CN110243816A - A kind of device detected for material concentration in body fluid - Google Patents
A kind of device detected for material concentration in body fluid Download PDFInfo
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- CN110243816A CN110243816A CN201910604882.5A CN201910604882A CN110243816A CN 110243816 A CN110243816 A CN 110243816A CN 201910604882 A CN201910604882 A CN 201910604882A CN 110243816 A CN110243816 A CN 110243816A
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- 210000001124 body fluid Anatomy 0.000 title claims abstract description 26
- 239000010839 body fluid Substances 0.000 title claims abstract description 26
- 239000000463 material Substances 0.000 title claims abstract description 20
- 238000001514 detection method Methods 0.000 claims abstract description 68
- 239000007788 liquid Substances 0.000 claims abstract description 43
- 239000012530 fluid Substances 0.000 claims abstract description 34
- 238000012360 testing method Methods 0.000 claims abstract description 33
- 239000012491 analyte Substances 0.000 claims abstract description 28
- 239000000126 substance Substances 0.000 claims abstract description 22
- 238000001914 filtration Methods 0.000 claims abstract description 15
- 238000012545 processing Methods 0.000 claims abstract description 11
- 239000000084 colloidal system Substances 0.000 claims description 29
- 238000006243 chemical reaction Methods 0.000 claims description 24
- 230000003287 optical effect Effects 0.000 claims description 14
- 239000011159 matrix material Substances 0.000 claims description 7
- 230000005540 biological transmission Effects 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000004243 sweat Anatomy 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000001574 biopsy Methods 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 230000010354 integration Effects 0.000 abstract description 2
- CNQCVBJFEGMYDW-UHFFFAOYSA-N lawrencium atom Chemical compound [Lr] CNQCVBJFEGMYDW-UHFFFAOYSA-N 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000008103 glucose Substances 0.000 description 6
- 238000004737 colorimetric analysis Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000012921 fluorescence analysis Methods 0.000 description 4
- 238000004448 titration Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000001138 tear Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000005431 Molecular Chaperones Human genes 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 229920001778 nylon Polymers 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The embodiment of the present invention provides a kind of device detected for material concentration in body fluid, and described device includes: sample collector, is split into multiple analyte sample fluids for holding sample liquid, and by the sample liquid；Sample detector obtains the detection signal of multiple analyte sample fluids for receiving and detecting the multiple analyte sample fluid；Data processing unit, it is connect with the sample detector, the detection signal is received and analyzed, the actual concentrations of test substance in sample to be tested liquid are calculated by the detection signal that the sample detector generates three analyte sample fluids and exports calculated result.Device of the embodiment of the present invention for material concentration detection in body fluid, realizes the integration by body fluid sample collection, filtering, detection and analytic function, entire structure of the detecting device is simple, easy to detect.
Description
Technical field
The present embodiments relate to the field of medical instrument technology, and in particular to a kind of for material concentration detection in body fluid
Device.
Background technique
Currently, the form of invasive blood sugar test is mainly the blood drawing analysis and blood glucose meter detection of hospital, the detection of blood glucose meter
Principle is usually colorimetric analysis.Colorimetric analysis can be existed as a kind of quantitative analysis method by detecting specific wavelength light wave
Intensity after analyte absorbs, to be associated with the concentration of the analyte.This method is widely used in if medicine is for power
It learns in the analyses experiments such as detection, the calibrating of material composition concentration.Fluorescence analysis has also been derived on the basis of colorimetric analysis,
The two is main difference is that the test object of fluorescence analysis can emit the light wave of another wavelength after absorbing exciting light.By
The wavelength of transmitting light wave will not be captured in detector, the background noise in fluorescence analysis is opposite to be reduced, so that detection is sensitive
Degree is opposite to be improved.
