CN110101826A - A kind of draft leads to nutrient solution and preparation method thereof - Google Patents
A kind of draft leads to nutrient solution and preparation method thereof Download PDFInfo
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- CN110101826A CN110101826A CN201811204021.XA CN201811204021A CN110101826A CN 110101826 A CN110101826 A CN 110101826A CN 201811204021 A CN201811204021 A CN 201811204021A CN 110101826 A CN110101826 A CN 110101826A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention discloses a kind of draft to lead to nutrient solution, and main traditional Chinese medicine ingredients include: Radix Angelicae Sinensis, rhizome of chuanxiong, ramulus cinnamomi, monkshood, safflower, Caulis Spatholobi, the root of Dahurain angelica, hairyvein agrimony, madder, sea lotus, Cortex Ampelopsis Aconitifoliae Radicis, peppermint, Radix Angelicae Pubescentis, kuh-seng, ginger and ginseng.The primary efficacy of these traditional Chinese medicine ingredients is dispelling, collateral-activating, clearing heat and detoxicating, activating blood circulation and reducing swelling, with good active pain effect of dispelling, in order to further enhance effect, guarantee the stability of curative effect and inhibits various bacteria effect, the invention joined Western medicine chlorhexidine acetate, and main function is: antibacterial antivirus, relaxing tendons and activating collaterals, activating microcirculation and removing stasis medicinal, waist, leg, shoulder and neck, arthralgia.Draft of the invention, which leads to nutrient solution, has extraordinary curative effect to treatment neck-shoulder pain, lumbago and leg pain and rheumatic arthralgia, it is particularly possible to promote the speed that takes effect that pain is sprained in treatment stiff neck strain.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of draft to lead to nutrient solution and preparation method thereof.
Background technique
Activating meridians to stop pain is the big research hotspot in Chinese medicine, also closely bound up with daily life.Currently on the market
Visible activating meridians to stop pain class drug, based on liquor.And such pain relieving liquid is although many kinds of, but there is ineffective, holds
A series of problems, such as continuous time is short.It is good that therefore, it is necessary to study a kind of effects, quick, the long activating meridians to stop pain class drug of actual effect.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of draft to lead to nutrient solution and preparation method thereof.
Technical scheme is as follows:
A kind of logical nutrient solution of draft, adds alcohol to impregnate: Radix Angelicae Sinensis, rhizome of chuanxiong, ramulus cinnamomi, monkshood, safflower, chicken blood by following traditional Chinese medicine ingredients
Rattan, the root of Dahurain angelica, hairyvein agrimony, madder, sea lotus, Cortex Ampelopsis Aconitifoliae Radicis, peppermint, Radix Angelicae Pubescentis, kuh-seng, ginger and ginseng.
Preferably, the draft leads to nutrient solution, adds alcohol to impregnate by the traditional Chinese medicine ingredients of following parts by weight: Radix Angelicae Sinensis 8-12
Part, 8-12 parts of rhizome of chuanxiong, 8-12 parts of ramulus cinnamomi, 8-12 parts of monkshood, 8-12 parts of safflower, 8-12 parts of Caulis Spatholobi, 10-18 parts of the root of Dahurain angelica, red crowned crane
6-10 parts careless, 6-10 parts of madder, 10-18 parts of sea lotus, 8-12 parts of Cortex Ampelopsis Aconitifoliae Radicis, 6-10 parts of peppermint, 8-12 parts of Radix Angelicae Pubescentis, kuh-seng 6-10
Part, 5-8 parts of ginger and 5-8 parts of ginseng.
Preferably, the draft leads to nutrient solution, adds alcohol to impregnate by the traditional Chinese medicine ingredients of following parts by weight: Radix Angelicae Sinensis 10
Part, 10 parts of rhizome of chuanxiong, 10 parts of ramulus cinnamomi, 10 parts of monkshood, 10 parts of safflower, 10 parts of Caulis Spatholobi, 12 parts of the root of Dahurain angelica, 9 parts of hairyvein agrimony, 9 parts of madder,
12 parts of sea lotus, 10 parts of Cortex Ampelopsis Aconitifoliae Radicis, 9 parts of peppermint, 10 parts of Radix Angelicae Pubescentis, 9 parts of kuh-seng, 6 parts of ginger and 6 parts of ginseng.
