CN1102064C - Chinese medicine for lowering blood pressure - Google Patents
Chinese medicine for lowering blood pressure Download PDFInfo
- Publication number
- CN1102064C CN1102064C CN99122430A CN99122430A CN1102064C CN 1102064 C CN1102064 C CN 1102064C CN 99122430 A CN99122430 A CN 99122430A CN 99122430 A CN99122430 A CN 99122430A CN 1102064 C CN1102064 C CN 1102064C
- Authority
- CN
- China
- Prior art keywords
- blood pressure
- chinese medicine
- blood
- liver
- lowering blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a Chinese medicine preparation for lowering blood pressure, which is prepared from raw medicinal materials: pueraria root, cassia seed, chrysanthemum flower and oyster shell.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation with hypotensive effect.
Modern medicine it " hypertension " shows as headache, dizzy, impetuous, irritability, bitter taste xerostomia, palpitation and insomnia more, and weight person can develop into apoplexy and see facial hemiparalysis, and hemiplegia belongs to disease categories such as the headache of the traditional Chinese medical science, dizzy, apoplexy." element ask the most pure virginity will discuss " be said: " all wind trembling and dizziness all belong to liver ".Though it is primary disease has multiple performance, the most common with excessive rising of liver-YANG.The present invention is grown liver and kidney tonifying having suppressing the hyperactive liver and subsiding YANG, blood circulation promoting and blood stasis dispelling, and the Chinese medicine of the medicine-food two-purpose of tranquilizing mind is formed, and modern pharmacology studies have shown that the relevant composition among the we has and brings high blood pressure down that blood lipid regulation improves coronary artery blood supply and calcium regulating action.
The object of the invention is to provide a kind of effectively controlling blood pressure and has no side effect, can be as the new Chinese medicine preparation of food additive.
The medicine that the present invention selects for use all has no side effect, wherein Radix Puerariae: sweet in the mouth, suffering, flat, nontoxic, people's liver,spleen,kidney three warps of property.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst cures mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, diabetes, hypertension, coronary heart disease.Clinical in recent years effect of borrowing Radix Puerariae to relax person's back, with its treatment hyperpietic's headache, person's back does not relax, and receives good effect.Pharmacodynamics test proof Radix Puerariae extract has antihypertensive function, the spontaneous hypertensive rat blood pressure is obviously descended, plasma renin activity obviously reduces, and expansible blood vessel, microcirculation improvement and coronary artery blood flow also have effects such as arrhythmia, blood fat reducing, blood sugar lowering and antiplatelet aggregation.
Semen Cassiae: bitter in the mouth, sweet, cool, nontoxic, go into liver, kidney channel.Function cures mainly: liver heat removing and eyesight improving, grow the liver benefiting benefit.Be used for giddy, the wind syndrome of head of hypertension, the wind heat ophthalmalgia.Modern pharmacological research proof Semen Cassiae open fire and ethanol extract have significantly hypotensive effect to the hypertension animal, and hyperlipidemia patient is had the serum cholesterol of reduction and blood viscosity, function of promoting blood circulation to disperse blood clots, and can improve headache, dizziness, symptom such as weak.
Flos Chrysanthemi: sweet in the mouth, hardship, cold, nontoxic, go into lung, liver,spleen,kidney four warps.Function cures mainly: wind and heat dispersing, the liver benefiting nourishing YIN, wind headache in the main liver-yang, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart.Pharmacological testing proves that Flos Chrysanthemi extract has remarkable coronary artery dilator, increases the effect of its blood flow extrasomatic rabbit heart, and can improve mice to the anoxybiotic tolerance that reduces pressure.Clinically be used for the treatment of hypertension and coronary heart disease has significant curative effect.
Concha Ostreae: nature and flavor are salty and bitter, and are cool, nontoxic, go into liver, kidney channel.Function cures mainly: yin fluid astringing, suppressing the hyperactive liver and subsiding YANG is controlled infantile convulsion, and is dizzy, pained depressed, takes a tonic or nourishing food to build up one's health and calms the nerves.Concha Ostreae contains calcium carbonate more than 90%, and contains various trace elements and aminoacid.Modern pharmacological research proves that parathyroid hypertensive factor (PHF) is one of pathogenic factor of hypertension, and it can cause that the hypertensive patient produces abnormal calcium metabolism, and additional calcium preparation can suppress the secretion of PHF, thereby regulates calcium metabolism, and certain secondary buck effect is arranged.