Conventional colorimetric/fluorescence analysis spectral detection link, has mainly been come by using microplate reader or spectrophotometer
At.The two, which is provided simultaneously with, covers the light source of a wide range of spectrum and corresponding OPTICAL SENSORS.However, microplate reader use need according to
96 orifice plates are relied to carry tested substance, this will receive the insufficient limitation of sample size and causes the waste of cost, use for individual
It not is very convenient that family, which uses,.On the other hand, the use of spectrophotometer then needs larger amount of liquid sample volume, this can give
The acquisition of some particular samples brings difficulty.Meanwhile both instruments require to be placed in the other environment of laboratory level, and by
Technical professional operates, and is not particularly suited for daily detection application.
The detection carrier that blood glucose meter itself is directed to is test paper.Since test paper itself is opaque, the meeting in reflection process
The loss of lightwave signal to a certain extent is caused, this loss will cause the decrease of light intensity signal, directly affect detection spirit
Sensitivity and Monitoring lower-cut, make testing result deviation occur.Blood glucose meter and the test format of test paper can not be suitable for detection Portugal
Grape sugar concentration is substantially less than the sample of the concentration of glucose in blood, such as tear, sweat and saliva.
In conclusion detection is inconvenient for providing in the instrument for detecting body fluid in traditional technology, detection sensitivity and inspection
Lower limit is surveyed by a degree of influence, testing result is not accurate enough.
Summary of the invention
For this purpose, the embodiment of the present invention provides a kind of device detected for material concentration in body fluid, to solve the prior art
For providing the instrument detection inconvenience of detection body fluid, the problem of testing result inaccuracy in middle traditional technology.
To achieve the goals above, the embodiment of the present invention provides the following technical solutions:
A kind of device detected for material concentration in body fluid, described device include:
Sample collector is split into multiple analyte sample fluids for holding sample liquid, and by the sample liquid；
Sample detector obtains the detection of multiple analyte sample fluids for receiving and detecting the multiple analyte sample fluid
Signal, wherein the analyte sample fluid is at least 3, and first analyte sample fluid is contacted with standard configuration detection colloid
Reaction generates detection signal, and second analyte sample fluid generates detection with the detection colloid haptoreaction without special component
Signal, the third analyte sample fluid and the detection colloid haptoreaction for the test substance standard items for being added to known concentration produce
Biopsy surveys signal；
Data processing unit is connect with the sample detector, is received and is analyzed the detection signal, pass through the sample
The reality that the detection signal that detector generates three analyte sample fluids calculates test substance in sample to be tested liquid is dense
It spends and exports calculated result.
Preferably, the sample collector includes sample collection unit, filter element and dividing cell, and the collection is single
Member is connect by the filter element with the dividing cell；
Sample liquid in the sample collection unit is divided into after filter element filtering, then through the dividing cell
At least three sample liquids.
Preferably, the sample collector further includes the piston being used cooperatively with the sample collection unit.
Preferably, the sample detector includes:
One matrix；
Laser diode is fixed on the side of described matrix；
First aperture adjusts the laser diode light inlet；
Pellicle mirror, the light of reflection and projection through first aperture；
Diffraction spectroscope, the light diffraction that the pellicle mirror is reflected is at multi beam parallel rays；
Multiple reaction colloids, the test substance reaction solution in multiple sample liquids being divided into for dividing cell are described more
Parallel ray beam transmission corresponding with the multiple reaction colloid, forms multiple transmitted light beams；
Multiple optical filterings carry out selection absorption to the multiple transmitted light beam；
Second aperture adjusts the amount light of the light beam penetrated through the multiple optical filtering；
Multiple avalanche photodides form the optical telecommunications of detection intensity for receiving the light through second aperture
Number.
Preferably, the laser diode transmitting photopeak value falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band:
450-485nm or green light band: 500-565nm.
Preferably, the avalanche photodide receives photopeak value and falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band:
450-485nm or green light band: 500-565nm.
Preferably, the pellicle mirror is located at the first aperture focal point, and with incident ray at 45 degree of angles.
Preferably, the data processing unit includes Wi-Fi module, single-chip microcontroller and digital display screen；At the single-chip microcontroller
The detection signal is managed, the data information of acquisition is sent to the digital display screen, or be transmitted to by the WiFi module
Cloud server.
