CN110122694A - Sow acylate compound acidulant and preparation method thereof - Google Patents

Sow acylate compound acidulant and preparation method thereof Download PDF

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Publication number
CN110122694A
CN110122694A CN201910475959.3A CN201910475959A CN110122694A CN 110122694 A CN110122694 A CN 110122694A CN 201910475959 A CN201910475959 A CN 201910475959A CN 110122694 A CN110122694 A CN 110122694A
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parts
acidulant
sow
acid
acylate compound
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赵成新
莫小见
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YANTAI JINHAI PHARMACEUTICAL Co Ltd
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YANTAI JINHAI PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
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Abstract

The present invention is suitable for field of feed additive technology, provides broad sow acylate compound acidulant and preparation method thereof, the parts by weight of each ingredient in acidulant are as follows: 28~43 parts of formic acid, 15~40 parts of acetic acid, 5~15 parts of propionic acid, 20~30 parts of lactic acid, 1~4 part of citric acid, 5~15 parts of acidity regulator, 0.2~1.4 part of mouthfeel corrigent, 12~26 parts of pure water, 0.04~6 part of metal salt, 2~20 parts of magnesium sulfate, 2~20 parts of Macrogol 4000；The present invention also provides the preparation methods of acidulant.Whereby, acidulant of the invention uses underground water or Drinking Water as dilution, after 1000 times of dilution, pH value is 3.6~4.2, it being capable of microorganism in effective purifying drinking water, the occurrence of reducing sow disease of digestive tract and constipation improves the growth performance of sow, reduces breeding production cost.

Description

Sow acylate compound acidulant and preparation method thereof
Technical field
The present invention relates to field of feed additive technology more particularly to broad sow acylate compound acidulant and its Preparation method.
Background technique
Acidulant be a kind of antibacterial activity with broad-spectrum high efficacy, low toxicity, noresidue feed addictive, add it to In sow feed or drinking water, the acidity of feed can be improved, improve sow digestive tract environment, meet sow nutritional need, and It can prevent disease；Acidulant in the prior art is generally concentrated in the anti-microbial property, the growth performance that improve acidulant, but It is, it is less for the buffer capacity research of acidulant.
CN106359895A discloses a kind of mixed feed additive liquid acidity regulator and preparation method thereof, acidity Regulator is made of the component of following parts by weight: formic acid 30~50, ammonium hydroxide 20~30, lactic acid 10~20, acetic acid 5~10, Citric acid 5~10, stoste and the one thousandth dilution pH of the regulator keep relative stability, and are maintained at 3.5~4.5.
Although acidulant buffer capacity with higher, the excessive wave of animal gastrointestinal tract acidity generation can be effectively avoided It is dynamic, still, dilution with water be GB/T 6682-2008 specified in tertiary effluent, which is with distillating method or ion Water made from exchange method, pH range are 5.0~7.5, oxidizable substance content≤0.4, but in actual production process, cultivation Field is time-consuming and laborious and at high cost using tertiary effluent；If directly using the tap water of farm or underground water or life drink 1000 times are diluted with water, acidulant pH value disclosed in CN106359895A has been above 4.5, and buffer capacity will be insufficient, uses Increased costs, sexual valence are relatively low.
In addition, developing with raising pigs to scale, intensive direction, the incidence of large-scale pig farm prevention of sow constipation is increasingly Height, prevention of sow constipation weight then cause dead sow, generation miscarriage, stillborn foetus, brood sow mortality to increase, gently then influence sow production Performance, such as sow prolonged labor, hysteritis, mammitis, malnutritive agalasisa leads to that piglet nutrition is bad, diarrhea, this A little phenomenons bring huge economic loss to breeding enterprise.
In summary, the existing technology has inconveniences and defects in actual use, so it is necessary to be improved.
Summary of the invention
For above-mentioned defect, the purpose of the present invention is to provide a broad sow acylate compound acidulants and its system Preparation Method uses underground water or Drinking Water as dilution, and after 1000 times of dilution, pH value is 3.6~4.2, energy Microorganism in enough effective purifying drinking waters, reduces the generation of sow disease of digestive tract；Acidulant of the invention can also improve mother Stress resistance of pigs avoids the occurrence of prevention of sow constipation, improves the growth performance of sow, reduces breeding production cost.
