CN110193136B - Nano-chip permeation promoting instrument - Google Patents
Nano-chip permeation promoting instrument Download PDFInfo
- Publication number
- CN110193136B CN110193136B CN201810162020.7A CN201810162020A CN110193136B CN 110193136 B CN110193136 B CN 110193136B CN 201810162020 A CN201810162020 A CN 201810162020A CN 110193136 B CN110193136 B CN 110193136B
- Authority
- CN
- China
- Prior art keywords
- shell
- push rod
- nano
- motor
- cantilever beam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micromachines (AREA)
- Percussion Or Vibration Massage (AREA)
Abstract
The invention discloses a nano-chip permeation promoting instrument which comprises a shell, wherein a driving component and a power supply component electrically connected with the driving component are arranged in the shell; the driving assembly comprises a motor and a cantilever beam with conductivity, and the motor is fixed and electrically connected with the cantilever beam; a push rod penetrates through the upper end of the shell and can reciprocate relative to the shell, a return spring is arranged between the push rod and the shell, the inward end of the push rod is arranged opposite to the cantilever beam and keeps a gap, and the outward end of the push rod is provided with a micro device which is only used for penetrating through the stratum corneum of the skin; and a metal sheet is arranged at one inward end of the push rod. According to the nano-chip permeation promoting instrument, the driving assembly adopts the cantilever beam as the steering mechanism, so that the rotation of the motor is converted into linear motion, the structure is simple, the production cost is reduced, the noise is reduced, and the reliability and the comfort are improved.
Description
Technical Field
The invention relates to the technical field of percutaneous conveying instruments, in particular to a nano-wafer permeation promoting instrument.
Background
Currently, nano-microneedles and nano-wafers are being widely applied in the technical field of transdermal delivery devices. The nano microneedle is a microneedle which opens a skin pipeline through a nanotechnology, a needle head is similar to a small wafer square, dense and thin invisible small needles are fully distributed on the small wafer square, and a drug can enter the epidermis by pressing the small wafer square on the skin, and people hardly feel the small wafer square. The nanometer wafer is a special nanometer tool for cleaning face and promoting permeation developed according to the structure of human skin, and is formed by carving monocrystalline silicon through a nanometer technology. The surface of the nano-chip is a series of micro-needle arrays which can open the outermost horny layer of the skin without damaging the dermis layer, thereby greatly improving the permeability of the delivery medium on the epidermis of the skin. The biological compatibility of the monocrystalline silicon ensures the safety of the nanocrystalline in the use process.
The existing beauty and face cleaning penetration-promoting instrument generally adopts a column-shaped structural design and comprises a working needle head and a driving device for driving the working needle head to do reciprocating pricking movement, wherein the driving device is used by combining a motor and a steering mechanism, and the rotation of the motor is converted into linear movement through the steering mechanism so as to drive the working needle head to do reciprocating pricking movement. For example, CN204017141U discloses a light-emitting electric micro-needle face-cleaning and penetration-promoting device for beauty treatment, which comprises a piston-type needle head and a driving device for driving the piston-type needle head to reciprocate. The driving device comprises a motor and a transmission rod; the motor is fixed in the body shell, and a convex block is arranged on the rotor of the motor at a position deviating from the axis; the transmission rod is arranged in the center of the body shell and has a self-guiding degree of longitudinal movement, a return spring is arranged between the transmission rod and the body shell, one end of the transmission rod is clamped with the ejector rod of the movable needle head, the other end of the transmission rod is provided with an inclined surface, and the inclined surface is contacted with the convex block of the motor rotor. The driving device realizes the conversion of rotation into linear motion by the matching use of the inclined plane and the convex block. However, the existing steering mechanism suitable for such small micro devices as the permeation-promoting instrument is complex in structure, high in production cost, and large in noise generated during working, and is not favorable for the experience comfort of users.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention aims to provide a nano-wafer permeation enhancer.
In order to achieve the purpose, the invention adopts the following technical scheme:
a nanometer wafer permeation promoting instrument comprises a shell, wherein a driving component and a power supply component electrically connected with the driving component are arranged inside the shell; the driving assembly comprises a motor and a cantilever beam with conductivity, and the motor is fixed and electrically connected with the cantilever beam; a push rod penetrates through the upper end of the shell and can reciprocate relative to the shell, a return spring is arranged between the push rod and the shell, the inward end of the push rod is arranged opposite to the cantilever beam and keeps a gap, when the return spring is compressed, the inward end of the push rod is contacted with the cantilever beam, and the outward end of the push rod is provided with a micro device which is only used for penetrating through the stratum corneum of skin; and a metal sheet is arranged at one inward end of the push rod, and when the metal sheet is contacted with the cantilever beam, the motor and the power supply assembly form a closed loop.
The invention also discloses a nano-chip permeation promoting instrument, which comprises a shell, wherein a driving component and a power supply component electrically connected with the driving component are arranged in the shell; the driving assembly comprises a motor and a cantilever beam, and the motor is fixedly connected with the cantilever beam; a push rod penetrates through the upper end of the shell and can reciprocate relative to the shell, a return spring is arranged between the push rod and the shell, the inward end of the push rod is arranged opposite to the cantilever beam and keeps a gap, when the return spring is compressed, the inward end of the push rod is in contact with the cantilever beam, and the outward end of the push rod is provided with a micro device used for penetrating only the stratum corneum of skin.
Further, the motor is an eccentric motor or a vibrator motor.
Further, the micro device is a micro needle, a nano micro needle or a nano wafer.
Further, the micro-device penetrates the stratum corneum between 1 and 3000 microns in length.
Furthermore, the upper end of the shell is an operation end, and the lower end of the shell is a handle end; the operation end is equipped with the recess seat, it is used for wearing to establish shaft hole and spacing groove of push rod to open in the recess seat.
Furthermore, a protection ring is arranged at the top of the groove seat.
Further, the cantilever is formed of a metal plate.
Further, the metal plate is a steel plate.
Furthermore, the power supply assembly comprises a power supply body and a switch electrically connected with the power supply body, and when the switch is turned on, the motor and the power supply assembly form a closed loop.
The invention has the outstanding effects that: according to the nano-wafer permeation promoting instrument, the driving component adopts the cantilever beam as the steering mechanism, so that the rotation of the motor is converted into linear motion, the structure is simple, the production cost is reduced, the noise is reduced, and the reliability and the comfort are improved.
Drawings
FIG. 1 is a schematic structural view of examples 1 and 2 of the present invention;
FIG. 2 is a partial schematic structural view of embodiment 1 of the present invention;
FIG. 3 is a partial structural view of embodiment 2 of the present invention;
FIG. 4 is a graph showing the change of permeability with time in the experimental example of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is to be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1
As shown in fig. 1 and fig. 2, the nano-chip permeation enhancer of the present embodiment comprises a housing 1, a driving component 2 and a power component 3 electrically connected to the driving component 2 are disposed inside the housing; the driving assembly 2 comprises a motor 21 and a cantilever beam 22 with conductivity, and the motor 21 is fixed and electrically connected with the cantilever beam 22; the push rod 4 penetrates through the upper end of the shell 1 and can reciprocate relative to the shell 1, a return spring 5 is arranged between the push rod 4 and the shell 1, the inward end of the push rod 4 is opposite to the cantilever beam 22 and keeps a gap, when the return spring 5 is compressed, the inward end of the push rod 4 is contacted with the cantilever beam 22, and the outward end of the push rod 4 is provided with a micro device 6 only penetrating through a skin stratum corneum; the push rod 4 is provided with a metal sheet 7 at an inward end, and when the metal sheet 7 is contacted with the cantilever beam 22, the motor 21 and the power supply component 3 form a closed loop.
Wherein the motor 21 is an eccentric motor.
The micro device 6 is a nano microneedle. The length of penetration of the microdevice 6 into the stratum corneum is between 1 and 3000 microns.
The upper end of the shell 1 is an operation end, and the lower end is a handle end; the operation end is provided with a groove seat 11, and a shaft hole 12 and a limiting groove 13 for penetrating the push rod are arranged in the groove seat 11. The top of the groove seat 11 is provided with a protective ring 14.
The cantilever beam 22 is formed of sheet metal. Optionally, the metal plate is a steel plate.
Example 2
As shown in fig. 1 and fig. 3, the nano-chip permeation enhancer of the present embodiment comprises a housing 1, wherein a driving component 2 and a power component 3 electrically connected to the driving component 2 are arranged inside the housing 1; the driving assembly 2 comprises a motor 21 and a cantilever beam 22, and the motor 21 is fixedly connected with the cantilever beam 22; the push rod 4 penetrates through the upper end of the shell 1 and can reciprocate relative to the shell 1, the return spring 5 is arranged between the push rod 4 and the shell 1, the inward end of the push rod 4 is arranged opposite to the cantilever beam 22 and keeps a gap, when the return spring 5 is compressed, the inward end of the push rod 4 is in contact with the cantilever beam 22, and the outward end of the push rod 4 is provided with the micro device 6 only penetrating through the stratum corneum.
The motor 21 is a vibrator motor.
The micro device 6 is a nano-chip. The micro-device 6 penetrates the stratum corneum of the skin to a length of between 1 and 3000 microns.
The upper end of the shell 1 is an operation end, and the lower end of the shell is a handle end; the operation end is equipped with recess seat 11, has seted up shaft hole 12 and the spacing groove 13 that is used for wearing to establish the push rod in the recess seat 11. The top of the groove seat 11 is provided with a protective ring 14.
The power module 3 includes a power body 31, and a switch 32 electrically connected to the power body 31, and when the switch 32 is turned on, the motor 21 and the power module 3 form a closed loop.
Example 3
This example is substantially identical to example 2, except that the microdevice 6 is a microneedle.
Examples of the experiments
This experiment compares the results of percutaneous absorption of a self-contained lidocaine gel after 20 seconds of treatment using the nanowafer permeation enhancer of the invention example 1 (group a) and the permeation enhancer with the nanowafer directly on the spindle (group B).
The experimental method is as follows:
taking pig ears in a refrigerator, taking the skin with the thickness of 800 μm, and removing the hair on the surface until the skin is smooth. Soaking in PBS (7.4) for 10-15 min, cutting 2 parts into outer edge of receiving pool, respectively, allowing group A and group B to act for 20s, placing between the receiving pool and administration pool, and balancing with PBS (7.4) at 37 + -0.2 deg.C for 1h. Using Franze diffusion cell, the dosage is 120mg, the receiving cell volume is 2.5mL, and the actual transdermal area is 0.66cm 2 The receiver was PBS (7.4), temperature 37. + -. 0.2 ℃ and magnetic stirring 280rmp.
As can be seen from FIG. 4 (wherein diamond-solid is group A, \9632; group B), the transdermal effect of lidocaine gel was inferior to that of group A, while the transdermal effect of lidocaine gel was significantly improved in group A. Most unexpectedly, although the nano-chips are adopted, the effect of the group A is obviously better than that of the group B, which shows that the invention can obviously improve the permeation promoting effect of the nano-chips and has advantages in application.
The nano micro needle and the nano wafer described in the invention refer to a micro apparatus with a tip projection less than 100 nanometers and a height between 1 and 3000 micrometers, and the material can be monocrystalline silicon, polycrystalline silicon, high molecules, metal and nonmetal. The micro-needle described by the invention is a micro-apparatus with a tip projection larger than 100 nanometers and a height of 1-5000 microns, and the material can be monocrystalline silicon, polycrystalline silicon, high polymer, metal and nonmetal.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention should be covered by the scope of the present invention.
Claims (10)
1. A nano-chip permeation promoting instrument is characterized in that: the device comprises a shell, wherein a driving component and a power supply component electrically connected with the driving component are arranged in the shell; the driving assembly comprises a motor and a cantilever beam with conductivity, and the motor is fixed and electrically connected with the cantilever beam; a push rod penetrates through the upper end of the shell and can reciprocate relative to the shell, a return spring is arranged between the push rod and the shell, the inward end of the push rod is arranged opposite to the cantilever beam and keeps a gap, and the outward end of the push rod is provided with a micro device which is only used for penetrating through the stratum corneum of the skin; a metal sheet is arranged at one inward end of the push rod;
the driving component converts the rotation of the motor into linear motion by adopting the cantilever beam as a steering mechanism.
2. A nanometer wafer permeation promoting instrument is characterized in that: the device comprises a shell, wherein a driving component and a power supply component electrically connected with the driving component are arranged in the shell; the driving assembly comprises a motor and a cantilever beam, and the motor is fixedly connected with the cantilever beam; a push rod penetrates through the upper end of the shell and can reciprocate relative to the shell, a return spring is arranged between the push rod and the shell, the inward end of the push rod is arranged opposite to the cantilever beam and keeps a gap, and the outward end of the push rod is provided with a micro device which is only used for penetrating through the stratum corneum of the skin;
the driving assembly converts the rotation of the motor into linear motion by adopting the cantilever beam as a steering mechanism.
3. The nano-wafer permeation enhancer of any one of claims 1 or 2, wherein: the motor is an eccentric motor or a vibrator motor.
4. The nano-wafer permeation enhancer of any one of claims 1 or 2, wherein: the micro device is a micro needle or a nano wafer.
5. The nano-wafer permeation promoting instrument according to claim 4, wherein: the length of the microdevice that penetrates the stratum corneum is between 1 micron and 3000 microns.
6. The nano-wafer permeation enhancer of any one of claims 1 or 2, wherein: the upper end of the shell is an operation end, and the lower end of the shell is a handle end; the operating end is provided with a groove seat, and a shaft hole and a limiting groove which are used for penetrating the push rod are formed in the groove seat.
7. The nano-wafer permeation promoting instrument according to claim 6, wherein: and a protective ring is arranged at the top of the groove seat.
