CN110250519A - A kind of dendrobium polysaccharide premixed powder and its preparation and application - Google Patents
A kind of dendrobium polysaccharide premixed powder and its preparation and application Download PDFInfo
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- CN110250519A CN110250519A CN201910566633.1A CN201910566633A CN110250519A CN 110250519 A CN110250519 A CN 110250519A CN 201910566633 A CN201910566633 A CN 201910566633A CN 110250519 A CN110250519 A CN 110250519A
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- Prior art keywords
- dendrobium polysaccharide
- polysaccharide
- dendrobium
- premixed powder
- powder
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- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 94
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 94
- 150000004676 glycans Chemical class 0.000 title claims abstract description 92
- 241001523681 Dendrobium Species 0.000 title claims abstract description 90
- 239000000843 powder Substances 0.000 title claims abstract description 82
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 208000019505 Deglutition disease Diseases 0.000 claims abstract description 25
- 235000013305 food Nutrition 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 16
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 14
- 230000000704 physical effect Effects 0.000 claims abstract description 14
- 239000003765 sweetening agent Substances 0.000 claims abstract description 14
- 239000002671 adjuvant Substances 0.000 claims abstract description 13
- 239000003607 modifier Substances 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 240000004638 Dendrobium nobile Species 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 244000269722 Thea sinensis Species 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 235000019640 taste Nutrition 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 208000002720 Malnutrition Diseases 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 208000006011 Stroke Diseases 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims description 3
- 230000018044 dehydration Effects 0.000 claims description 3
- 238000006297 dehydration reaction Methods 0.000 claims description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 230000001071 malnutrition Effects 0.000 claims description 3
- 235000000824 malnutrition Nutrition 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- 208000015380 nutritional deficiency disease Diseases 0.000 claims description 3
- 238000002390 rotary evaporation Methods 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 claims description 2
- 208000034657 Convalescence Diseases 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 238000010170 biological method Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 230000004064 dysfunction Effects 0.000 claims description 2
- 239000003792 electrolyte Substances 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- -1 polysaccharide compounds Chemical class 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 238000002627 tracheal intubation Methods 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 5
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- 210000004072 lung Anatomy 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 22
- 238000003756 stirring Methods 0.000 description 10
- 239000013065 commercial product Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 230000006872 improvement Effects 0.000 description 7
- 238000007792 addition Methods 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 235000014347 soups Nutrition 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 235000009569 green tea Nutrition 0.000 description 5
- 239000005457 ice water Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000000474 nursing effect Effects 0.000 description 4
- 210000003800 pharynx Anatomy 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- 241000167880 Hirundinidae Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 235000019629 palatability Nutrition 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 206010035669 Pneumonia aspiration Diseases 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001437 anti-cataract Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000009807 aspiration pneumonia Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009748 deglutition Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000002409 epiglottis Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/06—Treating tea before extraction; Preparations produced thereby
- A23F3/14—Tea preparations, e.g. using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L23/00—Soups; Sauces; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of dendrobium polysaccharide premixed powder and its preparations and application.The dendrobium polysaccharide premixed powder, which is characterized in that be made of the raw material of following weight percents: the freeze-dried powder 70-100% containing dendrobium polysaccharide or its modifier, adjuvant 0-20%, acid 0-5%, sweetener 0-5%.The present invention improves food and drug physical property using properties such as the viscosity of dendrobium polysaccharide aqueous solution and rheological characteristics, slows down the speed that alimentary fluid is swallowed, and reduces the danger that food flows into lung, food and drug modifying agent suitable for dysphagia.
Description
Technical field
The invention belongs to field of food science, specifically a kind of conducive to the dendrobium polysaccharide premixed powder swallowed and its preparation
Methods and applications.
Background technique
Dysphagia, which refers to exist during the transport by the substances such as solid-state or aqueous liquid foodstuff, drug from oral cavity to stomach, is stranded
It is difficult.Dysphagia can betide each age group crowd, have within 50 years old or more 22%, over-65s to have 10%~30%, 70 years old or more
There is 40% people to suffer from function of deglutition disorder, as the trend risen, the elderly's epiglottis reflection function drop is presented in the increase at age
Low, constrictor pharyngis activity weakens, and is more also easy to produce aphetite disorder.The especially patients such as neurodegenerative disease, there is 60%~80%
The puzzlement of neurodegenerative disease patient and stroke patient more than 30% by dysphagia.Dysphagia crowd largely exists
The problems such as dehydration, malnutrition, electrolyte disturbance, and easily lead to patient and food is sucked into tracheae, serious person when swallowing food
Aspiration pneumonia can occur and lead to death.