Preferably, the draft leads in nutrient solution, and the volumetric concentration of the alcohol of addition is 70-80%(V/V), it is further excellent
It is selected as 75%(V/V).
Preferably, the mass ratio of the traditional Chinese medicine ingredients and alcohol is 1:(8-15).
Preferably, the draft leads in nutrient solution, and chlorhexidine acetate can also be added.
Preferably, the additional amount of the chlorhexidine acetate is the 0.05-0.2% that draft leads to nutrient solution total weight.
Preferably, the draft leads to the preparation method of nutrient solution, comprising the following steps:
A, Chinese medical extract is obtained by extraction using supercritical carbon dioxide extraction method in the various Chinese medicines cooked respectively, it is standby
With；
B, the above Chinese medical extract is all put into container in proportion, and adds alcohol into container, then seal container,
So that wine is carried out soaking fermentation, obtains fermentation liquid；
C, the fermentation liquid for completing fermentation takes out, and then falls the contaminant filter in fermentation liquid, vinegar is then added into fermentation liquid
Sour Chlorhexidine, is filtered again after mixing evenly, is obtained draft and is led to nutrient solution；
D, the logical nutrient solution of packaged draft sterilized, sterilized, be then placed under room temperature environment and store.
Preferably, the draft leads to the application method of nutrient solution, comprising the following steps: takes draft to lead to nutrient solution and is continuously sprayed on trouble
Place 2 to 4 times, each 2-5ml, sticks preservative film, removes after 2-3min, once a day.
Radix Angelicae Sinensis, Chinese medicine name.For the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.It is main
The southeast of Gansu is produced, it is more with Minxian County yield, it is high-quality, it is secondly saved for Yunnan, Sichuan, Shaanxi, Hubei etc., is cultivation.Have
The effect of replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.It is usually used in blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, void
Cold abdominal pain, rheumatic arthralgia, injury from falling down, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatism numbness
Bitterly, injury from falling down.
Rhizome of chuanxiong is included as Rhizoma Chuanxiong in pharmacopeia, often writes Rhizoma Chuanxiong in prescription.Due to regional reason literary style habit etc. is different
It is written as rhizome of chuanxiong.Also known as big rhizome of chuanxiong, vault is comforted, separately there is wine rhizome of chuanxiong.Be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walk and
Do not keep, can go it is scattered, uplink up to mountain peak push up；Enter blood system again, downlink is up to the sea of blood.Promoting blood circulation effect is suitable for hemostasis resistance extensively
Stagnant various illnesss；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as cold and headache, rheumatic arthralgia.It is the gas in blood that former times people, which calls Rhizoma Chuanxiong,
Medicine nearly says its function such as pungent scattered, relieve stagnation, sensible, analgesic of residing.
Ramulus cinnamomi, Chinese medicine name.Belong to Laurales, the medium megaphanerophyte of Lauraceae；Annotinous branch is cylindrical, and terminal bud perula width egg shape is green
The leaf alternate of color, oblong to nearly lanceolar；Grey color, is about 4.5mm；Fruit ellipse, black purple, hairless when mature；
6~August of florescence, 10~December of fruiting period.Main product is in Guangxi, Guangdong and Yunnan and other places.Spring, summer cut spray, dry or dry in the shade,
It thinly slices or segment is used.Acrid, sweet, warm.Return heart, lung, bladder meridian.With sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi puts down punching
The effect of sending down abnormally ascending.It is usually used in anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, oedema, palpitaition etc..
Monkshood, Chinese medicine name.For dry female root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaelii Debx..June
The excavation of the last ten-days period to early August, removes sub- root, fibrous root and silt, dries.It is mainly used for wind-cold-dampness arthralgia, arthralgia, Xin Fuleng
Bitterly, cold hernia is had a pain and narcotic analgesic.
