CN110111907A - Intelligent digital Peptide systhesis system - Google Patents
Intelligent digital Peptide systhesis system Download PDFInfo
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- CN110111907A CN110111907A CN201910389772.1A CN201910389772A CN110111907A CN 110111907 A CN110111907 A CN 110111907A CN 201910389772 A CN201910389772 A CN 201910389772A CN 110111907 A CN110111907 A CN 110111907A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F15/00—Digital computers in general; Data processing equipment in general
- G06F15/76—Architectures of general purpose stored program computers
- G06F15/78—Architectures of general purpose stored program computers comprising a single central processing unit
- G06F15/7828—Architectures of general purpose stored program computers comprising a single central processing unit without memory
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
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Abstract
The invention discloses intelligent digital Peptide systhesis systems, including reaction kettle modular unit, material conveyor module unit, central control unit, intelligent computer software systems, RS485 communication module, Peptide systhesis system of the intelligent digital Peptide systhesis system of the present invention based on integrated intelligent program and digitized instrument control technology, configure valve, feed liquid delivery pump, RS485 communication module, Profinet communication network, instrument with digitized communication function is fed directly in control system, it is communicated by control system and Peptide systhesis intelligent software system, it is allowed to that data are authentic and valid and error free control system is run according to the intelligent program of setting.Meanwhile the present invention is configured using modularized design, user can determine configuration reaction kettle unit and feed liquid supply unit according to needs of production.Integrate different many peptide bonds synthesis programs in intelligent software system of the present invention, after certain program of user's unrestricted choice, operator directly initiates the i.e. full-automatic operation of system.
Description
Technical field
The present invention relates to a kind of device in peptide synthesis technology field, it is specifically a kind of realize it is intelligent digitalized more
Peptide synthesis system.
Background technique
Nearly ten years, the development advanced by leaps and bounds is achieved for the research of polypeptide, present scientist has polypeptide
Awake understanding.Till now, it has been discovered that and isolate more than the 100 kinds of peptides for being present in human body, for polypeptide research and
It utilizes, has worldwide had already appeared a unprecedented prosperity scene.
Polypeptide drugs are a kind of one kind of molecular weight between classical small organic molecule and protein-based large biological molecule
Individual drug categories.Usually contain 50 amino acid residues below.Polypeptide drugs growth rate of market is about 10%, is much higher than
Other drugs.
The synthetic method of polypeptide mainly has Solid phase synthesis and liquid phase method synthesis two ways.Liquid phase method synthesis is mainly used for
Small peptide synthesis, and have the defects of purification of intermediate is complicated for operation, post-processing operation is cumbersome, synthesis cycle is long.
R.BruceMerrifield has been put forward for the first time solid-phase peptide synthesis (SPPS) in 1963, this has on chemiluminescent polypeptide
Have the synthetic method of milestone significance, once occur due to its synthesis is convenient, rapidly so that Peptide systhesis have it is substantive into
Exhibition, and in acquisition Nobel chemistry Prize in 1984.1972,9-fluorenylmethyloxycarbonyl was used to protect α-ammonia first by LouCarpino
Base is used widely rapidly since reaction condition is mild, and current 85% or more polypeptide drugs are obtained by synthesis in solid state
It arrives.
Existing polypeptide is independent reaction kettle system, pump, valve, detector composition substantially, together by piping connection,
Each control is independent operating.When multiple peptide bonds are reacted, need very many more manipulations that could complete, editing procedure is suitable
It is complicated.The initial data of acquisition does not store, often subsequent to contact with equipment operation condition at that time, response situation one
It rises, and is discrete magnitude management to instrument signal.
Summary of the invention
The present invention In view of the above shortcomings of the prior art, provides one kind with integrated intelligent program and digital instrumentation
Peptide systhesis system based on control technology configures valve, feed liquid delivery pump, RS485 communication module, Profinet communication network
Network is fed directly to the instrument with digitized communication function in control system, intelligently soft with Peptide systhesis by control system
Part system communication, is allowed to that data are authentic and valid and error free control system is run according to the intelligent program of setting.
