CN110139671A - 用于治疗癌症的组合免疫疗法 - Google Patents
用于治疗癌症的组合免疫疗法 Download PDFInfo
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- CN110139671A CN110139671A CN201780076988.1A CN201780076988A CN110139671A CN 110139671 A CN110139671 A CN 110139671A CN 201780076988 A CN201780076988 A CN 201780076988A CN 110139671 A CN110139671 A CN 110139671A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K40/19—Dendritic cells
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- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- A61K2239/55—Lung
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423119P | 2016-11-16 | 2016-11-16 | |
| US62/423,119 | 2016-11-16 | ||
| PCT/US2017/061810 WO2018093907A1 (en) | 2016-11-16 | 2017-11-15 | Combination immunotherapies for treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110139671A true CN110139671A (zh) | 2019-08-16 |
Family
ID=62146828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780076988.1A Pending CN110139671A (zh) | 2016-11-16 | 2017-11-15 | 用于治疗癌症的组合免疫疗法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10675304B2 (https=) |
| EP (1) | EP3541417A4 (https=) |
| JP (1) | JP2020500847A (https=) |
| CN (1) | CN110139671A (https=) |
| CA (1) | CA3082779A1 (https=) |
| WO (1) | WO2018093907A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110904229A (zh) * | 2019-11-25 | 2020-03-24 | 济南市中心医院 | Ilt4在肿瘤诊治中的应用 |
| WO2022061811A1 (zh) * | 2020-09-27 | 2022-03-31 | 深圳华大生命科学研究院 | 药物组合物及其制备方法和应用 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9730989B2 (en) | 2015-07-02 | 2017-08-15 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for combination therapy with dengue virus and dendritic cells |
| CA2999881A1 (en) | 2015-09-26 | 2017-03-30 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for producing dendritic cells |
| JP2020500847A (ja) | 2016-11-16 | 2020-01-16 | プライムヴァックス イミュノ−オンコロジー,インク. | 癌の処置のための併用免疫療法 |
| EP3565567A4 (en) | 2017-01-04 | 2020-07-29 | Primevax Immuno-Oncology, Inc. | COMPOSITIONS AND METHODS OF THERAPY WITH DENGUE VIRUS |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP3721899A1 (en) * | 2019-04-08 | 2020-10-14 | China Medical University | Combination therapies comprising dendritic cells-based vaccine and immune checkpoint inhibitor |
| CR20220220A (es) | 2019-11-18 | 2022-09-20 | Janssen Biotech Inc | Vacunas basadas en calr y jak2 mutantes y sus usos |
| CA3187944A1 (en) | 2020-06-22 | 2021-12-30 | Ngm Biopharmaceuticals, Inc. | Lair-1-binding agents and methods of use thereof |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524587B1 (en) * | 1998-05-05 | 2003-02-25 | Bruce W. Lyday | Hyperthermia and immunotherapy for leukemias lymphomas, and solid tumors |
| US20100104598A1 (en) * | 2006-08-15 | 2010-04-29 | The Government Of The U.S.A., As Represented By The Secretary, Dept. Of Health | Development of dengue virus vaccine components |
| US20160058852A1 (en) * | 2014-02-14 | 2016-03-03 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| WO2017004567A1 (en) * | 2015-07-02 | 2017-01-05 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for combination therapy with dengue virus and dendritic cells |
| WO2017053873A1 (en) * | 2015-09-26 | 2017-03-30 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for producing dendritic cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US1015972A (en) | 1905-09-25 | 1912-01-30 | Westinghouse Electric & Mfg Co | Electric switch. |
| US1035755A (en) | 1908-07-21 | 1912-08-13 | Glenn S Smith | Draftsman's apparatus. |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| AU2872199A (en) | 1998-02-20 | 1999-09-06 | Rockefeller University, The | Apoptotic cell-mediated antigen presentation to dendritic cells |
| US6048686A (en) | 1998-05-05 | 2000-04-11 | Randy Kyle Brown | Hyperthermia and immunotherapy for cancer |
| WO2000057909A2 (en) | 1999-03-26 | 2000-10-05 | Walter Reed Army Institute Of Research | Attenuated dengue-2 virus vaccine |
| EP1165127B1 (en) * | 1999-03-26 | 2008-12-31 | Walter Reed Army Institute of Research | Multivalent dengue virus vaccine |
| EP1168924A4 (en) | 1999-03-31 | 2002-09-04 | Univ Pittsburgh | DERIVATIVED IMMUNOGENES IN VITRO INDUCTION OF ANTIQUE-SPECIFIC T-CELLS USING DENDRITIC CELL-TUMOR CELL OR DENDRITIC CELL-VIRAL CELL |
| EP1484064A1 (en) | 2003-06-04 | 2004-12-08 | Gesellschaft für Biotechnologische Forschung | Therapeutical composition containing dentritic cells and use thereof |
| WO2006001120A1 (ja) | 2004-06-24 | 2006-01-05 | Dnavec Research Inc. | マイナス鎖rnaウイルスを含む抗癌剤 |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| EP2714076A1 (en) | 2011-05-26 | 2014-04-09 | GlaxoSmithKline Biologicals S.A. | Inactivated dengue virus vaccine |
| JP2015513401A (ja) | 2012-03-02 | 2015-05-14 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | 樹状細胞ワクチンの調製方法 |
| US9879003B2 (en) | 2012-04-11 | 2018-01-30 | Dana-Farber Cancer Institute, Inc. | Host targeted inhibitors of dengue virus and other viruses |
| JP2015520196A (ja) | 2012-06-10 | 2015-07-16 | タケダ ワクチン, インコーポレイテッドTakeda Vaccines, Inc. | デングウイルスに対するワクチン投与のための組成物および方法 |
| EP3473708B1 (en) | 2012-07-24 | 2021-01-27 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
| KR102873947B1 (ko) * | 2015-05-07 | 2025-10-22 | 베이롤 칼리지 오브 메드신 | 수지상 세포 면역요법 |
| JP2020500847A (ja) | 2016-11-16 | 2020-01-16 | プライムヴァックス イミュノ−オンコロジー,インク. | 癌の処置のための併用免疫療法 |
| EP3565567A4 (en) | 2017-01-04 | 2020-07-29 | Primevax Immuno-Oncology, Inc. | COMPOSITIONS AND METHODS OF THERAPY WITH DENGUE VIRUS |
| SG11201912163WA (en) | 2017-06-15 | 2020-01-30 | Primevax Immuno Oncology Inc | Compositions and methods for cancer therapy with dengue virus and dendritic cells |
-
2017
- 2017-11-15 JP JP2019525727A patent/JP2020500847A/ja active Pending
- 2017-11-15 EP EP17871276.6A patent/EP3541417A4/en not_active Withdrawn
- 2017-11-15 CN CN201780076988.1A patent/CN110139671A/zh active Pending
- 2017-11-15 WO PCT/US2017/061810 patent/WO2018093907A1/en not_active Ceased
- 2017-11-15 CA CA3082779A patent/CA3082779A1/en active Pending
-
2019
- 2019-05-15 US US16/413,444 patent/US10675304B2/en active Active
-
2020
- 2020-05-14 US US15/931,787 patent/US11357795B2/en active Active
-
2022
- 2022-06-10 US US17/837,294 patent/US12377115B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524587B1 (en) * | 1998-05-05 | 2003-02-25 | Bruce W. Lyday | Hyperthermia and immunotherapy for leukemias lymphomas, and solid tumors |
| US20100104598A1 (en) * | 2006-08-15 | 2010-04-29 | The Government Of The U.S.A., As Represented By The Secretary, Dept. Of Health | Development of dengue virus vaccine components |
| US20160058852A1 (en) * | 2014-02-14 | 2016-03-03 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| WO2017004567A1 (en) * | 2015-07-02 | 2017-01-05 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for combination therapy with dengue virus and dendritic cells |
| WO2017053873A1 (en) * | 2015-09-26 | 2017-03-30 | PrimeVax Immuno-Oncology, Inc. | Compositions and methods for producing dendritic cells |
Non-Patent Citations (3)
| Title |
|---|
| BRUCE LYDAY等: "Overcoming tumor immune evasion with an unique arbovirus", 《J TRANSL MED》 * |
| HIROSHI FUKUHARA等: "Oncolytic virus therapy: A new era of cancer treatment at dawn", 《CANCER SCI》 * |
| WEIQING JING等: "Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma", 《J IMMUNOTHER CANCER》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110904229A (zh) * | 2019-11-25 | 2020-03-24 | 济南市中心医院 | Ilt4在肿瘤诊治中的应用 |
| WO2022061811A1 (zh) * | 2020-09-27 | 2022-03-31 | 深圳华大生命科学研究院 | 药物组合物及其制备方法和应用 |
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| EP3541417A1 (en) | 2019-09-25 |
| CA3082779A1 (en) | 2018-05-24 |
| WO2018093907A1 (en) | 2018-05-24 |
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