CN110193136A - A kind of nanometer of chip promotees to seep instrument - Google Patents
A kind of nanometer of chip promotees to seep instrument Download PDFInfo
- Publication number
- CN110193136A CN110193136A CN201810162020.7A CN201810162020A CN110193136A CN 110193136 A CN110193136 A CN 110193136A CN 201810162020 A CN201810162020 A CN 201810162020A CN 110193136 A CN110193136 A CN 110193136A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- push rod
- shell
- promotees
- cantilever beam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Percussion Or Vibration Massage (AREA)
- Micromachines (AREA)
Abstract
Promote to seep instrument, including shell, the power supply module that the inside of the shell is equipped with driving assembly and is electrically connected with the driving component the invention discloses a kind of nanometer of chip；The driving component includes motor and conductive cantilever beam, and the motor is fixed and is electrically connected with the cantilever beam；One push rod is through the upper end of the shell, and it can the relatively described reciprocal movement, reset spring is equipped between the push rod and the shell, the inside one end of the push rod and the cantilever beam are oppositely arranged and keep gap, and the outside one end of the push rod is equipped with the micro device for only penetrating keratoderma；The inside one end of the push rod is equipped with sheet metal.A kind of nanometer of chip of the invention promotees to seep instrument, and driving assembly, as steering mechanism, makes the rotation of motor be converted into moving along a straight line by using cantilever beam, and structure is simple, reduces production cost, reduces noise, improves reliability and comfort.
Description
Technical field
The present invention relates to percutaneous delivery instrument technical fields more particularly to a kind of nanometer of chip to promote to seep instrument.
Background technique
Currently, nanometer micropin and nanometer chip are just being widely used in percutaneous delivery instrument technical field.Nanometer micropin be
A kind of micropin of skin pipeline is opened by nanotechnology, syringe needle has been covered with close above similar to one piece slight of chip square
, carefully arrive the small needle that can't see, this small cube is pressed on the skin, drug can be allowed to enter epidermis, and people almost without
Feel.Nanometer chip is to be promoted to seep specific purpose tool according to the nanometer face cleaning of human skin mechanical development, passes through nanometer by monocrystalline silicon
Technical matters is carved.The surface of nanometer chip is a series of microneedle arrays, they can open the outmost cutin of skin
Layer, while skin corium will not be injured, greatly improve penetrating power of the pumped (conveying) medium on skin epidermis.The biology of monocrystalline silicon is simultaneous
Capacitive in turn ensures the safety of nano-crystal in use.
Existing beauty face cleaning promotees infiltration instrument and generally columnar structures is used to design, including work syringe needle and driving working needle
Head makees the driving device of reciprocal thorn campaign, and driving device therein is used in combination by motor and steering mechanism, and steering is passed through
The rotation of motor is changed into linear motion by mechanism, so that work syringe needle be driven to make reciprocal thorn campaign.Such as Chinese patent
A kind of luminous electronic micropin beauty face cleaning rush infiltration instrument disclosed in CN204017141U, including a piston type syringe needle and one
The reciprocating driving device of a driving piston type syringe needle.Driving device includes a motor and a drive rod；Motor is solid
It is scheduled in body casing body, the position of disalignment is equipped with a convex block on the rotor of motor；Drive rod is mounted in ontology shell
The heart and the freedom degree with longitudinally-moving are equipped with reset spring, one end of drive rod and activity between drive rod and ontology shell
The mandril of syringe needle is clamped, and the other end of drive rod is equipped with inclined-plane, the bump contact on inclined-plane and rotor.Driving device passes through
Inclined-plane and convex block are changed into linear motion with the use of realizing rotation.But it is existing this kind of small miniature suitable for promoting infiltration instrument
Often structure is complicated for the steering mechanism of device, high production cost, and the noise generated when work is very big, is unfavorable for user's
Experience comfort.
Summary of the invention
In view of above-mentioned defect existing in the prior art, promote to seep instrument the purpose of the present invention is to propose to a kind of nanometer of chip.