The present invention through the following technical solutions to achieve the above objectives:
Intelligent digital Peptide systhesis system, including reaction kettle modular unit, material conveyor module unit, center control list
Member, intelligent computer software systems, RS485 communication module, it is characterised in that reaction kettle modular unit and material conveyor module
The feed inlet of unit connects, and intelligent computer software systems are understood by central control unit and material conveyor module unit,
Central control unit by the valve and inductor of RS485 communication module and material conveyor module unit realize point-to- point communication and
Network communication.
Further, Peptide systhesis control system of the central control unit based on digitized communication technology, packet
Digital communication intelligence control system is included, wherein central controller and digital instrumentation Communication Control.
Further, the central controller of the central control unit and digital instrumentation directly carry out digital, interactive, real
When detection instrument signal and state.
Further, Peptide systhesis software system of the intelligent computer software systems based on intellectualized technology
System, including intelligent software system, the integrated predefined and customized program editing template of user.
Intelligent digital Peptide systhesis system of the present invention is with integrated intelligent program and digitized instrument control technology
The Peptide systhesis system on basis configures valve, feed liquid delivery pump, RS485 communication module, Profinet communication network, having
The instrument of digitized communication function is fed directly in control system, is led to by control system and Peptide systhesis intelligent software system
News, are allowed to that data are authentic and valid and error free control system is run according to the intelligent program of setting.The intelligence software is mainly used
In system human-computer interaction, monitoring device operating status predefines a variety of peptide bond response procedures, equipment can caller transport automatically
Row.The reaction kettle unit is activated for peptide bond and synthetic reaction.The feed liquid supply unit is for material transferring to reaction kettle
The polypeptide after synthesis is transported out from reaction kettle.The central control unit is transported for process control processing equipment
Row.The digital communication module directly can carry out digital communication with instrument, read or be written correlation values.The RS485 communication
Module directly can carry out digital communication with instrument, read or be written correlation values.The network communication module can be by field digital
Change instrument and network communication is carried out by communication network and communication module, is ultimately transmitted in control unit.Meanwhile the present invention uses
Modularized design configuration, user can determine configuration reaction kettle unit and feed liquid supply unit according to needs of production.The present invention
Integrate different many peptide bonds synthesis programs in the intelligent software system, after certain program of user's unrestricted choice, operator
Directly initiate the i.e. full-automatic operation of system.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention, in which:
1-reaction kettle modular unit, 2-material conveyor module units, 3-central control units, 4-intelligent computers
Software systems, 5-RS485 communication modules.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Intelligent digital Peptide systhesis system, including reaction kettle modular unit 1, material conveyor module unit 2, center control list
First 3, intelligent computer software systems 4, RS485 communication module 5, it is characterised in that reaction kettle modular unit 1 and material convey
The feed inlet of modular unit 2 connects, and intelligent computer software systems 4 pass through central control unit 3 and material conveyor module list
Member 2 understands, and central control unit 3 is real by the valve and sensor of RS485 communication module 5 and material conveyor module unit 2
Existing point-to- point communication and network communication.
Further, Peptide systhesis control system of the central control unit 3 based on digitized communication technology, packet
Digital communication intelligence control system is included, wherein central controller and digital instrumentation Communication Control.
Further, the central controller of the central control unit 3 and digital instrumentation directly carry out digital, interactive, real
When detection instrument signal and state.
Further, Peptide systhesis software system of the intelligent computer software systems 4 based on intellectualized technology
System, including intelligent software system, the integrated predefined and customized program editing template of user.
Intelligent digital Peptide systhesis system of the present invention is with integrated intelligent program and digitized instrument control technology
The Peptide systhesis system on basis configures valve, feed liquid delivery pump, RS485 communication module, Profinet communication network, having
The instrument of digitized communication function is fed directly in control system, is led to by control system and Peptide systhesis intelligent software system
News, are allowed to that data are authentic and valid and error free control system is run according to the intelligent program of setting.The intelligence software is mainly used
In system human-computer interaction, monitoring device operating status predefines a variety of peptide bond response procedures, equipment can caller transport automatically
Row.The reaction kettle unit is activated for peptide bond and synthetic reaction.The feed liquid supply unit is for material transferring to reaction kettle
The polypeptide after synthesis is transported out from reaction kettle.The central control unit 3 is transported for process control processing equipment
Row.The digital communication module directly can carry out digital communication with instrument, read or be written correlation values.The RS485 communication
Module 5 directly can carry out digital communication with instrument, read or be written correlation values.The network communication module can be by field digital
Change instrument and network communication is carried out by communication network and communication module, is ultimately transmitted in control unit.Meanwhile the present invention uses
Modularized design configuration, user can determine configuration reaction kettle unit and feed liquid supply unit according to needs of production.The present invention
Integrate different many peptide bonds synthesis programs in the intelligent software system, after certain program of user's unrestricted choice, operator
Directly initiate the i.e. full-automatic operation of system.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (4)
1. intelligent digital Peptide systhesis system, including reaction kettle modular unit, material conveyor module unit, central control unit,
Intelligent computer software systems, RS485 communication module, it is characterised in that reaction kettle modular unit and material conveyor module unit
Feed inlet connection, intelligent computer software systems are understood by central control unit and material conveyor module unit, center
Control unit realizes point-to- point communication and net by the valve and sensor of RS485 communication module and material conveyor module unit
Network communication.
2. intelligent digital Peptide systhesis system according to claim 1, it is characterised in that the central control unit is with number
Peptide systhesis control system based on word mechanics of communication, including digital communication intelligence control system, wherein central controller
With digital instrumentation Communication Control.
3. intelligent digital Peptide systhesis system according to claim 1, it is characterised in that in the central control unit
Centre controller and digital instrumentation directly carry out digital, interactive, real-time detection instrument signal and state.
4. intelligent digital Peptide systhesis system according to claim 1, it is characterised in that the intelligent computer software
Peptide systhesis software systems of the system based on intellectualized technology, including intelligent software system, integrated predefined and user
Customized program editing template.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910389772.1A CN110111907A (en) | 2019-05-10 | 2019-05-10 | Intelligent digital Peptide systhesis system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910389772.1A CN110111907A (en) | 2019-05-10 | 2019-05-10 | Intelligent digital Peptide systhesis system |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0909176A1 (en) * | 1997-02-11 | 1999-04-21 | Mallinckrodt Chemical, Inc. | Reactor and method for solid phase peptide synthesis |
| CN2614209Y (en) * | 2002-03-15 | 2004-05-05 | 成都法玛基因科技有限公司 | Solid phase synthesizing apparatus |
| CN1966515A (en) * | 2005-11-16 | 2007-05-23 | 上海赛瑞生化科技有限公司 | Full-automatic polypeptide synthetic instrument |
| CN106986916A (en) * | 2017-03-20 | 2017-07-28 | 珠海百世瑞生命科技有限公司 | Full automatic high efficiency solid phase peptide synthesizer and application method |
| CN107722104A (en) * | 2016-08-23 | 2018-02-23 | 安徽天达谱申生物科技有限公司 | A kind of microwave Peptide synthesizer |
-
2019
- 2019-05-10 CN CN201910389772.1A patent/CN110111907A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0909176A1 (en) * | 1997-02-11 | 1999-04-21 | Mallinckrodt Chemical, Inc. | Reactor and method for solid phase peptide synthesis |
| CN2614209Y (en) * | 2002-03-15 | 2004-05-05 | 成都法玛基因科技有限公司 | Solid phase synthesizing apparatus |
| CN1966515A (en) * | 2005-11-16 | 2007-05-23 | 上海赛瑞生化科技有限公司 | Full-automatic polypeptide synthetic instrument |
| CN107722104A (en) * | 2016-08-23 | 2018-02-23 | 安徽天达谱申生物科技有限公司 | A kind of microwave Peptide synthesizer |
| CN106986916A (en) * | 2017-03-20 | 2017-07-28 | 珠海百世瑞生命科技有限公司 | Full automatic high efficiency solid phase peptide synthesizer and application method |
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