CN110106065A - Cell, tissue are transported with without swing shell - Google Patents
Cell, tissue are transported with without swing shell Download PDFInfo
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- CN110106065A CN110106065A CN201910506633.2A CN201910506633A CN110106065A CN 110106065 A CN110106065 A CN 110106065A CN 201910506633 A CN201910506633 A CN 201910506633A CN 110106065 A CN110106065 A CN 110106065A
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- container holder
- container
- supporting arrangement
- guiding piece
- cell
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
A kind of cell, tissue is transported with without swing shell, main casing (C1) includes container holder (11), guiding piece (12) and supporting arrangement (13), guiding piece (11) has from the spherical face of container holder (12) extended underneath towards side complete cycle, supporting arrangement (13) is made of the spherical face contact along guiding piece (12) and the multiple free roller bearings (130) that can rotate in omnidirection, for the external force for the swaying direction for acting on main casing (C1), utilize the relative motion between supporting arrangement (13) and container holder (11), container holder (11) is supported to and is not swung.
Description
Present patent application is application No. is 201610390564.X, and entitled " cell, tissue transport no swing
The divisional application of the application for a patent for invention of shell ".
Technical field
The present invention relates to the cell used when transporting the cells such as iPS cell using vehicle or various other running tools,
Tissue is transported with without swing shell.
Background technique
Because of the appearance of iPS cell, the clinical research of domestic regenerative medicine is accelerated, the current research in relation to cultivating and breaking up
Exploitation is swift and violent to be promoted.In addition, recently, starting not freeze iPS cell but be distributed to research with the state of living body
Mechanism and enterprise eliminate the working hour of defrosting etc. as a result, can expect that efficiency improves.
But in the case where iPS cell not being freezed but being dispensed with living body, iPS cell is put into culture
It is transported after the containers such as ware (Japanese: シ ャ ー レ) using vehicle etc., but in this case, it is desirable that the cell to live is not caused
Damage, and transported in the state of maintaining activity, need to carry out temperature management, gas (oxygen, carbon dioxide) manages, in transport
From the protection etc. of the external force such as vibration.
The container of this cell transport refers in Japan Patent JP2014-83002A.The container that the document is recorded
Including atmosphere adjusting agent and cell accepting container, which there is gas permeable but liquid can not substantially penetrate
Isolation film, so as to carry out the transport and/or keeping of cell in the case where not applying stress to cell.In addition, in above-mentioned appearance
In device, the mounting portion kept to cell accepting container and swing mechanism portion can be set.In this case, mounting portion is arranged
In closed container, cell can be kept, mounting portion is supported to the interior wall relative to closed container by swing mechanism portion
Face can freely swing, and can steadily keep to contents such as cell and culture mediums.In addition, can be arranged in said vesse
Temperature control device and damping of shocks mechanism.
But in the container that above-mentioned document is recorded, cell accepting container is kept using mounting portion, and utilize pendulum
Above-mentioned mounting portion is supported to by motivation structure to freely swing, thus, for example when using automobile transportation said vesse, container can be because
Rocking and swinging in running car, whereby, there are the following problems: the culture medium of the iPS cell in container can rise and fall, because
The impact of the culture medium of above-mentioned fluctuating and iPS cell may be made to float and generate destruction.
Summary of the invention
The present invention is solves the problems, such as above-mentioned existing and make, and its purpose is to provide one kind in use vehicle or various other
Running tool is transported in the isocellular situation of iPS cell, can prevent from rocking and topple over due to causes cytoclasis because in transit
Cell, tissue conveying are with without swing shell.
To achieve the goals above, cell of the invention, tissue are transported is characterized in without swing shell, comprising: is held
Device holder, the container holder are used to the container for storing cell, tissue being kept into level；Guiding piece, guiding piece peace
It is supported loaded on the container holder, and to the container holder；And supporting arrangement, the supporting arrangement pass through described
Guiding piece supports the container holder, and a side of the guiding piece and the supporting arrangement has at least from the appearance
The spherical face extended to the side complete cycle underneath towards the container holder of device holder, another party is by along the ball
The face contact of the shape and multiple free roller bearings that can be rotated in omnidirection are constituted, for acting on the supporting arrangement and institute
The external force for stating the swaying direction of container holder, using the relative motion between the supporting arrangement and the container holder,
The container holder is supported to and is not swung.
Above-mentioned cell, tissue are transported further to be embodied by following manner with without swing shell.
(1) container holder is made of support plate, pressing plate and screw device, wherein the support plate carries out container
Bearing, for the pressing plate for pressing from top the container, the screw device is screwed into the support plate and institute
It states between pressing plate.
(2) guiding piece as can by container holder built in, at least bottom surface is formed as into spherical closed housing component
It constitutes, the minimum point in the bottom surface has axis insertion portion, and the container holder configuration is in the guiding piece, from the appearance
The lower central of device holder axis outstanding passes through the axis insertion portion and makes the container holder and guiding piece one
Change, and counterweight is installed in the lower end of the axis, supporting arrangement includes: multiple free roller bearings, multiple described freely to roll
The bottom surface that axis of a cylinder honours the housing component carries out multi-point support；And installation pedestal, the installation pedestal are used for each freedom
Roller bearing contacts the bottom surface for being configured at the guiding piece.
In this case, it may be desirable to, installation pedestal includes setting pedestal and stands up the setting base
Multiple free roller bearing mounting portions of seat.
(3) guiding piece is made of multiple free roller bearings, and each free roller bearing is installed on downward appearance
The bottom surface of device holder, supporting arrangement include: can by it is built in the container holder, at least bottom surface is formed as spherical close
The housing component of enclosed；And installation pedestal, the installation pedestal is for making the housing component to accept with each free roller axle
The bottom surface side that the mode of touching configured in the container holder.
In this case, it may be desirable to, installation pedestal includes: setting pedestal；Helical spring, helical spring folder
Between the center of the setting pedestal and the bottom center of housing component；And multiple bolsters, the multiple bolster exist
It is folded in around the helical spring between the setting pedestal and the housing component.
Cell according to the present invention, tissue are transported with without shell is swung, due to including: guiding piece, guiding piece installation
For the container for storing cell, tissue to be kept into horizontal container holder, and container holder is supported；
And supporting arrangement, the supporting arrangement support container holder via guiding piece, above-mentioned guiding piece and supporting arrangement
One side has the spherical face at least extended from the side complete cycle underneath towards container holder of container holder, another party
By being constituted along spherical face contact and the multiple free roller bearings that can be rotated in omnidirection, for acting on supporting arrangement
And the external force of the swaying direction of container holder, it can will be held using the relative motion between supporting arrangement and container holder
Device holder, which is supported to, not to be swung, therefore, have when use vehicle or various other running tools to the cells such as iPS cell into
In the case that row transports, the fluctuating of the culture medium of the cell caused by capable of reducing as much as possible because of in transit rock in container is dynamic
Make, with the remarkable result for preventing the present invention as cytoclasis exclusive.
Detailed description of the invention
Fig. 1 is the cell for indicating first embodiment of the invention, main view of the tissue transport without the structure for swinging shell
Figure.
Fig. 2 is the main view without the movement for swinging shell for indicating Fig. 1.
Fig. 3 is the cell for indicating second embodiment of the invention, main view of the tissue transport without the structure for swinging shell
Figure.
Fig. 4 is the main view without the movement for swinging shell for indicating Fig. 3.
(symbol description)
C1 cell, tissue are transported with without swing shell (main casing)
11 container holders
111 support plates
112 screw insertion holes
113 pressing plate
114 screw insertion holes
115 screw devices
116 screws
117 nuts
118 axis
119 counterweights (sliding weight of steelyard)
12 guiding pieces
121 lower cases
122 upper bodies
123 rings
124 rings
125 slots
126 O-rings
127 fasteners
A fixed substrate
B operating stick
C movable body
D hooks frame (Japanese: draw and hang け frame)
E bearing piece (Japanese: is had)
128 axis insertion portions
129 sealed tubes
13 supporting arrangements
130 free roller bearings
F shell
G ball
H nut cap
131 installation pedestals
132 setting pedestals
133 free roller bearing mounting portions
134 installing frames
1341 pillars
1342 pillars
1343 hinges
1344 locating parts
S0 slit
S1 sticking department
S2 lock hole
S3 locking component
S31 protrusion
1345 arms
135 installation axles
136 helical springs (spring member)
137 free roller bearing installing arms
The plate in the center P1
P2 arm
C2 cell, tissue are transported with without swing shell (main casing)
21 container holders
211 support plates
212 screw insertion holes
213 pressing plate
214 screw insertion holes
215 screw devices
216 screws
217 nuts
22 guiding pieces
220 free roller bearings
F shell
G ball
H nut cap
23 supporting arrangements
23A shell
231 lower cases
232 upper bodies
233 rings
234 rings
235 slots
236 O-rings
237 fasteners
238 holding sections
239 mounting portions
23B installation pedestal
241 setting pedestals
The holding section 241a
241b mounting portion
242 helical springs
243 bolsters
S container
M vehicle
M1 railway carriage
Specific embodiment
Next, being illustrated using attached drawing to embodiment for carrying out the present invention.
Fig. 1 shows first embodiment.
As shown in Figure 1, cell, tissue conveying with without swing shell C1 (in the explanation of first embodiment below,
Sometimes it is only called main casing C1) it include: container holder 11, the container holder 11 will be for that will receive cell, tissue
The container of appearance is kept into level；Guiding piece 12, which is installed on container holder 11, and carries out to container holder 11
Bearing；And supporting arrangement 13, the supporting arrangement 13 support container holder 11 by guiding piece 12.
Container holder 11 is made of support plate 111, pressing plate 113 and screw device 115, wherein above-mentioned support plate
111 pairs of containers support, and for pressing from top container, above-mentioned screw device 115 is screwed into above-mentioned pressing plate 113
Between above-mentioned support plate 111 and pressing plate 113.
In this case, support plate 111 is the circular slab with predetermined outside diameter, support plate 111 outer peripheral edge portion with
There are four screw insertion holes 112 for 90 degree of intervals formation.Pressing plate 113 is that have the defined outer diameter more slightly larger than support plate 111
Circular slab is accordingly formed in the peripheral part side of pressing plate 113 with each screw insertion hole 112 of support plate 111 with 90 degree of intervals
There are four screw insertion holes 114.Screw device 115 is made of four groups of screws 116 and nut 117.In this way, by using support plate
111 by the container that cell, tissue are stored support, and using pressing plate 113 above the container to container carry out by
Pressure, each screw 116 is passed through from each screw insertion hole 112 of support plate 111, and is inserted into each screw insert of pressing plate 113
In hole 114, each screw 116 and each nut 117 are fastened in pressing plate 113, so as to use support plate 111 and pressing plate
113 pairs of containers clamp.
In addition, axis 118 is prominent from the lower central of container holder 11, in the axis 118 on said vesse holder 11
On be hung with counterweight (sliding weight of steelyard) 119.In this case, axis 118 is as made of two axis connections, and axis 118 is from pressing plate 113
Side is formed through in the axis insertion portion in 111 center of pressing plate 113 and support plate of container holder 11, and one end passes through nut
117 are fixed in pressing plate 113, and another side protrudes downward from support plate 111.Pass through spiral shell in the lower end of above-mentioned axis 118
Nail etc. is equipped with one or more counterweights 119 in a manner of it can assemble and disassemble.In this way, the configuration of container holder 11 is in aftermentioned guiding piece
In 12, the counterweight 119 of 11 lower section of container holder is oriented along gravity direction, to obtain the level of container holder 11.
Guiding piece 12 has at least from the side complete cycle extension underneath towards container holder 12 of container holder 11
Spherical face.
Above-mentioned guiding piece 12 is bottom surface at least will to be formed as spherical closed shell built in container holder 11
Body part is at this time made of the shell for being integrally formed into sphere what can vertically be divided into two, and being included in upper surface has opening
Hemispherical lower case 121 and lower surface have opening hemispherical upper body 122.Above-mentioned lower case 121,
Upper body 122 is provided with ring 123,124 substantially in respective opening Inner peripheral portions mutually to abut, or spreads
The ring of one side, at this time for 121 side of lower case ring 123 upper surface complete cycle landform grooving 125, and O-ring 126 is embedded in
In the slot 125, so that lower case 121, upper body 122 be made mutually airtightly to combine.In addition, in above-mentioned lower case
121, between the engaging portion of upper body 122, along the circumferential direction at a prescribed interval (at this time be 90 degree interval) be equipped with it is multiple
(being at this time four) fastener 127, these fasteners 127 are for screwing and combining lower case 121 with upper body 122.
Above-mentioned fastener 127 as universal product generally to be known, by fixed substrate a, movable body c, substantially U-shaped shape hook
The bearing piece e of frame d and hook shape (inverted L-shaped shape), wherein above-mentioned movable body c be supported on a pivot on fixed substrate a and
Front end has operating stick b, and the pivot suspension point than movable body c that above-mentioned hook frame d is supported on a pivot on movable body c more leans on
The position of the side operating stick b, at this point, fixed substrate a is mounted on outside the close opening of upper body 122 by fixing pieces such as screws
On the outer surface of periphery, movable body c is set to be mounted on upper body 122 and lower case with being able to rotate using above-mentioned fixed substrate a
Between the engaging portion of body 121, bearing piece e is mounted on the close opening periphery edge of lower case 121 using fixing pieces such as screws
On outer surface.In this way, each shell 121,122 of top and the bottom makes mutual ring portion 123,124 be aligned and be combined, in above-mentioned state
Under, rotate movable body c towards from the direction that fixed substrate a is pulled open, and make to hook frame d court
It is rotated to bearing piece e, frame d will be hooked and be hooked into bearing piece e, in this state, and just now on the contrary, pushing operation bar b, makes
Movable body c is rotated towards fixed substrate a, and the hook frame d (shell toward upper of bearing piece e will be hooked in using movable body c
122 sides) it pulls, so that the effect of the drag force using above-mentioned hook frame d, screws guarantor for each shell 121,122 of top and the bottom
Hold into air-tight state.
In addition, in the minimum of central, i.e. lower case 121 the bottom surface in the bottom surface of the lower case 121 of above-mentioned guiding piece 12
Axis insertion portion 128 is provided at point.It is plugged with sealed tube 129 together in above-mentioned axis insertion portion 128, which is used for
By axis insertion portion 128 and across the axis 118 of the axis insertion portion 128 it is closed.
In this way, container holder 11 configures in the lower case 121 of guiding piece 12, from the lower part of container holder 11
Axis 118 outstanding is entreated to pass through the axis insertion portion 128 of lower case 121 and keep container holder 11 integrated with guiding piece 12,
The lower end of axis 118 is equipped with counterweight 119.In addition, as described above, upper body 122 is airtightly integrated to above-mentioned lower case
121, above-mentioned state is kept using each fastener 127.
Supporting arrangement 13 is by the spherical face contact along guiding piece 12 and the multiple free rollers that can rotate in omnidirection
Bearing 130 is constituted.
Above-mentioned supporting arrangement 13 includes: to carry out to the outer surface of the top surface side of the top surface of guiding piece 12, i.e. upper body 122
Multiple (being at this time four) free roller bearings 130 of multi-point support (being at this time four-point supporting)；To the bottom surface of guiding piece 12, i.e.
The outer surface of the bottom surface side of lower case 121 carries out multiple (being at this time four) of multi-point support (being at this time four-point supporting) freely
Roller bearing 130；And installation pedestal 131, the installation pedestal 131 are used to each free roller bearing 130 contacting configuration respectively
In the top surface and bottom surface of guiding piece 12.
Free roller bearing 130 as universal product generally to be known, by with hemispherical concave surface shell f, can revolve
It is configured at the ball g of the hemispherical concave surface of shell f with turning, is covered on the hemispherical concave surface of shell f and ball g is carried out
Nut cap h of holding etc. is constituted, and ball g can rotate in shell f in omnidirection.
Installation pedestal 131 includes: setting pedestal 132；Multiple (being at this time four) free roller bearing mounting portions 133, this
Center of a little free roller bearing mounting portions 133 away from setting pedestal 132 is equidistant and is mutually equally spaced in the setting base
At the specified altitude of seat 132；Installation frame 134, the installation frame 134 erect the ratio that setting pedestal 132 is arranged in shaped doorly
At height as defined in each free roller bearing mounting portion 133 is higher；And multiple (being at this time four) free roller bearing peace
Arm 137 is filled, these free roller bearing installing arms 137 can along the vertical direction telescopically via installation axle 135 and spring member 136
It is mounted on the top of installation frame 134, and is equally spaced extended along multiple directions.In this case, cutting for pedestal 132 is set
Face be assembled into the frame of L-shaped it is substantially rectangular, it is whole more slightly larger than the periphery of guiding piece.Each free roller bearing mounting portion
133 are made of the frame of the substantially U-shaped with specified altitude, top have can by free roller bearing 130 towards tiltedly on
The center of each frame all around of setting pedestal 132 is fixed in the free roller bearing mounting surface just installed, setting.Freely
Roller bearing 130 makes roller towards oblique upper be mounted on each free roller of above-mentioned free roller bearing mounting portion 133 respectively
On bearing mounting surface.Installation frame 134 is by a pair of posts 1341,1342, arm 1345, installation axle 135 and as spring member
Helical spring 136 constitute, wherein one end of said arm 1345 via 1343 pivot suspension of hinge above-mentioned pillar 1341,
Between 1342, the other end is connected by locating part 1344, and installation axle 135 is vertically set on the lower surface center of arm 1345, above-mentioned
Helical spring 136 is in above-mentioned installation axle 135.In addition, in this case, locating part 1344 is by sticking department s1, locking
Hole s2, locking component s3 are constituted, wherein above-mentioned sticking department s1 is formed in the upper end of the pillar 1342 of another side, and upward
Fang Yanshen in a part of sticking department s1 there is elongated in the horizontal direction slit s0, above-mentioned lock hole s2 to be formed in arm
1345 another side, and capable of inserting for the sticking department s1 of the pillar 1342 of another side, above-mentioned locking component s3 is with can be in water
Square mode rotated upwards is installed on the upper surface of the another side of arm 1345, and having can be with the pillar 1342 of another side
Sticking department s1 slit s0 engaging, disengage protrusion s31, by by the sticking department s1 of the pillar 1342 of another side pass through arm
1345 lock hole s2, and the locking component s3 on arm 1345 is made to rotate the slit so that its protrusion s31 and above-mentioned pillar 1342
S0 engaging, to the pillar 1342 of another side be connect with arm 1345, in the above-described state, by making the branch with another side
Locking component s3 on the arm 1345 of the slit s0 engaging of column 1342 rotates disengage above-mentioned protrusion s31 from slit s0, thus
The locking of the pillar 1342 and arm 1345 of another side can be made to disengage, it whereby can be by arm 1345 from the pillar 1342 of another side
Sticking department s1 is extracted, is above mentioned.Each free roller bearing installing arm 137 is made of the plate P1 in center and four arm P2, wherein above-mentioned
From the periphery of above-mentioned plate P1 equally spaced towards four direction horizontal extension, front end is formed four arm P2 towards obliquely downward, is had in front end
There are the free roller bearing mounting surface that free roller bearing 130 can be installed obliquely downward, the peace of installing frame 134 (arm 1345)
The center of the plate P1 in center is inserted and be installed on to dress axis 135, and helical spring 136 is compressed between the plate P1 and arm 1345 in center,
And be installed into stretch along the vertical direction.Free roller bearing 130 make respectively roller be mounted on obliquely downward it is above-mentioned from
By on each free roller bearing mounting surface of roller bearing installing arm 137.
