CN110236672A - A kind of brain tumor procedures plate and its manufacturing method - Google Patents
A kind of brain tumor procedures plate and its manufacturing method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/108—Computer aided selection or customisation of medical implants or cutting guides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
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Abstract
The present invention provides a kind of manufacturing method of brain tumor procedures plate, constructs threedimensional model;Curved projection surfaces are obtained later;The curved projection surfaces region of cranial portion is intercepted from threedimensional model and come out as a guide plate module together with two thick payment to a porter;The threedimensional model of brain tumor procedures guide plate is obtained so that the guide plate module includes: to retain tumour, neural blood vessel, outline border and positioning payment to a porter to the guide plate resume module that interception comes out;The three dimensional model printing is come out by three-dimensional printer;The present invention also provides a kind of brain tumor procedures plates, are assisted convenient for operative doctor when being performed the operation, so that the success rate of operation greatly increases.
Description
Technical field
The present invention relates to a kind of brain tumor procedures plate and its manufacturing methods.
Background technique
Brain tumor is a kind of the nervous system disease, seriously endangers the life and health of the mankind.Treatment brain tumor most directly has
The method of effect is neurosurgery, but the requirement performed the operation to doctor is very high, not only requires the accurate removal of lesions of doctor, and
Operative incision should be also minimized to avoid causing patient additional wound.And traditional neural surgical operation often relies on doctor's
Surgical experience, it is difficult to be accurately positioned, removal of lesions, and then be easy to cause the deviation of operative approach, bring additional injury to patient.
Location technology of the intracranial lesion on scalp is grasped, is the basis of neurosurgeon's surgical procedure, while being also related to operation
Complexity, the length of time, postoperative therapeutic effect and complication of operation etc..Lesion localization inaccuracy can injured patient
Brain domain and other encephalic vital tissues or the incomplete excision for causing tumour.Therefore, the incision of scalp positioning of intracranial lesion
It is a major issue of neurosurgery.
The basis of localization method of the various lesions on scalp is neuroimaging.The method of iconography guidance positioning has two
Kind: one is directly guide positioning mode and area of computer aided positioning mode.Directly guidance positioning is according to CT/MRI image
Intracranial lesion two-dimensional signal, in conjunction with various witness marker systems, by lesion localization on scalp.Another kind is area of computer aided
The faultage image of CT/MRI a series of is overlapped mutually with computer, forms the three-dimensional reconstruction image of intracranial lesion by positioning mode, auxiliary
The outer witness marker system of cranium is helped, the scalp positioning of lesion is carried out.
Currently, domestic way is mainly by drawing operation lines in patient's brain, later during operation according to the line
Item auxiliary is performed the operation, and is needed operative doctor to do very sufficient preparation before the surgery, is needed to do the brain phantom of patient
Adequately understand, lines drawn before the operation can only be leaned on to be referred to during operation;And if operative doctor has burst
When thing, operative doctor is replaced at this time, then will appear big problem.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of brain tumor procedures plate and its manufacturing method, convenient for operation
Doctor assists when performing the operation, so that the success rate of operation greatly increases.
One of present invention is achieved in that a kind of manufacturing method of brain tumor procedures plate, comprising:
Step 1, the cranium multi-mode image for obtaining patient carry out cranium brain three-dimensional reconstruction, obtain each institutional framework mask;
Step 2 carries out 3D solid calculating according to structure mask, completes the building of threedimensional model;
Step 3, the midpoint for taking threedimensional model external auditory canal line are starting point, select brain tumor and its peripheral nerve blood vessel
Spheric region is target area, is projected from starting point to target area, will in target area and skull on shortest direction
Target area projects on the inner surface of skull, obtains curved projection surfaces;
Step 4, using cranium brain threedimensional model place between the eyebrows as starting point, model back and place between the eyebrows are on the brain middle line of sustained height
Point be terminal, along scalp curved surface connect two-point drawing center line, to center line carry out five equal parts, since place between the eyebrows serial number one to
Five, each Along ent highlight mark respectively draws a thick payment to a porter into five serial numbers to the two sides in the curved projection surfaces region in step 3
Two it is upper as positioning, using the curved projection surfaces region of cranial portion together with two thick payment to a porter as a guide plate module, from three
Interception comes out on dimension module;
Step 5, the guide plate resume module that interception is come out, so that the guide plate module includes: to retain tumour, neural blood
Pipe, outline border and positioning payment to a porter, obtain the threedimensional model of brain tumor procedures guide plate;
Step 6 is come out the three dimensional model printing by three-dimensional printer.
Further, the step 1 is further specifically: certain patient with brain tumors cranium multi-mode image is obtained, using medicine
Image processing software, based on carrying out image threshold segmentation principle carry out cranium brain three-dimensional reconstruction, respectively according in CT image cerebral vessels,
The grey value difference of skull, head epidermis, tumour, brain tissue, head epidermis in MRI image is carried out using Threshold Segmentation Algorithm
Carry out image segmentation, then choose respectively they seed point carry out region growth, and be aided with template erasing method and template fill up
Method optimizes processing, each institutional framework mask after being divided.
Further, skull defines 125~3071HU of threshold value, 78~279HU of blood vessel, in brain tissue 137~1434HU, CT
Scalp -718~-177HU, 79~711HU of scalp in MRI.
Further, step 2 is further specifically: by carrying out 3D solid calculating to structure mask, rebuilds from CT
Blood vessel, skull and head epidermis out, and tumour, brain tissue and head epidermis are reconstructed from MRI image, finally with CT, MRI
Registration fusion is carried out on the basis of the scalp model rebuild respectively in data, realizes the unification of different modalities data coordinates, it is complete
At the building of cranium brain threedimensional model.
Further, the curved projection surfaces in the step 3 are marked using setpoint color.
Further, the step 5 is further specifically: to the guide plate module that interception comes out, retains tumour, important nerve
Blood vessel, outline border and positioning payment to a porter, excavate rest part, obtain the threedimensional model of brain tumor procedures guide plate.
Further, the step 6 is further specifically: color printer is used, by piezoelectric type spray head by liquid light
Quick resin is injected on workbench with ultra-thin layer state, forms geometric profile, then ultraviolet radiator emitting ultraviolet light is to resin layer
Carry out illumination curing;After completing solidification, workbench accurately declines a molding thickness, then carries out second layer liquid photosensitive tree
Rouge curing molding;So circulation, makes model integral thickness and shape reach design requirement, after printing, passes through water washing operations
Processing removal backing material, completes brain tumor procedures guide plate printing and making.
The two of the present invention are achieved in that a kind of brain tumor procedures plate, the brain tumor procedures plate are any among the above
It is obtained manufactured by one.
The present invention has the advantage that a kind of brain tumor procedures plate and its manufacturing method, are carrying out hand convenient for operative doctor
It is assisted when art, so that the success rate of operation greatly increases;And its cost of implementation is low, convenient for promoting.
Detailed description of the invention
The present invention is further illustrated in conjunction with the embodiments with reference to the accompanying drawings.
Fig. 1 is a kind of flow chart of the manufacturing method of brain tumor procedures plate of the present invention.
Fig. 2 is effect picture of the invention.
Specific embodiment
As shown in Figure 1, the manufacturing method of brain tumor procedures plate of the present invention, comprising:
Step 1 obtains certain patient with brain tumors cranium multi-mode image, using Medical Image Processing software, is based on image threshold
Divide principle and carry out cranium brain three-dimensional reconstruction, respectively according to the cerebral vessels in CT image, skull, head epidermis, in MRI image
Tumour, brain tissue, head epidermis grey value difference carry out using Threshold Segmentation Algorithm carry out image segmentation, then choose respectively
Their seed point carries out region growth, and is aided with template erasing method and template enthesis optimizes processing, after obtaining segmentation
Each institutional framework mask, skull defines 125~3071HU of threshold value, 78~279HU of blood vessel, in brain tissue 137~1434HU, CT
Scalp -718~-177HU, 79~711HU of scalp in MRI;
Step 2, by structure mask carry out 3D solid calculating, blood vessel, skull and head epidermis are reconstructed from CT,
And tumour, brain tissue and head epidermis are reconstructed from MRI image, the last head to be rebuild respectively in CT, MRI data
Registration fusion is carried out on the basis of skin model, realizes the unification of different modalities data coordinates, completes the building of cranium brain threedimensional model;
Step 3, the midpoint for taking threedimensional model external auditory canal line are starting point, select brain tumor and its peripheral nerve blood vessel
Spheric region is target area, is projected from starting point to target area, will in target area and skull on shortest direction
Target area projects on the inner surface of skull, obtains curved projection surfaces, and the curved projection surfaces are marked using setpoint color
Note;
Step 4, using cranium brain threedimensional model place between the eyebrows as starting point, model back and place between the eyebrows are on the brain middle line of sustained height
Point be terminal, along scalp curved surface connect two-point drawing center line, to center line carry out five equal parts, since place between the eyebrows serial number one to
Five, each Along ent highlight mark respectively draws a thick payment to a porter into five serial numbers to the two sides in the curved projection surfaces region in step 3
Two it is upper as positioning, using the curved projection surfaces region of cranial portion together with two thick payment to a porter as a guide plate module, from three
Interception comes out on dimension module;
Step 5, the guide plate module come out to interception retain tumour, important neural blood vessel, outline border and positioning payment to a porter, excavate
Rest part obtains the threedimensional model of brain tumor procedures guide plate;
Step 6, using color printer, liquid photosensitive resin is injected in ultra-thin layer state by work by piezoelectric type spray head
Make on platform, form geometric profile, then ultraviolet radiator emitting ultraviolet light carries out illumination curing to resin layer;After completing solidification, work
Make platform and accurately decline a molding thickness, then carries out second layer liquid photosensitive resin curing molding;So circulation, makes model
Integral thickness and shape reach design requirement, after printing, handle removal backing material by water washing operations, complete brain tumor
Surgical guide printing and making.
Brain tumor procedures plate of the present invention, the brain tumor procedures plate are to obtain manufactured by the above method.
A kind of specific embodiment of the present invention:
Brain tumor procedures guide plate, including following making steps:
S1: certain patient with brain tumors cranium multi-mode image (CT, MRI, dynamic enhancing image etc.) is obtained, at medical image
Software Mimics15.0 is managed, cranium brain three-dimensional reconstruction is carried out based on carrying out image threshold segmentation principle.Respectively according in CT cerebral vessels,
The grey value difference of skull, head epidermis, tumour, brain tissue, head epidermis in MRI image is carried out using Threshold Segmentation Algorithm
Image segmentation is carried out, skull defines 125~3071HU of threshold value, 78~279HU of blood vessel, head in brain tissue 137~1434HU, CT
Skin -718~-177HU, 79~711HU of scalp in MRI.Then the seed point for choosing them respectively carries out region growth, and is aided with
Template erasing method and template enthesis optimize processing, each institutional framework mask after being divided.
S2: by carrying out 3D solid calculating to mask, blood vessel, skull and head epidermis, Yi Jicong are reconstructed from CT
Tumour, brain tissue and head epidermis are reconstructed in MRI image.The finally scalp model to be rebuild respectively in CT, MRI data
On the basis of carry out registration fusion, realize the unification of different modalities data coordinates, complete the building of cranium brain threedimensional model.
S3: the midpoint for taking cranium brain threedimensional model external auditory canal line (line of i.e. two ear external auditory canals) is starting point, choosing
It selects brain tumor and its important neurovascular spheric region of surrounding is that (spheric region size is according to the size of brain tumor for target area
Determine, radius is set as being approximately 1.5 times of brain tumor radius), it is projected from starting point to target area, in target area and cranium
Bone projects to target area on the inner surface of skull on shortest direction, obtains important comprising brain tumor and its surrounding
Neurovascular curved projection surfaces, with special color by the curved projection surfaces zone marker.
S4: using cranium brain threedimensional model place between the eyebrows as starting point, the point of model back and place between the eyebrows on the brain middle line of sustained height
For terminal, two-point drawing center line is connected along scalp curved surface.To center line carry out five equal parts, since place between the eyebrows serial number one to
Five, each Along ent highlight mark.One thick payment to a porter is respectively drawn to two in five serial numbers to the two sides in the curved projection surfaces region of S3
It is a it is upper as positioning (respectively draw a position line from the two sides top terminal of curved surface area;It is connected to five serial numbers on middle line
Two points nearest from curved projection surfaces region in point).By the curved projection surfaces region of cranial portion (for the obtained projection of step S3
Curved surface) it intercepts and comes out from cranium brain threedimensional model as a guide plate module together with two thick payment to a porter.
S5: the surgical guide module come out to interception retains tumour, important neural blood vessel, outline border and positioning payment to a porter, excavates
Rest part.Obtain the threedimensional model of brain tumor procedures guide plate.
S6:, will by piezoelectric type spray head using the Objet350Connex3 color printer of Stratasys company, the U.S.
Liquid photosensitive resin is injected on workbench with ultra-thin layer state, forms certain geometric profile, and then ultraviolet radiator transmitting is ultraviolet
Light carries out illumination curing to resin layer;After completing solidification, workbench accurately declines a molding thickness, then carries out the second layer
Liquid photosensitive resin curing molding;So circulation, makes model integral thickness and shape reach design requirement.After printing, lead to
Water washing operations processing removal backing material is crossed, completes brain tumor procedures guide plate printing and making, as shown in Figure 2.
Although specific embodiments of the present invention have been described above, those familiar with the art should be managed
Solution, we are merely exemplary described specific embodiment, rather than for the restriction to the scope of the present invention, it is familiar with this
The technical staff in field should be covered of the invention according to modification and variation equivalent made by spirit of the invention
In scope of the claimed protection.
Claims (8)
1. a kind of manufacturing method of brain tumor procedures plate, it is characterised in that: include:
Step 1, the cranium multi-mode image for obtaining patient carry out cranium brain three-dimensional reconstruction, obtain each institutional framework mask;
Step 2 carries out 3D solid calculating according to structure mask, completes the building of threedimensional model;
Step 3, the midpoint for taking threedimensional model external auditory canal line are starting point, select the spherical shape of brain tumor and its peripheral nerve blood vessel
Region is target area, is projected from starting point to target area, in target area and skull on shortest direction, by target
On region projection to the inner surface of skull, curved projection surfaces are obtained;
Step 4, using cranium brain threedimensional model place between the eyebrows as starting point, the point of model back and place between the eyebrows on the brain middle line of sustained height is
Terminal connects two-point drawing center line along scalp curved surface, to center line five equal parts of progress, the serial number one to five since place between the eyebrows,
Each Along ent highlight mark respectively draws a thick payment to a porter into five serial numbers to the two sides in the curved projection surfaces region in step 3
Two upper as positioning, using the curved projection surfaces region of cranial portion together with two thick payment to a porter as a guide plate module, from three-dimensional
Interception comes out on model;
Step 5, the guide plate resume module that interception is come out, so that the guide plate module includes: to retain tumour, neural blood vessel, outer
Frame and positioning payment to a porter, obtain the threedimensional model of brain tumor procedures guide plate;
Step 6 is come out the three dimensional model printing by three-dimensional printer.
2. a kind of manufacturing method of brain tumor procedures plate according to claim 1, it is characterised in that: the step 1 is into one
Step specifically: certain patient with brain tumors cranium multi-mode image is obtained, it is former based on carrying out image threshold segmentation using Medical Image Processing software
Reason carries out cranium brain three-dimensional reconstruction, respectively according to the cerebral vessels in CT image, skull, head epidermis, tumour in MRI image,
Brain tissue, head epidermis grey value difference carry out using Threshold Segmentation Algorithm carry out image segmentation, then choose them respectively
Seed point carry out region growth, and be aided with template erasing method and template enthesis optimize processing, it is each after being divided
Institutional framework mask.
3. a kind of manufacturing method of brain tumor procedures plate according to claim 2, it is characterised in that: skull defines threshold value
125~3071HU, 78~279HU of blood vessel, scalp 79 in scalp -718~-177HU in brain tissue 137~1434HU, CT, MRI
~711HU.
4. a kind of manufacturing method of brain tumor procedures plate according to claim 2, it is characterised in that: step 2 further has
Body are as follows: by carrying out 3D solid calculating to structure mask, reconstruct blood vessel, skull and head epidermis from CT, and from MRI
Tumour, brain tissue and head epidermis are reconstructed in image, are finally with the scalp model rebuild respectively in CT, MRI data
Benchmark carries out registration fusion, realizes the unification of different modalities data coordinates, completes the building of cranium brain threedimensional model.
5. a kind of manufacturing method of brain tumor procedures plate according to claim 1, it is characterised in that: in the step 3
Curved projection surfaces are marked using setpoint color.
6. a kind of manufacturing method of brain tumor procedures plate according to claim 1, it is characterised in that: the step 5 is into one
Step specifically: to the guide plate module that interception comes out, retain tumour, important neural blood vessel, outline border and positioning payment to a porter, excavate its remaining part
Point, obtain the threedimensional model of brain tumor procedures guide plate.
7. a kind of manufacturing method of brain tumor procedures plate according to claim 1, it is characterised in that: the step 6 is into one
Step specifically: use color printer, liquid photosensitive resin is injected in ultra-thin layer state by workbench by piezoelectric type spray head
On, geometric profile is formed, then ultraviolet radiator emitting ultraviolet light carries out illumination curing to resin layer;After completing solidification, workbench
Accurately decline a molding thickness, then carries out second layer liquid photosensitive resin curing molding;So circulation keeps model whole
Thickness and shape reach design requirement, after printing, handle removal backing material by water washing operations, complete brain tumor procedures
Guide plate printing and making.
8. a kind of brain tumor procedures plate, it is characterised in that: the brain tumor procedures plate is any one of claim 1 to 7 institute
Manufacture obtains.
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CN113076948B (en) * | 2021-03-26 | 2024-04-16 | 浙江工业大学 | Method for segmenting auditory nerve under tumor compression |
CN113469945A (en) * | 2021-06-03 | 2021-10-01 | 山东大学 | Sacral nerve modeling method and system based on CT and MRI imaging fusion |
CN113469945B (en) * | 2021-06-03 | 2024-03-26 | 山东大学 | Sacral nerve modeling method and system based on CT and MRI imaging fusion |
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CN117838306B (en) * | 2024-02-01 | 2024-06-21 | 南京诺源医疗器械有限公司 | Target image processing method and system based on imager |
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