CN110141626A - A kind of patch and preparation method thereof for treating mammary gland disease - Google Patents
A kind of patch and preparation method thereof for treating mammary gland disease Download PDFInfo
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- CN110141626A CN110141626A CN201910606066.8A CN201910606066A CN110141626A CN 110141626 A CN110141626 A CN 110141626A CN 201910606066 A CN201910606066 A CN 201910606066A CN 110141626 A CN110141626 A CN 110141626A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A61K36/8888—Pinellia
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Abstract
The invention discloses a kind of patch and preparation method thereof for treating mammary gland disease, the raw material including following parts by weight: ox seed, Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Myrrha, lactogenesis is fragrant, Radix Aconiti, asafoetide, camphor, borneol, Moschus.Borneol, camphor, Moschus are added ethyl alcohol and rush sepage are made;Remaining pulverizing medicinal materials, is extracted with ethyl alcohol, and medicinal extract is made and is coated in patch, is sprayed and is promoted sepage to get finished product.Drug of the invention is produced using pure Chinese medicine, there is no any additive, drug ingedient used in formula has good therapeutic effect, and is free from side effects between drug, production method is simple, at low cost, therapeutic effect easy to use is good, drug primary treatment mammary gland disease of the invention, warming meridians and promoting circulation of qi, blood-activating and qi-promoting, eliminating dampness, mass dissipating and swelling eliminating have effects that the row stasis of blood, analgesic, cool blood, detumescence.
Description
Technical field
The present invention relates to a kind of patches and preparation method thereof for treating mammary gland disease.
Background technique
Breast disease is common clinical, frequently-occurring disease, is occupied the majority with female patient, and there are about 25% or more women according to statistics
Patient has different degrees of mammary gland disease.In mammary gland disease, cystic hyperplasia of mammary gland, mazoitis and breast cancer account for 70% or more,
Age of onset is more common in 25-50 years old age group, and the course of disease is different in size, the short then several months, the long then several years, shows as breast periodicity
Pain and breast lump seriously affect women physical and mental health, influence work and life.
Treatment mastosis method has the treatment methods such as hormone therapy, operation and traditional Chinese medicine for oral administration at present.Wherein operative treatment compared with
Common, although curative for effect, it is expensive, and postoperative patient physical recovery is slower, is not easy to be received by many patients.It is for oral administration to swash
Extract for treating method, side effect is larger, easy to recur, cannot eradicate pathogeny, and somewhat expensive, not frequently with.Therefore it is badly in need of a kind for the treatment of
The good drug of mammary gland disease effect.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the above technological deficiency, provide a kind of patch for treating mammary gland disease and
Its production method.
In order to achieve the above object of the invention, the technical solution adopted by the present invention are as follows: a kind of patch for treating mammary gland disease, packet
Include the raw material of following parts by weight: 4000 parts of ox seed, 4000 parts of Rhizoma Chuanxiong, 3000 parts of radix paeoniae rubra, 3000 parts of the root of Dahurain angelica, cortex cinnamomi 2000, dragon's blood
2000 parts, 2000 parts of safflower, 1000 parts of bombyx batryticatus, 1000 parts of pangolin, 1000 parts of semen momordicae, 20 parts of unprocessed Radix Aconiti Lateralis, 20 parts of Radix Aconiti Kusnezoffii,
20 parts of dried pinellia, 20 parts of arisacma consanguineum schott, 50 parts of Myrrha, lactogenesis is 50 parts fragrant, and 20 parts of Radix Aconiti, 30 parts of asafoetide, 50 parts of camphor, borneol
50 parts, 50 parts of Moschus.
A kind of patch production method for treating mammary gland disease, comprises the following steps that,
A. bulk pharmaceutical chemicals ox seed is weighed, is impregnated 3-4 hours with clean water, cleans and takes out, dry spare;
B. bulk pharmaceutical chemicals unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Radix Aconiti are weighed, toxic removing is processed;
C. weigh bulk pharmaceutical chemicals Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, Myrrha,
Lactogenesis perfume, asafoetide, are crushed after mixing;
D. bulk pharmaceutical chemicals obtained in step a, b, c mix, molten with the 8-9 times of 70-72% ethyl alcohol measured of weight after its mixing
Liquid refluxing extraction 2 times, 2.5 hours for the first time, second 1.5 hours, finally merge ethanol solution;
E. ethanol solution step d obtained filters, and ethyl alcohol is recovered under reduced pressure, obtains 1.05~1.20/25 DEG C of specific gravity of leaching
Cream;
F. borneol, camphor, Moschus are weighed, 75%~95% ethyl alcohol is added, is allowed to sufficiently dissolve, obtains promoting sepage, to
With;
G. medicinal extract step e obtained is coated in patch, is sprayed prepared for promoting epidermal penetration in step f
Rush sepage, make every 100 square centimeters containing promote 2.4 milliliters of sepage, cutting, rewinding, pack to get finished product.
The invention has the benefit that drug of the invention is produced using pure Chinese medicine, without any additive, institute in formula
The drug ingedient used has good therapeutic effect, and is free from side effects between drug, and production method is simple, at low cost,
Therapeutic effect easy to use is good, drug primary treatment mammary gland disease of the invention, warming meridians and promoting circulation of qi, blood-activating and qi-promoting, eliminating dampness, and dissipating bind disappears
It is swollen, have effects that the row stasis of blood, analgesic, cool blood, detumescence.
Specific embodiment
Ox seed, i.e. fructus arctii seed, the mild in medicine property, acrid flavour.Main function is dispelling wind and heat from the body;Clearing heat and detoxicating promoting eruption;For heat toxin
Sore swells.
Rhizoma Chuanxiong is used for blood-activating and qi-promoting, and wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walks without keeping, and can go scattered, and uplink is up to mountain peak
Top;Enter blood system again, downlink is up to the sea of blood.
Radix paeoniae rubra alias mountain Chinese herbaceous peony, careless Chinese herbaceous peony, radix paeoniae rubra have effects that yin-nourishing, the row stasis of blood, analgesic, cool blood, detumescence.
The root of Dahurain angelica is the dry root of the umbelliferae root of Dahurain angelica or Radix angelicae dahuricae.The root of Dahurain angelica is warm-natured, acrid flavour, can enter lung, stomach, large intestine
There is relieving exterior syndrome and dispelling cold, the effect of wind-expelling pain-stopping selects clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis.
Cortex cinnamomi, supplementing Yuanyang, warming spleen and stomach, removing internal cold, promoting blood circulation.The Yang-function insufficiency of kidneyzang, cold weak pulse of limb are controlled, yang depletion is collapsed, and abdominal pain is let out
It rushes down, cold hernia renal mass, waist and knee crymodynia, menostasis abdominal mass, negative subcutaneous ulcer, streamer, and empty sun is floating more, heat in the upper and cold in the lower.This product Xin Hangwen concerted effort is strong,
Warming meridians and promoting circulation of qi function victory, can be with the cold and deficiency of chong and ren channels be controlled, and congealing cold with blood stasis etc. is demonstrate,proved.Cassia bark has antibacterial and fungicidal action.
Dragon's blood, analgesic therapy of invigorating blood circulation, removing blood stasis and hemostasis, expelling pus and promoting granulation.
Safflower, blood circulation, removing blood stasis and acesodyne, facilitate controlling through closing, dysmenorrhea, lochia, chest impediment and cardialgia, stasis of blood,
Pricking pain in the chest, traumatic injury, sore swell and ache curative curative effect.There is the effect of activating microcirculation and removing stasis medicinal, dissipate wet effect going to swell.
Bombyx batryticatus, internal heat anticance, for carcinoma product poison, mass dissipating and swelling eliminating is used for tuberculosis lump.
Pangolin, blood circulation promoting and dispersing pathogen accumulation;It is newborn under promoting menstruation;Anti-stain in solid.Main blood stasis;Abdominal mass;Rheumatic arthralgia;Agalactia;
Carbuncle swells;Scrofula.
Semen momordicae, bitter, micro-sweet are cool;It is toxic.Return liver, spleen, stomach meridian.Mass dissipating and swelling eliminating attacks poison and treats sore.For sore swollen toxin, cream
Carbuncle, scrofula, anal fistula, chronic eczema, the favus of the scalp.
Unprocessed Radix Aconiti Lateralis, Shennong's Herbal are recorded: cure mainly chill cough against perverse trend, brothers' injured is controlled in middle benefit gas, eliminating cold-damp, muscular constricture,
Goinyalgia cannot walk, and break hard lump, blood lump in the abdomen, damaged metal sore wound.
Radix Aconiti Kusnezoffii, acrid flavour, hardship, property heat.Return heart, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.It is used for treating arthralgia due to cold and dampness, closes
Pain is saved, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
Dried pinellia, it is raw to use controlling outward carbuncle swells subcutaneous nodule, dissolving lump and resolving mass.
Arisacma consanguineum schott, detumescence pain.
Myrrha, dispersing blood stasis analgesic therapy, detumescence and promoting granulation, the stagnant pain of primary treatment traumatic injury, the stasis of blood, ulcer sore pain, after sore is burst
It does not close up and a variety of stasis pains long.Blood and dissolving stasis is dissipated, traumatic injury blood stasis and swelling pain is used for, is often equal with olibanum, dragon's blood, safflower
With.Chuan Yu lumps in the chest and abdomen, i.e. hepatosplenomegaly person can be used together with regulating qi to disperse stagnation medicines such as Radix Angelicae Sinensis, radix paeoniae rubras.
Radix Aconiti, dispelling wind and eliminating dampness, eliminating cold to stop pain.The pungent scattered hardship of this product is dry, and thermal energy overcomes the coldness, and chill is wet to dispel, and passages through which vital energy circulates is unimpeded, qi and blood
Capable then pain is stopped.
Asafoetide passive can dissipate ruffian desinsection, can be used for treating the lump in the abdomen extravasated blood in abdomen.
In order that the present invention can be more clearly and readily understood, below technical solution in the embodiment of the present invention into
Row clearly and completely describes.
Embodiment one
A kind of patch for treating mammary gland disease, the raw material including following parts by weight: 4000 parts of ox seed, 4000 parts of Rhizoma Chuanxiong, red
3000 parts of Chinese herbaceous peony, 3000 parts of the root of Dahurain angelica, cortex cinnamomi 2000,2000 parts of dragon's blood, 2000 parts of safflower, 1000 parts of bombyx batryticatus, 1000 parts of pangolin, wood
1000 parts of soft-shelled turtle, 20 parts of unprocessed Radix Aconiti Lateralis, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of dried pinellia, 20 parts of arisacma consanguineum schott, 50 parts of Myrrha, lactogenesis is 50 parts fragrant,
20 parts of Radix Aconiti, 30 parts of asafoetide, 50 parts of camphor, 50 parts of borneol, 50 parts of Moschus.
A kind of patch production method for treating mammary gland disease, comprises the following steps that,
A. bulk pharmaceutical chemicals ox seed is weighed, is impregnated 4 hours with clean water, cleans and takes out, dry spare;
B. bulk pharmaceutical chemicals unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Radix Aconiti are weighed, toxic removing is processed;
C. weigh bulk pharmaceutical chemicals Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, Myrrha,
Lactogenesis perfume, asafoetide, are crushed after mixing;
D. bulk pharmaceutical chemicals obtained in step a, b, c mix, and are flowed back with 72% ethanol solution of 9 times of amounts of weight after its mixing
It extracts 2 times, 2.5 hours for the first time, second 1.5 hours, finally merges ethanol solution;
E. ethanol solution step d obtained filters, and ethyl alcohol is recovered under reduced pressure, obtains 1.20/25 DEG C of specific gravity of medicinal extract;
F. borneol, camphor, Moschus are weighed, 95% ethyl alcohol is added, is allowed to sufficiently dissolve, obtains promoting sepage, for use;
G. medicinal extract step e obtained is coated in patch, is sprayed prepared for promoting epidermal penetration in step f
Rush sepage, make every 100 square centimeters containing promote 2.4 milliliters of sepage, cutting, rewinding, pack to get finished product.
Embodiment two
A kind of patch for treating mammary gland disease, the raw material including following parts by weight: 4000 parts of ox seed, 4000 parts of Rhizoma Chuanxiong, red
3000 parts of Chinese herbaceous peony, 3000 parts of the root of Dahurain angelica, cortex cinnamomi 2000,2000 parts of dragon's blood, 2000 parts of safflower, 1000 parts of bombyx batryticatus, 1000 parts of pangolin, wood
1000 parts of soft-shelled turtle, 20 parts of unprocessed Radix Aconiti Lateralis, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of dried pinellia, 20 parts of arisacma consanguineum schott, 50 parts of Myrrha, lactogenesis is 50 parts fragrant,
20 parts of Radix Aconiti, 30 parts of asafoetide, 50 parts of camphor, 50 parts of borneol, 50 parts of Moschus.
A kind of patch production method for treating mammary gland disease, comprises the following steps that,
A. bulk pharmaceutical chemicals ox seed is weighed, is impregnated 3 hours with clean water, cleans and takes out, dry spare;
B. bulk pharmaceutical chemicals unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Radix Aconiti are weighed, toxic removing is processed;
C. weigh bulk pharmaceutical chemicals Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, Myrrha,
Lactogenesis perfume, asafoetide, are crushed after mixing;
D. bulk pharmaceutical chemicals obtained in step a, b, c mix, and are flowed back with 70% ethanol solution of 8 times of amounts of weight after its mixing
It extracts 2 times, 2.5 hours for the first time, second 1.5 hours, finally merges ethanol solution;
E. ethanol solution step d obtained filters, and ethyl alcohol is recovered under reduced pressure, obtains 1.05/25 DEG C of specific gravity of medicinal extract;
F. borneol, camphor, Moschus are weighed, 75% ethyl alcohol is added, is allowed to sufficiently dissolve, obtains promoting sepage, for use;
G. medicinal extract step e obtained is coated in patch, is sprayed prepared for promoting epidermal penetration in step f
Rush sepage, make every 100 square centimeters containing promote 2.4 milliliters of sepage, cutting, rewinding, pack to get finished product.
Embodiment three
A kind of patch for treating mammary gland disease, the raw material including following parts by weight: 4000 parts of ox seed, 4000 parts of Rhizoma Chuanxiong, red
3000 parts of Chinese herbaceous peony, 3000 parts of the root of Dahurain angelica, cortex cinnamomi 2000,2000 parts of dragon's blood, 2000 parts of safflower, 1000 parts of bombyx batryticatus, 1000 parts of pangolin, wood
1000 parts of soft-shelled turtle, 20 parts of unprocessed Radix Aconiti Lateralis, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of dried pinellia, 20 parts of arisacma consanguineum schott, 50 parts of Myrrha, lactogenesis is 50 parts fragrant,
20 parts of Radix Aconiti, 30 parts of asafoetide, 50 parts of camphor, 50 parts of borneol, 50 parts of Moschus.
A kind of patch production method for treating mammary gland disease, comprises the following steps that,
A. bulk pharmaceutical chemicals ox seed is weighed, is impregnated 3.5 hours with clean water, cleans and takes out, dry spare;
B. bulk pharmaceutical chemicals unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Radix Aconiti are weighed, toxic removing is processed;
C. weigh bulk pharmaceutical chemicals Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, Myrrha,
Lactogenesis perfume, asafoetide, are crushed after mixing;
D. bulk pharmaceutical chemicals obtained in step a, b, c mix, and are flowed back with 71% ethanol solution of 9 times of amounts of weight after its mixing
It extracts 2 times, 2.5 hours for the first time, second 1.5 hours, finally merges ethanol solution;
E. ethanol solution step d obtained filters, and ethyl alcohol is recovered under reduced pressure, obtains 1.15/25 DEG C of specific gravity of medicinal extract;
F. borneol, camphor, Moschus are weighed, 85% ethyl alcohol is added, is allowed to sufficiently dissolve, obtains promoting sepage, for use;
G. medicinal extract step e obtained is coated in patch, is sprayed prepared for promoting epidermal penetration in step f
Rush sepage, make every 100 square centimeters containing promote 2.4 milliliters of sepage, cutting, rewinding, pack to get finished product.
The present invention and its embodiments have been described above, this description is no restricted, only reality of the invention
One of mode is applied, actual embodiment is not limited thereto.All in all if those skilled in the art are opened by it
Show, without departing from the spirit of the invention, not inventively design embodiment similar with the technical solution,
It is within the scope of protection of the invention.
Claims (2)
1. a kind of patch for treating mammary gland disease, it is characterised in that: the raw material including following parts by weight: 4000 parts of ox seed, Rhizoma Chuanxiong
4000 parts, 3000 parts of radix paeoniae rubra, 3000 parts of the root of Dahurain angelica, cortex cinnamomi 2000,2000 parts of dragon's blood, 2000 parts of safflower, 1000 parts of bombyx batryticatus, pangolin
It is 1000 parts, 1000 parts of semen momordicae, 20 parts of unprocessed Radix Aconiti Lateralis, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of dried pinellia, 20 parts of arisacma consanguineum schott, 50 parts of Myrrha, raw
50 parts of olibanum, 20 parts of Radix Aconiti, 30 parts of asafoetide, 50 parts of camphor, 50 parts of borneol, 50 parts of Moschus.
2. a kind of patch production method for treating mammary gland disease, it is characterised in that: it comprises the following steps that,
A. bulk pharmaceutical chemicals ox seed is weighed, is impregnated 3-4 hours with clean water, cleans and takes out, dry spare;
B. bulk pharmaceutical chemicals unprocessed Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii, dried pinellia, arisacma consanguineum schott, Radix Aconiti are weighed, toxic removing is processed;
C. bulk pharmaceutical chemicals Rhizoma Chuanxiong, radix paeoniae rubra, the root of Dahurain angelica, cortex cinnamomi, dragon's blood, safflower, bombyx batryticatus, pangolin, semen momordicae, Myrrha, lactogenesis are weighed
Fragrant, asafoetide, is crushed after mixing;
D. bulk pharmaceutical chemicals obtained in step a, b, c mix, and are returned with the 8-9 times of 70-72% ethanol solution measured of weight after its mixing
Stream extracts 2 times, 2.5 hours for the first time, second 1.5 hours, finally merges ethanol solution;
E. ethanol solution step d obtained filters, and ethyl alcohol is recovered under reduced pressure, obtains 1.05~1.20/25 DEG C of specific gravity of medicinal extract;
F. borneol, camphor, Moschus are weighed, 75%~95% ethyl alcohol is added, is allowed to sufficiently dissolve, obtains promoting sepage, for use;
G. medicinal extract step e obtained is coated in patch, is sprayed prepared for promoting the rush of epidermal penetration in step f
Sepage makes every 100 square centimeters containing promoting 2.4 milliliters of sepage, and cutting, rewinding is packed to get finished product.
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