In this way, supporting arrangement 13 uses multiple (four) free roller bearings 130 by the top of the guiding piece 12 of sphere
Face, i.e. 122 top surface side of upper body outer surface multi-point support (four-point supporting), and use multiple (four) free roller bearings
130 by the bottom surface of the guiding piece 12 of sphere, i.e. the outer surface multi-point support (four-point supporting) of 121 bottom surface side of lower case.
In this way, it transports in above-mentioned cell, tissue with without swinging in shell C1, passes through the upper and lower of supporting arrangement 13
Each free roller bearing 130 is supported to the integrated spherical guiding piece 12 of container holder 11, is propped up for acting on
The external force of the swaying direction of bearing apparatus 13 and container holder 11, using by guiding piece 12 spherical face and supporting arrangement 13
The engaging of each free roller bearing 130 is oriented to and the relative motion between the supporting arrangement 13 and container holder 11 of realization, will
Container holder 11, which is supported to, not to be swung, in addition, for the inertia force acted on to supporting arrangement 13 and container holder 11, benefit
The branch realized with the engaging guiding of each free roller bearing 130 in spherical face and supporting arrangement 13 by guiding piece 12 installs
The relative motion between 13 and container holder 11 is set, by container holder 11 towards relative to the acceleration generated by inertia force
(resultant acceleration) direction at right angles to supports.
Using Fig. 2, it is installed on the vehicles such as so-called minibus (Japanese: ミ ニ バ Application) to by main casing C1 using vehicle
The case where transporting to iPS cell is illustrated.
<installing of the main casing to vehicle>
As shown in Fig. 2 (a), firstly, main casing C1 is installed in vehicle M.In this case, by the branch of main casing C1
Bearing apparatus 13 (setting pedestal 132) setting is fixed on the microscope carrier M1 of vehicle M to be installed in vehicle.In addition, in this case,
It is preferable that main casing C1 to be arranged in the vehicle width direction center of microscope carrier M1.
<stacking of the iPS cell to vehicle>
When iPS cell is deposited into main casing C1, the locating part 1344 (locking component s3) of supporting arrangement 13 is disengaged,
Above to mention arm 1345 from pillar 1342, container holder 11 is taken from supporting arrangement 13 together with guiding piece 12 in this state
Under.
IPS cell is usually to be accommodated in the containers such as culture dish S after carrying out defined gas delivery, firstly, by container S
It is maintained in container holder 11.At this point, each fastener 127 of guiding piece 12 is unclamped, by upper body 122 from lower case
Body 121 is removed, and then, each nut 117 of container holder 11 is disengaged from each screw 116, pressing plate 113 is removed.It connects
, the container S for being placed with iPS cell is placed on the support plate 111 of container holder 11, covers pressing plate on container S
113, by the fastening of screw 116 and nut 117, container S is clamped using support plate 111 and pressing plate 113.Then,
It closes upper body 122 in lower case 121, will be fastened between the two using each fastener 127, and will be inside guiding piece 12
It is kept into airtight.At this time, the configuration of container holder 11 is in the lower case 121 of guiding piece 12, from container holder 11
Lower central axis 118 outstanding pass through the axis insertion portion 128 of lower case 121 so that container holder 11 and guiding piece 12
Integration, due to being equipped with counterweight 119 from the axis 118 outstanding of the bottom surface of lower case 121, counterweight 119 is located at weight
Power direction is held horizontally container S of the container holder 11 in lower case 121 in level, container holder 11.
Then, by it is above-mentioned integration after container holder 11 and guiding piece 12 be supported on supporting arrangement 13.At this point, first
First, the lower case 121 of guiding piece 12 is placed in each free roller of each free roller bearing mounting portion 133 of supporting arrangement 13
On bearing 130.Then, decline the arm 1345 of supporting arrangement 13, and make to be pivotally supported each free roller bearing peace in arm 1345
After each free roller bearing 130 of dress arm 137 is connected in the upper body 122 of guiding piece 12, helical spring 136 is overcome
Force depresses arm 1345,1345 connection lock of said arm is scheduled pillar 1342 using locating part 1344, to utilize up and down each
Eight dot points of free roller bearing 130 support the guiding piece 12 of sphere.Whereby, it is mounted on from the minimum of guiding piece 12
Counterweight 119 on point axis 118 outstanding is located at gravity direction, and container holder 11 in level in guiding piece 12, protect by container
Container S in gripping member 11 is held horizontally.
<iPS cell is transported using vehicle>
The above-mentioned vehicle equipped with iPS cell starts running, at this time when inertia force acts on main casing C1, such as Fig. 2 (b) institute
Show, on supporting arrangement 13, container holder 11 and guiding piece 12 and counterweight 119 are together towards the acceleration generated by inertia force
(resultant acceleration) direction vibrates (toppling over).For above-mentioned inertia force, the spherical face and supporting arrangement by guiding piece 12 is utilized
The engaging of 13 each free roller bearing 130 is oriented to and the opposite fortune between the supporting arrangement 13 and container holder 11 of realization
Dynamic, container holder 11 is at right angles to supported relative to the acceleration direction generated by inertia force, and container holder 11
Interior container S is at right angles to supported together with the culture medium of iPS cell towards the acceleration direction generated by above-mentioned inertia force, from
And the fluctuating of the culture medium of iPS cell can be eliminated or the fluctuating of the culture medium of iPS cell is inhibited minimum.This state
It is held until container holder 11 (counterweight 119) returns to gravity direction.
