CN110248957B - 经人工操纵的sc功能控制系统 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- General Health & Medical Sciences (AREA)
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- Microbiology (AREA)
- Physics & Mathematics (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201662421516P | 2016-11-14 | 2016-11-14 | |
| US62/421,516 | 2016-11-14 | ||
| PCT/KR2017/010897 WO2018088694A2 (ko) | 2016-11-14 | 2017-09-28 | 인위적으로 조작된 sc 기능 조절 시스템 |
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| CN110248957A CN110248957A (zh) | 2019-09-17 |
| CN110248957B true CN110248957B (zh) | 2023-12-19 |
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| US (1) | US20190276503A1 (ru) |
| EP (2) | EP3539980A4 (ru) |
| JP (1) | JP7338937B2 (ru) |
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| CN (1) | CN110248957B (ru) |
| AU (1) | AU2017358122B2 (ru) |
| BR (1) | BR112019009725A2 (ru) |
| CA (1) | CA3043148A1 (ru) |
| RU (2) | RU2022105597A (ru) |
| WO (1) | WO2018088694A2 (ru) |
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| RU2767201C2 (ru) * | 2017-09-28 | 2022-03-16 | Тулджен Инкорпорейтед | Искусственная модификация генома для регуляции экспрессии гена |
| US11572574B2 (en) | 2017-09-28 | 2023-02-07 | Toolgen Incorporated | Artificial genome manipulation for gene expression regulation |
| EP3628735A1 (en) * | 2018-09-25 | 2020-04-01 | Centre National De La Recherche Scientifique | Antisense rna targeting pmp22 for the treatment of charcot-marie-tooth 1a disease |
| EP3798301A1 (en) * | 2019-09-25 | 2021-03-31 | KWS SAAT SE & Co. KGaA | Promoter repression |
| WO2021184021A1 (en) * | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting pmp22 |
| CN114621922A (zh) * | 2022-02-15 | 2022-06-14 | 中山大学附属第五医院 | 一种大鼠海绵体神经来源施旺细胞的提取纯化和培养方法 |
Citations (2)
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|---|---|---|---|---|
| WO2015188056A1 (en) * | 2014-06-05 | 2015-12-10 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease design |
| CN105164264A (zh) * | 2012-12-12 | 2015-12-16 | 布罗德研究所有限公司 | 用于序列操纵和治疗应用的系统、方法和组合物的递送、工程化和优化 |
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| KR100613038B1 (ko) * | 2004-07-07 | 2006-08-16 | 공주대학교 산학협력단 | 염색체 17ｐ11.2-ｐ12 지역의 중복을 제외한 유전자돌연변이를 발병 원인으로 하는 ＣＭＴ 질환의 진단방법및 진단키트 |
| JP2010531638A (ja) * | 2007-06-12 | 2010-09-30 | ケース ウエスタン リザーブ ユニバーシティ | 標的化された細胞死 |
| SG11201503059XA (en) * | 2012-10-23 | 2015-06-29 | Toolgen Inc | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| CN106062197A (zh) * | 2013-06-17 | 2016-10-26 | 布罗德研究所有限公司 | 用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化 |
| WO2015048577A2 (en) | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| JP6721508B2 (ja) * | 2013-12-26 | 2020-07-15 | ザ ジェネラル ホスピタル コーポレイション | 多重ガイドｒｎａ |
| CN113789317B (zh) * | 2014-08-06 | 2024-02-23 | 基因工具股份有限公司 | 使用空肠弯曲杆菌crispr/cas系统衍生的rna引导的工程化核酸酶的基因编辑 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105164264A (zh) * | 2012-12-12 | 2015-12-16 | 布罗德研究所有限公司 | 用于序列操纵和治疗应用的系统、方法和组合物的递送、工程化和优化 |
| WO2015188056A1 (en) * | 2014-06-05 | 2015-12-10 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease design |
Non-Patent Citations (2)
| Title |
|---|
| Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9;DOENCH,J.G. et al;《nature biotechnology》;20160118;摘要及该文章的补充数据材料 * |
| 基因治疗假肥大型肌营养不良症后机体的免疫反应;赵翠萍等;《国际神经病学神经外科学杂志》;20050630(第03期);267-269 * |
Also Published As
| Publication number | Publication date |
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| EP3539980A2 (en) | 2019-09-18 |
| RU2768043C2 (ru) | 2022-03-23 |
| WO2018088694A2 (ko) | 2018-05-17 |
| KR20180054427A (ko) | 2018-05-24 |
| AU2017358122B2 (en) | 2022-12-22 |
| BR112019009725A2 (pt) | 2019-11-19 |
| RU2019118283A3 (ru) | 2021-04-26 |
| WO2018088694A3 (ko) | 2018-08-09 |
| KR20220122592A (ko) | 2022-09-02 |
| KR102437228B1 (ko) | 2022-08-30 |
| CN110248957A (zh) | 2019-09-17 |
| RU2022105597A (ru) | 2022-04-04 |
| EP3896162A1 (en) | 2021-10-20 |
| JP2019537446A (ja) | 2019-12-26 |
| RU2019118283A (ru) | 2020-12-14 |
| AU2017358122A1 (en) | 2019-07-04 |
| US20190276503A1 (en) | 2019-09-12 |
| CA3043148A1 (en) | 2018-05-17 |
| KR102621539B1 (ko) | 2024-01-09 |
| JP7338937B2 (ja) | 2023-09-05 |
| EP3539980A4 (en) | 2020-10-07 |
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