CN110122667A - A kind of feed antibacterial agent and preparation method thereof - Google Patents
A kind of feed antibacterial agent and preparation method thereof Download PDFInfo
- Publication number
- CN110122667A CN110122667A CN201910463290.6A CN201910463290A CN110122667A CN 110122667 A CN110122667 A CN 110122667A CN 201910463290 A CN201910463290 A CN 201910463290A CN 110122667 A CN110122667 A CN 110122667A
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- Prior art keywords
- acid
- chain fatty
- acyl group
- polyalcohol
- reaction
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- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002253 acid Substances 0.000 claims abstract description 17
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims abstract description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000021391 short chain fatty acids Nutrition 0.000 claims abstract description 15
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims abstract description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 12
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 12
- -1 Short-Chain Fatty Acids polyol ester Chemical class 0.000 claims abstract description 11
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 11
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims abstract description 10
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims abstract description 10
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 9
- 229930195729 fatty acid Natural products 0.000 claims abstract description 9
- 239000000194 fatty acid Substances 0.000 claims abstract description 9
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 9
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 8
- 239000005639 Lauric acid Substances 0.000 claims abstract description 8
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004310 lactic acid Substances 0.000 claims abstract description 6
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 6
- 229920005862 polyol Polymers 0.000 claims abstract description 6
- 235000019260 propionic acid Nutrition 0.000 claims abstract description 6
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims abstract description 6
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims abstract description 5
- 235000011054 acetic acid Nutrition 0.000 claims abstract description 5
- 125000002252 acyl group Chemical group 0.000 claims abstract description 5
- 235000019253 formic acid Nutrition 0.000 claims abstract description 5
- 239000001530 fumaric acid Substances 0.000 claims abstract description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 3
- 239000010452 phosphate Substances 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 238000010792 warming Methods 0.000 claims description 16
- 238000005070 sampling Methods 0.000 claims description 9
- 150000004666 short chain fatty acids Chemical class 0.000 claims description 9
- 239000003054 catalyst Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 150000004667 medium chain fatty acids Chemical class 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims 1
- 230000032050 esterification Effects 0.000 abstract description 6
- 238000005886 esterification reaction Methods 0.000 abstract description 6
- 229940088710 antibiotic agent Drugs 0.000 abstract description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 2
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract description 2
- 238000004821 distillation Methods 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 244000144977 poultry Species 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 125000005456 glyceride group Chemical group 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 241000723353 Chrysanthemum Species 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000007413 intestinal health Effects 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- ZJYFSPXGHKSDMR-UHFFFAOYSA-N dodecanoic acid 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCCCCCCCCCC(O)=O ZJYFSPXGHKSDMR-UHFFFAOYSA-N 0.000 description 1
- PCVZXIPDCYWKPQ-UHFFFAOYSA-N dodecanoic acid;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.CCCCCCCCCCCC(O)=O PCVZXIPDCYWKPQ-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000199 molecular distillation Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
Abstract
The invention discloses a kind of feed antibacterial agents and preparation method thereof, belong to feed additive field.The processes such as short fatty acid and polyalcohol are settled through esterification, acylation, transesterification, neutralization in present invention use, distillation refines obtain Short-Chain Fatty Acids polyol ester.The product meets feed addictive sanitary standard, can be used for feed antibacterial agent, and substitute antibiotics ensure food safety.Its structure is as follows:
Description
Technical field
The present invention relates to a kind of feed antibacterial agent, the Short-Chain Fatty Acids especially suitable for substitute antibiotics in feed are polynary
Alcohol ester and preparation method thereof belongs to feed additive field.
Background technique
China's feedstuff industry adds antibiotics maintenance poultry all the time in order to promote the growths of livestock and poultry in feed
The intestinal health of fowl.Metabolic breakdown not exclusively causes the bacterium in environment resistance in animal body after a large amount of uses of antibiotics
Pharmacological property enhancing, causes serious harm to the hepatic and renal function of human body, or even can cause allergic reaction, and it is strong to have seriously affected human body
Health and living standard.American-European countries does not allow to add antibiotic in feed, and China to the year two thousand twenty also no longer allows in feed
Add antibiotic.For this purpose, the development of antibiotic substitute products has realistic meaning in feed.
In order to ensure food safety, current development trend is had become using natural plants as feed antibacterial agent, China is specially
Benefit 201710689951.8 reports a kind of plant source feed stripped antibacterial additives and preparation method thereof, is with chu chrysanthemum essential oil
Main antibacterial agent prepares chu chrysanthemum essence oil nanometer liposome using film-ultrasonic wave dispersion technique；Chinese patent 201710689979.1 is reported
A kind of plant source poultry feed antibacterial additives in road and preparation method thereof, with thyme essential oil for main antibacterial agent, preparation hundred
In essential oil nano liposomes.Preparation method is complicated, and recovery rate is lower, and inconvenience promotes and applies.And utilize natural vegetable fats
Acid and polyalcohol synthesize lipid product, as feed antibacterial agent, substitute natural plants antibacterial agent, do not see related report at present
Road.
Summary of the invention
Natural plants antibacterial agent, and the feed antibacterial of good anti-bacterial effect can be substituted the purpose of the present invention is to provide a kind of
Agent；Another object is to provide preparation method.
Feed antibacterial agent of the present invention is Short-Chain Fatty Acids polyol ester or it mixes medium-chain fatty acid and more
First ester product.The Short-Chain Fatty Acids polyol ester has the following structure: for c and b mixture or c and a mixture or c,
B, a mixture:
a b c
Wherein RCOO is caproic acid, octanoic acid, capric acid, lauric acid acyl group or its fatty acid mixed acyl group；
Wherein R'COO is the low carbon chain acid with carboxyl structure such as formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, fumaric acid
Acyl group or phosphate；
The Short-Chain Fatty Acids glyceride is prepared by the following technical programs:
Short-Chain Fatty Acids and polyalcohol are put into reaction kettle according to the ratio, while adding catalyst, is warming up under vacuum
Then 150-200 DEG C of reaction is measured by sampling acid value and controls reaction end.Then cool down, neutralize, staticly settle.Short chain is put into again
Fatty acid and catalyst are warming up to 140-180 DEG C under vacuum, and the reaction was continued, and acid value is measured by sampling, and cooling obtains after reaction
Short-Chain Fatty Acids polyol ester product.
The catalyst is NaOH or KOH；
The polyalcohol is glycerol, polyglycereol etc.；
The medium chain fatty acid is caproic acid, octanoic acid, capric acid, lauric acid or its fatty acid mixed.
The short chain fatty acids are formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, fumaric acid or phosphoric acid etc.；
The molar ratio of three kinds of materials in production process: polyalcohol: medium chain fatty acid: short chain fatty acids=1:1:1~2.
The present invention utilizes natural vegetable fatty acids and polyalcohol synthesizing ester product, as feed antibacterial agent, substitution
Antibiotic substitutes natural plants antibacterial agent, this esters product is interior under the action of gastrointestinal lipase to livestock and poultry body, can be sustained point
Solution is Short-Chain Fatty Acids list acyl rouge and short chain fatty acids (short chain preferentially decomposes), has sterilization, antibacterial, adjusting gastrointestinal tract pH value
Etc. functions promote the growth of livestock and poultry to safeguard the intestinal health of livestock and poultry.With the substitute antibiotics side such as antibacterial peptide, Chinese medicine, essential oil
Case is compared, have the characteristics that can to design, quality it is stable, resourceful, nontoxic, just industrialize with realizing.
Specific embodiment
It is as follows for embodiment to be better illustrated to the present invention:
Embodiment 1
310 kg of glycerin measured and 600 kilograms of lauric acid are put into the reaction kettle of vacuum condition, while addition is urged
8.5 kilograms of agent NaOH, after stirring is warming up to 150 DEG C, after reacting two hours under vacuum conditions, then gradually it is warming up to 170
DEG C the reaction was continued two hours, rushes nitrogen sampling and measuring, and acid value is less than 3mgkOH/g, after reaching requirement, is cooled to 80 DEG C or so, in
With, quiescent settling, carry out thin-film distillation and molecular distillation remove unreacted glycerol and collect 80% or more lauric acid list it is sweet
Ester.
600 kilograms of Glycerol Monolaurate for weighing 80% or more content put into reaction kettle again, add 300 kilograms of butyric acid,
Add 3.2 kilograms of catalyst n aOH is warming up to 140 DEG C or more again simultaneously, and the reaction was continued 4 hours or so, and measurement acid value is less than
3mgkOH/g is cooled to 50 DEG C after reaching requirement, obtains butyryl lauric acid list double glyceride product.
Embodiment 2
Measure 850 kilograms of polyglycereol and 650 kilograms of lauric acid are put into reaction kettle of the esterification, while it is public to add 11.5
Jin catalyst n aOH is being stirred and is being warming up to 150 DEG C or so under vacuum, reacting about two hours, be then gradually warming up to 170 DEG C again
Left and right is reacted two hours again, is rushed nitrogen sampling and measuring and is cooled to 80 DEG C or so after acid value reaches requirement less than 3mgkOH/g, in
With, quiescent settling, unreacted polyglycereol is removed, then 400 kilograms and 200 kilograms of butyric acid, 5.5 kilograms of the product for measuring
KOH is put into reaction kettle, is being warming up between 150 DEG C -170 DEG C again under stirring and vacuum, the reaction was continued 4 hours or so, takes
Sample measures acid value and is less than 3mgkOH/g, is cooled to 50 DEG C after reaching requirement, obtains butyryl lauric acid polyglyceryl ester product.
Embodiment 3
80% or more lauric acid monoglyceride, 600 kilograms and 300 kilograms lactic acid made from Example 1,3.8 kilograms of KOH, simultaneously
It puts into the reaction kettle of esterification, is being warming up between 150 DEG C -170 DEG C again under stirring and vacuum, react about 4 hours or so, take
Sample measures acid value and is less than 6mgkOH/g, is cooled to 50 DEG C after reaching requirement, obtains lactic acid lauric acid list double glyceride product.
Embodiment 4
80% or more lauric acid monoglyceride, 600 kilograms and 250 kilograms propionic acid made from Example 1,7.5 kilograms of NaOH are simultaneously
It puts into reaction kettle of the esterification, is being warming up between 145 DEG C -165 DEG C again under stirring and vacuum, reacted about 4 hours or so, sampling
It measures acid value and is less than 3mgkOH/g, be cooled to 50 DEG C after reaching requirement, obtain propionyl lauric acid list double glyceride.
Embodiment 5
The octanoic acid of measure 850 kilograms of polyglycereol and 580 kilograms is put into reaction kettle of the esterification, while adding 20 kilograms
NaOH is being stirred and is being warming up to 150 DEG C or so under vacuum, reacting about two hours, be then gradually warming up to 170 DEG C or so again again instead
It answers two hours, rushes nitrogen sampling and measuring, after acid value reaches requirement less than 3mgkOH/g, be cooled to 80 DEG C or so, neutralize, it is static heavy
Drop removes unreacted polyglycereol, then 380 kilograms of the product that will be measured, 200 kilograms and 5.2 kilograms NaOH investments of butyric acid
It in reaction kettle, is being warming up between 158 DEG C -172 DEG C again under stirring and vacuum, the reaction was continued 4 hours or so, and acid is measured by sampling
Value is less than 3mgkOH/g, is cooled to 50 DEG C after reaching requirement, obtains butyryl octanoic acid polyglycerol ester product.
Embodiment 6
80% or more lauric acid monoglyceride, 600 kilograms and 404 kilograms anhydrous citric acids, 12 kilograms of KOH made from Example 1
It puts into reaction kettle of the esterification simultaneously, is stirring and be warming up to 158 DEG C -175 DEG C under vacuum again, reacting about 4 hours or so, sampling
It measures acid value and is less than 3mgkOH/g, be cooled to 50 DEG C after reaching requirement, obtain citric acid lauric acid list double glyceride.
Claims (2)
1. a kind of feed antibacterial agent, it is characterised in that: the antibacterial agent be Short-Chain Fatty Acids polyol ester, be c and b mixture or
C and a mixture or c, b, a mixture:
a b c
Wherein RCOO is caproic acid, octanoic acid, capric acid, lauric acid acyl group or its fatty acid mixed acyl group；
Wherein R'COO is formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, fumaric acid acyl group or phosphate；
Wherein polyalcohol is glycerol or polyglycereol.
2. preparing feed antibacterial agent method as described in claim 1, which is characterized in that prepared by following steps: by middle chain
Fatty acid and polyalcohol are put into reaction kettle according to the ratio, while being added catalyst and being warming up to 150-200 DEG C of reaction under vacuum, are taken
Sample measures acid value and controls reaction end；After reaction, cool down, neutralize, standing sedimentation；Then short chain fatty acids are put into again and are urged
Agent, being warming up to 140-180 DEG C under vacuum, the reaction was continued, and acid value is measured by sampling, after reaction, cooling, obtain in short chain rouge
Fat acid polyol ester product；
The medium chain fatty acid is caproic acid, octanoic acid, capric acid, lauric acid acyl group or its fatty acid mixed；
The short chain fatty acids are formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, fumaric acid or phosphoric acid；
Wherein polyalcohol is glycerol or polyglycereol；
The catalyst is NaOH or KOH；
Molar ratio: polyalcohol: medium chain fatty acid: short chain fatty acids=1:1:1~2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910463290.6A CN110122667B (en) | 2019-05-30 | 2019-05-30 | Feed antibacterial agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910463290.6A CN110122667B (en) | 2019-05-30 | 2019-05-30 | Feed antibacterial agent and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN110122667A true CN110122667A (en) | 2019-08-16 |
| CN110122667B CN110122667B (en) | 2023-06-23 |
Family
ID=67583028
Family Applications (1)
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| CN201910463290.6A Active CN110122667B (en) | 2019-05-30 | 2019-05-30 | Feed antibacterial agent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024003941A1 (en) * | 2022-07-01 | 2024-01-04 | Fine Organic Industries Limited | An ester product of polyglycerol |
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