CN110123791B - Dressing for promoting hair growth - Google Patents
Dressing for promoting hair growth Download PDFInfo
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- CN110123791B CN110123791B CN201811210048.XA CN201811210048A CN110123791B CN 110123791 B CN110123791 B CN 110123791B CN 201811210048 A CN201811210048 A CN 201811210048A CN 110123791 B CN110123791 B CN 110123791B
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
- D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
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Abstract
Unlike commercially available hair growth promoting compositions, which are complex in formulation and expensive in sale, the present inventors have fabricated a plurality of lanthanide series metal doped mesoporous silica nanoparticles and a polymer material into a plurality of biological yarns by electrospinning or filament drawing techniques, and then woven the plurality of biological yarns into a biological fabric using a weaving device, thereby serving as a hair growth promoting dressing of the present invention. It is conceivable that the dressing for promoting hair growth of the present invention has the absolute advantage of being inexpensive to manufacture compared to commercially available hair growth compositions. In addition, the experimental results also confirmed that the head of the nude mouse has a significant hair growth effect after continuously using the dressing for promoting hair growth of the present invention for seven days. Obviously, the dressing for promoting hair growth of the present invention exhibits immediate hair growth efficacy, compared to the commercially available hair growth composition which must be used for at least four months for exhibiting hair growth effects.
Description
Technical Field
The invention relates to the technical field of biotechnology, in particular to a dressing for promoting hair growth.
Background
Hair loss is the result of a combination of genetic factors, environmental factors and physiological states. With the increase of environmental pollutants and the accumulation of life pressure, hair loss becomes an inevitable trouble for most middle-aged men.
Currently, a variety of hair growth products are marketed, such as baekengei and koppei. Although the build-up has good clinical results, nearly half of the users can grow only thin and short hairs after the build-up. On the other hand, gentle hair also has the effect of increasing hair volume, but the hair-increasing effect is significantly reduced after one year of use. Before using the hair growth product, the side effects which the hair growth product will bring must be considered in detail, for example, the hair growth product can cause side effects such as scalp itch, blurred vision, chest pain, hypotension, decreased libido and the like, and the softness can cause the side effects such as decreased libido, erectile dysfunction and ejaculation disorder of male users.
On the other hand, the important point that must be considered at the same time is that the price of the commercial hair growth products is too expensive, resulting in users with poor income either preferring to suffer from the crisis of baldness or being willing to spend too much money on purchasing hair growth products. Therefore, the most important issue for manufacturers of hair growth promoting products is to provide a hair growth promoting product with simple process, low cost and easy use; moreover, the selling price of the hair growth product must be acceptable for general users. Therefore, the inventors of the present invention have made intensive studies and as a result, have developed a dressing for promoting hair growth according to the present invention.
Disclosure of Invention
The main object of the present invention is to provide a dressing for promoting hair growth. Unlike commercially available hair growth promoting compositions, which have complicated formulations and expensive prices, the present inventors processed a plurality of lanthanide doped mesoporous silica nanoparticles and a polymer material into a plurality of biological yarns by electrospinning or filament drawing, and woven the plurality of biological yarns into a biological fabric using a weaving device, thereby providing a hair growth promoting dressing of the present invention. It is conceivable that the dressing for promoting hair growth of the present invention has an absolute advantage of being inexpensive to manufacture compared to commercially available hair growth compositions. In addition, the experimental results also confirmed that the head of the nude mouse has a significant hair growth effect after continuously using the dressing for promoting hair growth of the present invention for seven days. Obviously, the dressing for promoting hair growth of the present invention exhibits immediate hair growth efficacy, as compared to a commercially available hair growth composition which must be used for at least four months for a long period of time to show hair growth effects.
In order to achieve the above-mentioned objectives, the present inventors provide an embodiment of the dressing for promoting hair growth, which is formed by interweaving a plurality of warp yarns and a plurality of weft yarns; wherein the warp yarn and the weft yarn are both biological yarns, and the biological yarns comprise:
a polymer sheath; and
a plurality of mesoporous silica nanoparticles doped with lanthanide metals, doped or encapsulated in the polymer sheath;
wherein the particle size of the lanthanide metal doped mesoporous silica nanoparticles is less than 100nm, and each 1 square centimeter of the dressing for promoting hair growth contains at least 16.48mg of the lanthanide metal doped mesoporous silica nanoparticles.
In order to achieve the above-mentioned main object of the present invention, the present inventors provide another embodiment of the dressing for promoting hair growth, which is formed by interweaving a plurality of warp yarns and a plurality of weft yarns; wherein the plurality of warp yarns and the plurality of warp yarns comprise a plurality of first yarns and a plurality of second yarns; wherein the first yarn is a biological yarn, and the second yarn is a natural yarn or a man-made yarn; the biological yarn comprises:
a polymer sheath; and
a plurality of mesoporous silica nanoparticles doped with lanthanide metals, doped or encapsulated in the polymer sheath;
wherein the particle size of the lanthanide metal doped mesoporous silica nanoparticles is less than 100nm, and each 1 square centimeter of the dressing contains at least 16.48mg of the lanthanide metal doped mesoporous silica nanoparticles.
Drawings
FIG. 1 shows a schematic perspective view of a first embodiment of a hair growth promoting dressing of the present invention;
fig. 2 shows a cross-sectional view of a biological yarn;
fig. 3A to 3B are schematic views illustrating a process of manufacturing a biological yarn;
FIG. 4 shows a schematic view of a biological yarn process;
FIGS. 5A to 5C are schematic views showing the manufacturing process of the dressing for promoting hair growth according to the present invention;
FIG. 6 shows an image of a nude mouse;
FIG. 7 shows a graph of data for time versus body weight;
FIG. 8A is a diagram showing a histological section of head skin of a nude mouse in which an animal experiment is completed;
FIG. 8B is a sectional view showing a dermal tissue of the head of a normal nude mouse;
fig. 9 shows a schematic perspective view of a second embodiment of a hair growth promoting dressing of the present invention;
fig. 10 shows a schematic perspective view of a third embodiment of a hair growth promoting dressing of the present invention; and
fig. 11 shows a schematic perspective view of a fourth embodiment of the hair growth promoting dressing of the present invention.
Detailed Description
In order to more clearly describe a dressing for promoting hair growth according to the present invention, a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.
First embodiment
Referring to fig. 1, there is shown a schematic perspective view of a first embodiment of a hair growth promoting dressing of the present invention. In the first embodiment, the dressing 1 for promoting hair growth of the present invention is a Bio-fabric (Bio-fabric) formed by interweaving a plurality of warp yarns 1WA and a plurality of weft yarns 1 WE. Referring also to fig. 2, a cross-sectional view of a biological yarn is shown. According to the design of the present invention, the warp yarn 1WA and the weft yarn 1WE are both a biological yarn 11, and the biological yarn 11 includes: a polymer sheath (polymer sheath) 111 and a plurality of lanthanide metal doped Mesoporous Silica Nanoparticles (MSN) 112. Specifically, the lanthanide metal doped mesoporous silica nanoparticles 112 are represented by the formula SiO2x EuyGdz, and are doped or encapsulated in the polymer sheath 111. It should be noted that x, y and z in the formula are weight percentage values; and, x is between 99wt% and 99.8wt%, and y and z are between 0.1wt% and 0.5 wt%.
The present invention is not particularly limited to the kind or material of the polymer sheath 111, and therefore the polymer sheath 111 may be any one of the following: gelatin/trifluoroethanol composite sheath, gelatin/trifluoroethanol/polycaprolactone composite sheath, gelatin/trifluoroethanol/polylactic acid sheath, polyester (PET) sheath, polyurethane (PU) sheath, polyvinyl chloride (Poly (vinyl chloride), PVC) sheath, polypropylene (PP) sheath, polyamide (PA) sheath, a combination of both, or a combination of two or more thereof. It should be noted that gelatin, polycaprolactone (PCL), and Polylactic acid (PLA) belong to biodegradable high molecular polymers, and others are common synthetic high molecular materials.
First manufacturing method
To obtain the dressing 1 for promoting hair growth of the present invention, it is necessary to prepare the lanthanide-doped Mesoporous Silica Nanoparticles (MSN) 112 first, comprising the following steps:
(1) Cetyl Trimethyl Ammonium Bromide (CTAB) as a surfactant and sodium hydroxide (NaOH) as the alkali metal compound, and adding both to secondary water (distilled deionized water), followed by heating and stirring;
(2) Sequentially adding Tetraethoxysilane (TEOS), europium chloride and gadolinium chloride into the solution obtained in the step (1), and stirring at constant temperature;
(3) Centrifuging, washing and filtering the solution obtained in the step (2);
(4) Drying the filtered precipitate obtained in the previous step (3); and
(5) Calcining the dried precipitate obtained in the step (4).
The lanthanide metal doped mesoporous silica nanoparticles 112 with the chemical formula SiO2x EuyGdz can be prepared according to the above steps (1) - (5). Continuously, the biological yarn 11 may be manufactured through an electro-spinning apparatus. Fig. 3A to 3B show a schematic view of a process for manufacturing a biological yarn. As shown in the schematic diagram (a) of fig. 3A, first, gelatin raw material 11a and solvent 11b are stirred and mixed in reaction flask 2; wherein the solvent 11b is 2,2,2-Trifluoroethanol (2,2,2-trifluoethanol, TFE). Next, as shown in the schematic diagram (b) of fig. 3A, the mesoporous silica nanoparticles 112 doped with lanthanide metal and the secondary water are added into the reaction flask 2 to be stirred and mixed. Continuously, as shown in fig. 3B, the solution in the reaction bottle 2 is poured into a spinning device 3, wherein a collecting device 4 is disposed below the spinning device 3, and the collecting device 4 and the spinning device 3 are electrically connected to a voltage generating device 5. As well known to those skilled in the art of electrospinning, the voltage generating device 5 is used to generate a high voltage to the spinning device 3, so that the spinning device 3 can spray the solution in the form of filaments, and the sprayed filaments are collected to the collecting device 4.
Since the collecting means 4 is shown as a collecting plate in fig. 3B, a plurality of biological yarns 11 can be directly integrated into the hair-growth promoting dressing 1 of the present invention. It should be noted that, as can be seen from the schematic process diagram of the biological yarn shown in fig. 4, if a collection reel is used as the collection device 4, the wound biological yarn 11 can be further woven into the dressing 1 for promoting hair growth by using a weaving device.
Second manufacturing method
It is known to engineers who have long involved textile technology that the first manufacturing method described above is to make a plurality of biological yarns 11 by using an electrospinning device, and then further weave the biological yarns 11 into the hair-growth promoting dressing 1 of the present invention by using a weaving device. Unlike the first manufacturing method, the second manufacturing method is to make a plurality of biological yarns 11 with a drawing device. Referring to fig. 5A to 5C, a schematic process of the dressing for promoting hair growth of the present invention is shown. In fig. 5A, the lanthanide metal doped mesoporous silica nanoparticles 112 are added into a polymer monomer solution 111a, and polymerized and granulated to obtain the multi-plastic master batch 6. In fig. 5B, the multi-plastic master batch 6 is processed into a plurality of biological yarns 11 by a spinning device. Finally, in fig. 5C, a plurality of biological yarns 11 are used as a plurality of warp yarns 1WA and a plurality of weft yarns 1WE, and the plurality of warp yarns 1WA and the plurality of weft yarns 1WE are woven into a biological fabric by a weaving device, that is, the dressing 1 for promoting hair growth of the present invention.
Feasibility verification
In order to confirm that the dressing 1 for promoting hair growth of the present invention has indeed the effect of promoting hair growth, the present inventors completed relevant animal experiments. Before animal experiments are carried out, a plurality of biological yarns 11 are manufactured by an electrospinning device, and the plurality of biological yarns 11 are gathered in a collecting device 4 (i.e., a collecting plate) as shown in fig. 3B to form the dressing 1 for promoting hair growth. In the animal experiment, 3 nude mice (BALB/c, farm) aged six weeks were used, and the body weight of the nude mice was 13 g. The experimental mode is as follows: the hair growth promoting dressing 1 was attached to the posterior part of the right thigh of a nude mouse in a width of 1cm2, wherein the hair growth promoting dressing 1 comprises 2.5mg of the lanthanide metal doped Mesoporous Silica Nanoparticles (MSN) 112. In the animal experiment, in order to stably adhere the dressing 1 for promoting hair growth to the buttocks of the nude mouse, a little secondary water was dropped on the buttocks of the nude mouse before the dressing 1 for promoting hair growth was attached.
It should be noted that the animal dose and the adult dose can be converted according to the Body Surface Area conversion formula (BSA) provided by the Food and Drug Administration (FDA). For example, the skilled engineer may perform the conversion of the adult dose to the mouse dose of the test sample according to the initial experimental estimation method (Estimating the maximum safe starting dose in initial clinical trials for therapeutic in administration health volumes) as promulgated by the U.S. food and drug administration. The calculation formula is shown below: recommended dose per kg body weight of mice = (human recommended dose ÷ 60 kg) × 9.1.
Please refer to fig. 6, which shows an image of a nude mouse. In FIG. 6, A1, B1 and C1 represent 3 nude mice (BALB/C, livestock) used in animal experiments, respectively. Also, it can be observed through the image of fig. 6 that the heads of the nude mice A1 and B1 have a significant hair growth effect after continuously using the dressing for promoting hair growth of the present invention for 1 day; also, the hairs stimulated to grow were not slightly shed until the twenty-first day. On the other hand, the nude mouse C1 showed a significant hair growth effect after continuously using the dressing for promoting hair growth of the present invention for 1 twelve days.
Further, in order to confirm whether the dressing 1 for promoting hair growth according to the present invention exerts adverse effects on the living body, the present inventors recorded the body weight of the nude mice daily during the animal experiment. From the data graph of time versus body weight shown in fig. 7, it was found that the body weight of three nude mice did not significantly decrease with the increase of the number of days of use of the dressing for promoting hair growth 1. With continued reference to FIG. 8A, a photograph of a histological section of the skin of the head of a nude mouse after completion of an animal experiment is shown. Meanwhile, please continue to refer to fig. 8B, which shows a sectional view of the skin tissue of the head of the normal nude mouse. Comparing fig. 8A and 8B, it can be seen that the nude mice to which the dressing 1 for promoting hair growth of the present invention is applied do not have serious head skin tissue damage or inflammation; also, it is noted that the head skin tissue of the nude mice subjected to the animal experiment was not significantly different from the head skin tissue of the normal nude mice. Accordingly, the experimental data of fig. 7, 8A, and 8B confirm that the dressing 1 for promoting hair growth of the present invention does not cause toxic reaction or other adverse effects on the living body.
Therefore, animal experiments confirmed that nude mice (BALB/c, female) whose right thigh rear buttocks was affixed with the dressing for promoting hair growth 1 of the present invention could indeed show hair growth effect seven days later, i.e., on their heads; wherein each 1 square centimeter of the hair growth promoting dressing 1 contains at least 2.5mg of the multi-particle lanthanide metal doped mesoporous silica nanoparticles 112. That is, for an adult user, at least 16.48mg of the mesoporous silica nanoparticles 112 of lanthanide doped metal must be contained per 1 square centimeter of the hair growth promoting dressing 1. Thus, the dressing 1 for promoting hair growth of the present invention can exhibit hair growth effect on the head of the adult user seven days later after being applied to the buttocks of the adult user.
Second embodiment
Referring to fig. 1 and 2, the foregoing description discloses a first embodiment of the hair growth promoting dressing 1 of the present invention, which is a piece of biological fabric woven from a plurality of biological yarns 11. Therefore, in order to improve the adhesion of the biological fabric, a small amount of secondary water was dropped onto the buttocks of the nude mouse in particular in the animal experiment. For the reason of improving the attachment of the fabric, as shown in fig. 9, which is a schematic perspective view of the second embodiment of the hair growth promoting dressing of the present invention, an adhesive layer 12 is bonded to the hair growth promoting dressing 1 to impart adhesion thereto. On the other hand, considering that the simple biological fabric is not strong and is easily damaged, the second embodiment further includes a substrate 10 for carrying and supporting the dressing 1 for promoting hair growth.
Third embodiment
Continuing to refer to fig. 10, a schematic perspective view of a third embodiment of the hair growth promoting dressing of the present invention is shown. It can be seen from fig. 10 that the third embodiment of the hair-growth promoting dressing 1 is designed in the manner of an OK-jump. The dressing 1 for promoting hair growth is formed by interweaving a plurality of warp yarns 1WA and a plurality of weft yarns 1WE, and the warp yarns 1WA and the weft yarns 1WE are both biological yarns 11 (as shown in fig. 2). As shown in fig. 10, the dressing 1 for promoting hair growth is disposed on a base layer 10, and an adhesive layer 12 is also formed on the base layer 10. In particular, in order to improve the air permeability of the dressing 1 for promoting hair growth of the present invention, a plurality of ventilation holes 101 are further formed in the base layer 10 in the third embodiment.
Fourth embodiment
Please refer to FIG. 11 for a further illustration of the present inventionA schematic perspective view of a fourth embodiment of the hair growth promoting dressing of (1). Comparing fig. 1 and fig. 11, it can be seen that, unlike the first embodiment, the fourth embodiment of the hair growth promoting dressing 1 is formed by interweaving a plurality of weft yarns 1WE and a plurality of warp yarns 1 WA; wherein the plurality of weft yarns 1WE and the plurality of warp yarns 1WA each comprise a plurality of first yarns and a plurality of second yarns; wherein the first yarn is a bio-physical yarn 11 and the second yarn is a (natural or synthetic) yarn 17. Referring to fig. 2, the biological yarn 11 of the fourth embodiment includes a polymer sheath 111 and a plurality of lanthanide series metal doped Mesoporous Silica Nanoparticles (MSNs) 112; wherein the lanthanide metal doped mesoporous silica nanoparticles 112 are formed from SiO 2 x :Eu y Gd z And is doped or encapsulated in the polymer sheath 111.
As can be easily inferred by the engineers familiar with textile technology, the yarn 17 can be either a synthetic yarn or a natural yarn, and it can be any of the following: gelatin/trifluoroethanol composite yarn, gelatin/trifluoroethanol/polycaprolactone composite yarn, gelatin/trifluoroethanol/polylactic acid yarn, polyester yarn, polyurethane yarn, polyvinyl chloride yarn, polypropylene yarn, polyamide yarn, a combination of the two, or a combination of more than two. It should be noted that the biological fabric of the fourth embodiment is woven by the biological yarns 11 and the (ordinary) yarns 17, and the manufacturing cost of the biological fabric of the fourth embodiment can be lower than that of the biological fabric of the first embodiment by adjusting the yarn mixing ratio between the plurality of biological yarns 11 and the plurality of yarns 17. For example, the plurality of biological yarns 11 have a ratio ranging from 20% to 55% in the plurality of warp yarns 1WA and the plurality of weft yarns 1 WE. It must be emphasized, however, that the biological fabric of the fourth embodiment can also be further processed to produce either the second embodiment of the hair-growth promoting dressing 1 as shown in fig. 9 or the third embodiment of the hair-growth promoting dressing 1 as shown in fig. 10.
Thus, the above description has fully and clearly demonstrated the composition and efficacy of the dressing 1 for promoting hair growth of the present invention, and from the above, it can be seen that the present invention has the following advantages:
(1) Unlike commercially available hair growth promoting compositions which are complex in formulation and expensive to sell, the present inventors have fabricated a plurality of lanthanide series doped Mesoporous Silica Nanoparticles (MSNs) 112 and a polymer material into a plurality of biological yarns 11 by electrospinning or filament drawing techniques, and then woven the plurality of biological yarns 11 into a biological fabric using a weaving device to serve as a hair growth promoting dressing 1 of the present invention. It is conceivable that the dressing 1 for promoting hair growth of the present invention has an absolute advantage of being inexpensive to manufacture compared to commercially available hair-growing compositions. In addition, the experimental results also confirmed that the head of the nude mouse had a significant hair growth effect after continuously using the dressing for promoting hair growth of the present invention for 1 seven days. It is apparent that the dressing 1 for promoting hair growth of the present invention exhibits immediate hair growth efficacy, relative to a commercially available hair growth composition which must be used for a long period of at least four months to show hair growth effects.
It should be emphasized that the above detailed description is specific to possible embodiments of the invention, but this is not to be taken as limiting the scope of the invention, and all equivalent implementations or modifications that do not depart from the technical spirit of the invention are intended to be included within the scope of the invention.
Claims (8)
1. A dressing for promoting hair growth is prepared by interweaving multiple warp yarns and multiple weft yarns; wherein the warp yarn and the weft yarn are both biological yarns, and the biological yarns comprise:
a polymer sheath; and
a plurality of mesoporous silica nanoparticles doped with lanthanide metals, doped or encapsulated in the polymer sheath;
wherein the lanthanide-doped mesoporous silica nanoparticles have the chemical formula SiO 2 x :Eu y Gd z And x is from 99wt% to 99Between 8wt%, y and z are between 0.1wt% and 0.5 wt%;
wherein the particle size of the lanthanide series metal doped mesoporous silica nanoparticles is less than 100nm, and each 1 square centimeter of the dressing for promoting hair growth contains at least 16.48mg of the lanthanide series metal doped mesoporous silica nanoparticles.
2. The hair growth promoting dressing of claim 1, further comprising:
a base layer for carrying and supporting a biological fabric woven by the plurality of warp yarns and the plurality of weft yarns in a staggered manner; and
an adhesive layer bonded to the biological fabric for providing adhesion of the biological fabric.
3. The hair growth promoting dressing of claim 1, wherein the polymer sheath is a combination of any one or more of: gelatin/trifluoroethanol composite sheath, gelatin/trifluoroethanol/polycaprolactone composite sheath, gelatin/trifluoroethanol/polylactic acid sheath, polyester sheath, polyurethane sheath, polyvinyl chloride sheath, polypropylene sheath and polyamide sheath.
4. The hair growth promoting dressing of claim 2, wherein the substrate further comprises at least one adhesive layer disposed thereon.
5. A dressing for promoting hair growth is prepared by interweaving multiple warp yarns and multiple weft yarns; wherein the plurality of warp yarns and the plurality of weft yarns comprise a plurality of first yarns and a plurality of second yarns; wherein the first yarn is a biological yarn, and the second yarn is a natural yarn or a man-made yarn; the biological yarn comprises:
a polymer sheath; and
a plurality of mesoporous silica nanoparticles doped with lanthanide metals, doped or encapsulated in the polymer sheath;
wherein the doped lanthanide metal mesoporous silica nanoparticlesThe particles are made of chemical formula SiO 2 x :Eu y Gd z And x is between 99wt% and 99.8wt%, y and z are between 0.1wt% and 0.5 wt%;
wherein the particle size of the lanthanide series metal doped mesoporous silica nanoparticles is less than 100nm, and each 1 square centimeter of the dressing for promoting hair growth contains at least 16.48mg of the lanthanide series metal doped mesoporous silica nanoparticles.
6. The hair growth promoting dressing of claim 5, further comprising:
a base layer for carrying and supporting a biological fabric woven by the plurality of warp yarns and the plurality of weft yarns in a staggered manner; and
an adhesive layer bonded to the biological fabric for providing adhesion of the biological fabric.
7. The hair growth promoting dressing of claim 5, wherein the polymer sheath is a combination of any one or more of: gelatin/trifluoroethanol composite sheath, gelatin/trifluoroethanol/polycaprolactone composite sheath, gelatin/trifluoroethanol/polylactic acid composite sheath, polyester sheath, polyurethane sheath, polyvinyl chloride sheath, polypropylene sheath and polyamide sheath.
8. The hair growth promoting dressing of claim 5, wherein the yarn is a natural yarn or a synthetic yarn, and is a combination of any one or more of: gelatin/trifluoroethanol composite yarn, gelatin/trifluoroethanol/polycaprolactone composite yarn, gelatin/trifluoroethanol/polylactic acid composite yarn, polyester yarn, polyurethane yarn, polyvinyl chloride yarn, polypropylene yarn and polyamide yarn.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018201840842 | 2018-02-02 | ||
| CN201820184084 | 2018-02-02 |
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| CN110123791B true CN110123791B (en) | 2023-03-24 |
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| CN201811210048.XA Active CN110123791B (en) | 2018-02-02 | 2018-10-17 | Dressing for promoting hair growth |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003137749A (en) * | 2001-10-29 | 2003-05-14 | Yukio Sato | Artificial hair restorer contained in spray container |
| US20090048571A1 (en) * | 2007-08-17 | 2009-02-19 | Kemal Vatansever Catalan | Durable Hydrophilic Coating Compositions |
| CN101516320A (en) * | 2006-08-25 | 2009-08-26 | 株式会社泰熊Eco生命科学 | Uses of rare earth elements for hair improvement |
| WO2010052191A2 (en) * | 2008-11-04 | 2010-05-14 | Universitetet I Oslo | Coated solid pliant materials |
-
2018
- 2018-10-17 CN CN201811210048.XA patent/CN110123791B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003137749A (en) * | 2001-10-29 | 2003-05-14 | Yukio Sato | Artificial hair restorer contained in spray container |
| CN101516320A (en) * | 2006-08-25 | 2009-08-26 | 株式会社泰熊Eco生命科学 | Uses of rare earth elements for hair improvement |
| US20090048571A1 (en) * | 2007-08-17 | 2009-02-19 | Kemal Vatansever Catalan | Durable Hydrophilic Coating Compositions |
| WO2010052191A2 (en) * | 2008-11-04 | 2010-05-14 | Universitetet I Oslo | Coated solid pliant materials |
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