In the vehicle driving for being loaded with iPS cell, when lateral wobble of vehicle etc. generates swing side on main casing C1
To external force when, for the external force, as shown in Fig. 2 (a), using by guiding piece 12 spherical face and supporting arrangement 13 it is respective
The relative motion between supporting arrangement 13 and container holder 11 realized by the engaging guiding of roller bearing 130, even if branch
Bearing apparatus 13 follows the vibration of vehicle, and container holder 11 is also supported to not swing.Whereby, the appearance in container holder 11
Device S is maintained level together with the culture medium of iPS cell, can eliminate the movement to rise and fall in the culture medium of iPS cell, or
It is that the movement to rise and fall in the culture medium of iPS cell is inhibited minimum.In addition, working as vehicle with high speed in longer bend
Upper traveling, and when centrifugal force being made to act on supporting arrangement 13 and container holder 11, as shown in Fig. 2 (b), in supporting arrangement 13
On, container holder 11 and guiding piece 12 vibrate (toppling over) towards centrifugal force direction together with counterweight 119.For above-mentioned centrifugal force,
The bearing realized using the engaging guiding of each free roller bearing 130 in spherical face and supporting arrangement 13 by guiding piece 12
Relative motion between device 13 and container holder 11, container holder 11 is relative to the acceleration direction generated by centrifugal force
At right angles to supported, and the container S in container holder 11 together with the culture medium of iPS cell relative to by above-mentioned centrifugation
Power generate acceleration direction at right angles to supported, so as to eliminate iPS cell culture medium fluctuating or by iPS it is thin
The fluctuating of the culture medium of born of the same parents inhibits minimum.This state is held container holder 11 (counterweight 119) and returns to gravity direction
Until.
Then, the above-mentioned vehicle for being loaded with iPS cell completes traveling, even if inertia force acts on main casing C1 at this time, equally
Ground can also utilize the spherical face by guiding piece 12 and each free roller bearing 130 of supporting arrangement 13 for above-mentioned inertia force
Engaging guiding and realize supporting arrangement 13 and container holder 11 between relative motion, by container holder 11 relative to
It is at right angles to supported by the acceleration direction that inertia force generates, and the also training with iPS cell of the container S in container holder 11
Feeding base is at right angles to supported relative to the acceleration direction generated by above-mentioned inertia force together, so as to eliminate iPS cell
The fluctuating of culture medium or the fluctuating of the culture medium of iPS cell is inhibited minimum.This state is held container holder
Until 11 (counterweights 119) return to gravity direction.
As described above it is found that, due to including: guiding piece 12, which is mounted on and will be used for according to main casing C1
Store cell, the container S of tissue is kept on horizontal container holder 11, and supports to container holder 11；With
And supporting arrangement 13, the supporting arrangement 13 support container holder 11 via guiding piece 12, above-mentioned guiding piece 12 has
The spherical face at least extended from the side complete cycle underneath towards container holder 11 of container holder 11, supporting arrangement 13
It is made of the spherical face contact along guiding piece 12 and the multiple free roller bearings 130 that can be rotated in omnidirection, for work
For the external force of supporting arrangement 13 and the swaying direction of container holder 11, using by guiding piece 12 spherical face and branch install
Set the engaging guiding of 13 each free roller bearing 130 and the opposite fortune between the supporting arrangement 13 and container holder 11 of realization
It is dynamic, container holder 11 is supported to and is not swung, in addition, being directed to main casing C1 (supporting arrangement 13 and container holder 11)
The inertia force of effect is led using the engaging of each free roller bearing 130 in spherical face and supporting arrangement 13 by guiding piece 12
To and realize supporting arrangement 13 and container holder 11 between relative motion, by container holder 11 relative to by inertia force
The acceleration direction of generation at right angles to supports, therefore, thin when transporting iPS cell etc. using vehicle or various other running tools
When born of the same parents, can reduce as it is in transit rock or container S caused by toppling in cell the movement that rises and falls of culture medium, with
Prevent cytoclasis.
In addition, in main casing C1, container holder 11 by container S is supported support plate 111, for from top
The container S pressing plate 113 pressed and the screw device 115 being screwed between support plate 111 and pressing plate 113 are constituted,
From clamping up and down to the container S equipped with cell, therefore, the air-tight state of container S can be reliably kept.
In addition, in main casing C1, due to upper and lower each free roller bearing 130 using supporting arrangement 13 to container
Therefore the guiding piece 12 of the integrated sphere shape of holder 11, which carries out eight dot points, can steadily support container holder 11
In supporting arrangement 13.
Fig. 3 shows second embodiment.
As shown in Fig. 2, cell, tissue transport with without swing shell C2 (in the explanation of second embodiment below,
Sometimes it is only called main casing C2) it include: container holder 21, the container holder 21 will be for that will receive cell, tissue
The container of appearance is kept into level；Guiding piece 22, which is installed on container holder 21, and carries out to container holder 21
Bearing；And supporting arrangement 23, the supporting arrangement 23 support container holder 21 by guiding piece 22.
Container holder 21 is made of support plate 211, pressing plate 213 and screw device 215, wherein above-mentioned support plate
211 pairs of containers support, and for pressing from top container S, above-mentioned screw device 215 is screwed into above-mentioned pressing plate 213
To between above-mentioned support plate 211 and pressing plate 213.
In this case, support plate 211 is the circular slab with predetermined outside diameter, support plate 211 outer peripheral edge portion with
There are four screw insertion holes 212 for 90 degree of intervals formation.Pressing plate 213 is that have the defined outer diameter more slightly larger than support plate 211
Circular slab is accordingly formed in the peripheral part side of pressing plate 213 with each screw insertion hole 212 of support plate 211 with 90 degree of intervals
There are four screw insertion holes 214.Screw device 215 is made of four groups of screws 216 and nut 217.In this way, by using support plate
211 support the containers such as the culture dish stored to cell, tissue, and use pressing plate 213 above the container to appearance
Device is pressed, and each screw 216 is passed through from each screw insertion hole 212 of support plate 211, and be inserted into each of pressing plate 213
In screw insertion hole 214, each screw 216 and each nut 217 are fastened in pressing plate 213, so as to use support plate 211
And pressing plate 213 clamps container.
Guiding piece 22 by the spherical face contact along aftermentioned supporting arrangement 23 and can be rotated in omnidirection it is multiple from
It is made of roller bearing 220.
Above-mentioned guiding piece 23 by it is multiple, at this time constitute for four free roller bearings 220, each free general of roller bearing 220
Ball downward in such a way that the center of the bottom surface of bottom surface, i.e. support plate 211 away from container holder 21 is equidistant mutually etc.
Compartment of terrain is installed on above-mentioned bottom surface.
In addition, as described above, free roller bearing 220 by with hemispherical concave surface shell f, be revolvably configured at
The ball g of the hemispherical concave surface of shell f, the nut cap h for covering on the hemispherical concave surface of shell f and ball g being kept
Deng composition, ball g can rotate in shell f in omnidirection.
Supporting arrangement 23, which has, at least to extend from the side complete cycle underneath towards container holder 21 of container holder 21
Spherical face.
Above-mentioned supporting arrangement 23 includes: that bottom surface at least can will be formed as spherical closed built in container holder 21
Housing component 23A；And installation pedestal 23B, installation pedestal 23B for make housing component 23A with each free roller bearing 220
The mode of contact is configured at the bottom surface side of container holder 21.
At this point, housing component 23A is made of the hemisphere and cylindrical body that can be vertically divided into two, being included in upper surface has
The hemispherical lower case 231 of opening and upper surface are closed and have the hemispherical upper body 232 of opening in lower surface.
Above-mentioned lower case 231, upper body 232 are provided with ring 233,234 substantially in respective opening Inner peripheral portions with phase
Mutually abut, or throughout the ring of a side, at this time for 231 side of lower case ring 233 upper surface complete cycle landform grooving
235, and by O-ring 236 in the slot 235, so that lower case 231, upper body 232 be made mutually airtightly to combine.
In addition, above-mentioned lower case 231, upper body 232 engaging portion between, along the circumferential direction at a prescribed interval (at this time for
90 degree of intervals) multiple (being at this time four) fasteners 237 are installed, these fasteners 237 are used for lower case 231 and top
Shell 232 is screwed and is combined.Above-mentioned fastener 237 as universal product generally to be known, by fixed substrate a, movable body c,
Substantially the bearing piece e of the hook frame d and hook shape (inverted L-shaped shape) of U-shaped shape are constituted, wherein above-mentioned movable body c
Be supported on a pivot on fixed substrate a and front end have that operating stick b, above-mentioned hook frame d be supported on a pivot on movable body c can than this
The pivot suspension point of dynamic main body c more leans on the position of the side operating stick b, at this point, fixed substrate a is mounted on by fixing pieces such as screws
On the outer surface of the close opening periphery edge of upper body 232, pacify movable body c with being able to rotate using above-mentioned fixed substrate a
Between upper body 232 and the engaging portion of lower case 231, bearing piece e is mounted on lower case using fixing pieces such as screws
On the outer surface of the close opening periphery edge of body 231.In this way, each shell 231,232 of top and the bottom makes 233,234 pairs of mutual ring
It is combined together, in the above-described state, makes movable body c court from the direction that fixed substrate a is pulled open by above mentioning operating stick b
Rotation, and make to hook frame d and be rotated towards bearing piece e, frame d will be hooked and be hooked into bearing piece e, in this state, and just now
On the contrary, pushing operation bar b, rotates movable body c towards fixed substrate a, will be hooked in bearing piece e using movable body c
Hook frame d (232 side of shell toward upper) pull, thus the effect of the drag force using above-mentioned hook frame d, by top and the bottom
Each shell 231,232, which screws, is kept into air-tight state.
In addition, lower case 231 bottom surface center, i.e. 231 bottom surface of lower case minimum point on, formed convexly
There is the holding section 238 for installing spring, in the mounting portion that the top of bottom surface is arranged at intervals with 90 degree for installing bolster
239。
Installation pedestal 23B includes: setting pedestal 241；Helical spring 242, the helical spring 242 are installed in setting pedestal
Between 241 center and the center of the bottom surface housing component 23A；And multiple bolsters 243, above-mentioned multiple bolsters 243 are in spiral
It is folded in around spring 242 between setting pedestal 241 and housing component 23A.In this case, the section of pedestal 241 is set
It is assembled into the frame of L-shaped substantially rectangular, is integrally formed into the size more roughly the same than the periphery of guiding piece 22.Above-mentioned
The center that pedestal 241 is arranged is provided with convexly for pacifying spring-loaded holding section 241a, is respectively arranged in four corners
For installing the mounting portion 241b of bolster.Helical spring 242 is installed in the holding section 238 of the bottom surface housing component 23A and is set to peace
It fills between the holding section 241a on the setting pedestal 241 of pedestal 23B.Bolster 243 is the universal product that is generally known, by cylinder
It is constituted with the bar for inserting cylinder in a manner of retractable.At this point, four bolsters 243 are folded in respectively on the bottom surface housing component 23A
Between each mounting portion 241b of each mounting portion 239 and installation pedestal 23B (four corners of setting pedestal 241) in portion.
In this way, supporting arrangement 23 is configured to via installation pedestal 23B (helical spring 242 and four bolsters
243) elastic bearing is carried out to housing component 23A, via multiple (four) the free rollers for constituting guiding piece 22 in housing component 23A
Bearing 220 supports container holder 21.
In this way, above-mentioned cell, tissue transport with without swing shell C2 in, container holder 21 via with container
The housing component 23A of the integrated guiding piece 22 being made of multiple free roller bearings 220 of holder 21 and device being supported 23
Bearing, for the external force for the swaying direction for acting on supporting arrangement 23 and container holder 21, using by the respective of guiding piece 22
The supporting arrangement 23 and container holder 21 realized by the engaging guiding in the spherical face of roller bearing 220 and supporting arrangement 23
Between relative motion, container holder 21 is supported to and is not swung, in addition, for supporting arrangement 23 and container holder
The inertia force of 21 effects, utilizes the engaging in the spherical face of each free roller bearing 220 and supporting arrangement 23 by guiding piece 22
Guiding and realize supporting arrangement 23 and container holder 21 between relative motion, container holder 21 is supported to and is not put
It is dynamic.