Preferably, the sample liquid is tear sample liquid, sweat samples liquid or saliva sample liquid.
In the embodiment of the present invention, " special component " refers to that test substance is reacted with the special component, can generate
For the signal strength of signal processing unit detection.
The embodiment of the present invention has the advantages that
Device of the embodiment of the present invention for material concentration detection in body fluid, realize by body fluid sample collection, filtering,
Detection and the integration of analytic function, entire structure of the detecting device is simple, easy to detect；The whole device of the embodiment of the present invention
Itself is easy to operate, after mating relevant detection colloid, has the technical capability of profession without using person, can be independent complete
At the use of detecting instrument.
Detailed description of the invention
It, below will be to embodiment party in order to illustrate more clearly of embodiments of the present invention or technical solution in the prior art
Formula or attached drawing needed to be used in the description of the prior art are briefly described.It should be evident that the accompanying drawings in the following description is only
It is merely exemplary, it for those of ordinary skill in the art, without creative efforts, can also basis
The attached drawing of offer, which is extended, obtains other implementation attached drawings.
Structure depicted in this specification, ratio, size etc., only to cooperate the revealed content of specification, for
Those skilled in the art understands and reads, and is not intended to limit the invention enforceable qualifications, therefore does not have technical
Essential meaning, the modification of any structure, the change of proportionate relationship or the adjustment of size are not influencing the function of the invention that can be generated
Under effect and the purpose that can reach, should all still it fall in the range of disclosed technology contents can cover.
Fig. 1 is the detecting instrument overall structure diagram that the embodiment of the present invention 2 provides；
Fig. 2 is the piston structure schematic diagram that the embodiment of the present invention 2 provides；
Fig. 3 is the sample collector structural schematic diagram that the embodiment of the present invention 2 provides；
Fig. 4 is the filter apparatus configuration schematic diagram that the embodiment of the present invention 2 provides；
Fig. 5 is the dividing cell structural schematic diagram that the embodiment of the present invention 2 provides；
Fig. 6 is the sample detector structural schematic diagram that the embodiment of the present invention 3 provides；
Fig. 7 is the schematic diagram for the body fluid glucose detection instrument that the embodiment of the present invention 1 provides；
In figure: 101- piston；102- sample collection unit；103- filter element；104- dividing cell；200- sample detection
Device；201- laser diode；The first aperture of 202-；203- pellicle mirror；204- diffraction spectroscope；205- reacts colloid；206- filter
Light microscopic；The second aperture of 207-；208- avalanche photodide.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily, it is clear that described embodiment is the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
As shown in Figure 1 and Figure 7, the embodiment of the present invention provides a kind of device detected for material concentration in body fluid, packet
Include: sample collector is split into multiple analyte sample fluids for holding sample liquid, and by sample liquid；Sample detector 200 is used
In receiving and detecting multiple analyte sample fluids, the detection signal of multiple analyte sample fluids is obtained, wherein the analyte sample fluid is extremely
It is less 3, first analyte sample fluid and standard configuration detection colloid haptoreaction generate detection signal, described in second
Analyte sample fluid generates detection signal, the third sample to be tested liquid with the detection colloid haptoreaction without special component
Detection signal is generated with the detection colloid haptoreaction for the test substance standard items for being added to known concentration, by three differences
It reacts signal generated to be analyzed, calculates the actual concentrations of test substance in liquid sample；Data processing unit,
Connect with sample detector 200, receive and analyze sample detector generation three detection signals, according to obtain detection signal and
The incidence relation of test substance concentration calculates the concentration of test substance in sample liquid and exports calculated result.
As shown in Figure 2-5, the sample collector of the embodiment of the present invention include sample collection unit 102, filter element 103 with
And dividing cell 104, collector unit are connect by filter element 103 with dividing cell 104；Sample in sample collection unit 102
Product liquid is divided at least three sample liquids after the filtering of filter element 103, then through dividing cell 104.Preferably, dividing cell
There are three mutually isostructural titration mouth, the shunting for sample fluid is discharged into sample detector 200 104 tools.The present invention is real
Apply sample liquid ocular fluid samples, sweat samples or the saliva sample of example.Specifically, sample collection unit 102 include cylinder and
The bottom of the conically shaped connecting with bottom of cylinder, conically shaped is equipped with liquid outlet；Whole in the form of annular discs, the upper end of filter element 103
Inlet can be connect with the liquid outlet of sample collection unit 102；Dividing cell 104 includes superposed sample liquid container,
Lower end is equidistantly positioned three titration mouths, and sample liquid passes through three titration mouth outflows, the upper port and overcurrent list of sample receiver
The liquid outlet connection of the lower end of member.
As shown in fig. 6, sample collector further includes the piston 101 being used cooperatively with sample collection unit 102, pass through piston
101 are pushed to sample fluid in sample collection unit 102 in dividing cell 104, realize the shunting of sample fluid.Sample collection
It is indicated respectively on unit 102 and dividing cell 104 and is used to indicate the volume markings line for holding liquid.Described in the embodiment of the present invention
The filtering of suspended particulate and the degerming of sample fluid in sample fluid may be implemented in sample collector, and can measure, distribute,
The sample fluid of determined volume is shifted to sample detector 200.
Wherein, filter element 103 uses filter membrane, the ingredient of filter membrane be polyvinylidene fluoride, polytetrafluoroethylene (PTFE), polyether sulfone and
One of nylon, filter sizes are 0.2 μm or 0.45 μm.
As shown in fig. 6, sample detector 200 includes: a matrix, for install laser diode 201, the first aperture 202,
Pellicle mirror 203, diffraction spectroscope 204, reaction colloid 205, optical filtering 206, the second aperture 207 and avalanche photodide
208；Laser diode 201 is fixed on the side of matrix；First aperture 202 adjusts 201 light inlet of laser diode；Half
Lens 203, the light of reflection and projection through the first aperture 202, pellicle mirror 203 are located at 202 focal point of the first aperture, and with incidence
Light is at 45 degree of angles.Diffraction spectroscope 204, the light diffraction that pellicle mirror 203 is reflected is at multi beam parallel rays；Multiple reaction glue
Body 205, the test substance reaction solution in multiple sample liquids being divided into for dividing cell 104, multi beam parallel rays with it is multiple
The corresponding transmission of colloid 205 is reacted, multiple transmitted light beams are formed；Multiple optical filterings 206, multiple transmitted light beams carry out selection suction
It receives；Second aperture 207 adjusts the amount light of the light beam penetrated through multiple optical filterings 206；Multiple avalanche photodides 208 are used
In receiving the light through the second aperture 207, the photosignal of detection intensity is formed.For example, diffraction spectroscope 204 will be incident together
Light is converted at least three collimated light beams, and invests three reaction colloids 205 respectively, the corresponding reaction colloid of light beam
205；Reaction colloid 205, optical filtering 206 and avalanche photodide 208, three are in same optical path.
The first aperture 202 and the second aperture 207 in the embodiment of the present invention are all made of pinhole, sample detector 200
The color change signals that reaction colloid 205 generates after contacting sample can be effectively acquired, the setting of pinhole can be reduced
The non-focusing light interference signal adjoint by reaction colloid 205, the use of pellicle mirror 203 can filter particular peak wavelength
Same light source equal part is guaranteed that at least three deblocking reaction colloids 205 are received in the same time by light wave in addition, diffraction spectroscope 204
The consistent incident light of intensity, and generate accordingly with the associated signal of color depth.Wherein, laser diode 201 emits photopeak
Value falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band: 450-485nm or green light band: 500-565nm.Avalanche optoelectronic two
Pole pipe 208 receives photopeak value and falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band: 450-485nm or green light band: 500-
565nm。
The data processing unit of the embodiment of the present invention includes Wi-Fi module, single-chip microcontroller and digital display screen；Single-chip microcontroller processing
After data, by treated, information feeds back to digital display screen, or is transmitted to cloud server by Wi-Fi module.It sets above
When meter reduces across comparison sample signal, because of the possible error of hardware environment disunity, further improve final
The accuracy of testing result, and Multi-example may be implemented while detecting.Meanwhile instrument itself is convenient for carrying and operates.
The testing principle for the device of material concentration detection in body fluid of the embodiment of the present invention is as follows:
Sample collection unit 102 is connected with filter element 103, then is connected with dividing cell 104, when sample liquids quilt
After being collected into sample collection unit 102, in the absence of external forces, the flowing of sample liquids can be stuck in filter element 103
Place.At this point, piston 101 is put into sample collection unit 102, slowly push, is filtered out by filter element 103 potential outstanding
Floating particles and bacterium reduce impurity possible interference in the detection process, flow into dividing cell 104 later.Reference point
The volume markings line marked on stream unit 104, slowly pushes piston 101, and the liquid of equal volume is made to pass through three identical structures
Titration mouth outflow, drip on the reaction colloid 205 of sample detector 200.When sample liquids drop is contacted with reaction colloid 205
Afterwards, start to chemically react.At room temperature, entire reaction process is not more than 30 minutes.Under conditions of 37 DEG C, needed for reaction
Time is most short.Quantified when sample detector 200 can be used in the color depth for after the reaction was completed, detecting colloid.Firstly, swashing
The laser that optical diode 201 emits specific wavelength is reflected into diffraction spectroscope by pellicle mirror 203 after the first aperture 202
On 204, and three laser being parallel to each other are divided equally by one of laser, pass through corresponding reaction colloid 205, optical filtering respectively
206 and second aperture 207, and finally absorbed by avalanche photodide 208, generate strength signal.
In the embodiment of the present invention, three reaction colloids 205 can generate a, b and c after the detection of sample detector 200
Three signal strength indications.The intensity of the signal value follows Beer-Lambert law (Beer Lambert law), i.e. A=i (λ) * j*
k.Wherein, i (λ) is absorbance, and wavelength λ, j are absorption coefficient, k by analysis object matrix concentration.In these three signals
In value, a is the reaction signal strength indication generated without chromogen, and b is standard reaction signal strength indication generated, and c is
The additional test substance standard items for adding micro-scale volume react signal strength indication generated, so a <b < c.These three signal values
It can be used to calculate actual test substance concentration in humoral sample.It is added additional where it is assumed that in third colloid
The concentration of test substance standard items is y, then test substance concentration can be calculated by the following formula out in actual sample:
The calculation method is to mix the test substance standard items of known concentration with body fluid to be measured, and do not added by comparison
The humoral sample signal generated of additional test substance makes known test substance concentration and detection signal in fluid environment
It is corresponding, then actual test substance concentration in humoral sample is associated with by the corresponding relationship.Due to the difference between individual, each
Biotic environment present in the body fluid of people is all different, such as pH value, viscosity, molecular chaperones.These inconsistent factor meetings
Different deviation is brought to everyone testing result.The signal method of bringing into recited above can be by potential signal interference
Factor normalization, will promote accuracy in detection to a certain extent.Finally, in entire calculating process data collection, processing with
And transmission, it is all to be completed by data processing unit.
Bibliography
1.Gasbarrini,A.et al.Methodology and indications of H2-breath testing
in gastrointestinal diseases:The Rome consensus conference.in Alimentary
Pharmacology and Therapeutics(2009).doi:10.1111/j.1365-2036.2009.03951.x
2.Chow,P.S.&S.M.A method for routine measurements of total
sugar and starch content in woody plant tissues.Tree Physiol.(2004).
3.Taylor,D.R.,Pijnenburg,M.W.,Smith,A.D.&De Jongste,J.C.Exhaled
nitric oxide measurements:Clinical application and interpretation.Thorax
(2006).doi:10.1136/thx.2005.056093
4.Rezaie,A.et al.Hydrogen and Methane-Based Breath Testing in
Gastrointestinal Disorders:The North American Consensus.Am.J.Gastroenterol.