The present invention is realized by following technical proposals:
Radix Puerariae 100-300 (weight portion)
Semen Cassiae 50-150 (weight portion)
Flos Chrysanthemi 100-200 (weight portion)
Concha Ostreae 30-120 (weight portion)
The above-mentioned raw materials medicine is made capsule.
By the capsule (return of spring blood pressure decreasing capsule) that this technology is made, through clinical test-meal and Ergonomy research, this invention has good curative effect, and technology is simple to operation, and is effective, has no side effect.
1, material and method
1.1 sample: return of spring blood pressure decreasing capsule, sample character are light brown powder, for experiment usefulness, are provided by Beijing pine institute of Pharmaceutical Research in age.
1.2 experimental animal: 45 of the SHR rats that is provided by Chinese Academy of Medical Sciences experimental animal center, female, hero all has, body weight 180 ± 40 grams, approval number: moving word 01-3080 number of doctor.
1.3 instrument and reagent: arteria caudalis blood pressure heart umber of beats recording equipment PS-100, East Asia F-820 type blood counting instrument, OLYMPUSAU600 type automatic clinical chemistry analyzer, to produce by Japan, the biochemical reagents box is all provided by middle living company.
1.4 experimental technique: room temperature remains on 23-24 ℃, raises the SHR rat with the BC feedstuff, observes 7 days, measures blood pressure with the arteria caudalis measuring cell, and rat is fixed in the calorstat, is preheated to about 38 ℃, measures blood pressure.Be divided into 3 dosage groups 0.75,1.5,2.25g/kg.b.w (be equivalent to human body recommended dose 10,20,30 times) and 1 matched group at random according to SHR rat basic blood pressure value level, every group of 11-12 only, female, hero all has.Tried thing and be assigned to desired concn with distilled water, irritate stomach and give rat, matched group is irritated stomach and is given isopyknic distilled water, and irritate the stomach amount and press 1ml/100g.b.w calculating, once a day, continuous 3 weeks.Pressure measurement is 1 time weekly, after 3 weeks, gets rat tail vein blood, carries out biochemical indicator and routine blood test and detects.
1.5 experimental data is handled with computer software analysis.
2, result
2.1 general performance of SHR rat and body weight change: in whole experiment, each treated animal well-grown, feed, movable normal down.
Table 1 return of spring blood pressure decreasing capsule is to the influence (g) of SHR rat body weight
In 0 week of dosage number of animals in 2 all 3 weeks of 1 week, (g/kg.b.w), (only) 0 11 185.82 ± 36.96 191.27 ± 39.23 194.55 ± 38.26 198.73 ± 36.700.75 11 169.27 ± 33.62 173.73 ± 37.06 177.82 ± 37.30 184.64 ± 36.801.50 11 187.09 ± 26.60 192.27 ± 30.13 198.55 ± 31.12 197.91 ± 33.662.25 12 174.83 ± 33.75 183.08 ± 37.14 184.25 ± 22.96 183.92 ± 25.43
Each experimental group body weight and matched group body weight comparing difference do not have significance (p>0.05).2.2 the SHR rat blood pressure changes
Table 2 return of spring blood pressure decreasing capsule is to the influence (mmHg) of SHR rat blood pressure
2 all 3 weeks (g/kg.b.w) of 1 week of dosage 0 week are (n=11) (n=11) (n=12) 0 205.91 ± 7.824 205.82 ± 6.90 210.55 ± 7.38 208.55 ± 6.500.75 205.18 ± 8.081 193.55 ± 11.12** l82.00 ± 4.60***, 182.55 ± 7.12***1.50,205.45 ± 10.13 192.00 ± 8.14***, 196.27 ± 8.58***, 193.18 ± 12.40***2,25 205.67 ± 7.73 194.17 ± 5.47***, 185.50 ± 6.40***, 185.17 ± 10.00*** (n=11)
Compare * * p<0.01 * * * p<0.001 with matched group
As seen table 2 is tried thing after 1 week, and each dosage group promptly has the effect that significantly brings high blood pressure down, and 2 each dosage group of week back all have the effect that obviously brings high blood pressure down, and still be that significantly blood pressure difference is 15.37-26.00mmHg after 3 weeks, and with in, heavy dose of organize the most obvious.
2.3 security inspection
2.3.1 SHR rat hemogram changes
Table 3 return of spring blood pressure decreasing capsule is to the project that influences 0 (g/kg.b.w) 0.75 (g/kg.b.w) 1.50 (g/kg.b.w) 2.25 (g/kg.b.w) of SHR rat hemogram
(n=11) (n=11) (n=11) (n=11)HGB(g/L) 140.91±11.10 141.18±11.11 141.27±7.740 136.75±14.78RBC(×10/L) 9.32±0.64 9.32±0.73 9.33±0.51 9.03±0.97WBC(×10/L) 6.01±1.54 6.18±1.18 7.06±3.15 5.12±1.74PT(×10/L) 363.09±166.32 239.91±73.99 233.55±56.464 224.08±60.24N 0.56±0.11 0.58±0.09 0.59±0.10 0.57±0.06L 0.44±0.11 0.42±0.09 0.41±0.09 0.43±0.06
Table 3 as seen, each experimental group and matched group hemogram detect index all in normal range.
2.3.2 the every changes of biochemical indexes of SHR rat
Table 4 return of spring blood pressure decreasing capsule is to the project that influences 0 (g/kg.b.w) 0.75 (g/kg.b.w) 1.50 (g/kg.b.w) 2.25 (g/kg.b.w) of SHR rat blood biochemical indicator
(n=11) (n=11) (n=11) (n=11)ALT(u/L) 99.04±28.42 80.33±14.51 85.15±12.23 84.79±27.16AST(u/L) 198.62±55.01 171.22±12.41 183.21±21.94 183.66±17.91GLU(mmol/L) 9.08±1.20 9.02±1.08 8.83±1.09 9.91±1.42CRE(umol/L) 56.45±2.34 53.64±3.20 56.18±3.06 58.73±4.08UREA(mmol/L) 8.55±0.58 8.74±0.93 8.34±0.76 8.47±1.09TC(mmol/L) 1.34±0.12 1.29±0.25 1.25±0.12 1.24±0.11TG(mmol/L) 0.59±0.26 0.56±0.28 0.47±0.16 0.33±0.13**HDL-c(mmol/L)?0.86±0.11 0.83±0.23 0.79±0.15 0.79±0.12
**P<0.01
Table 4 as seen, each experimental group and matched group blood biochemical respectively detect index all in normal range, heavy dose of group TG obviously reduces, and illustrates that return of spring blood pressure decreasing capsule does not have obvious influence to liver, the renal function of SHR rat, and the effect of obvious blood lipid regulation is arranged.
3, brief summary
The filling stomach gives the return of spring blood pressure decreasing capsule of SHR rat 0.75,1.50,2.25g/kg.b.w dosage, compare with matched group after 1 week, each dosage group promptly has the effect that brings high blood pressure down significantly, still is remarkable (P<0.001) after 2 weeks, 3 weeks, and blood pressure difference is 15.37-26.00mmHg.The body weight of experiment each experimental group of back and matched group SHR rat, hemogram, liver, renal function respectively detect index all in normal range.
Embodiment:
Radix Puerariae 200kg Semen Cassiae 100kg Flos Chrysanthemi 150kg Concha Ostreae 50kg
1, by recipe quantity Semen Cassiae, Radix Puerariae, Flos Chrysanthemi three flavor medicines are added 8 times of decoctings and boiled 1.5 hours, filter;
2, add 6 times of water gagings again, decoct filtration in 1.5 hours;
3,2 and 1 filtrate is merged, be concentrated into relatively to density 1.05-1.10 (70 ℃);
4, spray drying gets extract powder;
5, get extract powder and add recipe quantity Concha Ostreae powder (crossing 80 mesh sieves), granulate in right amount with ethanol;
6,60 ℃ of dryings, 40 order granulate;
7, encapsulated;
8, packing;
9 cobalt sources irradiations (dosage 3KGy, normotopia 3-4 hour, inferior outer ring 12 hours);
10, get finished product.
Claims (2)
1, a kind of Chinese medicine composition with hypotensive effect is characterized in that said composition is made up of following component:
Radix Puerariae 100-300 weight portion
Semen Cassiae 50-150 weight portion
Flos Chrysanthemi 100-200 weight portion
Concha Ostreae 30-120 weight portion
2, compositions according to claim 1 is characterized in that the component of said composition is:
Radix Puerariae 200 weight portions
Semen Cassiae 100 weight portions
Flos Chrysanthemi 150 weight portions
Concha Ostreae 50 weight portions
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN99122430A CN1102064C (en) | 1999-11-08 | 1999-11-08 | Chinese medicine for lowering blood pressure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN99122430A CN1102064C (en) | 1999-11-08 | 1999-11-08 | Chinese medicine for lowering blood pressure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1255368A CN1255368A (en) | 2000-06-07 |
CN1102064C true CN1102064C (en) | 2003-02-26 |
Family
ID=5282486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN99122430A Expired - Fee Related CN1102064C (en) | 1999-11-08 | 1999-11-08 | Chinese medicine for lowering blood pressure |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1102064C (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101549013B (en) * | 2009-05-13 | 2012-10-03 | 文永盛 | Capsule, tablet and granules of minium and preparation method |
CN106890276A (en) * | 2017-04-12 | 2017-06-27 | 吉林省德葆康医药科技股份有限公司 | A kind of Chinese medicine composition for treating hypertension and preparation method thereof |
CN112274627A (en) * | 2020-12-17 | 2021-01-29 | 姚忠泽 | A rapidly disintegrating Chinese medicinal tablet for lowering blood pressure, and its preparation method |
CN116270937A (en) * | 2023-02-06 | 2023-06-23 | 汉中市华瑞牡丹生物科技有限公司 | Composition for regulating blood fat and blood pressure and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1072860A (en) * | 1992-12-11 | 1993-06-09 | 唐山市龙山制药厂 | Prescription of capsule for treating encephalasthenia and its preparation process |
CN1125134A (en) * | 1995-07-05 | 1996-06-26 | 高培雄 | Traditional Chinese medicine for reducing blood-lipid and its preparing technology |
CN1205219A (en) * | 1997-07-16 | 1999-01-20 | 有维范 | Tea for reducing hypertension and fat |
-
1999
- 1999-11-08 CN CN99122430A patent/CN1102064C/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1072860A (en) * | 1992-12-11 | 1993-06-09 | 唐山市龙山制药厂 | Prescription of capsule for treating encephalasthenia and its preparation process |
CN1125134A (en) * | 1995-07-05 | 1996-06-26 | 高培雄 | Traditional Chinese medicine for reducing blood-lipid and its preparing technology |
CN1205219A (en) * | 1997-07-16 | 1999-01-20 | 有维范 | Tea for reducing hypertension and fat |
Also Published As
Publication number | Publication date |
---|---|
CN1255368A (en) | 2000-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1301666C (en) | Health food capable of raising immunity and its production process | |
CN102145128B (en) | Medicinal composition for preventing and treating cardiac and cerebral vascular diseases and preparation method thereof | |
CN100339111C (en) | Medicine for treating coronary heart disease and its prepn | |
CN101053621A (en) | Traditional Chinese medicinal composition for treating obesity and its preparation method | |
CN101037651A (en) | Lucidum mushroom health wine and production method thereof | |
CN1102064C (en) | Chinese medicine for lowering blood pressure | |
CN1259955C (en) | Chinese medicine preparation for treating climacteric metancholia of women | |
CN1304769A (en) | Blood-cleaning pill | |
CN1957972A (en) | Composition in use for invigorating primordial energy, benefiting pubic region, preparation method and usage | |
CN1178688C (en) | Health-care food for resisting fatigue | |
CN1211434A (en) | Oral liquid for resisting altitude stress and its preparation method | |
CN1060028C (en) | Health food macte from cereal, vegetable and fruit | |
CN1183936C (en) | Medicine for treating hypertension and method for preparing medicinal tea thereof | |
CN1233337C (en) | Medicine for treating Parkinson's disease and its preparing process | |
CN1087272A (en) | A kind of Chinese powder medicine capsule that is used for the treatment of chronic ischemic heart disease | |
CN1254252C (en) | Medicine for treating ischemic angiocardiopathy and cerebrovascular disease and its preparation method | |
CN1107711A (en) | Hypoglycemic compound capsule | |
CN101946849A (en) | Depressurization chewing gum and preparation method thereof | |
CN1079397A (en) | Improve Chinese medicine of body function and preparation method thereof | |
CN1242766C (en) | Medicine for preventing and treating chronic exhaustion syndrome and preparing method thereof | |
CN1053111C (en) | Chinese medical composite preparation with such functions as dispelling toxicity, detoxicating, recuperating, health preserving and face nursing | |
CN108813596A (en) | A kind of preparation method and applications of eucommia ulmoides seed oil soft capsule | |
CN1067231C (en) | Rose added granule | |
US20210008124A1 (en) | Composition for relieving stress and enhancing immunity and preparation method thereof | |
CN1099282A (en) | Compound lotus plumule liquid and its preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030226 Termination date: 20131108 |