It is installed on the vehicles such as so-called minibus to by main casing C2 come the case where transport using vehicle to iPS cell
It is illustrated.
<installing of the main casing to vehicle>
As shown in Fig. 4 (a), firstly, main casing C2 is installed in vehicle M.In this case, by the branch of main casing C2
Bearing apparatus 23 (setting pedestal 241) setting is fixed on the microscope carrier M1 of vehicle M to be installed in vehicle M.In addition, in such case
Under, it may be desirable to main casing C2 is arranged in the vehicle width direction center of microscope carrier M1.
<stacking of the iPS cell to vehicle>
When iPS cell is deposited into main casing C2, firstly, by each fastener 237 of the housing component 23A of supporting arrangement 23
It unclamps, upper body 232 is removed from lower case 231, then, by each nut 217 of container holder 21 from each screw
216 unclamp, and pressing plate 213 is removed.
As described above, iPS cell is accommodated in the containers such as culture dish S after carrying out defined gas delivery, firstly, should
Container S is maintained in container holder 21.At this point, container S is placed on the support plate 211 of container holder 21, from container S
Side's covering pressing plate 213, by the fastening of screw 216 and nut 217, Lai Liyong support plate 211 and pressing plate 213 are to container S
It is clamped.Then, it closes upper body 231 in lower case 232, will be fastened between the two using each fastener 237, and
It is airtight by being kept into inside guiding piece 22.At this time, housing component 23A is arranged on the helical spring 242 and spiral of underface
Four 243 elastic bearings of bolster around spring 242, to inhibit to rock, in above-mentioned housing component 23A, container holder 21
Level is retained in such a way that bottom surface is towards gravity direction.
<iPS cell is transported using vehicle>
The above-mentioned vehicle equipped with iPS cell starts running, at this time when inertia force acts on main casing C2, such as Fig. 4 (b) institute
Show, the housing component 23A of supporting arrangement 23 vibrates (toppling over) towards acceleration (resultant acceleration) direction generated by inertia force.Needle
To above-mentioned inertia force, using each free roller bearing 220 and supporting arrangement 23 by guiding piece 22 housing component 23A it is spherical
The engaging in face is oriented to and the relative motion between the supporting arrangement 23 and container holder 21 of realization, even if the shell of supporting arrangement 23
Body part 23A is vibrated towards acceleration (resultant acceleration) direction generated by inertia force, in above-mentioned housing component 23A inner pressurd vessel holder
21 are also supported to not swing, and the container S in container holder 21 is substantially horizontally protected together with the culture medium of iPS cell
It holds, so as to eliminate the movement to rise and fall in the culture medium of iPS cell, or will occur in the culture medium of iPS cell
The movement of fluctuating inhibits minimum.
In the vehicle driving for being loaded with iPS cell, swung when being generated on main casing C2 due tos lateral wobble of vehicle etc.
When the external force in direction, for the external force, as shown in Fig. 4 (a), using each free roller bearing 220 by guiding piece 22 and support
The engaging in the spherical face of the housing component 23A of device 23 is oriented to and the phase between the supporting arrangement 23 and container holder 21 of realization
To movement, even if supporting arrangement 23 follows the vibration of vehicle, in the housing component 23A of supporting arrangement 23, container holder 21
It is supported to not swing.Whereby, the container S in container holder 21 is maintained level, energy together with the culture medium of iPS cell
Eliminate the movement to rise and fall in the culture medium of iPS cell, or the movement that will be risen and fallen in the culture medium of iPS cell
Inhibit minimum.When being travelled on longer bend in addition, working as vehicle with high speed, and centrifugal force being made to act on main casing C2, branch
The housing component 23A of bearing apparatus 23 vibrates (toppling over) towards centrifugal force direction.For above-mentioned centrifugal force, as shown in Fig. 4 (b), using by
The engaging in the spherical face of the housing component 23A of each free roller bearing 220 and supporting arrangement 23 of guiding piece 22 is oriented to and realizes
Supporting arrangement 23 and container holder 21 between relative motion, even if the housing component 23A of supporting arrangement 23 is towards centrifugal force side
To vibration, also it is supported to not swing in above-mentioned housing component 23A inner pressurd vessel holder 21, the container S in container holder 21
Horizontally kept together with the culture medium of iPS cell, so as to eliminate rise and fall in the culture medium of iPS cell it is dynamic
Make, or the movement to rise and fall in the culture medium of iPS cell is inhibited minimum.
Then, the above-mentioned vehicle for being loaded with iPS cell completes traveling, even if inertia force acts on main casing C2 at this time, equally
Ground utilizes the housing component 23A of each free roller bearing 220 and supporting arrangement 23 by guiding piece 22 for above-mentioned inertia force
The engaging in spherical face is oriented to and the relative motion between the supporting arrangement 23 and container holder 21 of realization, even if supporting arrangement
23 housing component 23A vibrates, and is also supported to not swing in above-mentioned housing component 23A inner pressurd vessel holder 21, and container is protected
Container S in gripping member 21 is substantially horizontally kept together with the culture medium of iPS cell, so as to eliminate the training in iPS cell
The movement to rise and fall in base is supported, or the movement to rise and fall in the culture medium of iPS cell is inhibited minimum.
As described above it is found that, due to including: guiding piece 22, which is mounted on and will be used for according to main casing C2
Store cell, the container S of tissue is kept on horizontal container holder 21, and supports to container holder 21；With
And supporting arrangement 23, the supporting arrangement 23 support container holder 21 via guiding piece 22, above-mentioned guiding piece 22 is by edge
The spherical face contact of supporting arrangement 23 and the multiple free compositions of roller bearings 220 that can be rotated in omnidirection, supporting arrangement
23 have at least from the spherical face that the side complete cycle underneath towards container holder 21 of container holder 21 extends, for work
For the external force of supporting arrangement 23 and the swaying direction of container holder 21, each free roller bearing by guiding piece 22 is utilized
220 and supporting arrangement 23 spherical face engaging guiding and realize supporting arrangement 23 and container holder 21 between it is opposite
Movement, container holder 21 is supported to and is not swung, in addition, used for acting on to supporting arrangement 23 and container holder 21
Property power, using each free roller bearing 220 and supporting arrangement 23 by guiding piece 22 spherical face engaging be oriented to and realize
Supporting arrangement 23 and container holder 21 between relative motion, container holder 21 can be also supported to and not swung, because
This can reduce when transporting the cells such as iPS cell using vehicle or various other running tools and be rocked or toppled over by transit
Caused by cell in container S the movement that rises and falls of culture medium, to prevent cytoclasis.