8. The nano-wafer permeation enhancer of claim 1, wherein: the cantilever beam is formed of a metal plate.
9. The nano-wafer permeation promoting instrument according to claim 8, wherein: the metal plate is a steel plate.
10. The nano-wafer permeation enhancer of claim 2, wherein: the power supply assembly comprises a power supply body and a switch electrically connected with the power supply body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810162020.7A CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810162020.7A CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110193136A CN110193136A (en) | 2019-09-03 |
| CN110193136B true CN110193136B (en) | 2022-11-04 |
Family
ID=67750783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810162020.7A Active CN110193136B (en) | 2018-02-26 | 2018-02-26 | Nano-chip permeation promoting instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110193136B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN211675891U (en) * | 2019-12-02 | 2020-10-16 | 苏州纳生微电子有限公司 | Transmission mechanism and drug delivery device |
| CN110960789B (en) * | 2019-12-31 | 2023-03-03 | 苏州纳通生物纳米技术有限公司 | Automatic reversible skin pull throughs |
| CN219208697U (en) * | 2022-06-24 | 2023-06-20 | 厦门松霖科技股份有限公司 | Vibration structure of hydro-optical needle and hydro-optical instrument |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2080841U (en) * | 1990-08-18 | 1991-07-17 | 上海汇丰窗帘制造有限公司 | Minature massager |
| CN2231973Y (en) * | 1995-04-25 | 1996-07-31 | 游国耀 | Writing implement with massage device |
| CN2266517Y (en) * | 1996-09-18 | 1997-11-05 | 游国耀 | Writing implement with massaging device |
| CN2572958Y (en) * | 2002-09-30 | 2003-09-17 | 王宽渊 | Massage device with compound function |
| DE202004003430U1 (en) * | 2004-03-05 | 2005-07-21 | Wik Far East Ltd. | massage attachment |
| CN201132446Y (en) * | 2007-08-22 | 2008-10-15 | 旺生富兴业股份有限公司 | Writing pen with massaging function |
| CN204017141U (en) * | 2014-08-15 | 2014-12-17 | 赵明知 | A kind of electronic micropin beauty treatment of luminescence is short oozes instrument |
| CN104689466B (en) * | 2015-03-31 | 2018-02-16 | 苏州纳通生物纳米技术有限公司 | A kind of channel-style nanometer beauty instrument and its application method |
| CN204698059U (en) * | 2015-03-31 | 2015-10-14 | 苏州纳通生物纳米技术有限公司 | A kind of beauty instrument jockey |
| CN206355435U (en) * | 2016-08-30 | 2017-07-28 | 蒋志敏 | A kind of portable electric micropin |
| CN206660295U (en) * | 2016-10-10 | 2017-11-24 | 苏州纳通生物纳米技术有限公司 | A kind of liquid quantitative conveying device |
-
2018
- 2018-02-26 CN CN201810162020.7A patent/CN110193136B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110193136A (en) | 2019-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110193136B (en) | Nano-chip permeation promoting instrument | |
| KR101608179B1 (en) | Device for injecting drug into skin | |
| Yang et al. | Microneedle insertion force reduction using vibratory actuation | |
| AU2006286841B2 (en) | Method for producing a hole on the skin and suitable hand-held device therefor | |
| RU2465848C2 (en) | Method and apparatus for forming number of microcanals | |
| CA2792848C (en) | A built-in non-verbal instructional device integratable to applicators | |
| EP3096832B1 (en) | Shear-induced dermal infusion | |
| WO2004080437A1 (en) | Method of delivering substance by transdermal absorption, peeling agent to be used in delivery of substance by transdermal absorption, peeling apparatus and disposable pad for peeling apparatus | |
| US20190133634A1 (en) | Micro-Needling System | |
| CN111514451B (en) | Ultrasonic atomization-based microneedle cosmetic device | |
| CN107913460B (en) | Liquid quantitative conveying system | |
| JP4145628B2 (en) | Beauty treatment equipment | |
| CN114748778B (en) | Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device | |
| CN102988100A (en) | Low-resistance acupuncture method | |
| CN215135866U (en) | Transmission mechanism suitable for liquid feeding device and liquid feeding device | |
| CN210205599U (en) | Disposable self-destruction vibrating head component and infiltration promoting instrument using same | |
| CN109350842A (en) | Promote the idler wheel for seeping pen and its sheet metal, rush seep pen | |
| CN114733061A (en) | Microneedle patch and permeation-promoting device | |
| WO2019100903A1 (en) | Elastic micro-device assembly and penetration-enhancing instrument using same | |
| CN109833562B (en) | Disposable self-destruction type vibrating head assembly and permeation promoting instrument using same | |
| CN209548521U (en) | Promote the idler wheel for seeping pen and its sheet metal, rush seep pen | |
| CN111135451A (en) | Hand-held nano-chip massage leading-in beauty instrument | |
| CN215386996U (en) | Novel microneedle device | |
| CN212936438U (en) | A supporting structure for leading promoting appearance that oozes a little | |
| CN213131582U (en) | Micro-conduction penetration-promoting instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |