CN1102407C

CN1102407C - Antidepressive capsule and preparing process thereof

Info

Publication number: CN1102407C
Application number: CN99102619A
Authority: CN
Inventors: 仝孝云
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-03-15
Filing date: 1999-03-15
Publication date: 2003-03-05
Anticipated expiration: 2019-03-15
Also published as: CN1266702A

Abstract

The present invention relates to an antidepressive capsule which is characterized in that the antidepressive capsule is prepared from the following components of the proportion by weight: 20 to 30% of notoginseng, 35 to 45% of Virgate Wormwood Herb and 25 to 40% of gall. The antidepressive capsule is preapred by the steps that notoginseng, Virgate Wormwood Herb and gall are weighed according to the weight of the proportion; the Virgate Wormwood Herb is sieved by NO. 1 sieve after being pulverized and then is added with the gall so as to be stirred and baked over a slow fire by an iron pan so as to make the Wormwood Herb and become dry; 120g of powdered notoginseng is sieved by No. 4 sieve after being pulverized and then is mixed with the Wormwood Herb and the gall to be uniformly stirred and filled into hard capsules. After being verified by animal experiments, the present invention has no toxic or side effect; after being used by patients, the present invention has conspicuous curative effect.

Description

Antidepressive capsule and preparation method thereof

The invention belongs to the field of Chinese medicines, a kind of Antidepressive capsule and preparation method thereof.

Clinical symptoms, such as strongly fragrant disease, uncomfortable in chest, general edema, malaise, appetite decline, anorexia, belch, acid regurgitation, stomach neurosis, menoxenia, arrhythmia, insomnia, dreaminess, headache, neurasthenia, climacteric syndrome etc., think according to motherland's tcm theory: personal all diseases, to be born in strongly fragrantly more, stagnation of QI order is not healed for a long time, by gas and blood, become to give birth to multiterminal, " QI and blood dash and, ten thousand diseases are not given birth to; one strokes strongly fragrantly, and all diease occurrences here ".

Strongly fragrant have saying of six kinds of stagnation-syndromes, and melancholy, anxiety, with headed by the stagnation of QI then are all strongly fragrant could formation such as damp-stagnancy, phlegm stagnancy, heat stagnation, blood stagnation, food stagnancy.

The generation of strongly fragrant disease, by anger, think of, worry, compassion, sorrow, melancholy, anxious damaged by excess of seven emotions, cause depression of liver-QI, the internal organs disorder of QI and blood, the five stolen goods mind are not normal, and all diseases are living, make body be in the physiology under-balanced state of " having a surplus in gas; be not enough to blood ", liver is a viscus of storing blood, and body is cloudy and sun arranged, the gas then irritability depression of having a surplus, insufficiency of blood then loses and moistens fosterly, and feelings will is lost in accent, its catharsis function thereby relative deficiency, body also subtracts with regard to have thereupon the regulating action of internal organs, cause body stagnation of QI blood deficiency, normally fortune makes the source of vital function deficiency.

For this type of disease, theoretical and the diagnosis of modern doctor trained in Western medicine, every inspection with clinical laboratory, basically all be negative findings, have only heart some positive findingses can occur, doctor trained in Western medicine is thought: liver is a blood bank, it is the body of gland of human body maximum, the 1/40-1/50 of percentage of liveweight, on the physiology angle, liver has functions such as metabolism, detoxifcation, secretion and defence.

The traditional Chinese medical science is thought: " strongly fragrant disease can cause liver pent-up, liver being bold and firm viscera, and liver is that the blood storage is regulated, the regulatory function of all spiritual feelings will is closely related with liver.The traditional Chinese medical science thinks, the rising of all diseases, and many because strongly fragrant, controlling all must treating the liver.

Strongly fragrant disease makes body be in a compensatory phase or slight compensatory phase, the nerve of body and body fluid are regulated and microcirculation function is subjected in various degree influence, clinical symptoms is: all there is slight different performance in performance eight big systems, and each histiocyte all is subjected to influence in various degree.

Organism disease by Yu Yinfa shows as:

The gastrointestinal function compensatory is slightly lacked of proper care, and causes that the metabolism of gastrointestinal and body is slightly disorderly; The quality of stomach function is by soma's nerve, and body fluid and meridians directly have influence on cardiovascular normal activity.Arteriosclerosis progressively appears in the attenuating of blood vessel metabolic capacity and compensatory capacity, arrhythmia, coronary disease pain, myocardial ischemia, myocardial infarction; Endocrine hormone is impacted, often show as xerostomia, bitter taste, hypophysis, adrenal gland, thyroid, hormone etc. are all had different influences; To the respiratory system influence, strongly fragrant if irritability is stroked, influence temper fortuneization, then can gather wet is expectorant, or feelings will is unsuccessful; Stagnated QI transforming into fire shows as uncomfortable in chest, chest pain, the sense of calming the anger; To urinary system, show as waist and be stranded frequent micturition, chronic mild edema; To nervous system, show as headache, dizziness, insomnia and dreamful sleep.

By strongly fragrant and above-mentioned all diseases that cause, its patient's crowd, along with the continuous development of society, to the various social pressurees that the mankind produced, life stress all might cause the generation of this type of disease, gives society, family, the individual causes mentally and loss economically.

The objective of the invention is to invent a kind of Antidepressive capsule and preparation method thereof, to the various conditions of human body that cause owing to melancholy, anxiety, take stopgap measures from theory of Chinese medical science and to effect a permanent cure, adjustment viscera QI and blood, microcirculation improvement strengthens and exerts oneself the epidemic disease function, reaches healthy physique, improve people's total quality, to adapt to the needs of the modern life.

Antidepressive capsule of the present invention, according to the Chinese medicine theory, Radix Notoginseng, Herba Artemisiae Scopariae and biliary pharmacological property are analyzed the reasonable combination dosage:

Described Antidepressive capsule consists predominantly of Radix Notoginseng, Herba Artemisiae Scopariae, bile.

Wherein each constituent content is (weight ratio)

Radix Notoginseng: 20-30%, Herba Artemisiae Scopariae: 35-45%, bile: 25-40%.

The manufacture method of described Antidepressive capsule is got Radix Notoginseng, Herba Artemisiae Scopariae, and bile is weighed according to quantity, and Herba Artemisiae Scopariae is pulverized the back and crosses sieve No. one, mixes thoroughly with bile and Herba Artemisiae Scopariae.Dry with the iron pan low baking temperature, get again and cross sieve No. four after 120 Radix Notoginseng are pulverized, after stirring with above-mentioned medicine, in the hard capsule of packing into.

Pharmacological action: Radix Notoginseng: its seedling root has anastalsis; Coronary blood flow increasing, decreased heart rate reduces myocardium consumption effect, and can resist because of the hypertension due to the pituitrin, and to contraction coronarius, so be used for coronary heart disease at present, arasaponin is given the quiet notes of animal, and haemolysis is arranged.

[Herba Artemisiae Scopariae]: contained 6,7 dimethoxy coumarins in the Herba Artemisiae Scopariae, chlorogenic acid, caffeic acid through animal experiment, has the effect of the bile secretion of promotion, when increasing bile secretion, also increases the cholic acid in the bile and the output of gallbladder element; Significantly antipyretic effect is arranged, but the decoct refrigeration function a little less than; Hepatitis virus there is inhibitory action, the sick damage of liver parenchyma had the improvement effect; 6,7 contained in Artemisia anethoicles Mattf dimethoxy coumarins have hypotensive activity, and can increase blood flow coronarius, and report is arranged in the recent period, and it has antiasthmatic effect.

[bile]: based on pig, cattle, sheep gall bladder juice.Antitussive.Experiment showed, that sodium cholate has the central antitussive effect; To the effect of smooth muscle, sodium cholate has expansion bronchus, the effect of smooth muscle, and its effect is slow and lasting; Bacteriostasis, to the common alpha streptococcus of respiratory tract, staphylococcus aureus, streptococcus pneumoniae, micrococcus catarrhalises etc. have good inhibitory effect; Tubercule bacillus there is inhibitory action.

[Antidepressive capsule]: comparatively obvious to gastral dual regulation.Be that physiological is regulated, the swelling that gastrointestinal peristalsis is slowed down and caused, dyspepsia can increase wriggling, get rid of gastrointestinal pneumatosis, facilitating digestion, appetite stimulator, the recovery that is used for skin portion operation back gastrointestinal function is comparatively desirable, and gastrointestinal peristalsis speeds the diarrhoea that causes, swelling and ache, it is normal to can be adjusted to; To hepatitis virus, hepatitis B virus has inhibitory action, and sick damage of liver parenchyma has the improvement effect; Impel digestive gland secretion, activate digestion acid (comprising salivary gland) impels gastral normal stool to absorb, especially to the metabolism of digesting and assimilating of lipid; To cardiovascular effect, to hypotension, the therapeutical effect of anemia is comparatively obvious, and at coronary blood flow increasing, decreased heart rate increases cardiac output, reduces the effect of myocardium oxygen consumption, and is single better with the Radix Notoginseng effect; The effect of gynecological and reproductive system is regulated and is strengthened hypothalamus, adenohypophysis, ovary three's normal function.The male aspect, the physiological function of raising testis aspect; To respiratory tract, urinary system, nervous system all have physiological regulating action.

Toxicity (safety) test data sheet

Inspection product title: Antidepressive capsule

The date of inspection: on April 3rd, 1996

Grass Canis familiaris L. (stupid Canis familiaris L.)			Glue		Result's (day)	Response situation
Grass Canis familiaris L. (stupid Canis familiaris L.)			Glue		Result's (day)	Response situation	Numbering	Sex	Body weight	Dosage	Approach	Live	Extremely	There is not any reaction
1	Female	8.4	3.0g	Oral	2		Numbering	Sex	Body weight	Dosage	Approach	Live	Extremely
1	Female	8.4	3.0g	Oral	2	2	Female	7.3	3.0g	Oral	2
3	Male	9.4	3.0g	Oral	2	2	Female	7.3	3.0g	Oral	2		The pulse diet is movable normal
3	Male	9.4	3.0g	Oral	2	4	Male	8.6	3.0g	Oral	2

Conclusion: no any untoward reaction in 48 hours, all are normal.

Subacute toxicity test (experience of taking medicine in person)

Inspection product title: control No. 1, strongly fragrant glue

The date of inspection :-12 days on the 6th April in 1996

At inspection information repeatedly, and on the basis of careless Canis familiaris L. experiment, I take and control No. 1 check of strongly fragrant glue, three times on the one,, one time four, (1.2G)

The oral cavity was moistening in first day, and saliva is increased (a little) does not have uncomfortable reaction

Second day appetite has and increases the uncomfortable reaction of energetic nothing

The 3rd day the same

The 4th day appetite obviously has and increases, and the food back does not have incompatible, work and study, and after accelerating in 5 kilometers of energetic mornings, full of energy, endurance increases, and runs more energetically more, feels to breathe a bit rapid at last, but leg muscle does not have aching and tired sense of discomfort.(proof has obvious muscle strength reinforcing effect.)

Depth of sleep increased in the 5th day, and slight dried not scratching can be waken up.The same

The 6th day the same

The same no any untoward reaction in the 7th day

Blood test in the 8th day, routine urinalysis, hepatic and renal function, all are normal.

Embodiment:

Get Radix Notoginseng 275 grams, Herba Artemisiae Scopariae 440 grams, bile 10 grams.After the Herba Artemisiae Scopariae pulverizing, cross sieve No. one, stir with bile and Herba Artemisiae Scopariae powder, dry with the iron pan low baking temperature, get Radix Notoginseng again and pulverized sieve No. four, stir with said medicine, in the hard capsule of packing into.

Claims

1, a kind of Antidepressive capsule is characterized in that: it is made up of Radix Notoginseng 20-30%, Herba Artemisiae Scopariae 35-45%, bile 25-40%.

2, implement the manufacture method of Antidepressive capsule as claimed in claim 1, it is characterized in that: get Radix Notoginseng, Herba Artemisiae Scopariae, bile by weight and weigh; Herba Artemisiae Scopariae is pulverized, cross sieve No. one, stir with bile and Herba Artemisiae Scopariae, reuse iron pan low baking temperature dries; With 120 Radix Notoginseng, after the pulverizing, cross sieve No. four; After above-mentioned medicine stirred, in the hard capsule of packing into.