Safflower, Chinese medicine name.For the dry flower of compositae plant safflower Carthamus tinctorius L..Summer flower is by Huang
Picking when reddening is dried in the shade or is dried.It is in all parts of the country extensively to have cultivation.With blood circulation, the effect of removing blood stasis and acesodyne.For menostasis,
Dysmenorrhea, lochia, abdominal mass lump in the abdomen, chest impediment and cardialgia, stasis of blood, pricking pain in the chest, injury from falling down, sore swell and ache curative.
Caulis Spatholobi, Chinese medicine name.For the drying rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.
Autumn, the harvesting of two season of winter, branches and leaves are removed, slice dries.It is distributed in the ground such as Guangdong, Guangxi, Yunnan.With blood circulation promoting and enriching, menstruation regulating stops
Bitterly, the effect of relaxing tendons and activating collaterals.For irregular menstruation, dysmenorrhea, menostasis, rheumatic arthralgia, paralysis and numbness, blood deficiency chlorosis.
The root of Dahurain angelica, Chinese medicine name.1-2.5 meters high for perennial tall and big draft, root is cylindrical, 2-5 centimetres of basal part of stem diameter, and base is raw
Leaf one returns pinnation, and universal umbel basidixed or side are raw, fruit oblong to oval.Main mutation has Radix angelicae dahuricae, Qi Bai
The root of Dahurian angelica, the root of Dahurain angelica (former mutation), Taiwan Radix Angelicae Pubescentis.It is used as medicine with root, the functions such as the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain.Cure mainly chill
Flu, headache, rhinitis, toothache.The diseases such as leukorrhea with reddish discharge, pain furuncle poison, can also make fragrance.There are cultivation in some provinces and regions in the north, more
It markets one's own products, minority is adjusted outside the province.Generally be born in hayashishita, border, by small stream, shrubbery and mountain valley meadow.Anemofrigid cold is cured mainly, have a headache,
Toothache, rheumatic arthralgia, nasosinusitis, leukorrhagia card, sore and toxic.
Hairyvein agrimony, Chinese medicine name.For the dry aerial parts of rosaceous plant Agrimony.Summer, Qiu Erji cauline leaf are adopted when luxuriant
It cuts, removes impurity, it is dry.This product grows 50~100cm, and entirety is by white pubescence.The lower portion of the stem is cylindrical, diameter 4~6mm, reddish brown
Color, top square column type, four sides is slightly concave to be fallen into, and green and brown color has longitudinal furrow and crest line, there is section；Body is light, and matter is hard, frangibility, and section is hollow.
Singular pinnate compound leaf alternate, dark green packet, shrinkage curling；Matter is crisp, frangible；Blade has 2 kinds of size, alternate to be born on rachis, top
Leaflet is larger, is in oval or oblong after complete vanelets flattening, apex point, base portion wedge shape, there is sawtooth at edge；Stipule 2 is embraced
Stem, tiltedly avette.Raceme is elongated, and calyx lower part is cylindrical in shape, and hook thorn is arranged at calyx tube top, and apex 5 is split, petal yellow.Gas is micro-, taste
Slight bitter.It is mainly used for spitting blood, spits blood, metrostaxis, malaria, bloody flux, carbuncle sore tumefacting virus, pruritus vulvae leukorrhagia, de-power internal lesion caused by overexertion.
Madder, Chinese medicine name.This product is the root and rhizome of madder wort madder.Spring, autumn excavation, silt is removed, is shone
It is dry.Major function are as follows: cooling and activating blood, dissolving stasis, promoting menstruation.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrostaxis, traumatic hemorrhage, menostasis stasis blocking, close
Save numbness pain, tumbling and swelling.Cooling blood and hemostasis, promoting blood circulation: this product is stopped blooding without staying the stasis of blood, and heat symptom-complex bleeding, menostasis abdominal pain, bruise are used for
Damage.It is stronger with cuttle bone hemostasis power.
