CN110089997A - The method and its application of myocardial infarction and heart failure and rear degree are judged based on body surface autofluorescence bilateral symmetry and intensity - Google Patents
The method and its application of myocardial infarction and heart failure and rear degree are judged based on body surface autofluorescence bilateral symmetry and intensity Download PDFInfo
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- CN110089997A CN110089997A CN201810095596.6A CN201810095596A CN110089997A CN 110089997 A CN110089997 A CN 110089997A CN 201810095596 A CN201810095596 A CN 201810095596A CN 110089997 A CN110089997 A CN 110089997A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
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Abstract
The present invention is that the method and its application of myocardial infarction and heart failure and rear degree are judged based on body surface autofluorescence bilateral symmetry and intensity, a kind of left and right distribution and intensity based on the detection positions such as human arm and finger body surface autofluorescence is particularly provided, as detection myocardial infarction and heart failure morbidity and the detection method of prognosis degree.This method is noninvasive, efficient, simple, economy, accuracy are high and reproducible.
Description
Technical field
The present invention relates to a kind of left and right spatial distribution of human body surface autofluorescence and intensity, as judging myocardial infarction
With the method for degree after heart failure morbidity and myocardial infarction and heart failure more.Specifically refer to by comparing human body surface
The distribution of left and right fluorescence intensity and spontaneous fluorescence intensity, judge whether subject suffers from myocardial infarction or heart failure, Yi Jixin
Flesh infarct or the degree of heart failure morbidity also may determine that the rear degree as myocardial infarction and heart failure.
Background technique
In China and countries in the world, myocardial infarction and heart failure (heart failure) be cause death it is most heavy with lifelong disability
One of big disease.In recent years it is in obvious ascendant trend in Chinese myocardial infarction, is newly sent to few 500,000 every year, now suffers from least 2,000,000.
Serious and terminal stage of the heart failure as cardiovascular disease, patient numbers' sustainable growth.Heart failure illness rate may have reached 1.3%,
For existing disease patient there are about 8,000,000 to 1,000 ten thousand, China may have become the country for possessing the maximum patients with heart failure group in the whole world.At present
The main means of diagnosis be by the methods of electrocardiogram, it is more inconvenient for patient, time-consuming relatively long.So far without it is noninvasive,
Quickly, the method for judging myocardial infarction and heart failure and whether falling ill that is economic, being used with family, also can not be used to
When physical examination screening go out myocardial infarction and heart failure patient it is noninvasive, quick, economical, can be with family's application method.Meanwhile so far
Do not have it is noninvasive, quick, economical, can therefore be invented in the method for the judgement myocardial infarction and heart failure prognosis that family uses
The method for judging myocardial infarction and heart failure and whether falling ill that is noninvasive, quick, economic, being used with family can be used to
When physical examination screening go out myocardial infarction and heart failure patient noninvasive, quick, economic method and it is noninvasive, quick, economical,
Can in the method for the judgement myocardial infarction and heart failure prognosis that family uses, have extremely important social and economic significance and
Clinical value.
Summary of the invention
The purpose of the present inventor is to break through the problem of the prior art, proposes that one kind can be used for detecting myocardial infarction and mental and physical efforts
Failure and novel detection method and application to human zero damage.
The present inventor detects the body surface autofluorescence of subject, and myocardial infarction and heart failure (including urgency are found after detection
Property myocardial infarction and heart failure crowd and in convalescent myocardial infarction and heart failure crowd) patients fingers and arm
Equal sites show the left-right asymmetry state of significant human body spontaneous fluorescence, and myocardial infarction and heart failure patient
Body surface autofluorescence be significantly higher than non-salary motivation and heart failure crowd, and left-right asymmetry property is higher, fluorescence intensity more
Height, then myocardial infarction and heart failure severity are higher.The present invention is with left-right asymmetry upper of body surface autofluorescence
Liter and intensity rise detection method and its application as the new marker for judging myocardial infarction and heart failure.
