CN110121647A - 用于检测和治疗胰腺导管腺癌的方法 - Google Patents

用于检测和治疗胰腺导管腺癌的方法 Download PDF

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Publication number
CN110121647A
CN110121647A CN201780080968.1A CN201780080968A CN110121647A CN 110121647 A CN110121647 A CN 110121647A CN 201780080968 A CN201780080968 A CN 201780080968A CN 110121647 A CN110121647 A CN 110121647A
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antigen
patient
timp1
lrg1
biological sample
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CN201780080968.1A
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English (en)
Chinese (zh)
Inventor
S·哈纳希
M·卡佩罗
A·田口
Z·冯
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University of Texas at Austin
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University of Texas at Austin
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780080968.1A 2016-12-15 2017-12-15 用于检测和治疗胰腺导管腺癌的方法 Pending CN110121647A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662435024P 2016-12-15 2016-12-15
US201662435020P 2016-12-15 2016-12-15
US62/435,020 2016-12-15
US62/435,024 2016-12-15
PCT/US2017/066851 WO2018112428A1 (en) 2016-12-15 2017-12-15 Methods for the detection and treatment of pancreatic ductal adenocarcinoma

Publications (1)

Publication Number Publication Date
CN110121647A true CN110121647A (zh) 2019-08-13

Family

ID=62559366

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780080968.1A Pending CN110121647A (zh) 2016-12-15 2017-12-15 用于检测和治疗胰腺导管腺癌的方法

Country Status (6)

Country Link
US (3) US20200182876A1 (https=)
EP (1) EP3555628A4 (https=)
JP (3) JP2020514689A (https=)
KR (1) KR102549063B1 (https=)
CN (1) CN110121647A (https=)
WO (1) WO2018112428A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110646554A (zh) * 2019-09-12 2020-01-03 北京博远精准医疗科技有限公司 基于代谢组学的胰腺癌诊断标志物及其筛选方法和应用
CN113777309A (zh) * 2021-09-07 2021-12-10 复旦大学附属肿瘤医院 自身抗体在制备胰腺导管腺癌诊断试剂盒中的应用

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* Cited by examiner, † Cited by third party
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EP3578984A3 (en) * 2013-10-28 2020-03-04 Salivatech Co., Ltd. Salivary biomarkers for oral cancer
RU2745793C1 (ru) * 2020-02-26 2021-04-01 Государственное бюджетное учреждение здравоохранения города Москвы городская клиническая больница имени С.П. Боткина департамента здравоохранения города Москвы (ГБУЗ ГКБ им. С.П. Боткина ДЗМ) Способ расчета средней продолжительности жизни у пациентов с метастатической аденокарциномой поджелудочной железы
CN115125312B (zh) * 2021-03-26 2025-07-18 中国科学院上海营养与健康研究所 用于Basal型胰腺导管腺癌(PDAC)诊断的标志物组合及其应用
CN113917008A (zh) * 2021-09-09 2022-01-11 广州济士源生物技术有限公司 质谱检测尿液中代谢物水平的产品在制备用于早期评估肠道息肉和结直肠癌产品中的应用
CN114487201A (zh) * 2022-02-09 2022-05-13 江西省肿瘤医院(江西省第二人民医院、江西省癌症中心) 鼻咽癌相关尿液标志物组合的检测试剂的应用
US20230296610A1 (en) * 2022-02-15 2023-09-21 Kite Pharma, Inc. Predicting adverse events from immunotherapy
WO2024059549A2 (en) * 2022-09-12 2024-03-21 Board Of Regents, The University Of Texas System Methods for the detection and treatment of pancreatic ductal adenocarcinoma

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US20100092476A1 (en) * 2006-11-17 2010-04-15 Hanash Samir M Pancreatic cancer biomarkers
US20120202188A1 (en) * 2009-10-01 2012-08-09 Phenomenome Discoveries Inc. Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis
US20160282351A1 (en) * 2013-10-28 2016-09-29 Salivatech Co., Ltd. Salivary biomarkers for cancers, methods and devices for assaying the same, and methods for determining salivary biomarkers for cancers

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CA2857401A1 (en) * 2011-11-30 2013-06-06 Metanomics Health Gmbh Device and methods to diagnose pancreatic cancer
US20140271621A1 (en) * 2013-03-14 2014-09-18 Abbott Laboratories Methods of prognosis and diagnosis of pancreatic cancer
AU2014368412A1 (en) * 2013-12-20 2016-07-07 Metanomics Health Gmbh Means and methods for diagnosing pancreatic cancer in a subject based on a metabolite panel
WO2015157557A1 (en) * 2014-04-09 2015-10-15 Myriad Rbm, Inc. Methods of diagnosing pancreatic cancer and methods related thereto
KR20160045547A (ko) * 2014-10-17 2016-04-27 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법

Patent Citations (3)

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US20100092476A1 (en) * 2006-11-17 2010-04-15 Hanash Samir M Pancreatic cancer biomarkers
US20120202188A1 (en) * 2009-10-01 2012-08-09 Phenomenome Discoveries Inc. Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis
US20160282351A1 (en) * 2013-10-28 2016-09-29 Salivatech Co., Ltd. Salivary biomarkers for cancers, methods and devices for assaying the same, and methods for determining salivary biomarkers for cancers

Non-Patent Citations (2)

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J-Y JANG等: "FP13-03:novel biomarker panel the early detection of pancretic cancer and its clinical validation", 《INTERNATIONAL HEPATO-PANCREATO-BILIARY ASSOCIATION》 *
R.E. BRAND等: "serum biomarker panels for the detection of pancreatic cancer", 《CLINICAL CANCER RESEARCH》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110646554A (zh) * 2019-09-12 2020-01-03 北京博远精准医疗科技有限公司 基于代谢组学的胰腺癌诊断标志物及其筛选方法和应用
CN113777309A (zh) * 2021-09-07 2021-12-10 复旦大学附属肿瘤医院 自身抗体在制备胰腺导管腺癌诊断试剂盒中的应用

Also Published As

Publication number Publication date
EP3555628A4 (en) 2020-08-05
JP2020514689A (ja) 2020-05-21
US20200182876A1 (en) 2020-06-11
JP2023055806A (ja) 2023-04-18
EP3555628A1 (en) 2019-10-23
US20230324394A1 (en) 2023-10-12
US20250298025A1 (en) 2025-09-25
KR102549063B1 (ko) 2023-06-28
WO2018112428A1 (en) 2018-06-21
JP2025118850A (ja) 2025-08-13
KR20190101395A (ko) 2019-08-30

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