-09-29 | 2017-02-15 | 南京航空航天大学 | Super parameter optimization method of least squares support vector machine |
| CN108973154A (en) * | 2018-08-13 | 2018-12-11 | 哈尔滨汇恒科技有限公司 | Air based on biological 3D printing equipment compresses temperature control device |
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