Sea lotus, Chinese medicine name.This product is lumbaginaceae sea lotus Limonium arbusculum Makino, with root, entirely
Grass is used as medicine.Major function are as follows: according to the literature, inducing diuresis for removing edema cures mainly oedema.
Cortex Ampelopsis Aconitifoliae Radicis, Chinese medicine name.This product is the root skin of vitaceae ampelopsis aconitifolia.Whole year can adopt, and peel off surface layer
Cork, using fresh herb or dry use.Major function are as follows: promoting blood circulation to remove blood stasis, eliminating inflammation and expelling toxin, myogenic long bone, eliminate wind and clear damp.Control traumatic injury, bone
Folding, boil swelling and pain, rheumatic arthralgia.
Peppermint, Chinese medicine name.Popular name is Lamiaceae plant " lunar caustic grass ", that is, belongs to other drying herbs, be born in hill more
By wetland river, it is a kind of fragrant crop for having extraordinary economic value that rhizome, which grows wild underground,.It is sweating antipyretic medicine, controls popularity
The diseases such as flu, headache, hot eyes, body heat, throat, gum swelling and pain.
Radix Angelicae Pubescentis, Chinese medicine name.For umbelliferae Angelica pubescens Angelica pubescens Maxim.f.
The dry root of biserrata Shan et Yuan.It is excavated when Miao Gang germination at the beginning of the spring or withered autumn end cauline leaf, removes fibrous root and mud
Sand, is dried to half-dried, banks up 2~3 days, is dried to again after feeling like jelly absolutely dry.It is mainly used for wind-cold-dampness arthralgia, lumbocrural pain, few yin Fu Fengtou
Bitterly, headache caused by cold and dampness.
Kuh-seng, Chinese medicine name.For the dry root of leguminous plant kuh-seng, spring, the excavation of two season of autumn, root head and small supporting root is removed, is washed
Only, dry, or fresh slices are taken advantage of, it is dry.It is bitter, trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the function of diuresis.For hot dysentery, hematochezia, jaundice urine
It closes, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, castor controls trichomonas vaginitis outside.
Ginger (scientific name: Zingiber officinale Rosc.), Zingiber zingiber herbaceos perennial.It is provided with yellow green
The rhizome of colored and irritant fragrance.0.5-1 meters of plant height；Rhizome is plump, multi-branched, there is fragrance and acid.Blade lanceolar
Or wire lanceolar, hairless, stockless；Tip of a leaf film quality.Total bennet is up to 25 centimetres；Spike strobiloid；Bract is oval, pale green
Color or edge are faint yellow, and there is small cusp on top.Calyx tube is about 1 centimetre；Corolla yellow green, sliver lanceolar；It splits in lip center
Length of a film round shape obovate.Ginger relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, warm lung cough-relieving.It is usually used in deficiency-cold in spleen and stomach, appetite stimulator, nausea is vomitted
It spits or phlematic vomiting, the vomiting of disorder of stomach-energy, chill or cold productive cough is coughed, cold, fever with aversion to wind, nasal obstruction headache.The present invention
In ginger be ginger.
Ginseng (Panax ginseng C. A. Mey) is herbaceos perennial, and happiness is shady and cool, blade pore-free and fence
Tissue can not retain moisture, and temperature, which is higher than 32 degree of blades, to burn, canopy density 0.7-0.8.It blooms within usual 3 years, 5-6 annual bearing,
The month at florescence 5-6, the fruiting period 6-9 month.The wealthy mixed friendship of hundreds of meters of height above sea level of the needle based on Korean pine being grown between 33 degree -48 of north latitude degree
Woods or broad leaved and deciduous broad leaved hayashishita originate in Northeast China, Korea, South Korea, Japan, Russian east.The nickname of ginseng be kurarinone,
Essence, god grass, King of Herbs are one of well-known " northeast Triratnas ".It is physically weak to be taken off, cold weak pulse of limb, spleen eating less, deficiency syndrome of the lung asthma
Cough, injury thirst, Heat Diabetes, prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold；Heart failure, cardiogenic shock.For shortness of breath
Syndrome characterized by dyspnea, palpitation and amnesia, thirsty hidrosis, deficiency of food is powerless, caused shock, collapse after all acute and chronic diseases and blood loss.Big complement
Gas, prevent prolapse and engender liquid are calmed the nerves.It is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, regurgitation and emesis, defecate slipping diarrhea, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, shy
Throb with fear, amnesia, dizziness and headache, impotence, frequent micturition quenches one's thirst, woman uterine bleeding, infantile chronic fright and perennial and irrecoverable weakness, all qi-blood-body fluids are insufficient
Card.