Patients with deglutition disorders quality of life is adversely effected.Alleviate dysphagia method mainly swallow function training,
Nasal feeding substitutes feed, operative treatment, electronic stimulation and food drug physical property improving etc..From swallowing in terms of angle, liquid food increases
It is thick that viscosity can be improved, slow down its speed for flowing through throat, be conducive to swallow, reduces the danger of food sucking lung.Therefore, exist
In the diet nursing of dysphagia patients, improving the physical property such as viscosity, the rheological characteristic of dilute slop is critically important means.
Food requirement suitable for dysphagia patients is the viscosity that density is uniform, appropriate, is not easy loosely, by pharynx and food
It is easily deformed when road, is not easy the properties such as the bioactivity and the color that remain on mucous membrane, and take into account food.Dysphagia
The common slop thickener of therapy field is divided into two classes: starch and polysaccharide.Starch is since starch granules is in liquid
In swelling and partly soluble property, be easy to cause the mouthfeel of paste, influence the acceptance level of patient, and its thickening liquid
Viscosity it is very big with the variation of temperature at any time, hardly result in the thickened fluid of stable homogeneous.Polysaccharide is not easy by human oral cavity
In ptyalin decompose, tangled structure can be formed in aqueous solution and keep stable glutinous within the relatively long time
Degree, therefore it is used widely in dysphagia nursing field.
Xanthan gum due to it there are strong pseudoplastic rheological properties to show product in the diet nursing of dysphagia
The effect of pole.The fluid of dysphagia therapeutic purposes should also have stable viscosity, to meet the needs of patient safety is swallowed.It is yellow
Virgin rubber is as thickener, though it is widely used in dysphagia diet nursing, however, thixotroping possessed by the fluid of its thickening
Property, so that its viscosity is easy the factors such as at any time upon configuration and apparent variation occurs, to be difficult to ensure that it edible reaches setting
Value in turn results in eater and swallows that there are security risks.In addition, guar gum, locust bean gum, hyaluronic acid etc. are used also as gulping down
Difficult diet thickener is swallowed, however these hydrophilic colloid thickeners are difficult to provide other beneficial functions, and content is higher has
Certain disagreeable taste.
Main active constituent is polysaccharide compound in dendrobium nobile, has and improves immunity, hypoglycemic, antitumor, antioxygen
The effects of change, liver-protecting and stomach-protecting and anti-cataract.Since eighties of last century the fifties, researcher is in succession to the extraction of dendrobium polysaccharide
Purifying, structure elucidation and functional activity etc. have done numerous studies, and achieve certain achievement.We have found in scientific research
Dendrobium polysaccharide can be used as the food nature modifying agent for improving dysphagia crowd.
With the growth of aging populations quantity, dysphagia is just becoming an increasingly serious social concern, serious shadow
Human health and quality of life are rung, therefore studies the food or drug physical property improving for being suitable for the special medicine purposes of dysphagia
Agent will have great importance and great market potential.
Summary of the invention
It is an object of the present invention to provide a kind of conducive to the dendrobium polysaccharide premixed powder and its preparation method and application swallowed.
In order to achieve the above object, the present invention provides a kind of dendrobium polysaccharide premixed powders, which is characterized in that by following weight
The raw material of percentage is made:
Freeze-dried powder 70-100% containing dendrobium polysaccharide or its modifier,
Adjuvant 0-20%,
Acid 0-5%,
Sweetener 0-5%.
The dendrobium polysaccharide refers to the polyoses extract from orchid family Dendrobium Sw, it is including but not limited to fresh and
Dry stem of Dendrobium and polyoses extract in leaf, the dendrobium polysaccharide mixture for belonging to source not of the same race.
Preferably, the freeze-dried powder containing dendrobium polysaccharide or its modifier is by dendrobium polysaccharide or single group of its modifier
It is grouped as, or is dendrobium polysaccharide or its modifier and protein, lipoid substance and other plant and animal polysaccharide chemical combination
The compound of at least one of object.
