CN106890276A - A kind of Chinese medicine composition for treating hypertension and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating hypertension and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention provides a kind of Chinese medicine composition for treating hypertension and preparation method thereof, belongs to technical field of traditional Chinese medicine.Solve the problems, such as that the existing drug side-effect for treating hypertension is big and therapeutic effect is poor.The Chinese medicine composition in parts by weight, is made up of following bulk drug：30 50 parts of mulberries, 40 60 parts of oyster, 40 60 parts of corn stigma, 35 55 parts of the root of kudzu vine, 30 50 parts of cassia seed, 30 50 parts of chrysanthemum.The present invention also provides a kind of preparation method for treating the Chinese medicine composition of hypertension.All the components are all the traditional Chinese medicine ingredients of integration of drinking and medicinal herbs in Chinese medicine composition of the invention, all it is usually edible, tonic, the food materials of health, there is positive improvement result to various types of hypertension problems, can effectively treat both principal and secondary aspect of disease, regulation function of liver and spleen, and the equilibrium between yin and yang of body is adjusted, it is without any side effects, and therapeutic effect is notable.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, and in particular to a kind of Chinese medicine composition for treating hypertension and
Its preparation method.
Background technology
Hypertension belongs to traditional Chinese medical science dizziness disease, is the card of simulataneous insufficiency and excessive more caused by spleen kidney deficiency, liver-yang are partially high.It is liver
It is qi-blood disharmony, the disorder in ascending and descending of spleen, the imbalance of yin and yang of kidney.Needs are treated both principal and secondary aspect of disease, and have grown kidney, and brain has been supported, and liver is flat,
The purpose that wind puts out, blood pressure must drop is supported so as to reach liver.
The Western medicine of common treatment hypertension is main by diuretics, calcium antagonist (CCB), beta-blocker, the receptor blocks of α 1
Agent, angiotensin converting enzyme inhibitor (ACEI), Angiotensin Ⅱ receptor antagonist (ARB) etc., different types of step-down
Medicine has variety classes, different degrees of clinical common adverse effect, and relies on throughout one's life.In traditional Chinese medical science field, also having much is used for
Improve the product of the dietotherapy class of hypertension or the improvement blood pressure of Chinese patent drug class, but curative effect can treat both principal and secondary aspect of disease preferably and really, for a long time
The formula of blood pressure is controlled to also need to continue to study and perfect.
Goal of the invention
Drug side-effect the invention aims to solve existing treatment hypertension is big and therapeutic effect is poor asks
Topic, and a kind of Chinese medicine composition for treating hypertension and preparation method thereof is provided.
Present invention firstly provides a kind of Chinese medicine composition for treating hypertension, the Chinese medicine composition is according to parts by weight
Meter, is made up of following bulk drug：
Preferably, described a kind of Chinese medicine composition for treating hypertension, the Chinese medicine composition is according to weight portion
Number meter, is made up of following bulk drug：
The present invention also provides a kind of preparation method for treating the Chinese medicine composition of hypertension, and the method includes：
Step one：Mulberries, oyster, corn stigma, the root of kudzu vine, cassia seed and chrysanthemum are cleaned, is mixed, obtain mixture；
Step 2：The mixture that step one is obtained is extracted twice at 90-95 DEG C, each 2.5h, then with 300 mesh mistakes
Filter, obtains extract solution；
Step 3：Step 2 is obtained into extract solution to be concentrated under reduced pressure at 55-66 DEG C, by concentrate drying and screening, in obtaining
Drug composition.
Pharmacological action of the invention is as follows：
Mulberries：Nourishing yin and supplementing blood, is promoted the production of body fluid, and liver and kidney channel is returned in ease constipation；There are nourishing liver and kidney the moon and the effect enriched blood；
Oyster：Calming the liver, softening and resolving hard mass, convergence is astringent or styptic treatment for spontaneous sweating, returns liver and kidney channel；For liver-yang hyperactivity, have a dizzy spell, dizziness,
Tinnitus has calming the liver antihypertensive effect；
Corn stigma：Inducing diuresis for removing edema, removing dampness through diuresis and removing jaundice returns bladder, liver, gallbladder channel；Can Li Shui step-downs.
The root of kudzu vine：Returns spleen, stomach, promote the production of body fluid to quench thirst, Shengyang Zhixie；
Cassia seed：Clear liver and improve vision, relax bowel, Return liver, kidney, large intestine channel；Can clearing liver fire, and and kidney-nourishing it is cloudy；
Chrysanthemum：It is bitter in taste, sweet, cold, return lung, Liver Channel.With heat-clearing except fire, promote the production of body fluid to quench thirst, detoxify, relieving restlessness of calming the nerves, improving eyesight,
Effect of anti-inflammatory analgetic, hypotensive.
A kind of Chinese medicine composition for treating hypertension of the invention, can add conventional pharmaceutic adjuvant and be made pharmaceutically
Acceptable oral formulations such as decoction, pill, capsule or granule etc., and the decoction, pill, capsule or granule are equal
Can be obtained using the customary preparation methods of corresponding species preparation.
Beneficial effects of the present invention
The present invention provides a kind of Chinese medicine composition for treating hypertension and preparation method thereof, and the Chinese medicine composition can be mended
Spleen soothing the liver dredging collateral with hypotensive, and can good for heart and brain, the prosperous blood of gas is lived, heart arteries and veins must be logical, brain that must support, so as to reach good for heart and brain
The effect of.All the components are all the traditional Chinese medicine ingredients of integration of drinking and medicinal herbs in Chinese medicine composition of the invention, are all usually edible, foods
Various types of hypertension problems are had positive improvement result by benefit, the food materials of health, can effectively be treated both principal and secondary aspect of disease, and are adjusted
Section function of liver and spleen, and the equilibrium between yin and yang of body is adjusted, it is without any side effects, and therapeutic effect is notable.
Chinese medicine composition of the invention is used in 2012 to 2016 clinical observation hypertension, 110 patients, clinic report
Accuse as follows：
1st, clinical data
In this group 110, man 45, female 65, the age is minimum 20 years old, and maximum 58 years old, the course of disease was at 3 months to 4 years.
2nd, criterion of therapeutical effect
It is effective：Systolic pressure≤18.7kPa (140mmHg) and diastolic pressure≤12.0kPa (90mmHg)
Effectively：Systolic pressure >=18.7kPa (140mmHg) and diastolic pressure >=12.0kPa (90mmHg), but blood pressure dropped
It is low.
It is invalid：Blood pressure is unchanged, and other symptoms deteriorate.
3rd, treatment method
Routinely technique is made tablet (500mg), three times per day, one time four, surrounding be a course for the treatment of.
4th, treatment results
In 110 patients, 66 (60%) in effect is significant ground, effective 42 (38.18%), invalid 2
(1.82%), total effective rate 98.18%.
5th, model case
Case 1：
Chen, female, 40 years old, hypertension history 5 years, blood pressure felt dizzy, palpitation and insomnia often in more than 160/90mmHg,
It is thirsty, veins string.Take the present invention 4 weeks, blood pressure is down to 136/80mmHg, takes medicine continuously 8 weeks, and blood pressure is down to normally.
Case 2:
It is high certain, man, 42 years old.Readme has hypertension history 4 years, carrys out within one week dizziness headache, and limb fiber crops, mesh is puckery, insomnia, hidrosis.
The micro- red yellow tongue fur of tongue nature, wiry and rolling pulse, blood pressure 156/98mmHg.Take the present invention three weeks, blood pressure is down to 132/85mmHg.Dizziness headache
The diseases such as limb fiber crops disappear.
Specific embodiment
Form, is described in further detail again to the above of the invention by the following examples, but should not be by this
The scope for being interpreted as this bright above-mentioned theme is only limitted to following example, all technologies realized based on the above of the present invention,
Belong to the scope of the present invention.
Embodiment 1
Raw material (gram) is weighed by following weight ratio：
30 grams of mulberries, 40 grams of oyster, 40 grams of corn stigma, 35 grams of the root of kudzu vine, 30 grams of cassia seed, 30 grams of chrysanthemum.
Step one：According to above-mentioned formula, mulberries, oyster, corn stigma, the root of kudzu vine, cassia seed and chrysanthemum are cleaned, mixed, obtained
To mixture；
Step 2：The mixture that step one is obtained is extracted twice at 90 DEG C, each 2.5h, is then filtered with 300 mesh,
Obtain extract solution；
Step 3：Step 2 is obtained into extract solution to be concentrated under reduced pressure at 55 DEG C, 80 mesh sieving after concentrate is spray-dried,
Obtain Chinese medicine composition.
Embodiment 2
Raw material (gram) is weighed by following weight ratio：
50 grams of mulberries, 60 grams of oyster, 60 grams of corn stigma, 55 grams of the root of kudzu vine, 50 grams of cassia seed, 50 grams of chrysanthemum.
Step one：According to above-mentioned formula, mulberries, oyster, corn stigma, the root of kudzu vine, cassia seed and chrysanthemum are cleaned, mixed, obtained
To mixture；
Step 2：The mixture that step one is obtained is extracted twice at 95 DEG C, each 2.5h, is then filtered with 300 mesh,
Obtain extract solution；
Step 3：Step 2 is obtained into extract solution to be concentrated under reduced pressure at 66 DEG C, 80 mesh sieving after concentrate is spray-dried,
Obtain Chinese medicine composition.
Embodiment 3
Raw material (gram) is weighed by following weight ratio：
40 grams of mulberries, 50 grams of oyster, 50 grams of corn stigma, 45 grams of the root of kudzu vine, 40 grams of cassia seed, 40 grams of chrysanthemum.
Step one：According to above-mentioned formula, mulberries, oyster, corn stigma, the root of kudzu vine, cassia seed and chrysanthemum are cleaned, mixed, obtained
To mixture；
Step 2：The mixture that step one is obtained is extracted twice at 93 DEG C, each 2.5h, is then filtered with 300 mesh,
Obtain extract solution；
Step 3：Step 2 is obtained into extract solution to be concentrated under reduced pressure at 60 DEG C, 80 mesh sieving after concentrate is spray-dried,
Obtain Chinese medicine composition.
Claims (3)
1. a kind of Chinese medicine composition for treating hypertension, it is characterised in that the Chinese medicine composition in parts by weight, by
Following bulk drug is made：
2. a kind of Chinese medicine composition for treating hypertension according to claim 1, it is characterised in that the Chinese traditional medicine composition
Thing in parts by weight, is made up of following bulk drug：
3. a kind of preparation method for treating the Chinese medicine composition of hypertension according to claim 1-2 any one,
Characterized in that, the method includes：
Step one：Mulberries, oyster, corn stigma, the root of kudzu vine, cassia seed and chrysanthemum are cleaned, is mixed, obtain mixture；
Step 2：The mixture that step one is obtained is extracted twice at 90-95 DEG C, each 2.5h, is then filtered with 300 mesh,
Obtain extract solution；
Step 3：Step 2 is obtained into extract solution to be concentrated under reduced pressure at 55-66 DEG C, by concentrate drying and screening, Chinese medicine group is obtained
Compound.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710234688.3A CN106890276A (en) | 2017-04-12 | 2017-04-12 | A kind of Chinese medicine composition for treating hypertension and preparation method thereof |
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| CN201710234688.3A CN106890276A (en) | 2017-04-12 | 2017-04-12 | A kind of Chinese medicine composition for treating hypertension and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106890276A true CN106890276A (en) | 2017-06-27 |
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| CN201710234688.3A Pending CN106890276A (en) | 2017-04-12 | 2017-04-12 | A kind of Chinese medicine composition for treating hypertension and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108902621A (en) * | 2018-06-29 | 2018-11-30 | 贵港市壹益酒业科技发展有限公司 | A kind of draft solid beverage of aided blood pressure-lowering and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1255368A (en) * | 1999-11-08 | 2000-06-07 | 吉玲 | Chinese medicine for lowering blood pressure |
| CN102726577A (en) * | 2012-06-30 | 2012-10-17 | 姜阔 | Hypertension lowering tea |
-
2017
- 2017-04-12 CN CN201710234688.3A patent/CN106890276A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1255368A (en) * | 1999-11-08 | 2000-06-07 | 吉玲 | Chinese medicine for lowering blood pressure |
| CN102726577A (en) * | 2012-06-30 | 2012-10-17 | 姜阔 | Hypertension lowering tea |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108902621A (en) * | 2018-06-29 | 2018-11-30 | 贵港市壹益酒业科技发展有限公司 | A kind of draft solid beverage of aided blood pressure-lowering and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170627 |
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| RJ01 | Rejection of invention patent application after publication |