Chlorhexidine acetate is also Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double benzyl chloride chlorhexidine, for sun
Ionic surface active agent, has a broad antifungal spectrum have killing effect to most Grain-positives and negative bacteria, also have to Pseudomonas aeruginosa
Effect.For remote holder of performing the operation, skin, planing surface and sterilization of instruments.
The invention has the beneficial effects that: main traditional Chinese medicine ingredients include: Radix Angelicae Sinensis, rhizome of chuanxiong, ramulus cinnamomi, monkshood, safflower, chicken blood
Rattan, the root of Dahurain angelica, hairyvein agrimony, madder, sea lotus, Cortex Ampelopsis Aconitifoliae Radicis, peppermint, Radix Angelicae Pubescentis, kuh-seng, ginger and ginseng.These traditional Chinese medicine ingredients it is main
Effect is dispelling, collateral-activating, clearing heat and detoxicating, activating blood circulation and reducing swelling, has good active pain effect of dispelling, in order to further enhance effect,
The invention joined Western medicine chlorhexidine acetate, and main function is: relaxing tendons and activating collaterals, activating microcirculation and removing stasis medicinal, waist, leg, shoulder and neck,
Arthralgia.Draft of the invention, which leads to nutrient solution, has extraordinary curative effect to treatment neck-shoulder pain, lumbago and leg pain and rheumatic arthralgia, especially
It can promote the speed that takes effect that pain is sprained in treatment stiff neck strain.
Specific embodiment
Embodiment 1:
A kind of logical nutrient solution of draft, adds alcohol to impregnate: 10 parts of Radix Angelicae Sinensis, 10 parts of rhizome of chuanxiong, osmanthus by the traditional Chinese medicine ingredients of following parts by weight
Branch 10 parts, 10 parts of monkshood, 10 parts of safflower, 10 parts of Caulis Spatholobi, 12 parts of the root of Dahurain angelica, 9 parts of hairyvein agrimony, 9 parts of madder, 12 parts of sea lotus, mistake
10 parts of mountain dragon, 9 parts of peppermint, 10 parts of Radix Angelicae Pubescentis, 9 parts of kuh-seng, 6 parts of ginger and 6 parts of ginseng.
The draft leads in nutrient solution, and the volumetric concentration of the alcohol of addition is 75%(V/V).
The mass ratio of the traditional Chinese medicine ingredients and alcohol is 1:10.
The draft leads in nutrient solution, and chlorhexidine acetate can also be added.
The additional amount of the chlorhexidine acetate is that draft leads to the 0.15% of nutrient solution total weight.
The draft leads to the preparation method of nutrient solution, comprising the following steps:
A, Chinese medical extract is obtained by extraction using supercritical carbon dioxide extraction method in the various Chinese medicines cooked respectively, it is standby
With；
B, the above Chinese medical extract is all put into container in proportion, and adds alcohol into container, then seal container,
So that wine is carried out soaking fermentation, obtains fermentation liquid；
C, the fermentation liquid for completing fermentation takes out, and then falls the contaminant filter in fermentation liquid, vinegar is then added into fermentation liquid
Sour Chlorhexidine, is filtered again after mixing evenly, is obtained draft and is led to nutrient solution；
D, the logical nutrient solution of packaged draft sterilized, sterilized, be then placed under room temperature environment and store.