To achieve the goals above, present invention employs following technical solutions:
A kind of nanometer of chip promotees to seep instrument, including shell, the inside of the shell be equipped with driving assembly and with the driving group
The power supply module of part electrical connection；The driving component includes motor and conductive cantilever beam, and the motor is hanged with described
Arm beam is fixed and is electrically connected；One push rod through the upper end of the shell, and can the relatively described reciprocal movement, it is described to push away
Reset spring is equipped between bar and the shell, between the inside one end of the push rod and the cantilever beam are oppositely arranged and keep
Gap, when the reset spring compresses, the inside one end of the push rod is contacted with the cantilever beam, the outside one end of the push rod
Equipped with the micro device for only penetrating keratoderma；The inside one end of the push rod be equipped with sheet metal, the sheet metal with
When the cantilever beam contacts, the motor and the power supply module form closed loop.
Another nanometer chip of the invention promotees to seep instrument, including shell, the inside of the shell be equipped with driving assembly and with
The power supply module of the driving component electrical connection；The driving component includes motor and cantilever beam, the motor and the cantilever
Beam is fixedly connected；One push rod, and can the relatively described reciprocal movement, the push rod and institute through the upper end of the shell
It states and is equipped with reset spring between shell, the inside one end of the push rod and the cantilever beam are oppositely arranged and keep gap, institute
When stating reset spring compression, the inside one end of the push rod is contacted with the cantilever beam, and the outside one end of the push rod, which is equipped with, to be used
In the micro device for only penetrating keratoderma.
Further, the motor is eccentric motor or vibrator motor.
Further, the micro device is micropin, nanometer micropin or nanometer chip.
Further, the micro device is pierced into the length of keratoderma between 1 micron to 3000 microns.
Further, the upper end of the shell is operating side, and lower end is handle end；The operating side is equipped with groove seat, institute
State the axis hole and limiting slot offered in groove seat for wearing the push rod.
Further, the top of the groove seat is equipped with guard circle.
Further, the cantilever beam is made of metal plate.
Further, the metal plate is steel plate.
Further, the power supply module includes power supply body, the switch being electrically connected with the power supply body, described to open
When closing unlatching, the motor and the power supply module form closed loop.
Protrusion effect of the invention are as follows: a kind of nanometer of chip of the invention promotees to seep instrument, and driving assembly is by using cantilever
Beam makes the rotation of motor be converted into moving along a straight line as steering mechanism, and structure is simple, reduces production cost, reduces and makes an uproar
Sound improves reliability and comfort.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the embodiment of the present invention 1 and 2；
Fig. 2 is the partial structural diagram of the embodiment of the present invention 1；
Fig. 3 is the partial structural diagram of the embodiment of the present invention 2；
Fig. 4 is that permeability changes over time figure in experimental example of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Embodiment 1
As depicted in figs. 1 and 2, a kind of nanometer of chip of the present embodiment promotees to seep instrument, including shell 1, the inside of shell are equipped with
Driving assembly 2 and the power supply module 3 being electrically connected with driving assembly 2；Driving assembly 2 includes motor 21 and conductive outstanding
Arm beam 22, motor 21 is fixed with cantilever beam 22 and is electrically connected；Push rod 4 through the upper end of shell 1, and can opposite shell 1 it is past
Multiple movement, is equipped with reset spring 5, the inside one end of push rod 4 is oppositely arranged and keeps with cantilever beam 22 between push rod 4 and shell 1
Gap, when reset spring 5 compresses, the inside one end of push rod 4 is contacted with cantilever beam 22, and the outside one end of push rod 4 is equipped with for only
Penetrate the micro device 6 of keratoderma；The inside one end of push rod 4 is equipped with sheet metal 7, and sheet metal 7 is contacted with cantilever beam 22
When, motor 21 and power supply module 3 form closed loop.
Wherein, motor 21 is eccentric motor.
Micro device 6 is nanometer micropin.Micro device 6 be pierced into keratoderma length 1 micron to 3000 microns it
Between.
The upper end of shell 1 is operating side, and lower end is handle end；Operating side is equipped with groove seat 11, offers in groove seat 11
For wearing the axis hole 12 and limiting slot 13 of push rod.The top of groove seat 11 is equipped with guard circle 14.
Cantilever beam 22 is made of metal plate.Optionally, metal plate is steel plate.
Embodiment 2
As shown in figures 1 and 3, a kind of nanometer of chip of the present embodiment promotees to seep instrument, including shell 1, the inside of shell 1 are set
There are driving assembly 2 and the power supply module being electrically connected with driving assembly 23；Driving assembly 2 includes motor 21 and cantilever beam 22, motor
21 are fixedly connected with cantilever beam 22；Push rod 4 through the upper end of shell 1, and can opposite shell 1 move back and forth, push rod 4 and outer
Reset spring 5 is equipped between shell 1, the inside one end of push rod 4 and cantilever beam 22 are oppositely arranged and keep gap, and reset spring 5 is pressed
When contracting, the inside one end of push rod 4 is contacted with cantilever beam 22, and the outside one end of push rod 4 is equipped with for only penetrating keratoderma
Micro device 6.
Wherein, motor 21 is vibrator motor.
Micro device 6 is nanometer chip.Micro device 6 be pierced into keratoderma length 1 micron to 3000 microns it
Between.
The upper end of shell 1 is operating side, and lower end is handle end；Operating side is equipped with groove seat 11, offers in groove seat 11
For wearing the axis hole 12 and limiting slot 13 of push rod.The top of groove seat 11 is equipped with guard circle 14.
Power supply module 3 is including power supply body 31, the switch 32 being electrically connected with power supply body 31, when switch 32 is opened, motor
21 form closed loop with power supply module 3.
Embodiment 3
The present embodiment and embodiment 2 are almost the same, the difference is that micro device 6 is micropin.
Experimental example
The lidocaine gel that autogamy is compared in this experiment promotees to seep instrument (A group) in the nanometer chip using the embodiment of the present invention 1
The rush that nanometer chip is arranged directly on shaft seeps the Transdermal absorption result after instrument (B group) is handled 20 seconds respectively.
This experimental method is as follows:
Pig ear in refrigerator is taken, 800 μ m-thick of skin is taken, removes the hair on surface, until smooth.PBS (7.4) impregnate 10 minutes-
After 15 minutes, 2 parts are taken to be cut into reception tank outer rim size respectively, A group and B group act on 20s, are placed between reception tank and administration pond, 37
± 0.2 DEG C of PBS (7.4) balances 1h.With Franze diffusion cell, dosage 120mg, reception tank volume 2.5mL, practical transdermal face
Product 0.66cm2, receiving liquid be PBS (7.4), 37 ± 0.2 DEG C of temperature, magnetic agitation 280rmp.
By Fig. 4 (wherein ◆ be A group, ■ is B group) as it can be seen that compared with A group, the transdermal effect of the lidocaine gel of B group
It is poor, and the transdermal effect of the lidocaine gel of A group is obviously improved.It is most unexpected to be that while it is using nanocrystalline
Piece, the effect of A group are substantially better than B group, illustrate that the method can significantly improve the mechanisms of nanometer chip, using with advantage.
Nanometer micropin and nanometer chip described in the invention refer to it is jagged less than 100 nanometers, highly at 1-3000 microns
Between miniature instrument, material can be monocrystalline silicon, polysilicon, macromolecule, metal and nonmetallic.Described in the invention is micro-
Needle refer to it is jagged be greater than 100 nanometers, the highly miniature instrument between 1-5000 microns, material can be monocrystalline silicon, polycrystalline
Silicon, macromolecule, metal and nonmetallic.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited to
This, anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention
And its inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of nanometer of chip promotees to seep instrument, it is characterised in that: including shell, the inside of the shell be equipped with driving assembly and with institute
State the power supply module of driving assembly electrical connection；The driving component includes motor and conductive cantilever beam, the motor
It fixes and is electrically connected with the cantilever beam；One push rod through the upper end of the shell, and can the relatively described reciprocal movement,
Reset spring is equipped between the push rod and the shell, the inside one end of the push rod is oppositely arranged and protects with the cantilever beam
Gap is held, the outside one end of the push rod is equipped with the micro device for only penetrating keratoderma；The push rod it is inside one
End is equipped with sheet metal.
