CN110236672B - Brain tumor operation board and manufacturing method thereof - Google Patents
Brain tumor operation board and manufacturing method thereof Download PDFInfo
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- CN110236672B CN110236672B CN201910477104.4A CN201910477104A CN110236672B CN 110236672 B CN110236672 B CN 110236672B CN 201910477104 A CN201910477104 A CN 201910477104A CN 110236672 B CN110236672 B CN 110236672B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
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- B33—ADDITIVE MANUFACTURING TECHNOLOGY
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- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/108—Computer aided selection or customisation of medical implants or cutting guides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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Abstract
The invention provides a manufacturing method of a brain tumor operation plate, which comprises the steps of constructing a three-dimensional model; then obtaining a projection curved surface; taking the projection curved surface area of the skull part and the two thick foot lines as a guide plate module, and cutting out the guide plate module from the three-dimensional model; processing the cut out flipper modules such that the flipper modules comprise: retaining the tumor, the neurovascular, the outer frame and the positioning leg line to obtain a three-dimensional model of the brain tumor operation guide plate; printing the three-dimensional model by a three-dimensional printer; the invention also provides a brain tumor operation board which is convenient for an operator to assist in operation, so that the success rate of the operation is greatly increased.
Description
Technical Field
The invention relates to a brain tumor operation board and a manufacturing method thereof.
Background
Brain tumor is a disease of nervous system, seriously harming human life and health. The most direct and effective method for treating brain tumor is neurosurgery, but the operation has high requirements on doctors, so that not only is the doctors required to accurately cut off the focus, but also the operation incision is reduced as much as possible to avoid causing additional trauma to patients. Traditional neurosurgery often relies on doctor's operation experience, is difficult to pinpoint, excises the focus, and then causes the deviation of operation approach easily, brings extra injury for the patient. The grasping of the positioning technology of intracranial focus on scalp is the basis of the operation of neurosurgeons and also relates to the difficulty, the time, the treatment effect and the complications after the operation. Inaccurate lesion placement can damage the patient's brain functional areas and other intracranial important tissues or cause incomplete resection of the tumor. Thus, scalp incision positioning of intracranial lesions is an important issue for neurosurgery.
The basis of the localization method of various lesions on the scalp is neuroimaging. The imaging guiding and positioning method includes two methods: one is direct guided positioning and computer aided positioning. The direct guiding positioning is that according to the two-dimensional information of intracranial focus displayed by CT/MRI image, various positioning mark systems are combined to position the focus on scalp. The other method is computer aided positioning method, which includes superposing CT/MRI tomographic images in computer to form three-dimensional reconstructed image of intracranial focus, assisting extracranial positioning mark system to position the scalp of the focus.
At present, the domestic practice is mainly to draw an operation line on the brain of a patient, then to assist the operation according to the line during the operation, the operation doctor needs to make full preparation before the operation, the brain image of the patient needs to be fully understood, and the reference can be made only by the line drawn before the operation; and if the operating doctor has a sudden event, the operating doctor needs to be replaced at the moment, so that a big problem can occur.
Disclosure of Invention
The invention aims to solve the technical problem of providing a brain tumor operation plate and a manufacturing method thereof, which are convenient for an operator to assist in operation and greatly increase the success rate of the operation.
One of the present invention is realized by: a method for manufacturing a brain tumor surgical plate comprises the following steps:
step 1, acquiring a multi-mode image of a cranium of a patient, performing three-dimensional reconstruction of the cranium and acquiring a mask of each tissue structure;
step 2, performing three-dimensional entity calculation according to the structural mask to complete the construction of a three-dimensional model;
step 3, taking the middle point of the connecting line of the external auditory canal of the three-dimensional model as a starting point, selecting a spherical area of a brain tumor and peripheral nerve vessels thereof as a target area, projecting from the starting point to the target area, and projecting the target area onto the inner surface of the skull in the direction with the shortest distance between the target area and the skull to obtain a projection curved surface;
step 4, taking the eyebrow center of the three-dimensional model of the cranium as a starting point, taking the point of the back of the model on the brain central line at the same height as an end point, connecting two point drawing central lines along the scalp curved surface, dividing the central lines into five equal parts, wherein the serial numbers from the eyebrow center are one to five, each equal division point is marked in a high brightness mode, guiding a thick foot line to two of the five serial numbers on each of two sides of the projection curved surface area in the step 3 as positioning, and taking the projection curved surface area of the cranium part and the two thick foot lines as a guide plate module to be cut out from the three-dimensional model;
and 5, processing the intercepted guide plate module to ensure that the guide plate module comprises: retaining the tumor, the neurovascular, the outer frame and the positioning leg line to obtain a three-dimensional model of the brain tumor operation guide plate;
and 6, printing the three-dimensional model through a three-dimensional printer.
Further, the step 1 is further specifically: acquiring a multi-mode image of the skull of a certain brain tumor patient, performing three-dimensional reconstruction of the skull by adopting medical image processing software based on an image threshold segmentation principle, performing image segmentation by adopting a threshold segmentation algorithm according to gray value differences of brain blood vessels, the skull and the head epidermis in a CT image and the tumor, brain tissues and the head epidermis in an MRI image, selecting seed points of the brain blood vessels, the skull and the head epidermis in the CT image respectively to perform region growth, and performing optimization processing by assisting a template wiping method and a template filling method to obtain each tissue structure mask after segmentation.
Furthermore, the skull defines thresholds 125-3071 HU, blood vessels 78-279 HU, brain tissue 137-1434 HU, scalp-718-177 HU in CT, and scalp 79-711 HU in MRI.
Further, step 2 is further specifically: the method comprises the steps of reconstructing blood vessels, a skull and a head epidermis from CT through three-dimensional entity calculation on a structural mask, reconstructing tumors, brain tissues and the head epidermis from an MRI image, and finally performing registration fusion by taking scalp models respectively reconstructed from CT and MRI data as references, so that unification of data coordinates in different modes is realized, and the construction of a three-dimensional model of the cranium and the brain is completed.
Further, the projection curved surface in the step 3 is marked by a set color.
Further, the step 5 is further specifically: and (3) reserving the tumor, the important nerve vessel, the outer frame and the positioning leg line for the intercepted guide plate module, and excavating the rest parts to obtain the three-dimensional model of the brain tumor operation guide plate.
Further, the step 6 is further specifically: spraying liquid photosensitive resin on a workbench in an ultrathin layer state by using a piezoelectric type spray head to form a geometric profile by using a color printer, and then irradiating and curing the resin layer by using ultraviolet light emitted by an ultraviolet lamp; after the solidification is finished, the workbench is accurately lowered by a forming thickness, and then a second layer of liquid photosensitive resin is solidified and formed; the whole thickness and the shape of the model meet the design requirements, and after printing is finished, the supporting material is removed through water washing operation treatment, so that the brain tumor operation guide plate printing and manufacturing are completed.
The second invention is realized by the following steps: a brain tumor surgical plate, which is manufactured by any one of the above.
The invention has the following advantages: a brain tumor operation board and a manufacturing method thereof are convenient for an operator to assist in operation, so that the success rate of the operation is greatly increased; and the realization cost is low, and the popularization is convenient.
Drawings
The invention will be further described with reference to the following examples with reference to the accompanying drawings.
Fig. 1 is a flow chart of a method for manufacturing a brain tumor surgical plate according to the present invention.
Fig. 2 is an effect diagram of the present invention.
Detailed Description
As shown in fig. 1, the method for manufacturing a brain tumor surgical plate of the present invention includes:
step 1, acquiring a multi-mode image of a skull of a patient with certain brain tumor, performing three-dimensional reconstruction of the skull by adopting medical image processing software based on an image threshold segmentation principle, performing image segmentation by adopting a threshold segmentation algorithm according to gray value differences of brain blood vessels, the skull and the head epidermis in a CT image and the tumor, brain tissues and the head epidermis in the MRI image respectively, then selecting seed points of the seed points for region growth respectively, and performing optimization processing by assisting template erasure method and template filling method to obtain each segmented tissue structure mask, wherein the skull defines thresholds 125-3071 HU, blood vessels 78-279 HU, brain tissues 137-1434 HU, scalps-718-177 HU in CT and scalps 79-711 HU in MRI;
step 2, reconstructing blood vessels, a skull and a head epidermis from the CT through three-dimensional entity calculation on the structural mask, reconstructing a tumor, a brain tissue and a head epidermis from the MRI image, and finally performing registration fusion by taking scalp models respectively reconstructed from the CT and the MRI data as references to realize the unification of coordinates of different modal data and complete the construction of a three-dimensional model of the cranium;
step 3, taking the middle point of the connecting line of the external auditory canal of the three-dimensional model as a starting point, selecting a spherical area of a brain tumor and peripheral nerve vessels thereof as a target area, projecting the target area from the starting point to the target area, and projecting the target area onto the inner surface of the skull in the direction with the shortest distance between the target area and the skull to obtain a projection curved surface, wherein the projection curved surface is marked by adopting a set color;
step 4, taking the eyebrow center of the three-dimensional model of the cranium as a starting point, taking the point of the back of the model on the brain central line at the same height as an end point, connecting two point drawing central lines along the scalp curved surface, dividing the central lines into five equal parts, wherein the serial numbers from the eyebrow center are one to five, each equal division point is marked in a high brightness mode, guiding a thick foot line to two of the five serial numbers on each of two sides of the projection curved surface area in the step 3 as positioning, and taking the projection curved surface area of the cranium part and the two thick foot lines as a guide plate module to be cut out from the three-dimensional model;
step 5, reserving the tumor, the important nerve vessel, the outer frame and the positioning leg line for the intercepted guide plate module, and excavating the rest parts to obtain a three-dimensional model of the brain tumor operation guide plate;
step 6, spraying liquid photosensitive resin on a workbench in an ultrathin layer state by using a color printer through a piezoelectric type spray head to form a geometric profile, and then irradiating and curing the resin layer by using ultraviolet light emitted by an ultraviolet lamp; after the solidification is finished, the workbench is accurately lowered by a forming thickness, and then a second layer of liquid photosensitive resin is solidified and formed; the whole thickness and the shape of the model meet the design requirements, and after printing is finished, the supporting material is removed through water washing operation treatment, so that the brain tumor operation guide plate printing and manufacturing are completed.
The brain tumor operation board is manufactured by the method.
One specific embodiment of the present invention:
the brain tumor operation guide plate comprises the following manufacturing steps:
s1: obtaining multi-mode images (CT, MRI, dynamic enhanced images and the like) of the cranium of a patient with certain brain tumor, adopting medical image processing software Mimics15.0, and carrying out cranium three-dimensional reconstruction based on the image threshold segmentation principle. The image segmentation is carried out by adopting a threshold segmentation algorithm according to gray value differences of brain blood vessels, skull and head epidermis in CT and tumors, brain tissues and head epidermis in MRI images, the skull defines a threshold value of 125-3071 HU, blood vessels of 78-279 HU, brain tissues of 137-1434 HU, scalps of-718-177 HU in CT and scalps of 79-711 HU in MRI. Then, the seed points are respectively selected for region growing, and optimization processing is carried out by assisting a template erasing method and a template filling method, so that the mask of each divided organization structure is obtained.
S2: blood vessels, skull and head epidermis were reconstructed from CT and tumors, brain tissue and head epidermis from MRI images by three-dimensional solid computation of the mask. And finally, performing registration fusion by taking scalp models respectively reconstructed from CT and MRI data as references, realizing the unification of data coordinates in different modes, and completing the construction of a three-dimensional model of the cranium.
S3: taking the midpoint of the external auditory canal connecting line of the three-dimensional model of the cranium and the brain (namely the connecting line of the external auditory canals of the two ears) as a starting point, selecting a spherical area of a brain tumor and important peripheral nerve blood vessels as a target area (the size of the spherical area is determined according to the size of the brain tumor, and the radius is set to be about 1.5 times of the radius of the brain tumor), projecting the target area from the starting point to the target area, projecting the target area onto the inner surface of the cranium in the direction of the shortest distance between the target area and the cranium to obtain a projection curved surface containing the brain tumor and the important peripheral nerve blood vessels, and marking the projection curved surface area.
S4: and connecting two point drawing center lines along the curved surface of the scalp by taking the eyebrow center of the three-dimensional model of the cranium as a starting point and the point, on the brain center line, of the back and the eyebrow center of the model at the same height as an end point. And dividing the central line into five equal parts, wherein the serial numbers from the center of the eyebrow are one to five, and each equal division point is highlighted. And (4) respectively leading a thick leg line to two of the five serial numbers at two sides of the projection curved surface area of the S3 for positioning (respectively leading a positioning line from the upper end points of the two side edges of the curved surface area; and connecting to two points which are closest to the projection curved surface area in the five serial number points on the center line). The projected curved surface region of the skull portion (the projected curved surface obtained in step S3) and the two thick foot lines are taken out from the three-dimensional model of the cranium as a template module.
S5: and (4) reserving the tumor, the important nerve vessel, the outer frame and the positioning leg line for the intercepted surgical guide plate module, and excavating the rest parts. Obtaining a three-dimensional model of the brain tumor operation guide plate.
S6: adopting an Objet350Connex3 color printer of Stratasys corporation in America, spraying liquid photosensitive resin on a workbench in an ultrathin layer state through a piezoelectric type spray head to form a certain geometric outline, and then emitting ultraviolet light by an ultraviolet lamp to perform illumination curing on the resin layer; after the solidification is finished, the workbench is accurately lowered by a forming thickness, and then a second layer of liquid photosensitive resin is solidified and formed; the whole thickness and the shape of the model can meet the design requirements through the circulation. After printing is finished, the supporting material is removed through water washing operation processing, and the brain tumor operation guide plate printing manufacturing is completed, as shown in fig. 2.
Although specific embodiments of the invention have been described above, it will be understood by those skilled in the art that the specific embodiments described are illustrative only and are not limiting upon the scope of the invention, and that equivalent modifications and variations can be made by those skilled in the art without departing from the spirit of the invention, which is to be limited only by the appended claims.
Claims (8)
1. A method for manufacturing a brain tumor operation plate is characterized in that: the method comprises the following steps:
step 1, acquiring a multi-mode image of a cranium of a patient, performing three-dimensional reconstruction of the cranium and acquiring a mask of each tissue structure;
step 2, performing three-dimensional entity calculation according to the structural mask to complete the construction of a three-dimensional model;
step 3, taking the middle point of the connecting line of the external auditory canal of the three-dimensional model as a starting point, selecting a spherical area of a brain tumor and peripheral nerve vessels thereof as a target area, projecting from the starting point to the target area, and projecting the target area onto the inner surface of the skull in the direction with the shortest distance between the target area and the skull to obtain a projection curved surface;
step 4, taking the eyebrow center of the three-dimensional model of the cranium as a starting point, taking the point of the back of the model on the brain central line at the same height as an end point, connecting two point drawing central lines along the scalp curved surface, dividing the central lines into five equal parts, wherein the serial numbers from the eyebrow center are one to five, each equal division point is marked in a high brightness mode, guiding a thick foot line to two of the five serial numbers on each of two sides of the projection curved surface area in the step 3 as positioning, and taking the projection curved surface area of the cranium part and the two thick foot lines as a guide plate module to be cut out from the three-dimensional model;
and 5, processing the intercepted guide plate module to ensure that the guide plate module comprises: retaining the tumor, the neurovascular, the outer frame and the positioning leg line to obtain a three-dimensional model of the brain tumor operation guide plate;
and 6, printing the three-dimensional model through a three-dimensional printer.
