CN110522410A - The method and its application of stable coronary artery disease and myocardial infarction are judged based on many places sites spontaneous fluorescence intensity - Google Patents
The method and its application of stable coronary artery disease and myocardial infarction are judged based on many places sites spontaneous fluorescence intensity Download PDFInfo
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- CN110522410A CN110522410A CN201810515714.4A CN201810515714A CN110522410A CN 110522410 A CN110522410 A CN 110522410A CN 201810515714 A CN201810515714 A CN 201810515714A CN 110522410 A CN110522410 A CN 110522410A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
Abstract
The present invention provides detection methods and its application that the special overall combination regular (Pattern) that a kind of intensity based on the multiple position autofluorescences of comprehensive descision body surface and spontaneous fluorescence intensity rise left-right asymmetry property judges stable coronary artery disease and myocardial infarction.The special overall combination of the spontaneous fluorescence intensity and the left-right asymmetry property of autofluorescence at this method comprehensive analysis and calculating multiple positions detected is regular (Pattern), to judge whether detected person suffers from stable coronary artery disease or myocardial infarction.This method is noninvasive, efficient, simple, accuracy is high and reproducible.
Description
Technical field
Invention provides a kind of intensity and autofluorescence based on the multiple position autofluorescences of comprehensive descision body surface
The special overall combination regular (Pattern) that intensity rises left-right asymmetry property judges stable coronary artery disease and the heart
The detection method and its application of flesh infarct.This method comprehensive analysis and calculate multiple positions detected spontaneous fluorescence intensity and
The special overall combination of the left-right asymmetry property of autofluorescence is regular (Pattern), to judge whether detected person suffers from surely
Qualitative coronary artery disease or myocardial infarction.This method is noninvasive, efficient, simple, accuracy is high and reproducible.
Background technique
In China and countries in the world, myocardial infarction is most one of the major disease to cause death with lifelong disability.In
State's myocardial infarction is in obvious ascendant trend in recent years, is newly sent to few 500,000 every year, now suffers from least 2,000,000.Current diagnosis it is main
Means be by the methods of electrocardiogram, it is more inconvenient for patient, time-consuming relatively long.So far without it is noninvasive, quick, economical,
The method for judging myocardial infarction and whether falling ill that can be used with family can not be used to the screening in physical examination yet and go out myocardial infarction
It is noninvasive, quick, economical, can be with family's application method.Therefore, noninvasive, quick, economic, sentencing of can using with family is invented
The method and noninvasive, quick, warp that the screening in physical examination goes out myocardial infarction patient can be used to whether disconnected myocardial infarction falls ill
The method of Ji has extremely important social and economic significance and clinical value.
Summary of the invention
The purpose of the present invention is break through the prior art problem, propose one kind can be used for stable coronary artery disease or
Noninvasive, the quick method and its application for a possibility that myocardial infarction is fallen ill.
The specific technical solution of the present invention is: a method of judging stable coronary artery disease and myocardial infarction,
In, comprising the following steps: 1) pass through 400nm to the multiple human body surfaces of excitation test subject between 750nm；2) it receives
420nm is to the autofluorescence between 800nm；3) intensity of the analysis autofluorescence in specific position；4) in the position with normal person
Spontaneous fluorescence intensity average value make comparisons；5) total number of positions that there is tester spontaneous fluorescence intensity to rise is calculated；6) it calculates
The sum that tester has spontaneous fluorescence intensity anisopleual in body.Wherein, detection body surface refers specifically to the full table of human body
Face, preferably left and right sides facial skin, arm, palm, finger and nail.Wherein, when excitation subject's body surface a part
When fluorescence intensity level is higher than the average body surface autofluorescence at the Healthy People position measured, then it is assumed that body surface fluorescence intensity at this
It is high.
If the high position of subject's body surface fluorescence intensity is more than or equal to 1, it was initially believed that subject is likely to suffer from
There is stable coronary artery disease.And subject's body surface fluorescence intensity it is high position it is more, then it is assumed that subject suffer from stability
A possibility that coronary artery disease, is higher, stable coronary artery disease is more serious.
If the high position of subject's body surface fluorescence intensity is more than or equal to 2, it was initially believed that subject is likely to suffer from
There is or will suffer from myocardial infarction.And subject's body surface fluorescence intensity it is high position it is more, myocardial infarction degree is more serious.
When excitation subject's body surface a part fluorescence intensity left and right sides asymmetry is higher than the Healthy People measured
When the average body surface autofluorescence left and right sides asymmetry at the position, then it is assumed that body surface fluorescence left and right sides asymmetry is high at this.
If the subject asymmetric position of body surface fluorescence left and right sides is more than or equal to 1, it was initially believed that subject is very
Stable coronary artery disease may be suffered from.And subject's body surface fluorescence left and right sides asymmetry it is high position it is more, then it is assumed that
A possibility that subject is with stable coronary artery disease is higher, stable coronary heart disease is more serious.
If the high position of subject's body surface fluorescence left and right sides asymmetry is more than or equal to 2, it was initially believed that tested
Person is likely to suffer from or will suffer from myocardial infarction.And subject's body surface fluorescence asymmetry intensity it is high position it is more, cardiac muscle
Infarct degree is more serious.
There is spontaneous fluorescence intensity increase and the increase or so no to detected position upward stability coronary artery disease
The special overall combination of symmetry is regular (pattern).Such as hand and arm part are spontaneous glimmering at left and right sides of only detection
Light time, if the nail and elbow back side of subject's body bilateral side have significant spontaneous fluorescence intensity to rise, and in other portions
Position significantly rises without spontaneous fluorescence intensity, then may determine that a possibility that detected person is with stable coronary artery disease
It is bigger.If the spontaneous fluorescence intensity of testee is on the inside of nail, finger, finger back side, in this four positions of the back of the hand center
Position with autofluorescence luminous intensity asymmetry is more, without having spontaneous fluorescence intensity asymmetry at other positions
When, a possibility which suffers from stable coronary artery disease, is bigger.
Myocardial infarction has special overall group of spontaneous fluorescence intensity increase and asymmetry on being detected position
Close regular (Pattern).Such as the hand and when arm part autofluorescence at left and right sides of only detection, if testee is in body
The centre of the palm, finger veutro, Index finger and the elbow inside of body left and right sides have significant fluorescence intensity to rise, and at other positions
There is no spontaneous fluorescence intensity rising, then may determine that a possibility that detected person is with myocardial infarction is bigger.If tester
Spontaneous fluorescence intensity on this four positions of the centre of the palm, finger veutro, nail and elbow back side have autofluorescence luminous intensity
The position of asymmetry is more, without when other positions have autofluorescence luminous intensity asymmetry, which suffers from cardiac muscle
A possibility that infarct, is bigger.
Application scenarios of the invention include: to detect subject in family and situation of all-level hospitals whether to suffer from stability coronal
Arterial disease or myocardial infarction, or judge whether detected person suffers from stable coronary artery disease in physical examination or when Mass screening
Disease or myocardial infarction.
In a specific embodiment, detection body surface be facial skin 5 at, left and right arm back side veutro, left and right sides
The palm centre of the palm and the palm back, left and right hand finger, left and right finger nail.
In a specific embodiment, detection body surface be left and right arm back side veutro, the left and right sides palm centre of the palm and
Slap back, left and right hand finger, left and right finger nail.
In a specific embodiment, it has been measured when excitation subject's body surface a part fluorescence intensity level is higher than
At 1.5 times of average body surface autofluorescence of the non-coronary arterial disease tester position, then it is assumed that body surface fluorescence intensity is high at this.
In a specific embodiment, when the high position of subject's body surface fluorescence intensity is more than or equal at 2, then judge tested
Person has a possibility that height coronary artery disease.
In a specific embodiment, when the high position of subject's body surface fluorescence intensity is more than or equal at 2, then judge tested
Person suffers from coronary artery disease.
In a specific embodiment, it has been measured when excitation subject's body surface a part fluorescence intensity level is lower than
At 0.75 times of average body surface autofluorescence of the coronary artery disease acute stage tester position, then it is assumed that body surface fluorescence is strong at this
It spends low.
In a specific embodiment, when the low position of subject's body surface fluorescence intensity is more than or equal at 2, then judge tested
The period height of person's coronary artery disease is the convalescence a possibility that.
In a specific embodiment, when the low position of subject's body surface fluorescence intensity is more than or equal at 2, then judge tested
Person is in coronary artery disease convalescence.
In a specific embodiment, coronary artery disease acute stage crowd and coronary artery disease convalescence crowd or so
Finger nail, palm, finger, arm, face's autofluorescence asymmetry are all remarkably higher than people at highest risk.Wherein finger, arm, face
Autofluorescence asymmetry coronary artery disease acute stage crowd is significantly higher than coronary artery disease convalescence crowd.
In a specific embodiment, detection body surface be facial skin 5 at, left and right arm back side veutro, left and right sides
The palm centre of the palm and the palm back, left and right hand finger, left and right finger nail.
In a specific embodiment, detection body surface be left and right arm back side veutro, the left and right sides palm centre of the palm and
Slap back, left and right hand finger, left and right finger nail.
In a specific embodiment, it has been surveyed when excitation subject's body surface a part fluorescence left and right sides difference is higher than
At average 1.5 times of body surface autofluorescence difference of the fixed non-coronary arterial disease tester position, then it is assumed that body surface is glimmering at this
Light asymmetry is high.
In a specific embodiment, when the high position of subject's body surface fluorescence asymmetry is more than or equal at 2, then judge
Subject has a possibility that height coronary artery disease.
In a specific embodiment, when the high position of subject's body surface fluorescence asymmetry is more than or equal at 2, then judge
Subject suffers from coronary artery disease.
In a specific embodiment, when excitation subject's body surface a part fluorescence asymmetry difference is lower than
At 0.75 times of the average body surface autofluorescence difference at the coronary artery disease acute stage tester of the measurement position, then it is assumed that should
It is low to locate body surface fluorescence asymmetry degree.
In a specific embodiment, when the low position of subject's body surface fluorescence asymmetry is more than or equal at 2, then judge
The period height of subject's coronary artery disease is the convalescence a possibility that.
In a specific embodiment, when the low position of subject's body surface fluorescence asymmetry is more than or equal at 2, then judge
Subject is in coronary artery disease convalescence.
Specific embodiment
Below will be by specifically describing, the present invention is further illustrated.
Unless otherwise defined, all technical and scientific terms used herein have and the technical field of the invention
Those of ordinary skill be generally understood identical meaning.
As described herein, term " autofluorescence ", " autofluorescence ", " spontaneous fluorescence ", " auto-fluorescence "
It is interchangeable, refer to that tissue, cell, biological substance after by the irradiation of the exciting light of appropriate wavelength, absorb the energy of exciting light
Into excitation state, the phenomenon of light longer than excitation wavelength is launched when exiting excitation state, wherein autofluorescence is than swashing
The longer light of emission wavelength.
As described herein, term " exciting light " is the light for referring to excitation biomolecule and autofluorescence phenomenon occurring, wave
Length should be shorter than autofluorescence.
As described herein, term " coronary artery disease acute stage " refers to that coronary artery disease occurred within 1 week.
As described herein, term " coronary artery disease convalescence " refers to that it is more than week to occur 1 for coronary artery disease, one
Within year.
Described herein, body surface fluorescence refers to the full superficial cutaneous tissue of human body other than nail.
Embodiment 1: when exciting light is blue wave band, each position spontaneous fluorescence intensity of joint body surface and coronary artery disease
The relationship of acute stage and coronary artery disease convalescence.
According to the present invention, to the finger of coronary artery disease or non-coronary arterial disease crowd right-hand man's symmetric position, make
Skin green autofluorescence is carried out with instrument non-invasively imaged in real time.
According to the present invention, to people at highest risk, coronary artery disease acute stage crowd and coronary artery disease convalescence crowd,
Arm, palm, finger tripe, finger second knuckle back side, the back of the hand, using instrument to skin autofluorescence carry out in real time it is noninvasive at
Picture.Experimental result is shown, compared to the spontaneous fluorescence intensity of each sites of non-coronary arterial disease crowd, coronary artery disease
The spontaneous fluorescence intensity of the corresponding position of patient significantly increases.Autofluorescence intensity is higher than the people at highest risk position from glimmering by us
The value that 1.5 times of luminous intensity is considered the high position of fluorescence.
We have found that a possibility that subject is coronary artery disease, is high when the high position of fluorescence is greater than at 2.
Embodiment 2: when exciting light is blue wave band, each position spontaneous fluorescence intensity of joint body surface and coronary artery disease
The relationship of acute stage and coronary artery disease convalescence.
According to the present invention, to coronary artery disease acute stage crowd and coronary artery disease convalescence crowd, arm, hand
The palm, finger tripe, finger second knuckle back side, the back of the hand carry out skin autofluorescence using instrument non-invasively imaged in real time.Experiment knot
Fruit shows that, compared to the spontaneous fluorescence intensity of each sites of coronary artery disease acute stage crowd, coronary artery disease is extensive
The spontaneous fluorescence intensity of the corresponding position of multiple phase crowd significantly reduces.We are acute lower than coronary artery disease by autofluorescence intensity
The value of phase crowd 0.75 times of the position autofluorescence intensity is considered the low position of fluorescence.
We have found that a possibility that subject is coronary artery disease convalescence, is high when the low position of fluorescence is greater than at 2.
Embodiment 3: exciting light be blue wave band when, the spontaneous fluorescence intensity difference of subject's body surface bilateral symmetry position with
The relationship of coronary artery disease.
According to the present invention, instrument is used to coronary artery disease or non-coronary arterial disease patient, left and right sides symmetric position
Skin autofluorescence is carried out non-invasively imaged in real time.Experimental result shows, the body surface autofluorescence of non-coronary arterial disease crowd
Intensity bilateral symmetry, and the spontaneous fluorescence intensity of patients with coronary artery disease left and right sides symmetric position is asymmetric.Detect body surface portion
Position is left and right arm back side veutro, the left and right sides palm centre of the palm and the palm back, left and right hand finger, left and right finger nail.When exciting light swashs
Hair subject's body surface a part fluorescence left and right sides difference is higher than being averaged for the non-coronary arterial disease tester position measured
At 1.5 times of body surface autofluorescence difference, then it is assumed that body surface fluorescence asymmetry is high at this.Subject's body surface fluorescence asymmetry is high
Position be more than or equal to 2 at when, then judge that subject has a possibility that height coronary artery disease.
Embodiment 4: when exciting light is blue wave band, the joint each position autofluorescence left and right sides asymmetry of body surface and hat
The relationship of Coronary disease acute stage and coronary artery disease convalescence.
When excitation subject's body surface a part fluorescence asymmetry difference is lower than the coronary artery disease measured
At 0.75 times of the average body surface autofluorescence difference at the acute stage tester position, then it is assumed that body surface fluorescence asymmetry at this
Degree is low.When the low position of subject's body surface fluorescence asymmetry is more than or equal at 2, then subject's coronary artery disease is judged
Period height is high the convalescence a possibility that.
Embodiment 5: when exciting light is blue wave band, detect on subject's hand and elbow the green of totally ten four positions from
It fluoresces.Stable coronary artery disease and patients with myocardial infarction all have the special of spontaneous fluorescence intensity lifting position totality
Regular (Pattern).(table 1)
Embodiment 5: when exciting light is blue wave band, detect on subject's hand and elbow the green of totally ten four positions from
It fluoresces.All there is spontaneous fluorescence intensity to rise left-right asymmetry position for stable coronary artery disease and patients with myocardial infarction
Set overall particular law (Pattern).(table 2)
Based on technology of the invention, (including but not limited to) will be applied to: 1. coronary artery disease in crowd's physical examination
Period screening.2. being used for self screening of the coronary artery disease period of family.3. for situation of all-level hospitals (including community hospital and its
Its situation of all-level hospitals) coronary artery disease period diagnosis.4. for family and situation of all-level hospitals for patients with coronary artery disease health
The detection of multiple degree.
Those skilled in the art is it should be understood that although for illustrative purposes, this document describes tools of the invention
Body embodiment, but it can be carry out various modifications without departing from the spirit and scope of the present invention.Therefore, of the invention specific
Embodiments and examples should not be considered as limiting the scope of the invention.The present invention is limited only by the appended claims.This Shen
Please in quote all documents be fully incorporated herein by reference.
Table 1
Table 2.
Claims (13)
1. a kind of method that stable coronary artery disease and myocardial infarction are judged based on many places sites spontaneous fluorescence intensity,
It is with stable coronary artery disease or myocardial infarction to distinguish testee；The following steps are included:
(1) pass through 400nm to the multiple human body surfaces of excitation test subject between 750nm；
(2) 420nm is received to the autofluorescence between 800nm；
(3) intensity of the analysis autofluorescence in specific position；
(4) it makes comparisons with the spontaneous fluorescence intensity average value of normal person in the position；
(5) total number of positions that there is tester spontaneous fluorescence intensity to rise is calculated；
(6) sum that tester has spontaneous fluorescence intensity anisopleual in body is calculated.
2. the method for claim 1, wherein detection body surface refers specifically to the full surface of human body, preferably left and right sides face
Skin, arm, palm, finger or nail.
3. the method for claim 1, wherein when excitation subject's body surface a part fluorescence intensity level is higher than
When the average body surface autofluorescence at the Healthy People of the measurement position, then it is assumed that body surface fluorescence intensity is high at this.
4. the method as described in claim 1, when wherein the high position of subject's body surface fluorescence intensity is more than or equal to 1, then just
Step thinks that subject is likely to stable coronary heart disease；And subject's body surface fluorescence intensity it is high position it is more, then it is assumed that by
A possibility that examination person is with stable coronary heart disease is higher, stable coronary heart disease is more serious.
5. the method as described in claim 1, when wherein the high position of subject's body surface fluorescence intensity is more than or equal to 2, then just
Step thinks that subject is likely to suffer from or will suffer from myocardial infarction；And subject's body surface fluorescence intensity it is high position it is more, the heart
Flesh infarct degree is more serious.
6. the method for claim 1, wherein when excitation subject's body surface a part fluorescence intensity left and right sides not
When symmetry is higher than the average body surface autofluorescence left and right sides asymmetry at the Healthy People position measured, then it is assumed that body at this
Table fluorescence left and right sides asymmetry is high.
7. method according to claim 2, wherein when the subject asymmetric position of body surface fluorescence left and right sides is more than or equal to 1
When a, then it was initially believed that subject is likely to stable coronary artery disease；And subject's body surface fluorescence left and right sides is not right
The high position of title property is more, then it is assumed that subject suffers from a possibility that stable coronary artery disease higher, stable coronary heart disease
It is more serious.
8. the method for claim 1, wherein the high position of subject's body surface fluorescence left and right sides asymmetry is more than or equal to
At 2, then it was initially believed that subject is likely to suffer from or will suffer from myocardial infarction.And subject's body surface fluorescence asymmetry is strong
It is more to spend high position, myocardial infarction degree is more serious.
9. stable coronary artery disease has spontaneous glimmering the method for claim 1, wherein on being detected position
Luminous intensity increases and the special overall combination rule of the left-right asymmetry property of the increase；Hand and hand at left and right sides of only detection
When arm autofluorescence, if the nail and elbow back side of subject's body bilateral side have significant spontaneous fluorescence intensity to rise,
And there is no spontaneous fluorescence intensity to significantly rise at other positions, then it may determine that the detected person with stable coronary artery disease
A possibility that sick, is bigger；If the spontaneous fluorescence intensity of testee is on the inside of nail, finger, finger back side, the back of the hand center this
Position in four positions with autofluorescence luminous intensity asymmetry is more, without having spontaneous fluorescence intensity at other positions
When asymmetry, a possibility which suffers from stable coronary artery disease, is bigger.
10. myocardial infarction increases with spontaneous fluorescence intensity the method for claim 1, wherein on being detected position
And the special overall combination rule of asymmetry；When only detecting left and right sides hand and arm part autofluorescence, if
Testee has significant fluorescence intensity to rise on the inside of the centre of the palm of body bilateral side, finger veutro, Index finger and elbow,
And there is no spontaneous fluorescence intensity rising at other positions, then it may determine that the detected person gets over a possibility that myocardial infarction
Greatly；If the spontaneous fluorescence intensity of tester has certainly on this four positions of the centre of the palm, finger veutro, nail and elbow back side
The position of the luminous intensity that fluoresces asymmetry is more, without being somebody's turn to do when other positions have autofluorescence luminous intensity asymmetry
It is bigger that tester suffers from a possibility that myocardial infarction.
11. the method for claim 1, wherein the exciting light ranges preferably from 460nm-640nm, more preferably
460nm-580nm。
12. the method for claim 1, wherein the reception optical range is preferably 480nm-750nm, more preferably
500nm-620nm。
13. a kind of judge answering for stable coronary artery disease and myocardial infarction based on many places sites spontaneous fluorescence intensity
With, be family and situation of all-level hospitals diagnosis subject whether suffer from stable coronary artery disease or myocardial infarction or for being good for
Health screening.
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| CN101292046A (en) * | 2005-09-14 | 2008-10-22 | 人类遗传标记控股有限公司 | Assay for a health state |
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| CN103561639A (en) * | 2011-05-31 | 2014-02-05 | 罗兹工业大学 | A method and a system for evaluating vascular endothelium function |
| WO2015044979A1 (en) * | 2013-09-26 | 2015-04-02 | テルモ株式会社 | Information processing device, imaging system, information processing method and program |
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Application publication date: 20191203 |