(2017).doi:10.1038/ajg.2017.46
5.Sener,A.et al.Salivary glucose concentration and excretion in
normal and diabetic subjects.J.Biomed.Biotechnol.(2009).doi:10.1155/2009/
430426
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (9)
1. a kind of device detected for material concentration in body fluid, which is characterized in that described device includes:
Sample collector is split into multiple analyte sample fluids for holding sample liquid, and by the sample liquid；
Sample detector obtains the detection signal of multiple analyte sample fluids for receiving and detect the multiple analyte sample fluid,
Wherein, the analyte sample fluid is at least 3, and first analyte sample fluid and standard configuration detection colloid haptoreaction produce
Biopsy surveys signal, and second analyte sample fluid generates detection signal with the detection colloid haptoreaction without special component,
The third analyte sample fluid and the detection colloid haptoreaction for the test substance standard items for being added to known concentration generate inspection
Survey signal；
Data processing unit is connect with the sample detector, is received and is analyzed the detection signal, pass through the sample detection
The detection signal that device generates three analyte sample fluids calculates the actual concentrations of test substance in sample to be tested liquid simultaneously
Export calculated result.
2. the device for material concentration detection in body fluid as described in claim 1, which is characterized in that
The sample collector includes sample collection unit, filter element and dividing cell, and the collector unit passes through described
Filter element is connect with the dividing cell；
Sample liquid in the sample collection unit is divided at least after filter element filtering, then through the dividing cell
Three sample liquids.
3. the device for material concentration detection in body fluid as claimed in claim 2, which is characterized in that
The sample collector further includes the piston being used cooperatively with the sample collection unit.
4. the device for material concentration detection in body fluid as described in claim 1, which is characterized in that
The sample detector includes:
One matrix；
Laser diode is fixed on the side of described matrix；
First aperture adjusts the laser diode light inlet；
Pellicle mirror, the light of reflection and projection through first aperture；
Diffraction spectroscope, the light diffraction that the pellicle mirror is reflected is at multi beam parallel rays；
Multiple reaction colloids, the test substance reaction solution in multiple sample liquids being divided into for dividing cell, the multi beam are flat
Row light transmission corresponding with the multiple reaction colloid, forms multiple transmitted light beams；
Multiple optical filterings carry out selection absorption to the multiple transmitted light beam；
Second aperture adjusts the amount light of the light beam penetrated through the multiple optical filtering；
Multiple avalanche photodides form the photosignal of detection intensity for receiving the light through second aperture.
5. the device for material concentration detection in body fluid as claimed in claim 4, which is characterized in that
The laser diode transmitting photopeak value falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band: 450-485nm or green
Optical band: 500-565nm.
6. the device for material concentration detection in body fluid as claimed in claim 4, which is characterized in that
The avalanche photodide receives photopeak value and falls in ultraviolet light,long wave wave band: 320-400nm, blue wave band: 450-485nm or
Green light band: 500-565nm.
7. the device for material concentration detection in body fluid as claimed in claim 4, which is characterized in that
The pellicle mirror is located at the first aperture focal point, and with incident ray at 45 degree of angles.
8. the device for material concentration detection in body fluid as described in claim 1, which is characterized in that
The data processing unit includes Wi-Fi module, single-chip microcontroller and digital display screen；The single-chip microcontroller handles the detection letter
Number, the data information of acquisition is sent to the digital display screen, or cloud server is transmitted to by the WiFi module.
9. such as the device of any of claims 1-8 for material concentration detection in body fluid, which is characterized in that
The sample liquid is tear sample liquid, sweat samples liquid or saliva sample liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910604882.5A CN110243816A (en) | 2019-07-05 | 2019-07-05 | A kind of device detected for material concentration in body fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910604882.5A CN110243816A (en) | 2019-07-05 | 2019-07-05 | A kind of device detected for material concentration in body fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110243816A true CN110243816A (en) | 2019-09-17 |
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