Preferably, the dendrobium polysaccharide modifier is physics, chemistry and the biological method carried out to natural dendrobium polysaccharide
Single or combined treatment after resulting modified product.
Preferably, the adjuvant be in maltodextrin, other starchy materials and hy-drophilic polysaccharide substance extremely
Few one or more kinds of mixture.
Preferably, the acid is the combination of any one or two kinds of citric acid, malic acid.
Preferably, the sweetener be sucrose (such as white granulated sugar), the combination of any one or two kinds in honey.
Preferably, the mass ratio of the sweetener and acid is 50-100:1.
The present invention also provides the preparation methods of above-mentioned dendrobium polysaccharide premixed powder characterized by comprising presses quality hundred
Divide ratio, by the freeze-dried powder 70-100% containing dendrobium polysaccharide or its modifier, adjuvant 0-20%, acid 0-5% and sweetener
0-5% is mixed evenly, and obtains dendrobium polysaccharide premixed powder.
Preferably, the preparation method of the dendrobium polysaccharide freeze-dried powder includes: to shred fresh dendrobium nobile branch, and 50- is added
The ethanol water of 90vol% impregnates 72-100h, and filter residue is collected in filtering, and the distilled water that 5-10 times of volume is added boils 5-
Rotary evaporation after filtrate is collected in 30min, filtering, and the anhydrous second that final concentration reaches 70-90vol% is added in the concentrate after evaporation
Alcohol stands 36-72h, and precipitating is collected in centrifugation, is crushed after precipitating is freeze-dried, and sieving obtains dendrobium polysaccharide freeze-dried powder.
The present invention also provides the application methods of above-mentioned dendrobium polysaccharide premixed powder characterized by comprising dendrobium nobile is more
Sugared premixed powder directly within the scope of 0 DEG C -60 DEG C aqueous liquid foodstuff or drug mix, or first dendrobium polysaccharide premixed powder is made into molten
Liquid, then within the scope of 0 DEG C -60 DEG C aqueous liquid foodstuff or drug mix.
Preferably, the aqueous liquid foodstuff includes but is not limited to ice water, cold water, hot water, mineral water, distilled water, pure water,
Watery soup, gruel, syrup, milk, fruit juice, tea, coffee, soft drink, the various types of beverages containing low concentration (being less than 10vol%) ethyl alcohol,
But all kinds of drinks of ethyl alcohol containing 30vol% and concentrations above are not suitable for it.
The present invention also provides above-mentioned dendrobium polysaccharide premixed powder answering in the physical property or mouthfeel for improving food or drug
With.The physical property refers to the physical property of solution, including but not limited to viscosity, elasticity, brittleness, chewiness and rheological characteristic
Deng.The dendrobium polysaccharide premixed powder can be used for improving the physical property of food or drug, suitable for dysphagia crowd diet and
Medication.Dendrobium polysaccharide premixed powder can be used for improving the mouthfeel of food or drug, suitable for improving the life matter of dysphagia crowd
Amount.
The present invention also provides above-mentioned dendrobium polysaccharide premixed powder in preparation for improving or treating with dysphagia
Malnutrition, electrolyte dysfunction or the drug of dehydration of patient or the application in food.
Preferably, the patient with dysphagia include but is not limited to plant person, cerebral thrombosis, initial stage Parkinson,
Senile dementia, advanced diabetes, encephalatrophy, disability mistake intelligence, apoplexy, intubation nasal feeding patient, the convalescence after Miles operation etc., which have, swallows barrier
Hinder the crowd of behavior.
After dendrobium nobile involved in the present invention (Dendrobium nobile) is the fresh of orchid family Dendrobium Sw or is dry
Stem or leaf.Dendrobium polysaccharide involved in the present invention be it is fresh or dry after stem of Dendrobium or leaf freeze after water extract-alcohol precipitation and filtering
Dry powder.
Compared with prior art, the beneficial effects of the present invention are:
The present invention improves food and drug physical property, slows down using properties such as the viscosity of dendrobium polysaccharide aqueous solution and rheological characteristics
The speed that alimentary fluid is swallowed reduces the danger that food flows into lung, food and drug modifying agent suitable for dysphagia.
Present invention employs dendrobium polysaccharides, and the rheological property of its aqueous solution is on the one hand utilized, is on the other hand utilized
Its biological activity, colorless and odorless, appearance transparent do not influence the color, smell and taste of former food.Being simply mixed can be used, and compensate for existing
There is the deficiency of product.
The dendrobium polysaccharide premixed powder of method preparation of the invention, solution use is diluted with water at 0-60 DEG C, adds shape after water
At stable uniform solution, viscosity and rheological characteristic can be adjusted according to premixed powder additive amount, and solution is tasteless or sour and sweet palatability, can directly be eaten
With can also be used as ingredient and be added in other food or drug, conducive to swallowing.
With different viscosity when dendrobium polysaccharide premixed powder adds different solutions amount within the scope of 0 DEG C -60 DEG C in the present invention.
Suitable dendrobium polysaccharide premixed powder can be directly added in food and drug, formation density is uniform after addition solution, there have to be appropriate viscous
Property, it is viscosity stabilized, be not easy loose, by being easily deformed when pharynx, oesophagus and easy-to-swallow colloid, improve function of deglutition.It is gulping down
There is smooth slight thixotropy, delicate mouthfeel, sour and sweet palatability during pharynx and there is dendrobium polysaccharide to improve immunity and drop blood
The bioactivity such as sugar.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
Used each raw material is commercial product in following embodiment.
Embodiment 1
A kind of preparation method of dendrobium polysaccharide premixed powder, specific steps are as follows:
1) a dendrobium polysaccharide preparation step: fresh dendrobium nobile branch is shredded, and 80vol% ethanol water, room temperature is added
(25 DEG C) immersion 96h, 2 layers of filtered through gauze.Filter residue is collected, the distilled water that 10 times of volumes are added boils 30min, 6 layers of filtered through gauze,
The dehydrated alcohol that final concentration reaches 80vol% is added in 95 DEG C of rotary evaporations after collection filtrate, the concentrate after evaporation, stands 48h,
It is centrifuged (5000rpm, 15min), collects precipitating, crushed after precipitating is freeze-dried, cross 80 meshes, obtain dendrobium polysaccharide freeze-dried powder
(average molecular mass is about 11.5 × 104Da)；
2) dendrobium polysaccharide freeze-dried powder, adjuvant (maltodextrin), acid (citric acid), sweetener (sugarcane are weighed according to the ratio
Sugar), it is mixed evenly, obtains dendrobium polysaccharide premixed powder, packed.Every bag contains dendrobium polysaccharide premixed powder 0.5g.
Embodiment 2
The improvement of low temperature natural drink water physical property:
Take the dendrobium polysaccharide premixed powder prepared according to 1 method of embodiment, wherein dendrobium polysaccharide premixed powder ratio is that dendrobium nobile is more
Sugared freeze-dried powder 100%, adjuvant 0%, acid 0%, sweetener 0%.
The above-mentioned premixed powder of 0.5g is weighed, the ice water of 4 DEG C, 100mL is added, stirs evenly, passes through NDJ-5S rotational viscometer
The viscosity of solution is measured, the ice water that 4 DEG C, 100mL are added in 1 bag of product (2g, minimum package) is swallowed in the commercially available promotion of certain brand, stirring
Uniformly, pass through the viscosity of NDJ-5S rotary viscosity measuring solution.As a result it is compared.
The viscosity of ice water is 10mPaS, and 0.5g dendrobium polysaccharide premixed powder is added after mixing evenly, and viscosity reaches 310mPaS,
It has been more than the viscosity 256mPaS behind 1 bag of addition commercial product (2g).Meanwhile after 0.5g dendrobium polysaccharide premixed powder is added, solution is viscous
It is thick, there is certain mobility, has not been changed the taste of water.As a result illustrate, dendrobium polysaccharide premixed powder dosage is few and effect be better than it is commercially available
Product.
Embodiment 3
The improvement of low temperature Chef Kang green tea beverage physical property:
Take the dendrobium polysaccharide premixed powder prepared according to 1 method of embodiment, wherein dendrobium polysaccharide premixed powder ratio is that dendrobium nobile is more
Sugared freeze-dried powder 100%, adjuvant 0%, acid 0%, sweetener 0%.
The above-mentioned premixed powder of 0.5g is weighed, the refrigeration Chef Kang green tea of 4 DEG C, 100mL is added, stirs evenly, passes through NDJ-5S
The viscosity of rotary viscosity measuring solution, 1 bag of commercial like product (2g) are added the refrigeration Chef Kang green tea of 4 DEG C, 100mL, stir
It mixes uniformly, passes through the viscosity of NDJ-5S rotary viscosity measuring solution.As a result it is compared.
The viscosity of ice Chef Kang green tea is 27mPaS, 0.5g dendrobium polysaccharide premixed powder is added after mixing evenly, viscosity reaches
360mPaS has been more than the viscosity 300mPaS behind 1 bag of addition commercial product (2g).It is molten after 0.5g dendrobium polysaccharide premixed powder is added
Liquid is sticky, there is certain mobility, has not been changed the taste of Chef Kang's green tea.As a result illustrate, dendrobium polysaccharide premixed powder dosage it is few and
Effect is better than commercial product.
Embodiment 4
The improvement of room temperature drinking water physical property and taste:
Take the dendrobium polysaccharide premixed powder prepared according to 1 method of embodiment, wherein dendrobium polysaccharide premixed powder ratio is that dendrobium nobile is more
Sugared freeze-dried powder 80.0%, adjuvant 19.45%, acid 0.05%, sweetener 0.5%.
The above-mentioned premixed powder of 0.75g is weighed, the warm water of 20 DEG C, 100mL is added, stirs evenly, passes through NDJ-5S rotary viscosity
The viscosity of meter measurement solution, commercially available improvement are swallowed 2 bags of product (4g) and 3 bags (6g) warm water for being separately added into 20 DEG C, 100mL, are stirred
It mixes uniformly, passes through the viscosity of NDJ-5S rotary viscosity measuring solution.As a result it is compared.
The viscosity of 20 DEG C of water is 10mPaS, 0.75g dendrobium polysaccharide premixed powder is added after mixing evenly, viscosity reaches
882mPaS has been more than the 450mPaS viscosity behind 2 bags of addition commercial product (4g), after having approached 3 bags of addition commercial product (6g)
958mPaS viscosity.Moreover, solution is sticky after 0.75g dendrobium polysaccharide premixed powder is added, there is certain mobility, drinking water becomes
At the colloidal solution of sweet and sour taste.As a result illustrate, dendrobium polysaccharide premixed powder dosage is few and effect is better than commercial product.
Embodiment 5
The improvement of soup at normal temperature physical property:
Take the dendrobium polysaccharide premixed powder prepared according to 1 method of embodiment, wherein dendrobium polysaccharide premixed powder ratio is that dendrobium nobile is more
Sugared freeze-dried powder 100%, adjuvant 0%, acid 0%, sweetener 0%.
The above-mentioned premixed powder of 1.0g is weighed, the soup of the Forum on College Eating-room of 20 DEG C of 100mL is added, stirs evenly, passes through NDJ-5S
The soup of the Forum on College Eating-room of 4 bags of product (8g) additions, 20 DEG C of 100mL is swallowed in the viscosity of rotary viscosity measuring solution, commercially available improvement,
It stirs evenly, passes through the viscosity of NDJ-5S rotary viscosity measuring solution.As a result it is compared.
The viscosity of soup is 176mPaS at 20 DEG C, 1.0g dendrobium polysaccharide premixed powder is added after mixing evenly, viscosity reaches
2450mPaS has been more than that improvement is added to swallow the viscosity 2113mPaS after 4 bags of product (8g).Moreover, 1.0g dendrobium polysaccharide is added
After premixed powder, solution is very viscous, there is slow mobility, has not been changed the taste of soup.As a result illustrate, dendrobium polysaccharide premixed powder dosage
Less and effect is better than commercial product.
Embodiment 6
The thixotropy of 0.5% dendrobium polysaccharide premixing amidin:
Take the dendrobium polysaccharide premixed powder prepared according to 1 method of embodiment, wherein dendrobium polysaccharide premixed powder ratio is that dendrobium nobile is more
Sugared freeze-dried powder 100%, adjuvant 0%, acid 0%, sweetener 0%.
The above-mentioned premixed powder of 0.5g is weighed, the drinking water of 4 DEG C of 100mL is added, stirs evenly, passes through NDJ-5S rotary viscosity
The viscosity of meter measurement solution.It is stirred under different rates (0,30,60,120 rev/min) with magnetic stirring apparatus, simulation tongue exists
Stirring action in oral cavity passes through the viscosity of NDJ-5S rotary viscosity measuring solution.As a result it is compared.
The result shows that under 30,60,120 revs/min of stirring, the viscosity of solution is 146,145,146 respectively 0,
146mPaS, viscosity are very stable.This illustrates that dendrobium polysaccharide premixed powder solution viscosity is more steady than the principal component xanthan gum in commercial product
It is fixed, thixotropy very little.
Claims (9)
1. a kind of dendrobium polysaccharide premixed powder, which is characterized in that be made of the raw material of following weight percents:
Freeze-dried powder 70-100% containing dendrobium polysaccharide or its modifier,
Adjuvant 0-20%,
Acid 0-5%,
Sweetener 0-5%.
2. dendrobium polysaccharide premixed powder as described in claim 1, which is characterized in that described contains dendrobium polysaccharide or its modifier
Freeze-dried powder be made of dendrobium polysaccharide or its modifier one-component, or for dendrobium polysaccharide or its modifier, with protein, lipid
The compound of at least one of compound and other plant and animal polysaccharide compounds；The dendrobium polysaccharide modifier
For resulting modified product after the single or combined treatment of the physics, chemistry and the biological method that are carried out to natural dendrobium polysaccharide.
3. dendrobium polysaccharide premixed powder as described in claim 1, which is characterized in that the adjuvant is maltodextrin, other shallow lakes
At least one of powder substance and hy-drophilic polysaccharide substance or two or more mixtures；The acid is lemon
Acid, malic acid any one or two kinds combination；The sweetener is sucrose, any one or two kinds in honey
Combination；The mass ratio of the sweetener and acid is 50-100:1.
4. the preparation method of dendrobium polysaccharide premixed powder of any of claims 1-3 characterized by comprising press matter
Percentage is measured, by the freeze-dried powder 70-100% containing dendrobium polysaccharide or its modifier, adjuvant 0-20%, acid 0-5% and sweet tea
Taste agent 0-5% is mixed evenly, and obtains dendrobium polysaccharide premixed powder.
5. the preparation method of dendrobium polysaccharide premixed powder as claimed in claim 4, which is characterized in that described contains dendrobium polysaccharide
The preparation method of freeze-dried powder include: to shred fresh dendrobium nobile branch, the ethanol water of 50-90vol% is added, impregnates 72-
Filter residue is collected in 100h, filtering, and the distilled water that 5-10 times of volume is added boils 5-30min, is filtered, and rotary evaporation after filtrate is collected,
The dehydrated alcohol that final concentration reaches 70-90vol% is added in concentrate after evaporation, stands 36-72h, and precipitating is collected in centrifugation, sinks
Form sediment it is freeze-dried after crush, sieving, obtain the freeze-dried powder containing dendrobium polysaccharide.
6. the application method of dendrobium polysaccharide premixed powder of any of claims 1-3 characterized by comprising by stone
Dry measure used in former times polysaccharide premixed powder directly within the scope of 0 DEG C -60 DEG C aqueous liquid foodstuff or drug mix, or first dendrobium polysaccharide premixed powder is made into
Solution, then within the scope of 0 DEG C -60 DEG C aqueous liquid foodstuff or drug mix.
7. dendrobium polysaccharide premixed powder of any of claims 1-3 is in the physical property or mouthfeel for improving food or drug
Using.
8. dendrobium polysaccharide premixed powder of any of claims 1-3 is in preparation for improving or treating with dysphagia
Patient malnutrition, electrolyte dysfunction or the drug of dehydration or the application in food.
9. application as claimed in claim 8, which is characterized in that the patient with dysphagia is plant person, brain blood
Bolt, initial stage Parkinson, senile dementia, advanced diabetes, encephalatrophy, disability lose intelligence, apoplexy, intubation nasal feeding patient or are in art
The patient of convalescence afterwards.
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