In addition, in main casing C2, container holder 21 by container S is supported support plate 211, for from top
The container S pressing plate 213 pressed and the screw device 215 being screwed between support plate 211 and pressing plate 213 are constituted,
From clamping up and down to containers S such as the culture dishes that cell is housed, therefore, the air-tight state of container S can be reliably kept.
In addition, in main casing C2, due to the guided part 22 of container holder 21 multiple free roller bearings 220 and by
It is supported in the substantially hemispherical closed housing component 23A of supporting arrangement 23, it therefore, can be by container holder 21 steadily
It is supported on supporting arrangement 23.
In addition, in the case where main casing C2, it is hemispherical since the housing component 23A of supporting arrangement 23 to be shaped generally as,
And housing component 23A is supported using helical spring 242 and bolster 243, therefore, compared with first embodiment, it can make
Device integrally becomes compact, and can economical space saving be mounted on vehicle etc..
In addition, in the first embodiment, guiding piece 11 is formed as sphere, but can also be with the shell of second embodiment
Body part 23A is identically formed to be substantially hemispherical, even in this way, can also obtain effect effect same as the first embodiment
Fruit also has the advantage that capable of making device integral miniaturization in this case.
In addition, in this second embodiment, the housing component 23A of supporting arrangement 23 is shaped generally as it is hemispherical, but can also
It is identically formed with the guiding piece 12 (housing component) with first embodiment as sphere shape, even in this way, can also obtain and the
The identical function and effect of two embodiments.
Claims (2)
1. a kind of cell, tissue are transported with without swing shell characterized by comprising
Container holder, the container holder are used to the container for storing cell, tissue being kept into level；
Guiding piece, which is installed on the container holder, and supports to the container holder；And
Supporting arrangement, the supporting arrangement support the container holder by the guiding piece,
The guiding piece is made of multiple free roller bearings, and each free roller bearing is installed on downward container guarantor
The bottom surface of gripping member,
Supporting arrangement include: can by it is built in the container holder, at least bottom surface is formed as into spherical closed shell
Part；And installation pedestal, the installation pedestal is for configuring the housing component and each free roller bearing contiguously in institute
The bottom surface side of container holder is stated,
The installation pedestal includes: setting pedestal；Helical spring, the helical spring are installed in center and the shell of the setting pedestal
Between the bottom center of body part；And multiple bolsters, the multiple bolster are folded in institute around the helical spring
It states between setting pedestal and the housing component,
For the external force for the swaying direction for acting on the supporting arrangement and the container holder, using the supporting arrangement and
The container holder is supported to and does not swing by the relative motion between the container holder.
2. cell as described in claim 1, tissue are transported with without swing shell, which is characterized in that
Container holder is made of support plate, pressing plate and screw device, wherein the support plate supports container, institute
Pressing plate is stated for pressing from top the container, the screw device is screwed into the support plate and the pressing plate
Between.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-113585 | 2015-06-04 | ||
| JP2015113585A JP6580376B2 (en) | 2015-06-04 | 2015-06-04 | Non-oscillating case for cell / tissue fragment transportation |
| CN201610390564.XA CN106244415B (en) | 2015-06-04 | 2016-06-03 | Swing-free case for conveying cell and tissue slice |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610390564.XA Division CN106244415B (en) | 2015-06-04 | 2016-06-03 | Swing-free case for conveying cell and tissue slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110106065A true CN110106065A (en) | 2019-08-09 |
Family
ID=57612936
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610390564.XA Active CN106244415B (en) | 2015-06-04 | 2016-06-03 | Swing-free case for conveying cell and tissue slice |
| CN201910506633.2A Pending CN110106065A (en) | 2015-06-04 | 2016-06-03 | Cell, tissue are transported with without swing shell |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610390564.XA Active CN106244415B (en) | 2015-06-04 | 2016-06-03 | Swing-free case for conveying cell and tissue slice |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6580376B2 (en) |
| CN (2) | CN106244415B (en) |
| TW (1) | TWI627272B (en) |
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| CN112608847A (en) * | 2021-01-27 | 2021-04-06 | 张海甄 | Sealed cultivation device for biological cell cultivation and use method thereof |
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| JP6723142B2 (en) | 2016-11-11 | 2020-07-15 | 三菱重工サーマルシステムズ株式会社 | Capacitor unit, electric compressor |
| JP6963905B2 (en) * | 2017-04-17 | 2021-11-10 | タキゲン製造株式会社 | Walking transport vibration reduction device and transport case equipped with this |
| JP2019062855A (en) * | 2017-10-04 | 2019-04-25 | ヨン イ，ヒョ | Non-powered constant temperature cell transfer device |
| US11268655B2 (en) | 2018-01-09 | 2022-03-08 | Cryoport, Inc. | Cryosphere |
| SG11202012874YA (en) * | 2018-07-10 | 2021-01-28 | Terumo Corp | Device for transporting graft |
| EP3896144A4 (en) * | 2018-12-18 | 2022-02-16 | TERUMO Kabushiki Kaisha | Gripping tool |
| DE20909114T1 (en) * | 2019-12-30 | 2022-04-14 | Cryoport, Inc | CRYOSPHERE |
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Also Published As
| Publication number | Publication date |
|---|---|
| TWI627272B (en) | 2018-06-21 |
| TW201708531A (en) | 2017-03-01 |
| JP6580376B2 (en) | 2019-09-25 |
| CN106244415A (en) | 2016-12-21 |
| JP2016220658A (en) | 2016-12-28 |
| CN106244415B (en) | 2020-05-19 |
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Application publication date: 20190809 |