Embodiment 2:
A kind of logical nutrient solution of draft, adds alcohol to impregnate: 8 parts of Radix Angelicae Sinensis, 12 parts of rhizome of chuanxiong, ramulus cinnamomi by the traditional Chinese medicine ingredients of following parts by weight
8- parts, 12 parts of monkshood, 8 parts of safflower, 12 parts of Caulis Spatholobi, 10 parts of the root of Dahurain angelica, 10 parts of hairyvein agrimony, 6 parts of madder, 18 parts of sea lotus, excessively mountain
8 parts of dragon, 10 parts of peppermint, 8 parts of Radix Angelicae Pubescentis, 10 parts of kuh-seng, 5 parts of ginger and 8 parts of ginseng.
The draft leads in nutrient solution, and the volumetric concentration of the alcohol of addition is 80%(V/V), further preferably 75%(V/
V).
The mass ratio of the traditional Chinese medicine ingredients and alcohol is 1:8.
The draft leads in nutrient solution, and chlorhexidine acetate can also be added.
The additional amount of the chlorhexidine acetate is that draft leads to the 0.2% of nutrient solution total weight.
The draft leads to the preparation method of nutrient solution, comprising the following steps:
A, Chinese medical extract is obtained by extraction using supercritical carbon dioxide extraction method in the various Chinese medicines cooked respectively, it is standby
With；
B, the above Chinese medical extract is all put into container in proportion, and adds alcohol into container, then seal container,
So that wine is carried out soaking fermentation, obtains fermentation liquid；
C, the fermentation liquid for completing fermentation takes out, and then falls the contaminant filter in fermentation liquid, vinegar is then added into fermentation liquid
Sour Chlorhexidine, is filtered again after mixing evenly, is obtained draft and is led to nutrient solution；
D, the logical nutrient solution of packaged draft sterilized, sterilized, be then placed under room temperature environment and store.
Embodiment 3:
A kind of logical nutrient solution of draft, adds alcohol to impregnate: 12 parts of Radix Angelicae Sinensis, 8 parts of rhizome of chuanxiong, ramulus cinnamomi by the traditional Chinese medicine ingredients of following parts by weight
12 parts, 8 parts of monkshood, 12 parts of safflower, 8 parts of Caulis Spatholobi, 18 parts of the root of Dahurain angelica, 6 parts of hairyvein agrimony, 10 parts of madder, 10 parts of sea lotus, Cortex Ampelopsis Aconitifoliae Radicis
12 parts, 6 parts of peppermint, 12 parts of Radix Angelicae Pubescentis, 6 parts of kuh-seng, 8 parts of ginger and 5 parts of ginseng.
The draft leads to nutrient solution, adds alcohol to impregnate by the traditional Chinese medicine ingredients of following parts by weight: 10 parts of Radix Angelicae Sinensis, rhizome of chuanxiong 10
Part, 10 parts of ramulus cinnamomi, 10 parts of monkshood, 10 parts of safflower, 10 parts of Caulis Spatholobi, 12 parts of the root of Dahurain angelica, 9 parts of hairyvein agrimony, 9 parts of madder, sea lotus 12
Part, 10 parts of Cortex Ampelopsis Aconitifoliae Radicis, 9 parts of peppermint, 10 parts of Radix Angelicae Pubescentis, 9 parts of kuh-seng, 6 parts of ginger and 6 parts of ginseng.
The draft leads in nutrient solution, and the volumetric concentration of the alcohol of addition is 70-80%(V/V), further preferably 75%
(V/V).
The mass ratio of the traditional Chinese medicine ingredients and alcohol is 1:(8-15).
The draft leads in nutrient solution, and chlorhexidine acetate can also be added.
The additional amount of the chlorhexidine acetate is the 0.05-0.2% that draft leads to nutrient solution total weight.