To achieve the goals above, the present invention provides broad sow acylate compound acidulant, in the acidulant The parts by weight of each ingredient are as follows: 28~43 parts of formic acid, 15~40 parts of acetic acid, 5~15 parts of propionic acid, 20~30 parts of lactic acid, citric acid 1 ~4 parts, 5~15 parts of acidity regulator, 0.2~1.4 part of mouthfeel corrigent, 12~26 parts of pure water, 0.04~6 part of metal salt, 2~20 parts of magnesium sulfate, 2~20 parts of Macrogol 4000.
Sow according to the present invention acylate compound acidulant, the parts by weight of each ingredient in the acidulant are as follows: 36~39 parts of formic acid, 25~31 parts of acetic acid, 7~11 parts of propionic acid, 23~26 parts of lactic acid, 2.8~3.6 parts of citric acid, acidity adjustment 9~12 parts of agent, 0.6~1.0 part of mouthfeel corrigent, 17~21 parts of pure water, 0.29~3.18 part of metal salt, magnesium sulfate 11~16 Part, 9~14 parts of Macrogol 4000.
Sow according to the present invention acylate compound acidulant, the pH value of the acidulant stoste are 2.0~3.0.
Sow according to the present invention acylate compound acidulant, the pH value of the acidulant stoste are 2.4~3.0.
Sow according to the present invention acylate compound acidulant, the metal salt include mantoquita, molysite, manganese salt, cobalt Salt.
Sow according to the present invention acylate compound acidulant, the acidity regulator are ammonium hydroxide, ammonium salt or hydrogen Any one in sodium oxide molybdena.
Sow according to the present invention acylate compound acidulant, the dilution of the acidulant stoste be underground water or Any one in person's Drinking Water.
Sow according to the present invention acylate compound acidulant, after the acidulant stoste dilutes 1000 times, pH value It is 3.6~4.2.
Sow according to the present invention acylate compound acidulant prepares the acidulant the present invention also provides a kind of Method includes the following steps:
Step 1 weighs every raw material according to above-mentioned parts by weight；
Pure water is added into reaction kettle for step 2, and formic acid is then added, and is sufficiently mixed, and obtains intermediate product one；It is described The additional amount of formic acid is the 10%~20% of formic acid total amount；
It is slowly added to acidity regulator in intermediate product one described in step three-dimensional, is sufficiently stirred, is after mixing obtained Between product two；
It is slowly added to remaining formic acid in intermediate product two described in step four-way, is mixed after stirring, obtains intermediate product three；
Acetic acid, lactic acid, citric acid, propionic acid, mouthfeel corrigent, sulfuric acid are slowly added in intermediate product three described in step five-way Magnesium, Macrogol 4000, stir and evenly mix, and obtain intermediate product four；The mixing time of the reaction kettle is 30~40min；
It is slowly added to metal salt in intermediate product four described in step six-way, is stirred and evenly mixed, after completely dissolution, obtains acidulant Stoste；The mixing time of the reaction kettle is 30~40min.
The method according to the present invention for preparing the acidulant, in the step 3 and the step 4, the reaction kettle Mixing time be 20~30min.
The purpose of the present invention is to provide broad sow acylate compound acidulant and preparation method thereof, by by first Acid, acetic acid, propionic acid, lactic acid, citric acid, acidity regulator, mouthfeel corrigent, pure water, metal salt, magnesium sulfate, polyethylene glycol Acidulant is made according to constant weight number proportion in 4000 equal ingredients, and acidulant uses underground water or Drinking Water as dilute Liquid is released, after 1000 times of dilution, pH value is 3.6~4.2, meets the pH condition of acidulant needed for sow cultivates, due to not using Tertiary effluent, therefore, acidulant of the invention can reduce production cost, improve the convenience of sow cultivation；Meanwhile it is of the invention Acidulant can microorganism in effective purifying drinking water, remove the biomembrane in waterline, guarantee that waterline is unimpeded, reduce alimentary canal The generation of disease；The occurrence of acidulant of the invention can also improve sow intestinal health, reduce prevention of sow constipation is improved female Stress resistance of pigs promotes sow healthy growth, improves the growth performance of sow, reduces breeding production cost.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
The present invention provides broad sow acylate compound acidulant, the parts by weight of each ingredient in the acidulant Are as follows: 28~43 parts of formic acid, 15~40 parts of acetic acid, 5~15 parts of propionic acid, 20~30 parts of lactic acid, 1~4 part of citric acid, acidity regulator 5~15 parts, 0.2~1.4 part of mouthfeel corrigent, 12~26 parts of pure water, 0.04~6 part of metal salt, 2~20 parts of magnesium sulfate, gather 4,000 2~20 parts of ethylene glycol.
Acid in acidulant of the present invention selects short chain fatty acids, and short chain fatty acids can be used as reactant or intermediate product ginseng With the biochemical reaction of sow body, conducive to being absorbed and utilized for sow.Wherein, it after formic acid is absorbed by sow, can be risen in vivo at it To the effect for killing bacterium；Acetic acid and lactic acid can adjust the mouthfeel of entire acidulant；Propionic acid enters the internal of sow, Neng Gouqi To the effect of killing fungi, while the raising of sow calcium content of bone can be promoted；Citric acid be tricarboxylic acid cycle reactant or Intermediate product, the energetic supersession of body can directly be participated in by being added in feed, in addition, citric acid make entire acidulant to bacterium, The chela ability of fungi improves, and enhances the sterilizing function of acidulant；Lactic acid re-forms Portugal through blood transportation to liver or kidney, through gluconeogenesis Grape sugar participates in the lactic acid circulation of body.
Acidity regulator can be any one in ammonium hydroxide, ammonium salt or sodium hydroxide, and the present invention passes through multiple authentication Test discovery, uses ammonium hydroxide as acidity regulator, and the buffer capacity for obtaining acidulant is most strong, and the cost of ammonium hydroxide is minimum, because This, as a preferred solution, acidity regulator is ammonium hydroxide.
Metal salt includes mantoquita, molysite, manganese salt, cobalt salt etc., and mantoquita has the function of disinfection and sterilization, molysite, manganese salt, cobalt salt Deng have growth promoting function, due to acidulant main function of the invention be for sow drinking water pH adjust and myristylpicolinum bromide Change, therefore, the main component of metal salt is mantoquita, and mantoquita can be copper sulphate or basic copper chloride.
Magnesium sulfate is used for constipation, enteral abnormal fermentation；Macrogol 4000 is clinical most common permeability defaecation drug The main component of good fortune pine, can softer stool, promote intestines peristalsis；The two, which is used cooperatively, to be helped to alleviate prevention of sow constipation.
The pH value of acidulant stoste of the present invention is 2.0~3.0；Staff needs to be diluted when using acidulant, Since pH is lower, acid stronger, the risk in dilution is bigger, and therefore, as a preferred solution, acidulant is former The pH value of liquid is 2.4~3.0；As a kind of preferred scheme, the pH value of acidulant stoste is 2.6~3.0.
The pH value of sow drinking water is generally 4.0 or so, encountered pathogenic bacteria, true when the pH value of drinking water is 4.0 or so Bacterium does not breed, can effectively control the sum of bacterium in drinking water, reduce because drinking water it is unclean caused by intestines problem.
The dilution of acidulant of the present invention is I/II/III class underground water or GB5749- specified in GB14848-2017 The pH range of Drinking Water specified in 2006, the underground water or Drinking Water is 6.5~8.5, and oxidizable substance contains Amount≤3, compared to tertiary effluent specified in GB/T 6682-2008, the buffering of underground water or Drinking Water for acidulant The requirement of performance and bactericidal property is higher；Acidulant of the present invention is diluted using underground water or Drinking Water as diluent After 1000 times, pH value is 3.6~4.2, can satisfy the condition of acidulant pH needed for sow cultivates, illustrates acidulant of the present invention Cushion performance is stronger；In addition, under conditions of the acidulant pH needed for meeting sow and cultivating, acidulant of the present invention and the prior art Acidulant is compared, and identical multiple is diluted, and acidulant of the invention, which can more effectively press down, kills underground water or Drinking Water In the pathogenic microorganisms such as Escherichia coli reduce the generation of animal intestinal tract disease to guarantee that total number of bacteria therein is not exceeded, Reduce breeding production cost.
The sow method of acylate compound acidulant is prepared the present invention also provides a kind of, is included the following steps:
Step 1 weighs every raw material according to above-mentioned parts by weight；
Pure water is added into reaction kettle for step 2, and formic acid is then added, and is sufficiently mixed, and obtains intermediate product one；Formic acid Additional amount be formic acid total amount 10%~20%；
It is slowly added to acidity regulator in step three-dimensional intermediate product one, is sufficiently stirred, obtains intermediate production after mixing Object two；Mixing time in reaction kettle is 20~30min；
It is slowly added to remaining formic acid in step four-way intermediate product two, is mixed after stirring, obtains intermediate product three；Reaction Mixing time in kettle is 20~30min；
Since acid-base reaction is very violent, a large amount of heat can be generated, shortens reaction kettle and the use longevity of other ancillary equipments Life, meanwhile, safety is low；Therefore, a small amount of formic acid is first added in the present invention in step 2, then acidity tune is added in step 3 Agent is saved, since the amount of formic acid is less than acidity regulator, only part acidity regulator is reacted with formic acid, is generated a certain amount of Heat；It is slow added into remaining formic acid later, is reacted with remaining acidity regulator, continues to generate heat.During this, The heat of acid-base reaction generates in two times, reduces the severe degree of reaction, improves reaction kettle and the use longevity of other ancillary equipments Life, improves the safety of reaction.
Be slowly added in step five-way intermediate product three acetic acid, lactic acid, citric acid, propionic acid, mouthfeel corrigent, magnesium sulfate, Macrogol 4000 stirs and evenly mixs, and obtains intermediate product four；Mixing time in reaction kettle is 30~40min；
It is slowly added to metal salt in step six-way intermediate product four, is stirred and evenly mixed, after completely dissolution, obtains acidulant original Liquid；Mixing time in the reaction kettle is 30~40min.
The pH value of step 7 detection acidulant stoste；Meanwhile part acidic agent stoste is taken, it is drunk using underground water or life 1000 times are diluted with water, dilution is obtained, detects the pH value of dilution.
The application method of acidulant of the present invention are as follows: launch into the drinking water of sow, 1~1.5L is added in every 1000L water Acidulant stoste can make the pH value of drinking water reach 3.6~4.2；It launches in the feed of sow, complete diet pellet addition per ton 1.5~2L acidulant stoste can make up the deficiency of solid acidifier usage amount in complete feed, disappearing after improving feed intake Change efficiency.
Acidulant of the invention can effectively kill microorganisms and the bacteriums such as the Escherichia coli in drinking-water, to guarantee to drink With the cleaning of water；The pH value in sow stomach can also be reduced, the speed of gastric emptying is slowed down, promotes digestion, promotes minerals and dimension The absorption of raw element；It can be improved the activity of digestive ferment in sow body simultaneously, adjust gastrointestinal bacterial flora balance, improve the mucous membrane of small intestine Form participates in energetic supersession.In addition, acidulant of the present invention, which also has, improves sow feed intake, promote the effect of sow growth.
To obtain preferred forms, the present invention passes through the parts by weight formula test of secondary acidulant components up to a hundred, and setting is such as Under several embodiments；
Embodiment 1
39 parts of formic acid, 27 parts of acetic acid, 9 parts of propionic acid, 25 parts of lactic acid, 3.2 parts of citric acid, 11 parts of acidity regulator, mouthfeel is rectified Positive 1.0 parts of agent, 21 parts of pure water, 0.29 part of metal salt, 16 parts of magnesium sulfate, 14 parts of Macrogol 4000.
Embodiment 2
37 parts of formic acid, 25 parts of acetic acid, 7 parts of propionic acid, 23 parts of lactic acid, 3.6 parts of citric acid, 9 parts of acidity regulator, mouthfeel correction 0.8 part of agent, 17 parts of pure water, 1.37 parts of metal salt, 11 parts of magnesium sulfate, 9 parts of Macrogol 4000.
