CN110139855A - 新型的氘代脲类化合物 - Google Patents
新型的氘代脲类化合物 Download PDFInfo
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- CN110139855A CN110139855A CN201880006403.3A CN201880006403A CN110139855A CN 110139855 A CN110139855 A CN 110139855A CN 201880006403 A CN201880006403 A CN 201880006403A CN 110139855 A CN110139855 A CN 110139855A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Abstract
一种新型的氘代脲类化合物，具体涉及式(I)化合物或其药学上可接受的盐、其制备方法以及含有这些化合物的药物组合物。还公开了这些化合物以及包含这些化合物的药物组合物在制备治疗疼痛的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710024735 | 2017-01-13 | ||
| CN2017100247351 | 2017-01-13 | ||
| PCT/CN2018/071903 WO2018130140A1 (zh) | 2017-01-13 | 2018-01-09 | 新型的氘代脲类化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110139855A true CN110139855A (zh) | 2019-08-16 |
| CN110139855B CN110139855B (zh) | 2021-11-19 |
Family
ID=62839635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880006403.3A Active CN110139855B (zh) | 2017-01-13 | 2018-01-09 | 新型的氘代脲类化合物 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110139855B (zh) |
| WO (1) | WO2018130140A1 (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017007695A1 (en) * | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Mu opioid receptor modulators |
-
2018
- 2018-01-09 CN CN201880006403.3A patent/CN110139855B/zh active Active
- 2018-01-09 WO PCT/CN2018/071903 patent/WO2018130140A1/zh active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017007695A1 (en) * | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Mu opioid receptor modulators |
Non-Patent Citations (3)
| Title |
|---|
| AASHISH MANGLIK1 ET AL.,: "Structure-based discovery of opioid analgesics with reduced side effects", 《NATURE》 * |
| BRIGITTEL.KIEFFER: "Durg Discovery Designing the ideal opioid", 《NATURE》 * |
| 江文峰等: "氘代作用在药物研究中的应用", 《齐鲁药事》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018130140A1 (zh) | 2018-07-19 |
| CN110139855B (zh) | 2021-11-19 |
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Legal Events
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |