CN110141532A - The skin care item formula and preparation method thereof of molecular sieve targeting conveying active - Google Patents
The skin care item formula and preparation method thereof of molecular sieve targeting conveying active Download PDFInfo
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- CN110141532A CN110141532A CN201910525022.2A CN201910525022A CN110141532A CN 110141532 A CN110141532 A CN 110141532A CN 201910525022 A CN201910525022 A CN 201910525022A CN 110141532 A CN110141532 A CN 110141532A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses the skin care item formulas of molecular sieve targeting conveying active, the skin care item formula includes following raw material: glycerol, 1.3 butanediol, xanthan gum, Sodium Hyaluronate, hydrolecithin, lecithin, Polyoxyethylene Sorbitan Monooleate, cetearyl glucoside, cetostearyl alcohol, tocopherol acetate, caprylic/capric triglyceride, fragrant fresh ketone, 1.3 butanediol, glucose, glutamic acid, PCA calcium, PCA magnesium, 1.2 hexylene glycol, dipeptides diaminobutyryl benzyl amide diacetin and deionized water, all material rate additions constitute 100%, the invention also discloses the preparation methods of the skin care item formula of molecular sieve targeting conveying active.The present invention has the artificial regulatory for realizing macromolecular and particulate matter transdermal delivery, finally improves efficient skin effect.
Description
Technical field
The present invention relates to a kind of technical fields of cosmetic skincare product, the especially shield of molecular sieve targeting conveying active
Skin product formula and preparation method thereof.
Background technique
In view of skin itself from surface layer to deep layer, there are the conversion of the characteristics such as hydrophilic, lipophilic and the height selection of cell membrane
Etc. characteristics, be cause skin care item formula active constituent utilization rate it is not high the main reason for, eventually lead to the original of skin care item effect difference
Cause, so if not carrying out specially treated to formula, skin belongs to indifference absorbing state to formula components, and ingredient eventually arrives at
Position, conversion product all can not control.And molecular sieve is a kind of alumino-silicate compound with cubic lattice.Point
Sub- sifter device has uniform microcellular structure, its hole diameter is uniform, these holes can be the Molecular Adsorption smaller than its diameter
There is Preferential adsorption ability to the inside of vestibule, and to polar molecule and unsaturated molecule, thus polarity degree difference can be satisfied
Different with degree, the molecule that molecular size is different and boiling point is different separates, that is, has the function of " sieving " molecule, therefore claim to divide
Son sieve.Since molecular sieve has the unexistent advantages of other adsorbents such as adsorption capacity is high, and thermal stability is strong, so that molecular sieve obtains
It must be widely applied.Therefore how sieve technology to be integrated on skin care item, reaches best skin effect, it appears is especially heavy
It wants.
Summary of the invention
Molecular sieve targeting conveying active is provided the purpose of the present invention is to solve above-mentioned the deficiencies in the prior art
Skin care item formula and preparation method thereof, its advantage is that: by adjusting solute property, antagonism fatty acid synthesis, ion channel
Recipe combination adjusts permeability of cell membranes, and the ingredient for needing to act in the cell is transported in cell membrane,
Unwanted ingredient sifts out outside cell membrane, targeting, thus promoted formula active constituent utilization rate, and realize macromolecular and
The artificial regulatory of particulate matter transdermal delivery finally improves efficient skin effect, and having improves wrinkle of skin and elastic reaction.
To achieve the goals above, the skin care item formula of the molecular sieve targeting conveying active designed by the present invention, institute
Stating skin care item formula includes that manufactured raw material is equipped with according to following percentage:
Further, the glycerol, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water form A phase；
The Polyoxyethylene Sorbitan Monooleate, cetearyl glucoside, cetostearyl alcohol, tocopherol acetate and caprylic/capric triglyceride
Form B phase；Fragrant fresh ketone and 1.3 butanediols form C phase, and the glucose, glutamic acid, PCA calcium and PCA magnesium form D phase, 1.2 oneself
Two pure and mild dipeptides diaminobutyryl benzyl amide diacetins form E phase.
Further, the skin care item formula includes that manufactured raw material is equipped with according to following percentage:
Further, the skin care item formula includes that manufactured raw material is equipped with according to following percentage:
The invention also discloses the preparation methods of the skin care item formula of molecular sieve targeting conveying active, specifically include
Following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 80 DEG C -85 DEG C, be stirred homogeneous to being completely dissolved, stir
Then time control carries out insulated sterilizing half an hour between 1 hour in 20-30min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
55℃-60℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
48℃-50℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 35 DEG C -40 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
Further, the temperature heated in step s 2 is 82 DEG C.
Further, the minimum temperature reduced in step s3 is 58 DEG C.
Further, temperature is reduced to 48 DEG C in step s 4.
Further, temperature is reduced to 38 DEG C in step s 5.
Further, the temperature range of room temperature is 20 DEG C -25 DEG C in step s 6.
The skin care item formula and preparation method thereof for the molecular sieve targeting conveying active that the present invention obtains, the present invention passes through
Adjust solute property, the synthesis of antagonism fatty acid, ion channel Recipe combination adjust permeability of cell membranes,
The ingredient for needing to act in the cell is transported in cell membrane, and unwanted ingredient sifts out outside cell membrane, targeting, to mention
The utilization rate of formula active constituent is risen, and realizes the artificial regulatory of macromolecular and particulate matter transdermal delivery, it is final to improve efficiently
Skin effect, having improves wrinkle of skin and elastic reaction.
Specific embodiment
Innovation and creation are described further below with reference to embodiment.
Embodiment 1:
The skin care item formula of molecular sieve targeting conveying active provided in this embodiment, the skin care item formula include pressing
Manufactured raw material is equipped with according to following percentage:
Further, the glycerol, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water form A phase；
The Polyoxyethylene Sorbitan Monooleate, cetearyl glucoside, cetostearyl alcohol, tocopherol acetate and caprylic/capric triglyceride
Form B phase；Fragrant fresh ketone and 1.3 butanediols form C phase, and the glucose, glutamic acid, PCA calcium and PCA magnesium form D phase, 1.2 oneself
Two pure and mild dipeptides diaminobutyryl benzyl amide diacetins form E phase.
The skin care item formula includes that manufactured raw material is equipped with according to following percentage in the present embodiment:
The present embodiment also discloses the preparation method of the skin care item formula of molecular sieve targeting conveying active, specific to wrap
Include following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 80 DEG C -85 DEG C, be stirred homogeneous to being completely dissolved, stir
Then time control carries out 1 hour of insulated sterilizing in 20-30min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
55℃-60℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
48℃-50℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 35 DEG C -40 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
Further, the temperature heated in step s 2 is 82 DEG C.
Further, the minimum temperature reduced in step s3 is 58 DEG C.
Further, temperature is reduced to 48 DEG C in step s 4.
Further, temperature is reduced to 38 DEG C in step s 5.
Further, the temperature range of room temperature is 20 DEG C -25 DEG C in step s 6.
Embodiment 2:
The skin care item formula of molecular sieve targeting conveying active provided in this embodiment, the skin care item formula include pressing
Manufactured raw material is equipped with according to following percentage:
The present embodiment also discloses the preparation method of the skin care item formula of molecular sieve targeting conveying active, specific to wrap
Include following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 80 DEG C, be stirred homogeneous to being completely dissolved, mixing time control
Then system carries out insulated sterilizing half an hour in 20min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
55℃℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
48℃℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 3 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
Further, the temperature range of room temperature is 20 DEG C in step s 6.
Embodiment 3:
The skin care item formula of molecular sieve targeting conveying active provided in this embodiment, the skin care item formula include pressing
Manufactured raw material is equipped with according to following percentage:
The present embodiment also discloses the preparation method of the skin care item formula of molecular sieve targeting conveying active, specific to wrap
Include following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 82 DEG C, be stirred homogeneous to being completely dissolved, mixing time control
Then system carries out insulated sterilizing half an hour in 25min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
58℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
48℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 38 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
Further, the temperature range of room temperature is 23 DEG C in step s 6.
Embodiment 4:
The skin care item formula of molecular sieve targeting conveying active provided in this embodiment, the skin care item formula include pressing
Manufactured raw material is equipped with according to following percentage:
The present embodiment also discloses the preparation method of the skin care item formula of molecular sieve targeting conveying active, specific to wrap
Include following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 84 DEG C, be stirred homogeneous to being completely dissolved, mixing time control
Then system carries out insulated sterilizing half an hour between 1 hour in 28min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
59℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
49℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 39 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
Further, the temperature range of room temperature is 25 DEG C in step s 6.
Embodiment 5:
The skin care item formula of molecular sieve targeting conveying active provided in this embodiment, the skin care item formula include pressing
Manufactured raw material is equipped with according to following percentage:
The present embodiment also discloses the preparation method of the skin care item formula of molecular sieve targeting conveying active, specific to wrap
Include following steps:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, so
After sequentially add in vacuum emulsification pot, then carry out after being heated to 85 DEG C, be stirred homogeneous to being completely dissolved, mixing time control
Then system carries out 1 hour of insulated sterilizing in 30min；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopheryl acetate
Then ester and caprylic/capric triglyceride are placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and
A, B are carried out in the vacuum emulsification pot being pumped into step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then it is cooled to
60℃；
Then S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement are placed in neatly original oil cauldron individually
After heating for dissolving, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to
50℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add the vacuum emulsification in step S4
Progress A, B, C, D, which are mixed, in pot stirs evenly；It is cooled to 40 DEG C；
S6, finally 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are sequentially added in step S5
It is stirred in vacuum emulsification pot uniformly, after then cooling to normal temperature state, carries out packing processes.
The applicant is cell height it should be noted that since cell membrane is mainly made of lipid, protein and carbohydrate
The barrier of selectivity, can separate cytoplasm and external environment, so that cell obtains a metastable interior environment, and
It plays an important role during mass exchange, energy conversion and signal transduction between cell and environment etc..On the whole, this
The approach of a little substance cross-cell membrane transhipments is: the lesser small-molecule substance of fat-soluble or polarity can be saturating by way of physical diffusion
Cell membrane, soluble small molecular material need to complete transmembrane transport by a series of mediation of related membrane proteins, both
The major impetus passively transported is that the electrochemical gradient of substance is poor.
Therefore in different cell or in the different organelle of same cell and in different cell film layers, lipoid and
Protein ratio differs greatly.The bioactivity such as the protein content of film and the metabolism of cell, absorption, secretion are related.It is general next
It says, the more complicated and diversified film of function, the type of contained protein is more, and the ratio of shared weight is also bigger.
According to the mode with membrane interaction and the positioning scenarios in film, memebrane protein can be divided into peripheral protein and inherence
Albumen two major classes.Peripheral protein is mainly distributed on the inner and outer surfaces of film, loose with film rouge in a manner of weak bond (electrostatic, ion)
In conjunction with.When changing the ionic strength or pH value of environment, peripheral protein is easy to separate from film, in water solubility.More
This albuminoid accounts for the 20~30% of film total weight in number cell, and 40% is up in red blood cell.
Integrated protein is to combine closely to be inserted among the structure of lipid bilayer by hydrophobic force, non-bond forces and lipid bilayer,
It is not soluble in water, only by that could be separated from film after surfactant or organic solvent processing.General integrated protein accounts for film egg
The 70~80% of white total amount are the functional protein of film and the structural material of film.
The amino acid for forming this proteinoid is divided into hydrophobicity and hydrophily, therefore in the solid for forming protein molecule
When structure, the hydrone of hydrophilic amino acid envelope surface attracts and is exposed to the surface of lipid bilayer；Hydrophobic amino acid structure
At part be then deep into the hydrophobic interior of lipid bilayer and form the compound of protein type.
Therefore the present invention is by the way that addition mentioned component can be to the ornamental equivalent played to skin, such as in formula: PCA calcium
With PCA magnesium etc., relevant electronics transfer and particle channel are activated or inhibited, to change the transmitting of its cross-film, and then improves cell
Film plays screening effect to active constituent to the permeability of related activity ingredient, promotes the utilization rate of active constituent；It adds simultaneously
Dipeptides diaminobutyryl benzyl amide diacetin, and needs to act on extracellular active constituent homogeneous or polymerize, make its with
Cell membrane phosphoric acid head group forms ionic bond, has fettered neighbouring phospholipid molecule, weakens its diffusivity.So that needing
It acts on extracellular active constituent to be not easy to penetrate into cell interior, by adding the substance containing polar hydroxyl groups, makes itself and film rouge
Polar head group interaction, to limit the freedom of motion of phosphatide hydrocarbon chain, to reduce the mobility of cell membrane, subtract
Few permeability to formula active constituent, is additionally supplemented with solvent, to increase the mobility in lipid bilayer centre, makes to live
Property ingredient be easier to realize transdermal delivery ,-addition tocopherol acetate, can be in conjunction with the transmembrane protein on cell membrane, to realize
It is interacted with intracellular biology, realizes anti-aging；The identifiable active constituent of memebrane protein is added, such as glucose, glutamic acid, organic
Ester etc. opens rapidly the depolarising of ion channel and membrane potential, or activation enzyme system, so that promoting active constituent enters cell
The transmission channel of film, to accelerate the cross-film transmitting of formula intermediate ion.
Verified: the present embodiment is by adjusting solute property, the synthesis of antagonism fatty acid, the Recipe combination of ion channel
Mode adjusts permeability of cell membranes, the ingredient for needing to act in the cell is transported in cell membrane, unwanted ingredient
It sifts out outside cell membrane, targeting, to promote the utilization rate of formula active constituent, and realizes macromolecular and particulate matter cross-film
The artificial regulatory of transport finally improves efficient skin effect, and having improves wrinkle of skin and elastic reaction.
Experimental data illustrates: Ying Fuhe selection criteria, exclusion are not inconsistent adult female 5 of 28 years old of standard or more and (meet
The requirement of standard is the object that preparatory detection women has obvious wrinkle of skin and cutis laxa)
Experimental products: this product embodiment 5 is A product and existing common skin-protection product, that is, B product；
Specific test method:
During two weeks that test carries out, the A product of equivalent is used after daily morning and evening face cleaning on left cheek, in right side face
The B product that equivalent is used on cheek is smeared uniform along dermatoglyph；
Evaluation method:
Evaluation study is carried out according to " Dermatology research institute, South Korea standardization program guide (SOP) ", it is whole to be responsible for by profession
People exercises supervision audit to test process.
1. Instrument measuring:
1) carrying out elastic force using Ballistometer improves evaluation
2) carrying out wrinkle using ANTERA 3D improves evaluation
Test result:
1. carrying out elastic force using Ballistometer improves the result of evaluation:
Compared with using before test products, increase by 2.07% using the CoR value that A product represents skin elasticity after two weeks；
Using B product, CoR value is without substantially changeing after two weeks；
2. carrying out wrinkle of skin using ANTERA 3D improves the result of evaluation:
Compared with using before test products, subtracted using the Wrinkles medium value that A product represents wrinkle of skin after two weeks
Few 9.23%；Using B product after two weeks Wrinkles medium value without substantially changeing.
3. subject's adverse reaction is not observed in test during carrying out.
4. formulation product prepared by the present invention, which can have skin elasticity and wrinkle of skin, in summary is obviously improved effect
Fruit.
1) skin elasticity test value changes: CoR value
2) wrinkle of skin measured value changes
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from spirit of the invention or
In the case where essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention
It is interior.Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, it is possible to understand that
A variety of change, modification, replacement and modification can be carried out to these embodiments in the case where not departing from the principle and spirit of the invention,
The scope of the present invention is defined by the appended.
Claims (10)
1. molecular sieve targeting conveying active skin care item formula, which is characterized in that the skin care item formula include according to
Lower percentage is equipped with manufactured raw material:
2. the skin care item formula of molecular sieve targeting conveying active according to claim 1, which is characterized in that described sweet
Oil, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water form A phase；The Polyoxyethylene Sorbitan Monooleate, spermaceti
Stearyl glucoside, cetostearyl alcohol, tocopherol acetate and caprylic/capric triglyceride form B phase；Fragrant fresh ketone and 1.3 fourths
Glycol forms C phase, and the glucose, glutamic acid, PCA calcium and PCA magnesium form D phase, 1.2 hexylene glycols and dipeptides diaminobutyryl benzyl
Base amide diacetin forms E phase.
3. the skin care item formula of molecular sieve targeting conveying active according to claim 1 or 2, which is characterized in that institute
Stating skin care item formula includes that manufactured raw material is equipped with according to following percentage:
4. the skin care item formula of molecular sieve targeting conveying active according to claim 1 or 2, which is characterized in that institute
Stating skin care item formula includes that manufactured raw material is equipped with according to following percentage:
5. the preparation method that molecular sieve targets the skin care item formula of conveying active, it is characterised in that: specifically include following step
It is rapid:
It is S1, spare after cleaning-sterilizing processing to needing vacuum emulsification pot to be used to carry out；
S2, the glycerol for weighing sets requirement, 1.3 butanediols, xanthan gum, Sodium Hyaluronate, lecithin and deionized water, then according to
In secondary addition vacuum emulsification pot, then carry out after being heated to 80 DEG C -85 DEG C,
Homogeneous is stirred to being completely dissolved, then mixing time control carries out insulated sterilizing half an hour to 1 in 20-30min
Between hour；Constitute A phase；
S3, the Polyoxyethylene Sorbitan Monooleate for weighing sets requirement, cetearyl glucoside, cetostearyl alcohol, tocopherol acetate and
Then caprylic/capric triglyceride is placed in neatly original oil cauldron after individually dissolving by heating, constitute B phase, and be pumped into
A, B are carried out in vacuum emulsification pot in step S2 mixes stirring homogeneous to the uniform exquisiteness of Material；Then carry out being cooled to 55 DEG C-
60℃；
S4, the fragrant fresh ketone and 1.3 butanediols for weighing sets requirement, are then placed in neatly original oil cauldron and individually heat
After dissolution, C phase is constituted, and carries out A, B, C in the vacuum emulsification pot being pumped into step S3 and mixes and stir evenly；It is cooled to 48
℃-50℃；
S5, the glucose for weighing sets requirement, glutamic acid, PCA calcium and PCA magnesium sequentially add in the vacuum emulsification pot in step S4
Progress A, B, C, D, which are mixed, to stir evenly；It is cooled to 35 DEG C -40 DEG C；
S6,1.2 hexylene glycols and dipeptides diaminobutyryl benzyl amide diacetin are finally sequentially added into the vacuum in step S5
It is stirred in emulsion pot uniformly, after then cooling to normal temperature state, carries out packing processes.
6. the preparation method of the skin care item formula of molecular sieve targeting conveying active according to claim 5, feature
Be: the temperature heated in step s 2 is 82 DEG C.
7. the preparation method of the skin care item formula of molecular sieve targeting conveying active according to claim 5, feature
Be: the minimum temperature reduced in step s3 is 58 DEG C.
8. the preparation method of the skin care item formula of molecular sieve targeting conveying active according to claim 5, feature
Be: temperature is reduced to 48 DEG C in step s 4.
9. the preparation method of the skin care item formula of molecular sieve targeting conveying active according to claim 5, feature
Be: temperature is reduced to 38 DEG C in step s 5.
10. the preparation method of the skin care item formula of molecular sieve targeting conveying active according to claim 5, feature
Be: the temperature range of room temperature is 20 DEG C -25 DEG C in step s 6.
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| CN1882310A (en) * | 2003-11-17 | 2006-12-20 | Geo株式会社 | Cosmetic composition |
| CN102406576A (en) * | 2011-10-28 | 2012-04-11 | 何黎 | Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof |
| CN106176560A (en) * | 2016-07-13 | 2016-12-07 | 广州千百度化妆品有限公司 | A kind of skin whitener and preparation method thereof |
| KR101810160B1 (en) * | 2017-06-30 | 2018-01-25 | 주식회사 셀리제코스메틱 | Generating method for ethosome with bioactive compounds, ethosome and cosmetic composition including ethosome |
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2019
- 2019-06-18 CN CN201910525022.2A patent/CN110141532A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1882310A (en) * | 2003-11-17 | 2006-12-20 | Geo株式会社 | Cosmetic composition |
| CN102406576A (en) * | 2011-10-28 | 2012-04-11 | 何黎 | Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof |
| CN106176560A (en) * | 2016-07-13 | 2016-12-07 | 广州千百度化妆品有限公司 | A kind of skin whitener and preparation method thereof |
| KR101810160B1 (en) * | 2017-06-30 | 2018-01-25 | 주식회사 셀리제코스메틱 | Generating method for ethosome with bioactive compounds, ethosome and cosmetic composition including ethosome |
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