2. The method for manufacturing a brain tumor surgical plate according to claim 1, wherein: the step 1 is further specifically as follows: acquiring a multi-mode image of the skull of a certain brain tumor patient, performing three-dimensional reconstruction of the skull by adopting medical image processing software based on an image threshold segmentation principle, performing image segmentation by adopting a threshold segmentation algorithm according to gray value differences of brain blood vessels, the skull and the head epidermis in a CT image and the tumor, brain tissues and the head epidermis in an MRI image, selecting seed points of the brain blood vessels, the skull and the head epidermis in the CT image respectively to perform region growth, and performing optimization processing by assisting a template wiping method and a template filling method to obtain each tissue structure mask after segmentation.
3. The method for manufacturing a brain tumor surgical plate according to claim 2, wherein: skull defining thresholds 125-3071 HU, blood vessels 78-279 HU, brain tissue 137-1434 HU, scalps-718-177 HU in CT and scalps 79-711 HU in MRI.
4. The method for manufacturing a brain tumor surgical plate according to claim 2, wherein: the step 2 further comprises the following specific steps: the method comprises the steps of reconstructing blood vessels, a skull and a head epidermis from CT through three-dimensional entity calculation on a structural mask, reconstructing tumors, brain tissues and the head epidermis from an MRI image, and finally performing registration fusion by taking scalp models respectively reconstructed from CT and MRI data as references, so that unification of data coordinates in different modes is realized, and the construction of a three-dimensional model of the cranium and the brain is completed.
5. The method for manufacturing a brain tumor surgical plate according to claim 1, wherein: and marking the projection curved surface in the step 3 by adopting a set color.
6. The method for manufacturing a brain tumor surgical plate according to claim 1, wherein: the step 5 is further specifically as follows: and (3) reserving the tumor, the important nerve vessel, the outer frame and the positioning leg line for the intercepted guide plate module, and excavating the rest parts to obtain the three-dimensional model of the brain tumor operation guide plate.
7. The method for manufacturing a brain tumor surgical plate according to claim 1, wherein: the step 6 is further specifically as follows: spraying liquid photosensitive resin on a workbench in an ultrathin layer state by using a piezoelectric type spray head to form a geometric profile by using a color printer, and then irradiating and curing the resin layer by using ultraviolet light emitted by an ultraviolet lamp; after the solidification is finished, the workbench is accurately lowered by a forming thickness, and then a second layer of liquid photosensitive resin is solidified and formed; the whole thickness and the shape of the model meet the design requirements, and after printing is finished, the supporting material is removed through water washing operation treatment, so that the brain tumor operation guide plate printing and manufacturing are completed.
8. A brain tumor surgical panel, comprising: the brain tumor surgical plate manufactured according to any one of claims 1 to 7.
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| CN111658196A (en) * | 2020-06-22 | 2020-09-15 | 美尚(广州)医疗科技有限公司 | Instant-pulling and instant-planting detachable layered guide plate and processing and application method thereof |
| CN113076948B (en) * | 2021-03-26 | 2024-04-16 | 浙江工业大学 | Method for segmenting auditory nerve under tumor compression |
| CN113469945B (en) * | 2021-06-03 | 2024-03-26 | 山东大学 | Sacral nerve modeling method and system based on CT and MRI imaging fusion |
| CN117838306A (en) * | 2024-02-01 | 2024-04-09 | 南京诺源医疗器械有限公司 | Target image processing method and system based on imager |
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