CN1101829A - Health toothpaste for lowering and stabilizing blood pressure - Google Patents
Health toothpaste for lowering and stabilizing blood pressure Download PDFInfo
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- CN1101829A CN1101829A CN 93119259 CN93119259A CN1101829A CN 1101829 A CN1101829 A CN 1101829A CN 93119259 CN93119259 CN 93119259 CN 93119259 A CN93119259 A CN 93119259A CN 1101829 A CN1101829 A CN 1101829A
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- toothpaste
- blood pressure
- lowering
- radix
- nifedipine
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Abstract
The toothpaste for lowering and stabilizing blood pressure is prepared with Chinese medicinal active components, trace calcium antagon and Nifedipine as additive and the medicinal components are absorbed through oral mucosa, capillary network under tongue and acupoint channel to obtain obvious curative effect without by-effect.
Description
The invention belongs to health care toothpaste, be specifically related to a kind of with Chinese herbal medicine active ingredient extract and micro-calcium antagonist antihypertensive drugs and the pained health toothpaste for lowering and stabilizing blood pressure that is decided to be additive.
In recent years, toothpaste production development both at home and abroad is rapid, and toothpaste variety becomes more diverse, and diversification not only has the toothpaste of numerous different flavors and taste to come out, but also many toothpaste with the odontopathy of preventing and treating and its disease of tool occurred.Though the numerous medicated toothpaste on the market also not all has the effect of satisfied disease preventing and treating, there is the medicated toothpaste of many types to obtain the effect of reasonable disease preventing and treating really.Theory and practice shows, as long as pharmaceutical formulation and dosage are proper, with brush teeth, the method for oral administration, can the through port transmucosal, Sublingual capillary network and meridian point, rapid permeability, diffusion, absorption directly enter human body, avoid gastrointestinal tract and Liver and kidney etc. that medicine is destroyed, although therefore dosage is little, effect piece, effect remarkable and nothing pair an effect and an adverse effect.Be that a kind of can the residence very easily prevented and treated auxiliary treatment means among daily life, very worth exploratory development produces the health-care toothpaste of the dissimilar diseases of more controls.
The object of the present invention is to provide and a kind ofly can effectively prevent and treat hypertensive medicinal health-care toothpaste.
The present invention adds having of an amount of preferred assembly of process and adjusts body function balance, liver heat removing pathogenic fire reducing, blood circulation promoting and blood stasis dispelling, the medicated premix of relieving constipation, lowering and stabilizing blood pressure in traditional formulation of tooth-paste, by brushing teeth, medicine in the toothpaste is dissolved in saliva, oral transmucosal, Sublingual capillary network and meridian point, rapid permeability, control is loose, is absorbed, and avoids gastrointestinal tract and the Liver and kidney destruction to medicine, directly enters human circulation, reach quick blood pressure lowering, continue the effect of voltage stabilizing.
Health toothpaste for lowering and stabilizing blood pressure of the present invention is to add the 4-8%(percetage by weight in the batching of traditional toothpaste) by Folium Apocyni Veneti.The combination drug additive that the extract of Flos Chrysanthemi, Semen Cassiae, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and bovine calculus powder, nifedipine are formed is formulated.
The medicated premix amount is too small, can affect the treatment, and excessive waste, the increase cost that not only can cause medicine of medicated premix amount also can produce the effect of paying.
The combination drug additive that medicated premix amount in the toothpaste of the present invention is formed by Chinese medicine medicines and Calculus Bovis, nifedipine assembly.According to Chinese medicine compatibility prescription principle; suitably select the Chinese herbal medicine and the dosage assembly of corresponding effect all certain curative effect can be arranged; but test shows; the combination drug additive that is formed by Folium Apocyni Veneti, Flos Chrysanthemi, Semen Cassiae, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Calculus Bovis and nifedipine assembly has curative effect preferably, and preferred compositing range (percetage by weight) is:
Folium Apocyni Veneti 30-45, Flos Chrysanthemi 5-11
Semen Cassiae 10-18 Radix Et Rhizoma Rhei 8-12
Radix Angelicae Sinensis 5-15 Radix Salviae Miltiorrhizae 10-13
Rhizoma Chuanxiong 7-14, bovine calculus powder 0.8-1.2
Nifedipine 0.004-0.008
Above-mentioned component except that Calculus Bovis, nifedipine, all is an extract, wherein Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, adopt alcohol-pickled extraction usually, generally soaked 10-24 hour, reflux 2-4 hour, filter, concentrate, dry; Folium Apocyni Veneti, Flos Chrysanthemi, Semen Cassiae, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis are then used water boiling and extraction; usually add crude drug amount 12-18 water doubly; divide and decoct for three times; 3 hours for the first time; 1 hour for the second time; 0.5 hour for the third time, merge concentrated, the dried for standby of medicinal liquid three times, nifedipine, especially Calculus Bovis must be levigate.
Each medicated premix composition adds in the batching of traditional toothpaste according to the above ratio, prepares health toothpaste for lowering and stabilizing blood pressure of the present invention by the preparation method of traditional toothpaste.
Tradition toothpaste batching generally includes abrasivus, wetting agent, surfactant, thickening agent, spice, flavoring agent, and the present invention can select the batching of tradition traditional toothpaste commonly used arbitrarily.The batching in the following compositing range (percetage by weight) is selected in recommendation for use:
Silicon dioxide 32-50 dodecyl vinic acid sodium 1.8-2.4
Sorbitol 16-34 essence 1.3-1.7
SE 6-9 glucide 0.12-0.55
Sodium alginate 1.7-2.2 water surplus
Blood pressure lowering of the present invention, the appearance of voltage stabilizing health-care toothpaste, it is single tentatively to have changed the Chinese medicine route of administration, the situation that dosage form is ancient, by popular hygienic habit teeth brushing way, take the multifrequency vice-minister means of brushing teeth at interval, make the medicine in the toothpaste dissolve in saliva, the through port transmucosal, Sublingual capillary network and meridian point, rapid permeability, diffusion, absorb, avoid the destruction to medicine such as gastrointestinal tract and Liver and kidney, directly enter human circulation, reach the effect of quick blood pressure lowering and lasting voltage stabilizing, compare with traditional oral administration mode, dosage is little, effect is fast, do not have any medicine and pay effect, and because this product does not contain any pharmaceutical compositions of sleeping peacefully, patient does not have dizziness, untoward reaction such as drowsiness grade.
Use toothpaste of the present invention not only can reduce patient's blood pressure rapidly; And patient's blood pressure drops to after the normal level, from line stabilization, no longer descends, and is better than any oral blood pressure lowering medicine.According to clinical observation over one year, 198 routine patients (wherein male 109 people, women 89 people; Age 32-74 year, average 56.3 years old, hypertension history 1-38, average 17.58), using after three days, effective percentage reaches 98%, and produce effects is more than 85%.
Embodiment one
Medicated premix 5% silicon dioxide 39.8%
Sorbitol 23.5% SE 6%
Sodium alginate 1.5% sodium lauryl sulphate 1.8%
Essence 1.35% glucide 0.15%
Water surplus
Wherein, the composition of medicated premix (percetage by weight) is:
Folium Apocyni Veneti 37, Flos Chrysanthemi 8.2. Semen Cassiae 14.2
Radix Et Rhizoma Rhei 9.5, Radix Angelicae Sinensis 9.7 Radix Salviae Miltiorrhizaes 11.8
Rhizoma Chuanxiong 8.5, bovine calculus powder 1.1, nifedipine 0.005
Above-mentioned batching is pressed traditional method through mixing, stirring, glue, and grinding emulsifying, the degassing, fill form toothpaste.
Mean value of blood pressure is 28.42 ± 2.12/15.69 ± 2.41KPa(213.2 ± 15.9/117.7 ± 18.1mmHg) before brushing teeth, use this toothpaste about 30 minutes of back of brushing teeth, mean value of blood pressure is reduced to 23.14 ± 2.41/12.45 ± 2.69KPa(170.5 ± 18.1/98.4 ± 20.2mmHg)
Embodiment two
Medicated premix 6% silicon dioxide 44.5%
Sorbitol 17.2% SE 7.5%
Sodium alginate 2.0% sodium lauryl sulphate 2.0%
Essence 1.5% glucide 0.4%
Water surplus
Wherein, the composition of medicated premix (percetage by weight) is:
Folium Apocyni Veneti 30.6, Flos Chrysanthemi 5.4 Semen Cassiaes 17.3
Radix Et Rhizoma Rhei 8.3% Radix Angelicae Sinensis 13.5 Radix Salviae Miltiorrhizaes 10.5
Rhizoma Chuanxiong 13.5 bovine calculus powders 0.85 nifedipine 0.007
The toothpaste that above-mentioned batching is made is used for clinical trial, and the result is as follows, use this toothpaste to brush teeth 30 minutes after, mean value of blood pressure is reduced to 15.7 ± 2.02KPa(117.8 ± 15.2mmHg) from 19.88 ± 1.94KPa(146.7 ± 15.2mmHg).
Embodiment three
Medicated premix 7% silicon dioxide 32.2
Sorbitol 31.5% SE 8.5
Sodium alginate 1.8 sodium lauryl sulphates 2.2
Essence 1.6 glucide 0.25
Water surplus
Wherein the composition of medicated premix (percetage by weight) is:
Folium Apocyni Veneti 40.5 Flos Chrysanthemis 10.4 Semen Cassiaes 10.5
Radix Et Rhizoma Rhei 10.7 Radix Angelicae Sinensis 5.3 Radix Salviae Miltiorrhizaes 12.1
Rhizoma Chuanxiong 9.5 bovine calculus powders 0.98 nifedipine 0.006
Clinical trial shows, after using this toothpaste to brush teeth about 30 minutes, mean value of blood pressure is reduced to 20.5 ± 1.96/11.5 ± 2.01KPa(154.3 ± 12.8/86.4 ± 8.7mmHg) from 24.8 ± 2.51/14.1 ± 2.3KPa(186.2 ± 13.6/105.1 ± 10.2mmHg).
Learn by statistics and handle, use before and after the medicated toothpaste of the present invention, the mean arterial pressure value changes difference highly significant (P＜0.01)
Claims (3)
1, a kind of health toothpaste for lowering and stabilizing blood pressure that includes traditional toothpaste basis is characterised in that the medicated premix that the extract by Folium Apocyni Veneti, Flos Chrysanthemi, Semen Cassiae, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, bovine calculus powder and the nifedipine that contain in addition 4--8% (percetage by weight) again formed.
2, health toothpaste for lowering and stabilizing blood pressure as claimed in claim 1 is characterized in that the compositing range (percetage by weight) of described medicated premix is:
Folium Apocyni Veneti 30-45
Flos Chrysanthemi 5-11
Semen Cassiae 10-18
Radix Et Rhizoma Rhei 8-12
Radix Angelicae Sinensis 5-15
Radix Salviae Miltiorrhizae 10-13
Rhizoma Chuanxiong 7-14
Bovine calculus powder 0.8-1.2
Nifedipine 0.004-0.008
Above-mentioned component except that Calculus Bovis, nifedipine, all is an extract.
3,, it is characterized in that the basic composition scope (percetage by weight) of described traditional toothpaste is as claim 1 or 2 said health toothpaste for lowering and stabilizing blood pressure:
Silicon dioxide 32-50
Sorbitol 16-34
SE 6-9
Sodium alginate 1.7-2.2
Sodium lauryl sulphate 1.8-2.4
Essence 1.3-1.7
Glucide 0.12-0.55
Water surplus
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93119259 CN1101829A (en) | 1993-10-20 | 1993-10-20 | Health toothpaste for lowering and stabilizing blood pressure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93119259 CN1101829A (en) | 1993-10-20 | 1993-10-20 | Health toothpaste for lowering and stabilizing blood pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1101829A true CN1101829A (en) | 1995-04-26 |
Family
ID=4992835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93119259 Pending CN1101829A (en) | 1993-10-20 | 1993-10-20 | Health toothpaste for lowering and stabilizing blood pressure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1101829A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074268C (en) * | 1999-05-21 | 2001-11-07 | 黄映珠 | Series products containing extracts of apocynum venetum and preparing method thereof |
| CN105816391A (en) * | 2016-05-16 | 2016-08-03 | 哈尔滨康鸿生物科技有限公司 | Healthcare toothpaste for reducing pressure and protecting heart |
| CN110251597A (en) * | 2019-07-18 | 2019-09-20 | 中国人民解放军第四军医大学 | A kind of pharmaceutical composition for treating hypertension |
| CN113924076A (en) * | 2019-06-06 | 2022-01-11 | 联合利华知识产权控股有限公司 | Use of oral care compositions |
-
1993
- 1993-10-20 CN CN 93119259 patent/CN1101829A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074268C (en) * | 1999-05-21 | 2001-11-07 | 黄映珠 | Series products containing extracts of apocynum venetum and preparing method thereof |
| CN105816391A (en) * | 2016-05-16 | 2016-08-03 | 哈尔滨康鸿生物科技有限公司 | Healthcare toothpaste for reducing pressure and protecting heart |
| CN113924076A (en) * | 2019-06-06 | 2022-01-11 | 联合利华知识产权控股有限公司 | Use of oral care compositions |
| CN110251597A (en) * | 2019-07-18 | 2019-09-20 | 中国人民解放军第四军医大学 | A kind of pharmaceutical composition for treating hypertension |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |