CN110143900B - 使用sirt2调节剂的治疗方法 - Google Patents

使用sirt2调节剂的治疗方法 Download PDF

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Publication number
CN110143900B
CN110143900B CN201910002021.XA CN201910002021A CN110143900B CN 110143900 B CN110143900 B CN 110143900B CN 201910002021 A CN201910002021 A CN 201910002021A CN 110143900 B CN110143900 B CN 110143900B
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China
Prior art keywords
sirt2
group
compound
sirt
carbon
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Expired - Fee Related
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CN201910002021.XA
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English (en)
Chinese (zh)
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CN110143900A (zh
Inventor
林合宁
何彬
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Cornell University
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Cornell University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201910002021.XA 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法 Expired - Fee Related CN110143900B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161544452P 2011-10-07 2011-10-07
US61/544,452 2011-10-07
CN201280059788.2A CN103974934B (zh) 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法

Related Parent Applications (1)

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CN201280059788.2A Division CN103974934B (zh) 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法

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CN110143900A CN110143900A (zh) 2019-08-20
CN110143900B true CN110143900B (zh) 2021-08-03

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910002021.XA Expired - Fee Related CN110143900B (zh) 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法
CN201280059788.2A Expired - Fee Related CN103974934B (zh) 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法

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CN201280059788.2A Expired - Fee Related CN103974934B (zh) 2011-10-07 2012-10-05 使用sirt2调节剂的治疗方法

Country Status (6)

Country Link
US (2) US9359293B2 (cg-RX-API-DMAC7.html)
EP (1) EP2763962B1 (cg-RX-API-DMAC7.html)
CN (2) CN110143900B (cg-RX-API-DMAC7.html)
ES (1) ES2773266T3 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN03077A (cg-RX-API-DMAC7.html)
WO (1) WO2013052727A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110143900B (zh) * 2011-10-07 2021-08-03 康奈尔大学 使用sirt2调节剂的治疗方法
WO2014149196A1 (en) * 2013-03-22 2014-09-25 University Of Florida Research Foundation, Inc. Polymer nanocomposites for early diagnosis of diseases
WO2014197775A1 (en) * 2013-06-06 2014-12-11 Cornell University Thiourea compounds and their use as inhibitors of sirt2 or sirt5
JP2020506707A (ja) * 2017-02-03 2020-03-05 ザ マクリーン ホスピタル コーポレーション 細胞の運命を操作するための方法
CN110551048B (zh) * 2018-06-04 2021-08-10 中国科学院上海药物研究所 一类sirt2抑制剂、其制备方法及用途
US12161639B2 (en) 2018-07-17 2024-12-10 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating PACS1 and PACS2 syndromes
CN114315670B (zh) * 2022-01-19 2024-03-29 贵州医科大学 一种sirt2/hdac6双靶标抑制剂及其应用
CN116178340B (zh) * 2023-04-28 2023-08-18 细胞生态海河实验室 一种protac化合物、制备方法及药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063008A1 (de) 2000-12-16 2002-06-20 Merck Patent Gmbh Carbonsäureamidderivate
CN1898227A (zh) * 2003-12-22 2007-01-17 安斯泰来制药有限公司 作为前列腺素e2激动剂或拮抗剂的鸟氨酸衍生物
EP1910279A2 (en) * 2005-06-24 2008-04-16 Migenix Inc. Non-nucleoside anti-hepacivirus agents and uses thereof
US20080171783A1 (en) * 2006-12-28 2008-07-17 Migenix Inc. Compositions and methods for treating hyperproliferative disease
CN110143900B (zh) * 2011-10-07 2021-08-03 康奈尔大学 使用sirt2调节剂的治疗方法

Also Published As

Publication number Publication date
EP2763962A1 (en) 2014-08-13
US9359293B2 (en) 2016-06-07
ES2773266T3 (es) 2020-07-10
EP2763962B1 (en) 2019-12-04
WO2013052727A1 (en) 2013-04-11
US9572789B2 (en) 2017-02-21
US20140249216A1 (en) 2014-09-04
CN103974934B (zh) 2019-07-23
CN103974934A (zh) 2014-08-06
US20160279091A1 (en) 2016-09-29
IN2014DN03077A (cg-RX-API-DMAC7.html) 2015-05-15
CN110143900A (zh) 2019-08-20
EP2763962A4 (en) 2015-08-19

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Granted publication date: 20210803