Embodiment 3
36 parts of formic acid, 31 parts of acetic acid, 11 parts of propionic acid, 26 parts of lactic acid, 2.8 parts of citric acid, 12 parts of acidity regulator, mouthfeel is rectified Positive 0.6 part of agent, 20 parts of pure water, 3.18 parts of metal salt, 14 parts of magnesium sulfate, 12 parts of Macrogol 4000.
In the present invention up to a hundred times formula tests, such as 42 parts of formic acid, 29 parts of acetic acid, 14 parts of propionic acid, 30 parts of lactic acid, lemon 1 part of lemon acid, 0.5 part of mouthfeel corrigent, 18 parts of pure water, 0.83 part of metal salt, 20 parts of magnesium sulfate, gathers by 13 parts of acidity regulator The effect of the formulas such as 4,000 5 parts of ethylene glycol is general, and therefore, the implementation procedure of other embodiments is repeated no more, and chooses it The embodiment of middle preferable ten group of formula of effect, the other data that part is not shown of each embodiment are shown in Table one.
The parts by weight of each ingredient in each embodiment acidulant of table one
In order to verify the performance of acidulant of the present invention, the present invention preferably matches choose in above-described embodiment ten groups of effects Side is made acidulant, and by ten kinds of acidulants carry out respectively cushion performance, bactericidal property, resisting stress performance and its to sow Growth performance test regard these tests as application examples, and counts to the effect of ten kinds of acidulants in application examples.
Application examples 1- cushioning characteristics test
In the prior art, tertiary effluent is generally selected to the dilution of acidulant, it is at high cost and inconvenient；But most of sow Cultivating in factory's breeding process is typically all water intaking nearby, selects underground water or Drinking Water, therefore, the present invention is in resiliency In capable of testing, the 130m underground water of the prosperous abundant printing Co., Ltd in Yantai Qixia is selected, the water quality of the underground water is supported close to most of That grows factory drinks water state.
Using the underground water by ten kinds of acidulants and import acidulant S of the invention, certain homemade goods L, certain domestic production Product S dilutes 10 times, 100 times, 500 times, 1000 times, 1500 times, 2000 times respectively, measures pH value after dilution respectively, as a result sees Table two.
Table two is respectively acidified the pH value after dilution agent
10 times 100 times 500 times 1000 times 1500 times 2000 times
Imported product S 2.87 2.98 3.21 3.97 4.14 4.42
Certain homemade goods L 3.43 3.93 4.36 5.01 5.74 6.19
Certain homemade goods S 1.93 3.21 4.21 5.34 6.01 6.84
Embodiment 1 2.76 2.93 3.11 3.88 4.04 4.15
Embodiment 2 2.68 2.91 3.15 3.98 4.10 4.25
Embodiment 3 2.81 2.97 3.20 3.91 4.09 4.36
Embodiment 4 2.73 2.99 3.17 3.89 4.07 4.18
Embodiment 5 2.71 2.94 3.22 3.87 4.11 4.16
Embodiment 6 2.79 2.95 3.19 3.87 4.05 4.17
Embodiment 7 2.82 2.90 3.18 3.91 4.12 4.21
Embodiment 8 2.80 2.96 3.20 3.94 4.16 4.29
Embodiment 9 2.77 2.97 3.24 3.97 4.09 4.33
Embodiment 10 2.84 2.97 3.21 3.96 4.13 4.28
Farm is when using acidulant, typically according to 1000 times of uses of dilution, from the above data, it can be seen that dilute After releasing 1000 times, the pH value of ten kinds of acidulants of the invention is 3.87~3.98, and the pH value of imported product S is 3.97, due to sow The optimum pH of drinking water is 4.0 or so, illustrates that the cushion performance of ten kinds of acidulants of the invention is suitable with imported product S, can Meet pH requirement of the farm to acidulant；Meanwhile ten kinds of acidulants of the invention are when diluting 1500~2000 times, it can also be with It uses, greatly reduces the cost of farm.
After 1000 times of dilution, the pH value of certain homemade goods L is 5.01, the pH value of certain homemade goods S is 5.34, can only be dilute When releasing 100~500 times, it can satisfy pH requirement of the farm to acidulant, improve the cost of farm.
In addition, four kinds of acidulant cushion performances in embodiment 1,4,5,6 are best in ten kinds of acidulants of the invention.
The test of application examples 2- bactericidal property
Ten kinds of acidulants and import acidulant S of the invention, certain homemade goods L, certain homemade goods S are diluted respectively 1000 times, respectively obtain ten kinds of acidulant dilutions of the invention, import acidulant S dilution, certain homemade goods L dilution, Certain homemade goods S dilution；
Take that ten kinds of acidulant dilutions of the invention, import acidulant S dilution, certain homemade goods L dilution, certain is domestic Waterline end water sample is added in product S dilution thereto respectively, mixes, and stands under the conditions of 25 DEG C and measures bacterial population in water afterwards for 24 hours Amount calculates sterilizing rate；
Separately take ten kinds of acidulant dilutions of the invention, import acidulant S dilution, certain homemade goods L dilution, certain state Product S dilution is produced, the water pipe segment of 5~10cm long is added thereto respectively, after impregnating 48~72h, measurement water pipe segment Bacterial number on inner wall calculates sterilizing rate.Sterilizing rate of each acidulant in waterline end and pipe inner wall is shown in Table three.
The sterilizing rate of each acidulant of table three
Acidulant is added by drinking-water approach, the microbial contamination from water source can be effectively killed, guarantee defending for water It is raw.Meanwhile the microorganism of pipe inner wall attachment can be effectively killed, the formation of biomembrane is prevented, to control water in water pipe " secondary pollution ".
To be found out by above-mentioned data, waterline end sterilizing rate, the sterilizing rates of ten kinds of acidulants of the invention is 98.74~ The sterilizing rate of 99.99%, imported product S are 99.72%, and the sterilizing rate of two kinds of homemade goods is respectively 84.44 and 85.32%, Illustrate that the waterline end sterilizing rate of ten kinds of acidulants of the invention will be good than import acidulant and domestic acidulant；Waterline inner wall Sterilizing rate, the sterilizing rate of ten kinds of acidulants of the invention are 96.47~99.18%, and the sterilizing rate of imported product S is 96.42%, The sterilizing rate of two kinds of homemade goods is respectively 74.56 and 78.28%, illustrates the waterline inner wall sterilization of ten kinds of acidulants of the invention Rate will be good than import acidulant and domestic acidulant.
In addition, the bactericidal property of four kinds of acidulants in embodiment 4,5,6,7 is most in ten kinds of acidulants of the invention It is good.
Application examples 3- resisting stress performance test
The defense system oxidation resistance of body is contacted with health in the presence of close, and the effect of this defense system has: being decomposed Free radical and active oxygen, peroxynitrite decomposition compound, the metal ion for having removed catalytic action etc. measure total antioxidant capacity in body (T-AOC) content can react the health status of body.
Glutamic-pyruvic transaminase (ALT) is distributed mainly in liver cell in body, is referred to for the most sensitive detection of hepatic disorder One of mark, the activity for measuring glutamic-pyruvic transaminase (ALT) in body can react the liver function of body.
Ten kinds of acidulants of the invention are added in drinking water, 1000 times is diluted, is drunk for sow, are tested as ten Group does not add acidulant in the drinking water of another set sow, as a control group；Then to the sow point of experimental group and control group Not carry out heat stress processing, and heat stress handle 1h, heat stress processing 3h, heat stress processing 9h when measure each group sow respectively T-AOC content and ALT activity in blood.T-AOC content and ALT activity are shown in Table four in each group sow blood.
T-AOC content and ALT activity in four each group sow blood of table
Found out by above-mentioned data, after handling 1h to sow heat stress, the sow blood of ten kinds of acidulants of the invention is added Middle T-AOC content is 3.2~3.9U/mL, and T-AOC content is 3.2U/mL in control group sow blood；To the processing of sow heat stress After 3h, it is 2.5~3.1U/mL, control group sow blood that T-AOC content in the sow blood of ten kinds of acidulants of the invention, which is added, Middle T-AOC content is 1.9U/mL；After handling 9h to sow heat stress, it is added in the sow blood of ten kinds of acidulants of the invention T-AOC content is 2.5~3.7U/mL, and T-AOC content is 1.8U/mL in control group sow blood；Illustrate ten kinds of acid of the invention Agent can improve the concentration of T-AOC in heat stress sow blood to a certain extent, improve the oxidation resistance of sow body.
After handling 1h to sow heat stress, it is 15.9 that ALT activity in the sow blood of ten kinds of acidulants of the invention, which is added, ~17.8U/L, ALT activity is 7.3U/L in control group sow blood；After handling 3h to sow heat stress, the present invention ten is added ALT activity is 9.0~10.4U/L in the sow blood of kind acidulant, and ALT activity is 10.9U/L in control group sow blood；It is right After sow heat stress handles 9h, it is 8.9~11.3U/L that ALT activity in the sow blood of ten kinds of acidulants of the invention, which is added, right It is 15.8U/L according to ALT activity in group sow blood；Illustrate that ten kinds of acidulants of invention can alleviate to a certain extent heat stress and make At hepar damnification.
In addition, the resisting stress performance of four kinds of acidulants in embodiment 4,5,6,9 is most in ten kinds of acidulants of invention It is good.
The test of application examples 3- growth performance
33 farrowing sows are chosen, are equally divided into 11 groups, wherein 1 group of sow conventionally feeds, as a control group； Ten kinds of acidulants for adding invention in the drinking-water of remaining 10 groups of sows respectively are acidified 1000 times of dilution agent uses, other various aspects It is parallel management.Feeding after a week, counts the growth performance of sow.
Respectively observe a sow fecal character sooner or later daily.According to the grade (0: not discharge feces of fecal character；I: being constipated (granular)；II: being solid；III: being slight solid；IV: soft；V: diarrhea) the constipation situation of sow is recorded.Sow growth Five can be shown in Table.
The growth performance of five sow of table
In the test of sow growth performance, the average daily gain of control group is 1.5kg, average daily gain 496g, excrement It is constipated；It is added in ten groups of ten kinds of acidulants of the invention, average daily gain is 1.81~1.95kg, and average daily gain is 509~530g, excrement are slight solid or soft；Illustrate that adopting average day for sow can be improved in ten kinds of acidulants of the invention Appetite and average daily gain, the occurrence of capable of also preventing prevention of sow constipation.In addition, implementing in ten kinds of acidulants of invention The growth performance of four kinds of acidulants in example 3,4,5,6 is best.
By above-mentioned cushion performance, bactericidal property, resisting stress performance and its test of the growth performance of sow can be seen Out, the acidulant of above-mentioned ten group of formula of the present invention, three kinds of acidulant effects in embodiment 4,5,6 are best.
In conclusion the present invention is by correcting formic acid, acetic acid, propionic acid, lactic acid, citric acid, acidity regulator, mouthfeel Acidulant is made according to constant weight number proportion in the ingredients such as agent, pure water, metal salt, magnesium sulfate, Macrogol 4000, is acidified Agent uses underground water or Drinking Water as dilution, and after 1000 times of dilution, pH value is 3.6~4.2, meets sow and supports The pH condition for growing required acidulant, due to not using tertiary effluent, acidulant of the invention can reduce production cost, mention The convenience of high sow cultivation；Meanwhile acidulant of the invention can microorganism in effective purifying drinking water, remove in waterline Biomembrane, guarantee waterline it is unimpeded, reduce the generation of disease of digestive tract；It is strong that acidulant of the invention can also improve sow enteron aisle The occurrence of health, reduction prevention of sow constipation, sow anti-stress ability is improved, promotes sow healthy growth, improve the growth of sow Performance reduces breeding production cost.
Certainly, the present invention can also have other various embodiments, without deviating from the spirit and substance of the present invention, ripe It knows those skilled in the art and makes various corresponding changes and modifications, but these corresponding changes and change in accordance with the present invention Shape all should fall within the scope of protection of the appended claims of the present invention.

Claims (10)

1. broad sow acylate compound acidulant, which is characterized in that the parts by weight of each ingredient in the acidulant are as follows: 28~43 parts of formic acid, 15~40 parts of acetic acid, 5~15 parts of propionic acid, 20~30 parts of lactic acid, 1~4 part of citric acid, acidity regulator 5~ 15 parts, 0.2~1.4 part of mouthfeel corrigent, 12~26 parts of pure water, 0.04~6 part of metal salt, 2~20 parts of magnesium sulfate, poly- second two 4,000 2~20 parts of alcohol.
2. sow according to claim 1 acylate compound acidulant, which is characterized in that in the acidulant respectively at The parts by weight divided are as follows: 36~39 parts of formic acid, 25~31 parts of acetic acid, 7~11 parts of propionic acid, 23~26 parts of lactic acid, citric acid 2.8~ 3.6 parts, 9~12 parts of acidity regulator, 0.6~1.0 part of mouthfeel corrigent, 17~21 parts of pure water, metal salt 0.29~3.18 Part, 11~16 parts of magnesium sulfate, 9~14 parts of Macrogol 4000.
3. sow according to claim 2 acylate compound acidulant, which is characterized in that the acidulant stoste PH value is 2.0~3.0.
4. sow according to claim 3 acylate compound acidulant, which is characterized in that the acidulant stoste PH value is 2.4~3.0.
5. sow according to claim 2 acylate compound acidulant, which is characterized in that the acidity regulator is Any one in ammonium hydroxide, ammonium salt or sodium hydroxide.
6. sow according to claim 2 acylate compound acidulant, which is characterized in that the metal salt includes copper Salt, molysite, manganese salt, cobalt salt.
7. sow acylate compound acidulant described in any one according to claim 1~6, which is characterized in that described The dilution of acidulant stoste is any one in underground water or Drinking Water.
8. sow according to claim 7 acylate compound acidulant, which is characterized in that the acidulant stoste is dilute After releasing 1000 times, pH value is 3.6~4.2.
9. a kind of prepare the sow according to any one of claims 8 method of acylate compound acidulant, which is characterized in that including such as Lower step:
Step 1 weighs every raw material according to above-mentioned parts by weight；
Pure water is added into reaction kettle for step 2, and formic acid is then added, and is sufficiently mixed, and obtains intermediate product one；The formic acid Additional amount be formic acid total amount 10%~20%；
It is slowly added to acidity regulator in intermediate product one described in step three-dimensional, is sufficiently stirred, obtains intermediate production after mixing Object two；
It is slowly added to remaining formic acid in intermediate product two described in step four-way, is mixed after stirring, obtains intermediate product three；
Be slowly added in intermediate product three described in step five-way acetic acid, lactic acid, citric acid, propionic acid, mouthfeel corrigent, magnesium sulfate, Macrogol 4000 stirs and evenly mixs, and obtains intermediate product four；The mixing time of the reaction kettle is 30~40min；
It is slowly added to metal salt in intermediate product four described in step six-way, is stirred and evenly mixed, after completely dissolution, obtains acidulant original Liquid；The mixing time of the reaction kettle is 30~40min.
10. the method according to claim 9 for preparing compound acidulant, which is characterized in that the step 3 and the step In rapid four, the mixing time of the reaction kettle is 20~30min.
CN201910475959.3A 2019-06-03 2019-06-03 Sow acylate compound acidulant and preparation method thereof Pending CN110122694A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110679594A (en) * 2019-11-22 2020-01-14 湖南加农正和生物技术有限公司 Compound acidifier and preparation method and application thereof
CN113575769A (en) * 2021-08-09 2021-11-02 天津市中升挑战生物科技有限公司 Compound acidifier and preparation method and application thereof

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CN107397066A (en) * 2016-05-18 2017-11-28 中创云牧科技咨询(北京)股份有限公司 One kind acidifying milk and preparation method thereof and application method
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Publication number Priority date Publication date Assignee Title
CN102948610A (en) * 2012-10-16 2013-03-06 安徽省正大源饲料集团有限公司 Biological organic compound acidifying agent for feed
CN107397066A (en) * 2016-05-18 2017-11-28 中创云牧科技咨询(北京)股份有限公司 One kind acidifying milk and preparation method thereof and application method
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110679594A (en) * 2019-11-22 2020-01-14 湖南加农正和生物技术有限公司 Compound acidifier and preparation method and application thereof
CN113575769A (en) * 2021-08-09 2021-11-02 天津市中升挑战生物科技有限公司 Compound acidifier and preparation method and application thereof

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Application publication date: 20190816