The draft leads to the preparation method of nutrient solution, comprising the following steps:
A, Chinese medical extract is obtained by extraction using supercritical carbon dioxide extraction method in the various Chinese medicines cooked respectively, it is standby
With；
B, the above Chinese medical extract is all put into container in proportion, and adds alcohol into container, then seal container,
So that wine is carried out soaking fermentation, obtains fermentation liquid；
C, the fermentation liquid for completing fermentation takes out, and then falls the contaminant filter in fermentation liquid, vinegar is then added into fermentation liquid
Sour Chlorhexidine, is filtered again after mixing evenly, is obtained draft and is led to nutrient solution；
D, the logical nutrient solution of packaged draft sterilized, sterilized, be then placed under room temperature environment and store.
Comparative example 1
By the chlorhexidine acetate removal in embodiment 1, remaining proportion and preparation method are constant.
Comparative example 2
Chlorhexidine acetate in embodiment 1 is replaced with into commercially available thimerosal hydrogen peroxide, remaining proportion and preparation method are constant.
Experiment 1
Irritation, anaphylaxis experiment
Small white mouse back cuts off hair, and the draft for smearing embodiment 1-3 preparation respectively leads to nutrient solution in cutting plucked position, and no painting portion
Position is compared, as a result without irritation and allergic reaction.
The resulting draft of Example 1-3 leads to 1 gram of nutrient solution and is applied in volunteer (35-65 years old, 100 people) gesture and facial expression, crosses 30 points
It is observed after clock, does not occur rubescent, dermexanthesis, foaming phenomena.
Experiment 2
Lead to nutrient solution progress rheumatic arthralgia to the draft of embodiment 1-3 and comparative example 1-2 below to treat, detection is treated
Effect.
Specific test method
Nutrient solution, morning and evening each one are led to according to draft made from specific embodiment 1-3 and comparative example 1-2 using the present invention in treatment group
It is secondary.It the course for the treatment of 15 days, takes draft to lead to nutrient solution and is continuously sprayed on affected part 2 to 4 times, each 2-5ml sticks preservative film, takes after 2-3min
Under, once a day, the course for the treatment of 15 days；Blank group oral placebo capsule, once in the morning and once at night, the course for the treatment of 15 days.Treatment group and blank group
Each to choose rheumatic arthralgia patient 50, difference of 6 groups of patients in terms of the basic documents such as gender, age, the state of an illness is unknown
It is aobvious, compare without statistical significance (P > 0.05).
Criterion of therapeutical effect and treatment results
Criterion of therapeutical effect: recovery from illness: clinical symptoms all disappear, and laboratory checks normal；Effective: clinical symptoms significantly mitigate, the state of an illness
It is effectively controlled；Effective: clinical symptoms are mitigated, and the state of an illness is controlled；It is invalid: clinical symptoms without be clearly better or add
Weight.Treatment statistics are shown in Table 1.
Table 1: the Comparison of therapeutic result of sample；
| Recovery from illness | It is effective | Effectively | In vain | Efficient % | Reach effective average required time d | |
| Embodiment 1 | 32 | 8 | 7 | 3 | 94 | 5.5 |
| Embodiment 2 | 30 | 10 | 6 | 4 | 92 | 5.7 |
| Embodiment 3 | 31 | 8 | 6 | 5 | 90 | 7.1 |
| Comparative example 1 | 5 | 8 | 13 | 24 | 52 | 12.4 |
| Comparative example 2 | 6 | 10 | 13 | 21 | 58 | 11.5 |
| Blank group | 0 | 2 | 11 | 37 | 26 | / |
There is extraordinary treatment to imitate rheumatic arthralgia it is recognised that draft of the invention leads to nutrient solution by the above test data
Fruit, and chlorhexidine acetate is added, to being promoted, therapeutic effect effect is significant；And other thimerosals, which are added, influences not therapeutic effect
Greatly.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of draft leads to nutrient solution, which is characterized in that add alcohol to impregnate by following traditional Chinese medicine ingredients: Radix Angelicae Sinensis, rhizome of chuanxiong, ramulus cinnamomi,
Monkshood, safflower, Caulis Spatholobi, the root of Dahurain angelica, hairyvein agrimony, madder, sea lotus, Cortex Ampelopsis Aconitifoliae Radicis, peppermint, Radix Angelicae Pubescentis, kuh-seng, ginger and ginseng.
2. draft as described in claim 1 leads to nutrient solution, which is characterized in that add alcohol to impregnate by the traditional Chinese medicine ingredients of following parts by weight
It forms: 8-12 parts of Radix Angelicae Sinensis, 8-12 parts of rhizome of chuanxiong, 8-12 parts of ramulus cinnamomi, 8-12 parts of monkshood, 8-12 parts of safflower, 8-12 parts of Caulis Spatholobi, the root of Dahurain angelica
10-18 parts, 6-10 parts of hairyvein agrimony, 6-10 parts of madder, 10-18 parts of sea lotus, 8-12 parts of Cortex Ampelopsis Aconitifoliae Radicis, 6-10 parts of peppermint, Radix Angelicae Pubescentis 8-
12 parts, 6-10 parts of kuh-seng, 5-8 parts of ginger and 5-8 parts of ginseng.
3. draft as claimed in claim 2 leads to nutrient solution, which is characterized in that the draft leads to nutrient solution, by following parts by weight
Traditional Chinese medicine ingredients add alcohol to impregnate: 10 parts of Radix Angelicae Sinensis, 10 parts of rhizome of chuanxiong, 10 parts of ramulus cinnamomi, 10 parts of monkshood, 10 parts of safflower, Caulis Spatholobi 10
Part, 12 parts of the root of Dahurain angelica, 9 parts of hairyvein agrimony, 9 parts of madder, 12 parts of sea lotus, 10 parts of Cortex Ampelopsis Aconitifoliae Radicis, 9 parts of peppermint, 10 parts of Radix Angelicae Pubescentis, 9 parts of kuh-seng,
6 parts and 6 parts of ginseng of ginger.
4. draft as claimed in claim 2 or claim 3 leads to nutrient solution, which is characterized in that the draft leads in nutrient solution, the alcohol of addition
Volumetric concentration be 70-80%(V/V).
5. draft as claimed in claim 2 or claim 3 leads to nutrient solution, which is characterized in that the draft leads in nutrient solution, the alcohol of addition
Volumetric concentration be 75%(V/V).
6. draft as described in claim 4 or 5 leads to nutrient solution, which is characterized in that the mass ratio of the traditional Chinese medicine ingredients and alcohol
For 1:(8-15).
7. draft as claimed in claim 6 leads to nutrient solution, which is characterized in that the draft leads in nutrient solution, and vinegar can also be added
Sour Chlorhexidine.
8. draft as claimed in claim 7 leads to nutrient solution, which is characterized in that the additional amount of the chlorhexidine acetate is logical for draft
The 0.05-0.2% of nutrient solution total weight.
9. draft as claimed in claim 8 leads to nutrient solution, which is characterized in that preparation method, comprising the following steps:
A, Chinese medical extract is obtained by extraction using supercritical carbon dioxide extraction method in the various Chinese medicines cooked respectively, it is standby
With；
B, the above Chinese medical extract is all put into container in proportion, and adds alcohol into container, then seal container,
So that wine is carried out soaking fermentation, obtains fermentation liquid；
C, the fermentation liquid for completing fermentation takes out, and then falls the contaminant filter in fermentation liquid, vinegar is then added into fermentation liquid
Sour Chlorhexidine, is filtered again after mixing evenly, is obtained draft and is led to nutrient solution；
D, the logical nutrient solution of packaged draft sterilized, sterilized, be then placed under room temperature environment and store.
10. the draft as described in claim 1-9 is any leads to nutrient solution, which is characterized in that its application method, comprising the following steps:
It takes draft to lead to nutrient solution and is continuously sprayed on affected part 2 to 4 times, each 2-5ml sticks preservative film, removes after 2-3min, be once a day
It can.
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Application publication date: 20190809 |