Meanwhile the inventors discovered that, the spontaneous fluorescence intensity that descendant group table is cured in myocardial infarction and heart failure is significantly low
In myocardial infarction or heart failure crowd, and human body autofluorescence bilateral symmetry degree is also above myocardial infarction or heart failure people
Group.And the fluorescence intensity is lower, the fluorescence intensity difference value of left and right corresponding position is smaller, then myocardial infarction and force failure restore journey
It spends higher.The present invention provides a kind of detection method of the new marker after diagnosing myocardial infarction and heart failure more and its answer
With.
And lung cancer population and non-lung cancer population comparisons, increase without the green autofluorescence of significant human body surface, does not also have
There is significant left and right fluorescence asymmetric.
On the one hand, the present invention provides a kind of molecular marked compounds to prepare for judging myocardial infarction and heart failure morbidity
With the application in the product of prognosis degree, wherein the molecular marked compound uses 400nm to the excitation between 750nm
The spontaneous fluorescence intensity of subject's body surface everywhere, the wave-length coverage of the autofluorescence is in 420nm between 800nm.
In a specific embodiment, after the excitation, subject's body surface or so corresponding position it is spontaneous glimmering
Light intensity value is when there were significant differences, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, when the autofluorescence of the excitation subject body surface or so corresponding position is strong
When angle value difference is bigger, myocardial infarction or severity of heart failure are more serious.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject arm skin is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject finger skin is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of palm of hand is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of dorsum of hand is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of face is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin surface is higher
When, myocardial infarction or severity of heart failure are more serious.
In a specific embodiment, the exciting light ranges preferably from 460nm-640nm, more preferably 460nm-
580nm。
In a specific embodiment, the reception optical range is preferably 480nm-750nm, more preferably 500nm-
620nm。
On the other hand, the invention discloses a kind of detection myocardial infarction or the methods of heart failure, wherein including following step
It is rapid:
(1) pass through 400nm to excitation patient's human body surface between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity of autofluorescence is analyzed, it is determined whether be myocardial infarction or heart failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject arm skin is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject finger skin is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of palm of hand is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of dorsum of hand is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin of face is higher than
The spontaneous fluorescence intensity value of non-salary motivation or heart failure patient arm skin, it is determined that subject suffers from myocardial infarction or the heart
Force failure.
In a specific embodiment, when the autofluorescence of the excitation subject bilateral symmetry skin site is strong
Angle value is when there were significant differences, it is determined that subject suffers from myocardial infarction or heart failure.
In a specific embodiment, when the spontaneous fluorescence intensity value of the excitation subject skin surface is higher
It is that myocardial infarction or severity of heart failure are more serious.
In a specific embodiment, when the autofluorescence of excitation subject body surface bilateral symmetry position is strong
When angle value difference is bigger, myocardial infarction or severity of heart failure are more serious.
On the other hand, the invention discloses a kind of detection myocardial infarction or the methods of heart failure recovery extent, wherein packet
Include following steps:
(1) pass through 400nm to excitation patient's human body surface between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity and left and right distribution for analyzing autofluorescence, to judge myocardial infarction or the degree that heart failure restores.
In a specific embodiment, when the excitation suffered from subject's arm of myocardial infarction or heart failure
The spontaneous fluorescence intensity value of skin is lower than myocardial infarction or the average spontaneous fluorescence intensity value of heart failure patient arm skin, then
Determine that subject's myocardial infarction or heart failure have certain recovery.
In a specific embodiment, when the excitation suffered from subject's finger of myocardial infarction or heart failure
The spontaneous fluorescence intensity value of skin is lower than myocardial infarction or the spontaneous fluorescence intensity value of heart failure patient finger skin, it is determined that
Subject's myocardial infarction or heart failure have certain recovery.
In a specific embodiment, after the excitation, some is in convalescent myocardial infarction or mental and physical efforts
The spontaneous fluorescence intensity difference value of failure subject's left hand and right hand skin of arm be significantly higher than lower than in convalescent myocardial infarction or
The autofluorescence difference value of the average left hand and right hand skin of arm of heart failure group, it is determined that subject's myocardial infarction or heart failure
Exhausting has certain recovery.
In a specific embodiment, after the excitation, convalescent myocardial infarction or heart failure are in
When the spontaneous fluorescence intensity value of subject's body surface is closer to the average value of non-salary motivation or heart failure patient, myocardial infarction or
Heart failure recovery extent is better.
In a specific embodiment, after the excitation, convalescent myocardial infarction or heart failure are in
The spontaneous fluorescence intensity value difference of subject's body surface bilateral symmetry position different more hour, myocardial infarction or heart failure recovery extent are got over
It is good.
The present invention has done many experiments, and the body surface of many other Disease body surface fluorescence and healthy population has also been made
Fluorescence.It was found that the body surface autofluorescence of normal person and the patient of other type diseases all do not rise significantly, left and right phase
The fluorescence for the position answered does not have difference.For example it is found that the body surface autofluorescence of patients with lung cancer does not rise significantly, it is left
The fluorescence of right corresponding position does not have difference.
Detailed description of the invention:
Fig. 1 is shown to be excited down using blue light, the autofluorescence of detection subject's arm, palm and finger surface, cardiac muscle stalk
Dead or heart failure or non-salary motivation or the spontaneous fluorescence intensity of heart failure represent figure.
Under using blue light to excite, detect spontaneous glimmering with the symmetrical position of subject's arm, palm and finger
Luminous intensity.Myocardial infarction or heart failure or non-salary motivation or the spontaneous fluorescence intensity of heart failure represent figure.
Specific embodiment
Below will be by specifically describing, the present invention is further illustrated.
Unless otherwise defined, all technical and scientific terms used herein have and the technical field of the invention
Those of ordinary skill be generally understood identical meaning.
As described herein, term " autofluorescence ", " autofluorescence ", " spontaneous fluorescence ", " auto-fluorescence "
It is interchangeable, refer to that tissue, cell, biological substance after by the irradiation of the exciting light of appropriate wavelength, absorb the energy of exciting light
Into excitation state, the phenomenon of light longer than excitation wavelength is launched when exiting excitation state, wherein autofluorescence is than swashing
The longer light of emission wavelength.
As described herein, term " exciting light " is the light for referring to excitation biomolecule and autofluorescence phenomenon occurring, wave
Length should be shorter than autofluorescence.
Described herein, body surface fluorescence refers to the full superficial cutaneous tissue of human body other than nail.
Embodiment 1: exciting light is each position spontaneous fluorescence intensity of body surface and myocardial infarction or heart failure for blue wave band
The relationship exhausted.
According to the present invention, to myocardial infarction or heart failure or non-salary motivation or heart failure crowd, arm, palm,
Finger tripe, finger second knuckle back side, the back of the hand carry out skin autofluorescence using instrument non-invasively imaged in real time.Experimental result
It has been shown that, compared to non-salary motivation or the spontaneous fluorescence intensity of each sites of heart failure crowd, myocardial infarction or mental and physical efforts
The spontaneous fluorescence intensity of the corresponding position of failure patients significantly increases.(Fig. 1)
Embodiment 2: exciting light is for blue wave band, the spontaneous fluorescence intensity difference of subject's body surface bilateral symmetry position with
Myocardial infarction or the relationship of heart failure.
According to the present invention, symmetrical to myocardial infarction or heart failure or non-salary motivation or heart failure patient, left and right sides
Position carries out skin autofluorescence using instrument non-invasively imaged in real time.Experimental result shows, non-salary motivation or heart failure
The body surface spontaneous fluorescence intensity bilateral symmetry of crowd, and myocardial infarction or heart failure patient left and right sides symmetric position is spontaneous glimmering
Luminous intensity is asymmetric.(Fig. 2)
Embodiment 3: exciting light is for blue wave band, each position spontaneous fluorescence intensity of body surface and a myocardial infarction or the heart
Force failure more after relationship.
According to the present invention, to crowd, non-salary motivation or heart failure crowd after a myocardial infarction or heart failure more
And a myocardial infarction or crowd in heart failure 7 days, arm, palm, finger tripe, finger second knuckle back side, the back of the hand make
Skin autofluorescence is carried out with instrument non-invasively imaged in real time.Experimental result is shown, compared to myocardial infarction or in heart failure 7 days
The spontaneous fluorescence intensity of each sites of crowd, a myocardial infarction or heart failure more after patient corresponding position from
The intensity that fluoresces significantly reduces.The change that body surface fluorescence can be used, the finger as degree after myocardial infarction or heart failure more
Mark.
Embodiment 4: exciting light is for blue wave band, the spontaneous fluorescence intensity difference of subject's body surface bilateral symmetry position with
Relationship after myocardial infarction or heart failure more.
According to the present invention, to crowd, non-salary motivation or heart failure crowd after a myocardial infarction or heart failure more
And a myocardial infarction or crowd in heart failure 7 days, left and right sides symmetric position carry out skin autofluorescence using instrument
It is non-invasively imaged in real time.Experimental result shows, crowd after a myocardial infarction or heart failure more, and with after more, degree is increasingly
Good, body surface fluorescence is intended to bilateral symmetry.
Based on technology of the invention, (including but not limited to) will be applied to: 1. myocardial infarction or the heart in crowd's physical examination
Force failure screening.2. myocardial infarction and heart failure self screening for family.3. for situation of all-level hospitals (including community hospital
With other situation of all-level hospitals) diagnosis of myocardial infarction and heart failure.4. for family and situation of all-level hospitals for myocardial infarction and the heart
The detection of force failure Rehabilitation degree.
Those skilled in the art is it should be understood that although for illustrative purposes, this document describes tools of the invention
Body embodiment, but it can be carry out various modifications without departing from the spirit and scope of the present invention.Therefore, of the invention specific
Embodiments and examples should not be considered as limiting the scope of the invention.The present invention is limited only by the appended claims.This Shen
Please in quote all documents be fully incorporated herein by reference.
Claims (24)
1. it is a kind of based on body surface autofluorescence bilateral symmetry and intensity judge myocardial infarction and heart failure and more after degree
Using being biomarker for diagnosing myocardial infarction and heart failure and judges that myocardial infarction and heart failure are pre- in preparation
The application in product afterwards, wherein the molecular marked compound is to use 400nm to the excitation subject between 750nm
The spontaneous fluorescence intensity of human body surface, the wave-length coverage of the autofluorescence is in 420nm between 800nm.
2. application as described in claim 1, detects the position of human body surface, wherein the exciting light ranges preferably from
460nm-640nm, more preferably 460nm-580nm.
3. application as described in claim 1, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
4. application as described in claim 1, wherein the human body surface fluorescence intensity when subject's left and right side has asymmetry
When, it is determined that subject suffers from myocardial infarction or heart failure.
5. application as described in claim 1, wherein the human body surface fluorescence intensity when subject's left and right side is more asymmetric,
Then subject's myocardial infarction or severity of heart failure are more serious.
6. application as described in claim 1, wherein the human body surface refer to do not include nail all human body surfaces, it is excellent
It is selected as finger, palm, arm and face.More preferably finger and arm.
7. application as described in claim 1, wherein when subject's human body surface fluorescence intensity is higher than the non-cardiac muscle stalk measured
When dead or heart failure tester average body surface fluorescence, it is determined that subject suffers from myocardial infarction or heart failure.
8. application as described in claim 1, wherein subject's human body surface fluorescence intensity is higher, myocardial infarction or heart failure
Degree is more serious.
9. a kind of detection myocardial infarction or the method for heart failure, wherein the following steps are included:
(1) pass through 400nm to excitation patient's human body surface between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity of autofluorescence is analyzed, it is determined whether be myocardial infarction or heart failure.
(4) whether the intensity left and right sides for analyzing autofluorescence is symmetrical, it is determined whether is myocardial infarction or heart failure.
10. method as claimed in claim 9, wherein subject's body surface fluorescence intensity level or so is distributed after excitation
When different, it is determined that subject suffers from myocardial infarction or heart failure.
11. method as claimed in claim 9, wherein the human body surface fluorescence intensity when subject's left and right side the not right
Claim, then subject's myocardial infarction or severity of heart failure are more serious.
12. method as claimed in claim 9, wherein measured when excitation subject's body surface fluorescence intensity level is higher than
Non-salary motivation or heart failure tester average body surface autofluorescence when, it is determined that subject suffer from myocardial infarction or the heart
Force failure.
13. method as claimed in claim 9, wherein subject's human body surface fluorescence intensity is higher, myocardial infarction or heart failure
It is more serious to exhaust degree.
14. application as claimed in claim 9, wherein the exciting light ranges preferably from 460nm-640nm, more preferably
460nm-580nm。
15. application as claimed in claim 9, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
16. a kind of method of detection myocardial infarction or heart failure recovery extent, wherein the following steps are included:
(1) pass through 400nm to the full surface of excitation patient's human body between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) difference value of autofluorescence in the intensity and left and right same position of autofluorescence is analyzed, it is determined whether be myocardium stalk
Dead or heart failure restores.
17. the method described in claim 16, wherein after excitation, tested myocardial infarction or heart failure are suffered from
Fluorescence intensity level difference of person's body surface on left and right sides corresponding position is bigger, then the prognosis of myocardial infarction or heart failure is poorer.
18. the method described in claim 16, wherein after excitation, tested myocardial infarction or heart failure are suffered from
Fluorescence intensity level difference of person's body surface on left and right sides corresponding position is smaller, then the prognosis of myocardial infarction or heart failure is better.
19. the method described in claim 16, wherein myocardial infarction or HF subject are a certain after excitation
Average body surface fluorescence intensity of the body surface fluorescence intensity level at a position close to non-salary motivation or heart failure patient at the position
When value, it is determined that subject's myocardial infarction or heart failure restore.
20. the method described in claim 16, after excitation, the body surface of myocardial infarction or HF subject are glimmering
When average body surface fluorescence intensity level of the light intensity value closer to non-salary motivation or heart failure patient at the position, it is determined that by
Examination person's myocardial infarction or heart failure restore better.
21. application as claimed in claim 16, wherein the exciting light ranges preferably from 460nm-640nm, more preferably
460nm-580nm。
22. the method described in claim 16, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
23. a kind of according to the method for detecting myocardial infarction and heart failure generation and prognosis degree, it is established that detection cardiac muscle stalk
The instrument and equipment of dead and heart failure generation and prognosis degree.
24. judging myocardial infarction based on body surface autofluorescence bilateral symmetry and intensity to any described in 8 according to claim 1
It is that whether screening detection subject suffers from myocardial infarction or heart failure in physical examination with heart failure and the application of rear degree
It exhausts, or detect whether subject suffers from myocardial infarction or heart failure in family and situation of all-level hospitals；Be in family and
The rehabilitation degree of tested myocardial infarction or heart failure patient is detected in situation of all-level hospitals.
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| CN105699659A (en) * | 2016-01-29 | 2016-06-22 | 苏州联辰生物技术有限公司 | Tachysynthesis fluorescent quantitation detection kit for multi-index detection of myocardial infarction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098104A1 (en) * | 2006-04-24 | 2009-04-16 | Medizinische Universitat Wien | Method for Diagnosing Cardiovascular Diseases |
| US20110118611A1 (en) * | 2006-06-29 | 2011-05-19 | Vincent Luciano | Module mounting mirror endoscopy |
| CN102762978A (en) * | 2009-11-17 | 2012-10-31 | 薇拉莱特公司 | Method and apparatus to detect coronary artery calcification or disease |
| CN104587493A (en) * | 2015-02-05 | 2015-05-06 | 东南大学 | Detection reagents for fast and real-time dynamic monitoring and multimode imaging in early stage of cardio-cerebrovascular related diseases |
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Application publication date: 20190806 |