CN110132906A - The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity - Google Patents
The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity Download PDFInfo
- Publication number
- CN110132906A CN110132906A CN201810108965.0A CN201810108965A CN110132906A CN 110132906 A CN110132906 A CN 110132906A CN 201810108965 A CN201810108965 A CN 201810108965A CN 110132906 A CN110132906 A CN 110132906A
- Authority
- CN
- China
- Prior art keywords
- heart failure
- myocardial infarction
- nail
- subject
- autofluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to methods and its application that myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity, it is provided in particular in a kind of left and right distribution and intensity based on detection human nails' autofluorescence, as detection myocardial infarction and heart failure morbidity and the detection method of prognosis degree.This method is noninvasive, efficient, simple, economy, accuracy are high and reproducible.
Description
Technical field
The present invention relates to a kind of left and right spatial distribution of human nails' autofluorescence and intensity, as judging myocardial infarction
With the method for heart failure morbidity.Specifically refer to strong by comparing the distribution of human nails or so fluorescence intensity and autofluorescence
Degree, judges whether subject suffers from the degree of myocardial infarction or heart failure and myocardial infarction or heart failure morbidity.
Background technique
In China and countries in the world, myocardial infarction and heart failure (heart failure) be cause death it is most heavy with lifelong disability
One of big disease.In recent years it is in obvious ascendant trend in Chinese myocardial infarction, is newly sent to few 500,000 every year, now suffers from least 2,000,000.
Serious and terminal stage of the heart failure as cardiovascular disease, patient numbers' sustainable growth.Heart failure illness rate may have reached 1.3%,
For existing disease patient there are about 8,000,000 to 1,000 ten thousand, China may have become the country for possessing the maximum patients with heart failure group in the whole world.At present
The main means of diagnosis be by the methods of electrocardiogram, it is more inconvenient for patient, time-consuming relatively long.So far without it is noninvasive,
Quickly, the method for judging myocardial infarction and heart failure and whether falling ill that is economic, being used with family, also can not be used to
When physical examination screening go out myocardial infarction and heart failure patient it is noninvasive, quick, economical, can be with family's application method.Meanwhile so far
Do not have it is noninvasive, quick, economical, can therefore be invented in the method for the judgement myocardial infarction and heart failure prognosis that family uses
The method for judging myocardial infarction and heart failure and whether falling ill that is noninvasive, quick, economic, being used with family can be used to
When physical examination screening go out myocardial infarction and heart failure patient noninvasive, quick, economic method and it is noninvasive, quick, economical,
Can in the method for the judgement myocardial infarction and heart failure prognosis that family uses, have extremely important social and economic significance and
Clinical value.
Summary of the invention
The purpose of the present inventor is to break through the problem of the prior art, proposes that one kind can be used for detecting myocardial infarction and mental and physical efforts
Failure and novel detection method and application to human zero damage.
The present inventor detects the nail autofluorescence of subject, and myocardial infarction and heart failure patient nail are found after detection
Show the left-right asymmetry state of significant human body spontaneous fluorescence, and the nail of myocardial infarction and heart failure patient is spontaneous
Fluorescence is significantly higher than non-salary motivation and heart failure crowd, and left-right asymmetry property is higher, fluorescence intensity is higher, then cardiac muscle stalk
Dead and heart failure severity is higher.The present invention is in body surface autofluorescence left-right asymmetry rising and intensity
Rise the detection method and its application as the new marker for judging myocardial infarction and heart failure.
And lung cancer population and non-lung cancer population comparisons, increase without the green autofluorescence of significant human body surface, does not also have
There is significant left and right fluorescence asymmetric.
On the one hand, the present invention provides a kind of molecular marked compounds to prepare for judging myocardial infarction and heart failure morbidity
Application in product, wherein the molecular marked compound uses 400nm to excitation subject's nail between 750nm
Spontaneous fluorescence intensity, the wave-length coverage of the autofluorescence is in 420nm between 800nm.
In a specific embodiment, after the excitation, subject's nail or so corresponding position it is spontaneous glimmering
Light intensity value is when there were significant differences, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, when the autofluorescence of the excitation subject nail or so corresponding position is strong
When angle value difference is bigger, myocardial infarction or severity of heart failure are more serious.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject nail is higher than the non-heart
The spontaneous fluorescence intensity value of flesh infarct or heart failure patient nail, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, when the excitation subject nail spontaneous fluorescence intensity value is bigger, the heart
Flesh infarct or severity of heart failure are more serious.
On the other hand, the invention discloses a kind of detection myocardial infarction or the methods of heart failure, wherein including following step
It is rapid:
(1) pass through 400nm to the excitation patient human nails between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity of autofluorescence is analyzed, it is determined whether be myocardial infarction or heart failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject nail is higher than the non-heart
The spontaneous fluorescence intensity value of flesh infarct or heart failure patient nail, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, when the autofluorescence of excitation subject bilateral symmetry nail position is strong
Angle value is when there were significant differences, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, it is when the spontaneous fluorescence intensity value of the excitation subject nail is higher,
Myocardial infarction or severity of heart failure are more serious.
In a specific embodiment, when the autofluorescence of excitation subject nail bilateral symmetry position is strong
When angle value difference is bigger, myocardial infarction or severity of heart failure are more serious.
The present invention has done many experiments, and the body surface of many other Disease body surface fluorescence and healthy population has also been made
Fluorescence.It was found that the nail autofluorescence of normal person and the patient of other type diseases all do not rise significantly, left and right phase
The fluorescence for the position answered does not have difference.For example it is found that the nail autofluorescence of patients with lung cancer does not rise significantly, it is left
The nail fluorescence of right corresponding position does not have difference.
Detailed description of the invention:
Fig. 1 is shown to be excited down using blue light, detects the autofluorescence of subject's nail, myocardial infarction or heart failure or non-
Myocardial infarction or the spontaneous fluorescence intensity of heart failure represent figure.
Under using blue light to excite, detect with the symmetrical position spontaneous fluorescence intensity of subject's nail.Cardiac muscle
Infarct or heart failure or non-salary motivation or the spontaneous fluorescence intensity of heart failure represent figure.
Specific embodiment
Below will be by specifically describing, the present invention is further illustrated.
Unless otherwise defined, all technical and scientific terms used herein have and the technical field of the invention
Those of ordinary skill be generally understood identical meaning.
As described herein, term " autofluorescence ", " autofluorescence ", " spontaneous fluorescence ", " auto-fluorescence "
It is interchangeable, refer to that tissue, cell, biological substance after by the irradiation of the exciting light of appropriate wavelength, absorb the energy of exciting light
Into excitation state, the phenomenon of light longer than excitation wavelength is launched when exiting excitation state, wherein autofluorescence is than swashing
The longer light of emission wavelength.
As described herein, term " exciting light " is the light for referring to excitation biomolecule and autofluorescence phenomenon occurring, wave
Length should be shorter than autofluorescence.
Embodiment 1: exciting light is the pass of nail spontaneous fluorescence intensity and myocardial infarction or heart failure for blue wave band
System.
According to the present invention, it to the nail of myocardial infarction or heart failure or non-salary motivation or heart failure crowd, uses
Instrument carries out skin autofluorescence non-invasively imaged in real time.Experimental result is shown, compares non-salary motivation or heart failure crowd
Nail spontaneous fluorescence intensity, the nail spontaneous fluorescence intensity of myocardial infarction or heart failure patient significantly increases (Fig. 1)
Embodiment 2: exciting light is for blue wave band, the spontaneous fluorescence intensity difference of subject's nail bilateral symmetry position with
Myocardial infarction or the relationship of heart failure.
According to the present invention, to myocardial infarction or heart failure or non-salary motivation or the symmetrical position of heart failure patient left and right sides
The nail set carries out skin autofluorescence using instrument non-invasively imaged in real time.Experimental result shows, non-salary motivation or mental and physical efforts
The nail spontaneous fluorescence intensity bilateral symmetry of failure crowd, and myocardial infarction or heart failure patient left and right sides symmetric position nail
Spontaneous fluorescence intensity it is asymmetric.(Fig. 2)
Based on technology of the invention, (including but not limited to) will be applied to: 1. myocardial infarction or the heart in crowd's physical examination
Force failure screening.2. myocardial infarction and heart failure self screening for family.3. for situation of all-level hospitals (including community hospital
With other situation of all-level hospitals) diagnosis of myocardial infarction and heart failure.
Those skilled in the art is it should be understood that although for illustrative purposes, this document describes tools of the invention
Body embodiment, but it can be carry out various modifications without departing from the spirit and scope of the present invention.Therefore, of the invention specific
Embodiments and examples should not be considered as limiting the scope of the invention.The present invention is limited only by the appended claims.This Shen
Please in quote all documents be fully incorporated herein by reference.
Claims (16)
1. it is a kind of based on nail autofluorescence bilateral symmetry and intensity judge myocardial infarction and heart failure and more after degree
Using being biomarker for diagnosing myocardial infarction and heart failure and judges that myocardial infarction and heart failure are pre- in preparation
The application in product afterwards, wherein the molecular marked compound is to use 400nm to the excitation subject between 750nm
The spontaneous fluorescence intensity of nail, the wave-length coverage of the autofluorescence is in 420nm between 800nm.
2. application as described in claim 1, wherein the exciting light ranges preferably from 460nm-640nm, more preferably
460nm-580nm。
3. application as described in claim 1, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
4. application as described in claim 1, wherein when the nail fluorescence intensity of subject's left and right side has asymmetry, then
Determine subject with myocardial infarction or heart failure.
5. application as described in claim 1, wherein the nail fluorescence intensity when subject's left and right side is more asymmetric, then by
Examination person's myocardial infarction or severity of heart failure are more serious.
6. application as described in claim 1, wherein when subject's nail surface fluorescence intensity is higher than the non-cardiac muscle stalk measured
When dead or heart failure tester average body surface fluorescence, it is determined that subject suffers from myocardial infarction or heart failure.
7. application as described in claim 1, wherein subject's nail fluorescence intensity is higher, myocardial infarction or severity of heart failure
It is more serious.
8. it is a kind of based on nail autofluorescence bilateral symmetry and intensity judge myocardial infarction and heart failure and more after degree
Method, wherein the following steps are included:
(1) pass through 400nm to excitation patient's nail between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity of nail autofluorescence is analyzed, it is determined whether be myocardial infarction or heart failure.
(4) whether the intensity left and right sides for analyzing nail autofluorescence is symmetrical, it is determined whether is myocardial infarction or heart failure.
9. method as claimed in claim 9, wherein subject's nail fluorescence intensity level or so is distributed not after excitation
Simultaneously, it is determined that subject suffers from myocardial infarction or heart failure.
10. method as claimed in claim 9, wherein the nail fluorescence intensity when subject's left and right side is more asymmetric, then
Subject's myocardial infarction or severity of heart failure are more serious.
11. method as claimed in claim 9, wherein measured when excitation subject's nail fluorescence intensity level is higher than
Non-salary motivation or heart failure tester average nail autofluorescence when, it is determined that subject suffer from myocardial infarction or the heart
Force failure.
12. method as claimed in claim 9, wherein subject's nail fluorescence intensity is higher, myocardial infarction or heart failure journey
It spends more serious.
13. method as claimed in claim 9, wherein the exciting light ranges preferably from 460nm-640nm, more preferably
460nm-580nm。
14. method as claimed in claim 9, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
15. a kind of according to the method for detecting myocardial infarction and heart failure generation and prognosis degree, it is established that detection cardiac muscle stalk
The instrument and equipment that dead and heart failure occurs.
16. a kind of according to any one of claims 1 to 7 based on nail autofluorescence bilateral symmetry and intensity judgement cardiac muscle
Infarct and heart failure and the application of rear degree are that whether screening detection subject suffers from myocardial infarction or mental and physical efforts in physical examination
Failure detects whether subject suffers from myocardial infarction or heart failure in family and situation of all-level hospitals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810108965.0A CN110132906A (en) | 2018-02-02 | 2018-02-02 | The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810108965.0A CN110132906A (en) | 2018-02-02 | 2018-02-02 | The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110132906A true CN110132906A (en) | 2019-08-16 |
Family
ID=67567483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810108965.0A Pending CN110132906A (en) | 2018-02-02 | 2018-02-02 | The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110132906A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098104A1 (en) * | 2006-04-24 | 2009-04-16 | Medizinische Universitat Wien | Method for Diagnosing Cardiovascular Diseases |
-
2018
- 2018-02-02 CN CN201810108965.0A patent/CN110132906A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098104A1 (en) * | 2006-04-24 | 2009-04-16 | Medizinische Universitat Wien | Method for Diagnosing Cardiovascular Diseases |
Non-Patent Citations (2)
| Title |
|---|
| 刘刚等: "自体荧光诊断技术的研究进展及发展方向", 《生物医学工程学杂志》 * |
| 金妙文，方祝元主编: "《中医辩治心脑血管疾病》", 31 May 2017 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106226275A (en) | A kind of based on fingernail autofluorescence as the detection method of biomarker of detection stroke onset and application thereof | |
| CN110132906A (en) | The method and its application of myocardial infarction and heart failure and rear degree are judged based on nail autofluorescence bilateral symmetry and intensity | |
| CN110763844A (en) | Method for detecting cardiovascular and cerebrovascular disease onset risk product based on nail keratin fragments and keratin content and distribution and application thereof | |
| CN110095440A (en) | The method and its application of cerebral apoplexy generation and rear degree are judged based on body surface autofluorescence bilateral symmetry and intensity | |
| CN110432862A (en) | Based on many places sites spontaneous fluorescence intensity variation comprehensive analysis with judge distinguish lung cancer and cerebral apoplexy method and its application | |
| CN110403569A (en) | Rise the method and its application of comprehensive descision cerebral apoplexy based on the left-right asymmetry property of many places sites autofluorescence and intensity | |
| CN110089997A (en) | The method and its application of myocardial infarction and heart failure and rear degree are judged based on body surface autofluorescence bilateral symmetry and intensity | |
| CN110161251A (en) | The application of keratin protein fraction and keratin level as biomarker in the product that preparation is used for diagnosing outside based on nail | |
| CN110089999A (en) | Detection based on keratin protein fraction and keratin level and bilateral symmetry judges the application and method of cardiovascular and cerebrovascular disease | |
| CN110160998A (en) | Application and method for diagnosing cerebral apoplexy product are being prepared as biomarker based on the left-right asymmetry property of nail autofluorescence | |
| CN110090001A (en) | Autofluorescence is judging the application in cardiovascular and cerebrovascular diseases | |
| CN110313892A (en) | The pathogenetic method and its application of Parkinson are judged based on body surface autofluorescence | |
| CN107290319A (en) | A kind of detection method and its application of autofluorescence distribution and intensity based on lung tissue | |
| CN110313891A (en) | The pathogenetic method and its application of Parkinson are judged based on nail autofluorescence | |
| CN110141189A (en) | Application based on the body surface spontaneous fluorescence intensity in addition to nail as biomarker in the product that preparation occurs for diagnosing | |
| CN110151125A (en) | A kind of application and method based on nail spontaneous fluorescence intensity as biomarker in the product that preparation occurs for diagnosing | |
| CN110881952A (en) | Method for detecting human body clogging product based on human body skin autofluorescence intensity and spatial distribution and application thereof | |
| CN111407228A (en) | Method for judging and distinguishing brain injury, lung injury and heart injury products based on skin autofluorescence and application of method | |
| CN110881948A (en) | Detection method for comprehensively judging senile dementia product based on autofluorescence rule of multiple body surface positions and application thereof | |
| CN110763663A (en) | Method for detecting cardiovascular and cerebrovascular sub-health products based on skin keratin fragments and keratin content and distribution and application thereof | |
| CN110522410A (en) | The method and its application of stable coronary artery disease and myocardial infarction are judged based on many places sites spontaneous fluorescence intensity | |
| CN110623633A (en) | Method for detecting human tissue inflammation based on skin autofluorescence and application thereof | |
| CN110755035A (en) | Method for judging and evaluating cancer onset risk product based on skin autofluorescence and application thereof | |
| CN110763662A (en) | Method for detecting cardiovascular and cerebrovascular sub-health products based on nail keratin fragments and keratin content and distribution and application thereof | |
| CN110887786A (en) | Method for detecting Alzheimer disease occurrence and severity products based on skin keratin fragments and keratin content and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190816 |