CN110151862A - A kind of Chinese medicine composition and preparation method thereof with alleviation asthenopia prevention and treatment myopia - Google Patents

A kind of Chinese medicine composition and preparation method thereof with alleviation asthenopia prevention and treatment myopia Download PDF

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CN110151862A
CN110151862A CN201910478402.5A CN201910478402A CN110151862A CN 110151862 A CN110151862 A CN 110151862A CN 201910478402 A CN201910478402 A CN 201910478402A CN 110151862 A CN110151862 A CN 110151862A
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radix
chinese medicine
seed
medicine composition
myopia
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叶松宽
周冬焦
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Hangzhou Loose Biological Technology Co Ltd
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Hangzhou Loose Biological Technology Co Ltd
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Abstract

The present invention relates to a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, the Chinese medicine material including following parts by weight: cortex moutan 10-12, pearl powder 3-5, seed of feather cockscomb 8-12, Semen Leonuri 8-12, cassia seed 8-12, Semen Cuscutae 8-12, fructus lycii 8-12, (water mentions) borneol 3-5, Radix Salviae Miltiorrhizae 8-15, Rhizoma Chuanxiong 8-13, radix paeoniae rubra 5-10, peach kernel 7-13, Schisandra chinensis 8-12, radix bupleuri 10-15, dried immature fruit of citron orange 7-12, radix aucklandiae 6-10, Radix Angelicae Sinensis 8-12, scouring rush 5-9, loyal sub- 8-15, Eclipta prostrata 8-15, herba taxilli 8-14.

Description

A kind of Chinese medicine composition and preparation method thereof with alleviation asthenopia prevention and treatment myopia
Technical field
The present invention relates to a kind of Chinese medicine composition more particularly to a kind of Chinese traditional medicine compositions with alleviation asthenopia prevention and treatment myopia Object and preparation method thereof.
Background technique
It is referred to as near-sighted before parallel rays focuses on retina after eye refraction system in the state that adjusting is loosened. Because this eye, which can only be seen, cannot closely see far, during the break, the directional light come from unlimited distance passes through the dioptric system of eye to this eye After refractive power, focus is assembled before retina, then form on the retina it is unclear as, distant vision is substantially reduced, but Near vision is still normal.Myopia has been recognized certain genetic predisposition, even more so to high myopia.But to general myopia, This tendency is not just apparent.There is inherent cause person, the illness age is more early, and degree is mostly at 600 degree or more.But also there is high myopia Eye person, no family history.High myopic eye category autosomal recessive inheritance, general myopia category multifactorial inheritance disease.There are also one Point myopia belongs to caused by developmental factors, and baby is long sight, but with advancing age because eyeball is smaller, and axis oculi is also gradually It lengthens, until rear development in 6 years old is normal.Such as overdevelopment, then myopia is formed, such myopia is known as simple myopia, mostly at school age Phase is generally lower than 600 degree.Stopped development to 20 years old or so.If made much progress in petticoats, until 15~20 years old Shi Jinzhan More rapidly, slow down later, this kind of myopia is often higher than 600 degree, can be to 2000~2500 or 3000 degree.This myopia is known as height Myopia or progressive myopia or pathological myopia.Retrogression can occur to old age for such myopia, therefore eyesight can fade, It cannot correct defects of vision with mirror.But have only a few be it is geneogenous, just have myopia at birth.
Currently, the technology of prevention and treatment myopia, instrument, drug etc. are varied, respectively there are advantage and disadvantage, but except wearing Outside spectacles, other are received few by numerous A nearsighted persons.The drug of some treatment myopia, these drugs are being controlled at present It is unobvious in therapeutic effect, and there are also side effects.Although improving eyesight can be played by playing the role of a lot of health care products currently on the market, to controlling Myopia is treated without any effect.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia And preparation method thereof.
In order to solve the above technical problems, the technical scheme is that
A kind of Chinese medicine composition with alleviation asthenopia prevention and treatment myopia, which is characterized in that including in following parts by weight Medicine raw material:
Cortex moutan 10-12, pearl powder 3-5, seed of feather cockscomb 8-12,
Semen Leonuri 8-12, cassia seed 8-12, Semen Cuscutae 8-12,
Fructus lycii 8-12, (water mentions) borneol 3-5, Radix Salviae Miltiorrhizae 8-15,
Rhizoma Chuanxiong 8-13, radix paeoniae rubra 5-10, peach kernel 7-13, Schisandra chinensis 8-12,
Radix bupleuri 10-15, dried immature fruit of citron orange 7-12, radix aucklandiae 6-10, Radix Angelicae Sinensis 8-12,
Scouring rush 5-9, loyal sub- 8-15, Eclipta prostrata 8-15, herba taxilli 8-14.
As a preferred technical solution, include the Chinese medicine material of following parts by weight:
Cortex moutan 10, pearl powder 3, the seed of feather cockscomb 8,
Semen Leonuri 8, cassia seed 8, Semen Cuscutae 8,
Fructus lycii 8, (water mentions) borneol 3, Radix Salviae Miltiorrhizae 8,
Rhizoma Chuanxiong 8, radix paeoniae rubra 5, peach kernel 7, Schisandra chinensis 8,
Radix bupleuri 10, the dried immature fruit of citron orange 7, radix aucklandiae 6, Radix Angelicae Sinensis 8,
Scouring rush 5, loyal sub 8, Eclipta prostrata 8, herba taxilli 8.
As a preferred technical solution, include the Chinese medicine material of following parts by weight:
Cortex moutan 12, pearl powder 5, the seed of feather cockscomb 12,
Semen Leonuri 12, cassia seed 12, Semen Cuscutae 12,
Fructus lycii 12, (water mentions) borneol 5, Radix Salviae Miltiorrhizae 15,
Rhizoma Chuanxiong 13, radix paeoniae rubra 10, peach kernel 13, Schisandra chinensis 12,
Radix bupleuri 15, the dried immature fruit of citron orange 12, radix aucklandiae 10, Radix Angelicae Sinensis 12,
Scouring rush 9, loyal sub 15, Eclipta prostrata 15, herba taxilli 14.
As a preferred technical solution, include the Chinese medicine material of following parts by weight:
Cortex moutan 11, pearl powder 4, the seed of feather cockscomb 10,
Semen Leonuri 10, cassia seed 10, Semen Cuscutae 10,
Fructus lycii 10, (water mentions) borneol 4, Radix Salviae Miltiorrhizae 11.5,
Rhizoma Chuanxiong 10.5, radix paeoniae rubra 7.5, peach kernel 10, Schisandra chinensis 10,
Radix bupleuri 12.5, the dried immature fruit of citron orange 9.5, radix aucklandiae 8, Radix Angelicae Sinensis 10,
Scouring rush 7, loyal sub 11.5, Eclipta prostrata 11.5, herba taxilli 11.
A kind of method prepared with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia as a preferred technical solution, Comprising steps of
1) each component is weighed by formula；
2) by cortex moutan, pearl powder, Semen Leonuri, cassia seed, Semen Cuscutae, fructus lycii, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix paeoniae rubra, peach kernel, five Taste, radix bupleuri, the dried immature fruit of citron orange, scouring rush, loyal son, herba taxilli mixing are smashed, and are put into steamer and are steamed 10-15 minutes；
3) radix aucklandiae, the seed of feather cockscomb, Eclipta prostrata, Radix Angelicae Sinensis are mixed and is put into steamer after smashing, the composition in steamer is cooked simultaneously It is cooling；
4) after impregnating dry composition 4-8 hours with alcohol, the dregs of a decoction is filtered off and obtain filtrate, (water mentions) ice is added The filtrate decompression is evaporated by piece, obtains paste plant extracts.
The leavening is red yeast rice as a preferred technical solution, and red yeast rice additive amount is the weight of the composition of the cooling 1/4 to the 1/3 of amount, fermentation temperature are 36-39 degree.
The evaporated under reduced pressure condition is negative pressure 0.08pa, temperature 55-60 degree as a preferred technical solution,.
As a preferred technical solution, further include:
5) 4) one or more of lotion, essential oil, oral agents are made in the paste plant extracts in.
Beneficial effects of the present invention:
In above-mentioned Chinese medicine composition, cortex moutan has effects that clearing heat and cooling blood activating microcirculation and removing stasis medicinal；
Pearl powder has effects that clear liver and improve vision；
The seed of feather cockscomb has effects that treat the hot hot eyes of liver, screen of looking unfamiliar film, blurring of vision, hepatopyretic vertigo；
Semen Leonuri has effects that promoting blood circulation for regulating menstruation, clears liver and improve vision；
Cassia seed has effects that clear liver and improve vision, and is mainly used for the puckery pain of hot eyes, the more tears of photophobia, headache and dizziness, and mesh is secretly unknown；
Semen Cuscutae has effects that improving eyesight；
Fructus lycii has effects that antifatigue, raising eyesight；
The effect of (water mentions) borneol has treatment red eye, swell pain, and eye droppings is applied alone to imitate；
Radix Salviae Miltiorrhizae has effects that promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle；
Rhizoma Chuanxiong has effects that blood-activating and qi-promoting, treatment headache vertigo and head dark；
Radix paeoniae rubra has effects that clearing heat and cooling blood, removing blood stasis and acesodyne；
Peach kernel has effects that promoting blood circulation；
Schisandra chinensis has astringency inducing, nourishing generate fluid, kidney calming；
Radix bupleuri have effects that and inducing diaphoresis in, soothing liver-qi stagnation, yang invigorating；
The dried immature fruit of citron orange has effects that relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass；
Radix aucklandiae has effects that promoting qi circulation and relieving pain, promoting in tune；
Radix Angelicae Sinensis, which has, enriches blood, invigorates blood circulation, menstruction regulating and pain relieving, moisturizing sliding effect；
Scouring rush has effects that dissipating wind-heat, moves back mesh screen, for wind-heat hot eyes, tearing against wind, the raw cloudiness of mesh；
The fruit of glossy privet has effects that improving eyesight；
Eclipta prostrata has nourishing liver and kidney effect, for treating the deficiency of liver-yin and kidney-yin, dizziness and tinnitus；
Herba taxilli has effects that nourishing liver and kidney, degrading the channel, beneficial blood.
By adopting the above-described technical solution, a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia and its preparation Method alleviates asthenopia, repairing retina, dissipates the thin arteries and veins of the stasis of blood, invigorates blood circulation and relax it is an advantage of the current invention that the present composition has Muscle, sensible improving eyesight, active cell, prevents the effect of dry eyes and astringent eyes at moistening for dryness and clearing away heat, can to prevention and treatment adolescent myopia significant effect Significantly to reduce myopia degree.The present invention uses advanced preparation process, and pharmaceutical compositions is made to keep high bioactivity, and nothing Pollution, effective component extraction is more completely, content is higher, stability is more preferable, and this method purifies extract, curative effect simultaneous interpretation Technics comparing unite there has also been significantly improving, is also greatly reduced production cost；The improved technique of the present invention also added in right amount Crospovidone and sodium carboxymethyl starch, adding made tablet after auxiliary material, not only disintegration time is short, and stability is good, dissolution Spend the advantages that higher.
Application of the continuous someone's studying enzyme in traditional Chinese medicine extraction in recent years, and achieve good results.The present invention adopts The advanced technology is optimized and improves to traditional decoction technique according to the property feature of raw material pharmaceutically active ingredient.For enzyme Lot of experiments has been done in the selection of type and dosage.Finally obtain tablet made from above-mentioned preparation method and the method.This method Extract is purified, in the case where reducing a large amount of impurity, obtained extract (medicinal extract) is improved than conventional method Significantly, and effective component also more former traditional handicraft is stablized, curative effect is more also significantly increased with traditional handicraft, also substantially reduces Production cost.
Specific embodiment
A kind of Chinese medicine composition with alleviation asthenopia prevention and treatment myopia, the Chinese medicine material including following parts by weight:
Cortex moutan 10-12, pearl powder 3-5, seed of feather cockscomb 8-12,
Semen Leonuri 8-12, cassia seed 8-12, Semen Cuscutae 8-12,
Fructus lycii 8-12, (water mentions) borneol 3-5, Radix Salviae Miltiorrhizae 8-15,
Rhizoma Chuanxiong 8-13, radix paeoniae rubra 5-10, peach kernel 7-13, Schisandra chinensis 8-12,
Radix bupleuri 10-15, dried immature fruit of citron orange 7-12, radix aucklandiae 6-10, Radix Angelicae Sinensis 8-12,
Scouring rush 5-9, loyal sub- 8-15, Eclipta prostrata 8-15, herba taxilli 8-14.
That states has the method for the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, which is characterized in that comprising steps of
1) each component is weighed by formula；
2) by cortex moutan, pearl powder, Semen Leonuri, cassia seed, Semen Cuscutae, fructus lycii 8, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix paeoniae rubra, peach kernel, five Taste, radix bupleuri, the dried immature fruit of citron orange, scouring rush, loyal son, herba taxilli mixing are smashed, and are put into steamer and are steamed 10-15 minutes；
3) radix aucklandiae, the seed of feather cockscomb, Eclipta prostrata, Radix Angelicae Sinensis are mixed and is put into steamer after smashing, the composition in steamer is cooked simultaneously It is cooling；
4) after impregnating dry composition 4-8 hours with alcohol, the dregs of a decoction is filtered off and obtain filtrate, (water mentions) ice is added The filtrate decompression is evaporated by piece, obtains paste plant extracts.
The leavening is red yeast rice, and red yeast rice additive amount is 1/4 to the 1/3 of the weight of the composition of the cooling, fermentation temperature Degree is 36-39 degree.
The evaporated under reduced pressure condition is negative pressure 0.08pa, temperature 55-60 degree.
A kind of preparation method with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, further includes:
5) by the paste plant extracts in 4) according to common process be added customary adjuvant be made clinical receiving capsule, One of tablet, granule, pill, oral solution, eye drops, eye sticker agent, Eye ointments or eye lotion are a variety of.
Embodiment one:
A kind of Chinese medicine composition with alleviation asthenopia prevention and treatment myopia, the Chinese medicine material including following parts by weight:
Cortex moutan 10, pearl powder 3, the seed of feather cockscomb 8,
Semen Leonuri 8, cassia seed 8, Semen Cuscutae 8,
Fructus lycii 8, (water mentions) borneol 3, Radix Salviae Miltiorrhizae 8,
Rhizoma Chuanxiong 8, radix paeoniae rubra 5, peach kernel 7, Schisandra chinensis 8,
Radix bupleuri 10, the dried immature fruit of citron orange 7, radix aucklandiae 6, Radix Angelicae Sinensis 8,
Scouring rush 5, loyal sub 8, Eclipta prostrata 8, herba taxilli 8.
Embodiment two:
A kind of Chinese medicine composition with alleviation asthenopia prevention and treatment myopia, the Chinese medicine material including following parts by weight:
Cortex moutan 12, pearl powder 5, the seed of feather cockscomb 12,
Semen Leonuri 12, cassia seed 12, Semen Cuscutae 12,
Fructus lycii 12, (water mentions) borneol 5, Radix Salviae Miltiorrhizae 15,
Rhizoma Chuanxiong 13, radix paeoniae rubra 10, peach kernel 13, Schisandra chinensis 12,
Radix bupleuri 15, the dried immature fruit of citron orange 12, radix aucklandiae 10, Radix Angelicae Sinensis 12,
Scouring rush 9, loyal sub 15, Eclipta prostrata 15, herba taxilli 14.
Embodiment three:
A kind of Chinese medicine composition with alleviation asthenopia prevention and treatment myopia, the Chinese medicine material including following parts by weight:
Cortex moutan 11, pearl powder 4, the seed of feather cockscomb 10,
Semen Leonuri 10, cassia seed 10, Semen Cuscutae 10,
Fructus lycii 10, (water mentions) borneol 4, Radix Salviae Miltiorrhizae 11.5,
Rhizoma Chuanxiong 10.5, radix paeoniae rubra 7.5, peach kernel 10, Schisandra chinensis 10,
Radix bupleuri 12.5, the dried immature fruit of citron orange 9.5, radix aucklandiae 8, Radix Angelicae Sinensis 10,
Scouring rush 7, loyal sub 11.5, Eclipta prostrata 11.5, herba taxilli 11.
Experimental animal
Rat (SHR) 140 is selected, female, male fifty-fifty, weight 200-220g is provided by Guangdong Medical Lab Animal Center.
Modeling method
By 140 rat feedings in several same sizes, lighttight chest, identical fluorescent lamp, journey are hung in case top-hung Sequence controls the illuminance and lighting method of lamp, and using flashing optical illumination, flashing mode is to recycle for bright 2 seconds, dark 2 seconds, uses illumination photometer The illuminance for measuring bottom, by illuminance control in about 200 lumens, illumination is raised 6 weeks altogether, measures the eye refractive diopter of rat, The results show that 140 big rathole refractive diopter is remarkably decreased, show as obvious myopia, prompt myopia model modeling at Function.
Test method
Test grouping
By 140 after modeling, 7 groups are randomly divided into, every group each 20 groups, i.e. embodiment 1- embodiment 6 and blank group.
Medication
Blank group gives the physiological saline of corresponding amount.6 groups of 1-embodiment of other embodiments are given corresponding drug respectively (being administered according to 300mg/kg), daily morning and evening gastric infusion is primary, and treatment continues 30 days.
Test result
Observation index: eye diopter measurement value (takes the big rathole diopter measurement average value of each group).
Measurement record the time: before first administration, administration after 15 days and administration after 30 days.
Experimental result: being administered in terms of the eye diopter measurement result of front and back from each test group animal, compared with before administration, removes blank Outside group eye dioptric optical value further decreases, remaining each group eye dioptric optical value has different degrees of raising, prompts each group rat
Myopic degree is mitigated, and wherein the dioptric optical value of embodiment 3 increases the most significant, is secondly 1 He of embodiment The dioptric optical value of embodiment 2 increases unobvious.Embodiment 3 and other embodiments 1, embodiment 2 compare that there were significant differences.Therefore former Expect that medicine matches preferred embodiment 3, it is desirable that this, which illustrates that beneficial effect can be reached not being arbitrary proportion between each bulk pharmaceutical chemicals, Specific proportion and synergistic effect can be only achieved significant effect.
The above shows and describes the basic principle, main features and advantages of the invention.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims (8)

1. a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, which is characterized in that the Chinese medicine including following parts by weight Raw material:
Cortex moutan 10-12, pearl powder 3-5, seed of feather cockscomb 8-12,
Semen Leonuri 8-12, cassia seed 8-12, Semen Cuscutae 8-12,
Fructus lycii 8-12, (water mentions) borneol 3-5, Radix Salviae Miltiorrhizae 8-15,
Rhizoma Chuanxiong 8-13, radix paeoniae rubra 5-10, peach kernel 7-13, Schisandra chinensis 8-12,
Radix bupleuri 10-15, dried immature fruit of citron orange 7-12, radix aucklandiae 6-10, Radix Angelicae Sinensis 8-12,
Scouring rush 5-9, loyal sub- 8-15, Eclipta prostrata 8-15, herba taxilli 8-14.
2. as described in claim 1 a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, which is characterized in that including The Chinese medicine material of following parts by weight:
Cortex moutan 10, pearl powder 3, the seed of feather cockscomb 8,
Semen Leonuri 8, cassia seed 8, Semen Cuscutae 8,
Fructus lycii 8, (water mentions) borneol 3, Radix Salviae Miltiorrhizae 8,
Rhizoma Chuanxiong 8, radix paeoniae rubra 5, peach kernel 7, Schisandra chinensis 8,
Radix bupleuri 10, the dried immature fruit of citron orange 7, radix aucklandiae 6, Radix Angelicae Sinensis 8,
Scouring rush 5, loyal sub 8, Eclipta prostrata 8, herba taxilli 8.
3. as described in claim 1 a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, which is characterized in that including The Chinese medicine material of following parts by weight:
Cortex moutan 12, pearl powder 5, the seed of feather cockscomb 12,
Semen Leonuri 12, cassia seed 12, Semen Cuscutae 12,
Fructus lycii 12, (water mentions) borneol 5, Radix Salviae Miltiorrhizae 15,
Rhizoma Chuanxiong 13, radix paeoniae rubra 10, peach kernel 13, Schisandra chinensis 12,
Radix bupleuri 15, the dried immature fruit of citron orange 12, radix aucklandiae 10, Radix Angelicae Sinensis 12,
Scouring rush 9, loyal sub 15, Eclipta prostrata 15, herba taxilli 14.
4. as described in claim 1 a kind of with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, which is characterized in that including The Chinese medicine material of following parts by weight:
Cortex moutan 11, pearl powder 4, the seed of feather cockscomb 10,
Semen Leonuri 10, cassia seed 10, Semen Cuscutae 10,
Fructus lycii 10, (water mentions) borneol 4, Radix Salviae Miltiorrhizae 11.5,
Rhizoma Chuanxiong 10.5, radix paeoniae rubra 7.5, peach kernel 10, Schisandra chinensis 10,
Radix bupleuri 12.5, the dried immature fruit of citron orange 9.5, radix aucklandiae 8, Radix Angelicae Sinensis 10,
Scouring rush 7, loyal sub 11.5, Eclipta prostrata 11.5, herba taxilli 11.
5. a kind of prepare the method described in 1 to 4 any claim with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, Characterized in that it comprises the following steps:
1) each component is weighed by formula；
2) by cortex moutan, pearl powder, Semen Leonuri, cassia seed, Semen Cuscutae, fructus lycii 8, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix paeoniae rubra, peach kernel, the five tastes Son, radix bupleuri, the dried immature fruit of citron orange, scouring rush, loyal son, herba taxilli mixing are smashed, and are put into steamer and are steamed 10-15 minutes；
3) radix aucklandiae, the seed of feather cockscomb, Eclipta prostrata, Radix Angelicae Sinensis are mixed and is put into steamer after smashing, the composition in steamer is cooked and cooled down；
4) after impregnating dry composition 4-8 hours with alcohol, the dregs of a decoction is filtered off and obtain filtrate, (water mentions) borneol is added, it will The filtrate decompression is evaporated, and obtains paste plant extracts.
6. the method that preparation as claimed in claim 5 has the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia, feature exist In: the leavening is red yeast rice, and red yeast rice additive amount is 1/4 to the 1/3 of the weight of the composition of the cooling, and fermentation temperature is 36-39 degree.
7. the preparation method of the plant extracts for the treatment of hemorrhoid as claimed in claim 5, which is characterized in that the evaporated under reduced pressure Condition is negative pressure 0.08pa, temperature 55-60 degree.
8. a kind of preparation method with the Chinese medicine composition for alleviating asthenopia prevention and treatment myopia as claimed in claim 5, special Sign is, further includes:
5) 4) capsule, the piece that clinical receiving is made in customary adjuvant is added according to common process in the paste plant extracts in One of agent, granule, pill, oral solution, eye drops, eye sticker agent, Eye ointments or eye lotion are a variety of.
CN201910478402.5A 2019-06-03 2019-06-03 A kind of Chinese medicine composition and preparation method thereof with alleviation asthenopia prevention and treatment myopia Withdrawn CN110151862A (en)

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