2. a kind of nanometer of chip promotees to seep instrument, it is characterised in that: including shell, the inside of the shell be equipped with driving assembly and with institute
State the power supply module of driving assembly electrical connection；The driving component includes motor and cantilever beam, the motor and the cantilever beam
It is fixedly connected；One push rod through the upper end of the shell, and can the relatively described reciprocal movement, the push rod and described outer
Reset spring is equipped between shell, the inside one end of the push rod and the cantilever beam are oppositely arranged and keep gap, the push rod
Outside one end is equipped with the micro device for only penetrating keratoderma.
3. any one nanometer of chip according to claim 1 or 2 promotees to seep instrument, it is characterised in that: the motor is bias
Motor or vibrator motor.
4. any one nanometer of chip according to claim 1 or 2 promotees to seep instrument, it is characterised in that: the micro device is
Micropin, nanometer micropin or nanometer chip.
5. a kind of nanometer of chip according to claim 4 promotees to seep instrument, it is characterised in that: the micro device is pierced into skin angle
The length of matter layer is between 1 micron to 3000 microns.
6. any one nanometer of chip according to claim 1 or 2 promotees to seep instrument, it is characterised in that: the upper end of the shell
For operating side, lower end is handle end；The operating side is equipped with groove seat, offers in the groove seat for wearing the push rod
Axis hole and limiting slot.
7. a kind of nanometer of chip according to claim 6 promotees to seep instrument, it is characterised in that: the top of the groove seat, which is equipped with, to be protected
Guard ring.
8. a kind of nanometer of chip according to claim 1 promotees to seep instrument, it is characterised in that: the cantilever beam is by metal plate structure
At.
9. a kind of nanometer of chip according to claim 8 promotees to seep instrument, it is characterised in that: the metal plate is steel plate.
10. a kind of nanometer of chip according to claim 2 promotees to seep instrument, it is characterised in that: the power supply module includes power supply
Ontology, the switch being electrically connected with the power supply body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810162020.7A CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810162020.7A CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110193136A true CN110193136A (en) | 2019-09-03 |
| CN110193136B CN110193136B (en) | 2022-11-04 |
Family
ID=67750783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810162020.7A Active CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110193136B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110960789A (en) * | 2019-12-31 | 2020-04-07 | 苏州纳通生物纳米技术有限公司 | Automatic reversible skin pull throughs |
| WO2021109004A1 (en) * | 2019-12-02 | 2021-06-10 | 苏州纳生微电子有限公司 | Transmission mechanism and drug delivery device |
| WO2023246475A1 (en) * | 2022-06-24 | 2023-12-28 | 厦门松霖科技股份有限公司 | Vibration structure for hyaluronic acid injection and device for hyaluronic acid injection |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2080841U (en) * | 1990-08-18 | 1991-07-17 | 上海汇丰窗帘制造有限公司 | Minature massager |
| CN2231973Y (en) * | 1995-04-25 | 1996-07-31 | 游国耀 | Writing implement with massage device |
| CN2266517Y (en) * | 1996-09-18 | 1997-11-05 | 游国耀 | Writing implement with massaging device |
| CN2572958Y (en) * | 2002-09-30 | 2003-09-17 | 王宽渊 | Massage device with compound function |
| CN2770636Y (en) * | 2004-03-05 | 2006-04-12 | 伟嘉电业有限公司 | Massage part |
| CN201132446Y (en) * | 2007-08-22 | 2008-10-15 | 旺生富兴业股份有限公司 | Writing pen with massaging function |
| CN204017141U (en) * | 2014-08-15 | 2014-12-17 | 赵明知 | A kind of electronic micropin beauty treatment of luminescence is short oozes instrument |
| CN104689466A (en) * | 2015-03-31 | 2015-06-10 | 苏州纳通生物纳米技术有限公司 | Passage type nano beauty instrument and application method thereof |
| CN204698059U (en) * | 2015-03-31 | 2015-10-14 | 苏州纳通生物纳米技术有限公司 | A kind of beauty instrument jockey |
| CN206355435U (en) * | 2016-08-30 | 2017-07-28 | 蒋志敏 | A kind of portable electric micropin |
| CN206660295U (en) * | 2016-10-10 | 2017-11-24 | 苏州纳通生物纳米技术有限公司 | A kind of liquid quantitative conveying device |
-
2018
- 2018-02-26 CN CN201810162020.7A patent/CN110193136B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2080841U (en) * | 1990-08-18 | 1991-07-17 | 上海汇丰窗帘制造有限公司 | Minature massager |
| CN2231973Y (en) * | 1995-04-25 | 1996-07-31 | 游国耀 | Writing implement with massage device |
| CN2266517Y (en) * | 1996-09-18 | 1997-11-05 | 游国耀 | Writing implement with massaging device |
| CN2572958Y (en) * | 2002-09-30 | 2003-09-17 | 王宽渊 | Massage device with compound function |
| CN2770636Y (en) * | 2004-03-05 | 2006-04-12 | 伟嘉电业有限公司 | Massage part |
| CN201132446Y (en) * | 2007-08-22 | 2008-10-15 | 旺生富兴业股份有限公司 | Writing pen with massaging function |
| CN204017141U (en) * | 2014-08-15 | 2014-12-17 | 赵明知 | A kind of electronic micropin beauty treatment of luminescence is short oozes instrument |
| CN104689466A (en) * | 2015-03-31 | 2015-06-10 | 苏州纳通生物纳米技术有限公司 | Passage type nano beauty instrument and application method thereof |
| CN204698059U (en) * | 2015-03-31 | 2015-10-14 | 苏州纳通生物纳米技术有限公司 | A kind of beauty instrument jockey |
| CN206355435U (en) * | 2016-08-30 | 2017-07-28 | 蒋志敏 | A kind of portable electric micropin |
| CN206660295U (en) * | 2016-10-10 | 2017-11-24 | 苏州纳通生物纳米技术有限公司 | A kind of liquid quantitative conveying device |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021109004A1 (en) * | 2019-12-02 | 2021-06-10 | 苏州纳生微电子有限公司 | Transmission mechanism and drug delivery device |
| CN110960789A (en) * | 2019-12-31 | 2020-04-07 | 苏州纳通生物纳米技术有限公司 | Automatic reversible skin pull throughs |
| CN110960789B (en) * | 2019-12-31 | 2023-03-03 | 苏州纳通生物纳米技术有限公司 | Automatic reversible skin pull throughs |
| WO2023246475A1 (en) * | 2022-06-24 | 2023-12-28 | 厦门松霖科技股份有限公司 | Vibration structure for hyaluronic acid injection and device for hyaluronic acid injection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110193136B (en) | 2022-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110193136A (en) | A kind of nanometer of chip promotees to seep instrument | |
| JP5350473B2 (en) | Massage device for skin care | |
| KR101508878B1 (en) | Micro needle driving apparatus | |
| CN101257850A (en) | Hand-held device for producing a hole on the skin | |
| KR101494219B1 (en) | Apparatus for inducting the absorption of drug | |
| CN110812689A (en) | Hot compress type micro-nano wafer and medicine-mechanical integrated transdermal drug delivery device | |
| EP3096832B1 (en) | Shear-induced dermal infusion | |
| CN107913459A (en) | A kind of liquid quantitative conveying device | |
| US20190133634A1 (en) | Micro-Needling System | |
| US20150174387A1 (en) | Combined sonic and ultrasonic skin care device | |
| CN107913460B (en) | Liquid quantitative conveying system | |
| CN206660295U (en) | A kind of liquid quantitative conveying device | |
| JP2011167476A (en) | Apparatus for administration of microneedle array using motor power | |
| CN111672023A (en) | Needle head structure and electric microneedle device | |
| CN209500517U (en) | A kind of elastic miniatured device assembly and the rush infiltration instrument using the component | |
| CN114748778B (en) | Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device | |
| CN102988100A (en) | Low-resistance acupuncture method | |
| TW200302078A (en) | Massage machine | |
| CN215135866U (en) | Transmission mechanism suitable for liquid feeding device and liquid feeding device | |
| CN109833562B (en) | Disposable self-destruction type vibrating head assembly and permeation promoting instrument using same | |
| JP2019509867A (en) | Chemical injection device | |
| CN209612009U (en) | A kind of portable magnetic physical therapy massage instrument | |
| CN215386996U (en) | Novel microneedle device | |
| CN208756777U (en) | A kind of hand-held nanometer chip face cleaning rush infiltration instrument | |
| JPS626A (en) | Germanium-containing cosmetic and beauty tool |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |