CN107349264A - Treat Chinese medicine composition of cervical spondylopathy and its preparation method and application - Google Patents
Treat Chinese medicine composition of cervical spondylopathy and its preparation method and application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention discloses a kind of Chinese medicine composition for treating cervical spondylopathy and its preparation method and application, is related to technical field of traditional Chinese medicine, to improve the poor technical problem of existing Chinese medicine preparation treatment cervical spondylopathy effect.The Chinese medicine composition of present invention treatment cervical spondylopathy is mainly made up according to mass fraction meter of following Chinese medicine material：5 15 parts of Radix Angelicae Sinensis, 5 15 parts of Ligusticum wallichii, 5 15 parts of cassia twig, 5 15 parts of monkshood, 12 25 parts of safflower, 5 15 parts of reticulate millettia, 8 16 parts of the root of Dahurain angelica, 10 20 parts of bush, 5 15 parts of hairyvein agrimony.The Chinese medicine composition of present invention treatment cervical spondylopathy is directly applied in affected part, the effect of with promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin and damp-clearing pain-relieving, neck fatigue can fast and effeciently be alleviated, nonirritant or anaphylaxis, percutaneous absorbability is good, it is easy to use, cervical spondylopathy can be effectively treated, short treating period is quick, cure rate is high, and recurrence rate is low and has no toxic side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, in particular to a kind of Chinese medicine composition for treating cervical spondylopathy
And its preparation method and application.
Background technology
With the quickening pace of modern life, the transformation of working method and the influence of working environment, increasing people suffer from neck
Vertebra disease, the working clan of most bowed for the long campaigns people to bend over one's desk working, such as long-term use of computer.
Cervical spondylopathy is also known as cervical spine syndrome, be due to long-term chronic strain and gradually form a kind of osteoproliferation, vertebra
Spondylosis, ligament thicken, and then cervical vertebra spinal cord, nerve root or vertebral artery occur and be pressurized and cause a series of dysfunctions occur
Syndrome.Common illness is that neck or occiput are stiff, and pain is uncomfortable, more numb with dizzy, insomnia or upper limbs
Wood etc..What treatment cervical spondylopathy was more common at present is manipulation, oral drugs or adhesive plaster, if but manipulation gimmick slightly not
When the pain for easily aggravating patient, the patient with osteoarthritis or senile osteoporosis can not only be aggravated the pain, also
Sclerotin, infection diffusion can be damaged；Oral drugs curative effect is poor, easily produces toxic side effect, and the easy recurrent exerbation of the state of an illness；
The course for the treatment of of ointment is long, slowly effect and cure rate are low.
In view of this, it is special to propose the present invention.
The content of the invention
First purpose of the present invention is to provide a kind of Chinese medicine composition for treating cervical spondylopathy, to improve existing Chinese medicine
The poor technical problem of preparation for treating cervical spondylopathy effect.The present invention can effectively treat cervical spondylopathy, and short treating period is quick, cure
Rate is high, and recurrence rate is low and has no toxic side effect.The Chinese medicine composition for the treatment of cervical spondylopathy is directly applied in affected part, is had promoting blood circulation and removing blood stasis, easypro
It the effect of muscle qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin and damp-clearing pain-relieving, can fast and effeciently alleviate neck fatigue, treat cervical vertebra
Disease, nonirritant or anaphylaxis, percutaneous absorbability is good, easy to use.
Second object of the present invention is to provide a kind of preparation of the Chinese medicine composition for the treatment of cervical spondylopathy of the present invention
Method, this method fully merge the active ingredient in Chinese medicine material of the present invention, retain effective component, remove each Chinese medicine material
Toxicant, excitant and side effect, effectively strengthen drug effect, relax the property of medicine, the Chinese medicine of present invention treatment cervical spondylopathy is prepared
Composition, has that preparation method is easy, workable, the advantages that product good effect, suitable for large-scale production.
Third object of the present invention is the application for providing the Chinese medicine composition for the treatment of cervical spondylopathy of the present invention, this hair
The Chinese medicine composition of Mingzhi's treatment cervical spondylopathy has the work(of promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin and damp-clearing pain-relieving
Effect, can realize the effect to the fast and effective analgesic of cervical vertebra, can effectively treat cervical spondylopathy, quick, good effect is nontoxic
Side effect.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
The present invention provides a kind of Chinese medicine composition for treating cervical spondylopathy, mainly former by following Chinese medicine according to mass fraction meter
Material is made：Radix Angelicae Sinensis 5-15 parts, Ligusticum wallichii 5-15 parts, cassia twig 5-15 parts, monkshood 5-15 parts, safflower 12-25 parts, reticulate millettia 5-15 parts,
Root of Dahurain angelica 8-16 parts, bush 10-20 parts, hairyvein agrimony 5-15 parts.
Alternatively, the Chinese medicine composition for the treatment of cervical spondylopathy provided by the invention, according to mass fraction meter, mainly by following
Medicine raw material is made：Radix Angelicae Sinensis 6-14 parts, Ligusticum wallichii 7-14 parts, cassia twig 6-14 parts, monkshood 6-14 parts, safflower 15-24 parts, reticulate millettia 6-14
Part, root of Dahurain angelica 9-15 parts, bush 12-18 parts, hairyvein agrimony 6-14 parts.
Preferably, the Chinese medicine composition for the treatment of cervical spondylopathy provided by the invention, according to mass fraction meter, mainly by following
Medicine raw material is made：Radix Angelicae Sinensis 7-12 parts, Ligusticum wallichii 8-12 parts, cassia twig 8-12 parts, monkshood 7-12 parts, safflower 16-20 parts, reticulate millettia 7-12
Part, root of Dahurain angelica 10-14 parts, bush 13-16 parts, hairyvein agrimony 7-12 parts.
Alternatively, the Chinese medicine composition for the treatment of cervical spondylopathy provided by the invention, according to mass fraction meter, in addition to ginger 5-
10 parts.
Meanwhile the present invention also provides a kind of preparation method of the Chinese medicine composition of the treatment cervical spondylopathy, including following step
Suddenly：Each Chinese medicine material soaked with ginger juice repeatedly steam and shone, is then crushed, the Chinese traditional medicine composition for the cervical spondylopathy that obtains medical treatment
Thing.
Alternatively, in the preparation method of the Chinese medicine composition of present invention treatment cervical spondylopathy, the preparation process of ginger juice is：It will match somebody with somebody
The ginger just measured adds clear water and stirs evenly into ginger juice after crushing, the mass ratio of ginger and clear water is 1:(5-10)；Preferably, ginger juice
The time for soaking each Chinese medicine material is 20-30h.
Alternatively, each Chinese medicine material soaked with ginger juice is carried out repeatedly steaming concretely comprising the following steps for solarization：Ginger juice is soaked
Each Chinese medicine material crossed, which is placed in, to be steamed in container, Steam by water bath 2-6h, is then dried, and is repeated to steam and shone repeatedly.
Alternatively, in the preparation method of the Chinese medicine composition of present invention treatment cervical spondylopathy, crushing mesh number is 80-200 mesh.
Preferably, the present invention provides a kind of preparation method of the Chinese medicine composition of the treatment cervical spondylopathy, including following step
Suddenly：
(a) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:(5-
10)；
(b) with after each Chinese medicine material 20-30h of the ginger juice immersion formula ratio of step (a), each Chinese medicine material is placed in and steamed
In container, Steam by water bath 2-6h, then dry, and repeat to steam and shine repeatedly；
(c) it is 80-200 mesh that each Chinese medicine material after being dried in step (b), which crushes, mixes packaging, obtain medical treatment cervical vertebra
The Chinese medicine composition of disease.
In addition, the present invention, which also provides a kind of Chinese medicine composition of the treatment cervical spondylopathy, is preparing the medicine for the treatment of cervical spondylopathy
In application.
Compared with prior art, beneficial effects of the present invention are：
(1) each Chinese medicine material coordinated in the Chinese medicine composition of present invention treatment cervical spondylopathy, can effectively treat cervical vertebra
Disease, short treating period is quick, and cure rate is high, and recurrence rate is low and has no toxic side effect.The Chinese medicine composition of the treatment cervical spondylopathy directly applies
In affected part, there is the effect of promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin and damp-clearing pain-relieving, can be fast and effeciently
Alleviate neck fatigue, treat cervical spondylopathy, nonirritant or anaphylaxis, percutaneous absorbability is good, easy to use.
(2) preparation method of the Chinese medicine composition of present invention treatment cervical spondylopathy can effectively facilitate each material effective component
Fully fusion, and specification scientific and reasonable with operating procedure, it is easy to the advantages that standardization mass produces.This method is by the present invention
Active ingredient in Chinese medicine material makes full use of, and retains effective component, removes toxicant, excitant and the pair of each Chinese medicine material
Effect, effectively strengthening drug effect, relax the property of medicine, the Chinese medicine composition of present invention treatment cervical spondylopathy is prepared, preparation method is easy,
It is workable, product good effect.
(3) Chinese medicine composition of present invention treatment cervical spondylopathy has promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, the logical natural fibre line of meat of temperature
The effect of reason and damp-clearing pain-relieving, the effect to the fast and effective analgesic of cervical vertebra can be realized, effectively treats cervical spondylopathy, is taken effect
It hurry up, good effect, have no toxic side effect.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment and embodiment, but this area skill
Art personnel will be understood that following embodiments and embodiment are merely to illustrate the present invention, and be not construed as the model of the limitation present invention
Enclose.Unreceipted actual conditions person in embodiment, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or instrument
The unreceipted production firm person of device, it is the conventional products that can be obtained by commercially available purchase.
According to the first aspect of the invention, embodiment of the present invention provides a kind of Chinese medicine composition for treating cervical spondylopathy,
According to mass fraction meter, mainly it is made up of following Chinese medicine material：Radix Angelicae Sinensis 5-15 parts, Ligusticum wallichii 5-15 parts, cassia twig 5-15 parts, monkshood 5-
15 parts, safflower 12-25 parts, reticulate millettia 5-15 parts, root of Dahurain angelica 8-16 parts, bush 10-20 parts, hairyvein agrimony 5-15 parts.
Below to being illustrated in the present invention the effect of each Chinese medicine material.
Radix Angelicae Sinensis, also known as it is dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis or contain return tail, it is sweet, bitter, it is warm-natured, in the present invention
In there is blood circulation promoting and enriching, menstruction regulating and pain relieving, the effect of dispelling wind and eliminating dampness.
Ligusticum wallichii, also known as mountain bring up that poor, rhizome of chuanxiong perfume (or spice) fruit, Hu Maxian rhizomes of chuanxiong or rhizome of chuanxiong are poor, and acrid flavour is warm-natured, is dispelled in the present invention with promoting blood circulation
The stasis of blood, promote breath and open depression, the effect of wind-expelling pain-stopping.
Cassia twig, also known as Chinese cassia tree, beautiful osmanthus or cassia bark, it is acrid flavour, sweet, it is warm-natured, in the present invention with sweating expelling pathogenic factors from muscles and skin, Wen Jingtong
Arteries and veins, helps yang transforming qi, the effect of eliminating cold to stop pain.
Monkshood, also known as goose is spent, the ornamental work of iron or the five poisonous creatures: scorpion, viper, centipede, house lizard, toad, acrid flavour, hardship, property heat, in the present invention with dispelling wind and eliminating dampness, Wen Jingzhi
The effect of pain.
Safflower, also known as shuteria pampaniniana, thorn safflower, Flos Carthami or golden red flower, acrid flavour is warm-natured, in the present invention with invigorate blood circulation,
The effect of stasis-dispelling and pain-killing.
Reticulate millettia, also known as CAULIS SPATHOLOBI, it is bitter, sweet, it is warm-natured, in the present invention with blood circulation promoting and enriching, channels sootheing and network vessel quickening, menstruation regulating
The effect of analgesic.
The root of Dahurain angelica, also known as big work, membrane inside the rush stalk Li, Ze Fen, Bai Chen, angelica anomala or Radix angelicae dahuricae, acrid flavour, bitter are warm-natured, in the present invention
With wind-damp dispelling, apocenosis of invigorating blood circulation, the effect of myogenic pain relieving.
Bush, also known as Soviet Union's a tree, used in making timber for boats, the Soviet side, lignum sappan, wooden, the red wooden or red bavin of palm fibre, it is taste glycosides, salty, it is mild-natured, have in the present invention
Promoting circulation of blood dissolving stasis, the effect of swelling and pain relieving.
Hairyvein agrimony, also known as fortune silene herb with root, old Cowhells, melon vanilla or Agrimony, it is acrid flavour, puckery, slightly warm in nature, have in the present invention
Astringing to arrest bleeding, the effect of anti-inflammation.
Compared with prior art, the beneficial effect of the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides
For：
Each Chinese medicine material coordinated in the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, Neng Gouyou
Effect treatment cervical spondylopathy, short treating period is quick, and cure rate is high, and recurrence rate is low and has no toxic side effect.The Chinese medicine group of the treatment cervical spondylopathy
Compound is directly applied in affected part, has the effect of promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin and damp-clearing pain-relieving, can
Fast and effeciently alleviate neck fatigue, treat cervical spondylopathy, nonirritant or anaphylaxis, percutaneous absorbability is good, easy to use.
Alternatively, the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides can make Chinese medicine moxibustion bag, directly
Connect to apply before affected part, sleep every night to apply and removed in affected part, morning, just feel cervical vertebra moving freely, pain and discomfort
Disappearing, cervical spondylopathy can be alleviated or fully recover after being used continuously 15 times, and without any toxic side effect.
In the Chinese medicine composition of present invention treatment cervical spondylopathy, " mainly by ... " means it in addition to the component, can be with
Including other components, these other components assign the Chinese medicine composition of the present invention for treating cervical spondylopathy different characteristics.Except this
Outside, " mainly by ... " of the present invention, it may be replaced by enclosed " for " or " by ... ".
Alternatively, it is 5 parts that the mass fraction of Radix Angelicae Sinensis is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Alternatively, it is 5 parts that the mass fraction of Ligusticum wallichii is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Alternatively, it is 5 parts that the mass fraction of cassia twig is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Alternatively, it is 5 parts that the mass fraction of monkshood is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Alternatively, it is 12 parts that the mass fraction of safflower is typical but non-limiting, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18
Part, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts or 25 parts.
Alternatively, it is 5 parts that the mass fraction of reticulate millettia is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts, 13 parts, 14 parts or 15 parts.
Alternatively, it is 8 parts that the mass fraction of the root of Dahurain angelica is typical but non-limiting, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14
Part, 15 parts or 16 parts.
Alternatively, it is 10 parts that the mass fraction of bush is typical but non-limiting, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16
Part, 17 parts, 18 parts, 19 parts or 20 parts.
Alternatively, it is 5 parts that the mass fraction of hairyvein agrimony is typical but non-limiting, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts, 13 parts, 14 parts or 15 parts.
Alternatively, the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, according to mass fraction meter, mainly
It is made up of following Chinese medicine material：Radix Angelicae Sinensis 6-14 parts, Ligusticum wallichii 7-14 parts, cassia twig 6-14 parts, monkshood 6-14 parts, safflower 15-24 parts, chicken
Blood rattan 6-14 parts, root of Dahurain angelica 9-15 parts, bush 12-18 parts, hairyvein agrimony 6-14 parts.
Preferably, the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, according to mass fraction meter, mainly
It is made up of following Chinese medicine material：Radix Angelicae Sinensis 7-12 parts, Ligusticum wallichii 8-12 parts, cassia twig 8-12 parts, monkshood 7-12 parts, safflower 16-20 parts, chicken
Blood rattan 7-12 parts, root of Dahurain angelica 10-14 parts, bush 13-16 parts, hairyvein agrimony 7-12 parts.
By the adjustment and optimization to each Chinese medicine material dosage, the Chinese medicine composition for treating cervical spondylopathy can be further improved
Therapeutic effect, percutaneous absorbability is good, quick, and curative effect is lasting, has no toxic side effect, it is corresponding one late (6-12h) is applied in affected part after
Just cervical vertebra ache can be eliminated, mitigates pain and discomfort, continuous use just can be alleviated or cure cervical spondylopathy for 15-30 days.
Alternatively, the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, according to mass fraction meter, is also wrapped
Include ginger 5-10 parts.
Ginger：It is pungent, warm；Return lung, spleen, stomach；Helped with pungent-warm surname dissipate, Tong Ying defend, inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, wind-dispelling
Cold dispelling, open the effect of phlegm, warm lung cough-relieving；Inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, warm lung cough-relieving, solving toxin of fish and crab, antidote poison；Function is virtue
The pungent stomachic tonic of fragrance, there is the effect such as warm, excited, sweating, preventing or arresting vomiting, removing toxic substances.
In the present invention, ginger is used to ginger juice be made, and then soaks Radix Angelicae Sinensis, Ligusticum wallichii, cassia twig, monkshood, safflower, chicken with ginger juice
Blood rattan, the root of Dahurain angelica, bush and hairyvein agrimony, soak above-mentioned each Chinese medicine material by using ginger juice, can reduce each medicinal material toxicant,
Excitant or side effect, while strengthen drug effect, relax the property of medicine；In addition during follow-up Steam by water bath being also helped after maceration, respectively
The abundant confluent invasion of active ingredient of Chinese medicine material, further enhances drug effect.
According to the second aspect of the invention, embodiment of the present invention also provides a kind of Chinese medicine group of above-mentioned treatment cervical spondylopathy
The preparation method of compound, comprises the following steps：Each Chinese medicine material soaked with ginger juice repeatedly steam and shone, is then crushed,
The Chinese medicine composition for the cervical spondylopathy that obtains medical treatment.
The preparation method of the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides can effectively facilitate each original
Expect the abundant fusion of active ingredient, and specification scientific and reasonable with operating procedure, be easy to the advantages that standardization mass produces.Should
Method makes full use of the active ingredient in Chinese medicine material of the present invention, retains effective component, removes the toxic substance of each Chinese medicine material
Matter, excitant and side effect, effectively strengthen drug effect, relax the property of medicine, the Chinese medicine composition of present invention treatment cervical spondylopathy is prepared,
Preparation method is easy, workable, product good effect.
Alternatively, in the preparation method for the cervical spondylopathy that embodiment of the present invention provides, the preparation process of ginger juice is：Will formula
The ginger of amount adds clear water and stirs evenly into ginger juice after crushing, the mass ratio of ginger and clear water is 1：(5-10)；Preferably, ginger juice soaks
The time for steeping each Chinese medicine material is 20-30h.
Soak above-mentioned each rational duration of Chinese medicine material by using ginger juice, can effectively reduce each medicinal material toxicant,
Excitant or side effect, while strengthen drug effect, relax the property of medicine；In addition during follow-up Steam by water bath being also helped after maceration, respectively
The abundant confluent invasion of active ingredient of Chinese medicine material, further enhances drug effect.
Alternatively, in ginger juice, the typical but non-limiting mass ratio of ginger and clear water is 1:5、1:6、1:7、1:8、1:9 or
1:10；The preferred mass of ginger and clear water ratio is 1:8.
Alternatively, ginger juice soak each Chinese medicine material time it is typical but it is non-limiting for 20h, 21h, 22h, 23h, 24h,
25h, 26h, 27h, 28h, 29h or 30h；The time that ginger juice soaks each Chinese medicine material is preferably 24h.
Alternatively, in the preparation method of the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, to ginger
Each Chinese medicine material that juice soaked carries out repeatedly steaming concretely comprising the following steps for solarization：Each Chinese medicine material that ginger juice was soaked, which is placed in, to be steamed
In container, Steam by water bath 2-6h, then dry, and repeat to steam and shine repeatedly.
Alternatively, steam container it is typical but it is non-limiting be food steamer, the time of Steam by water bath it is typical but it is non-limiting for 2h,
3h, 4h, 5h or 6h；The typical but non-limiting number that steaming is shone is that four steamings four are shone, five steam five solarizations or the solarization of six steaming six.
Steam by water bath is carried out by each Chinese medicine material soaked to ginger juice, noxious material can be further removed, melt simultaneously
The effective component of each raw material is closed, relaxes the property of medicine；In addition, the process of solarization, Neng Goujin Exposure to Sunlight and are repeatedly steamed by Steam by water bath again
One step mediation property of medicine, strengthen drug effect, reduce toxic side effect, be advantageous to the Chinese medicine composition product drug effect for the treatment of cervical spondylopathy prepared
Stable homogeneous, it is quick, have no toxic side effect, percutaneous absorbability is good, and curative effect is persistently effective.
Alternatively, in the preparation method of the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides, ginger juice is used
Each Chinese medicine material soaked is carried out after repeatedly steaming solarization, and crushing mesh number is 80-200 mesh.
Alternatively, the crushing mesh number of each Chinese medicine material it is typical but non-limiting be 80 mesh, 100 mesh, 120 mesh, 150 mesh or
200 mesh；It is preferred that it is 100 mesh to crush mesh number.
By being fully crushed to specific mesh number to each Chinese medicine material, and it is well mixed, obtained treatment neck can be ensured
The Chinese medicine composition product property stable homogeneous of vertebra disease, it is quick, be advantageous to give full play to drug effect, fast and effeciently treat cervical vertebra
Disease.
Alternatively, embodiment of the present invention provides a kind of preparation method of the Chinese medicine composition of above-mentioned treatment cervical spondylopathy, bag
Include following steps：
(a) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:(5-
10)；
(b) with after each Chinese medicine material 20-30h of the ginger juice immersion formula ratio of step (a), each Chinese medicine material is placed in and steamed
In container, Steam by water bath 2-6h, then dry, and repeat to steam and shine repeatedly；
(c) it is 80-200 mesh that each Chinese medicine material after being dried in step (b), which crushes, mixes packaging, obtain medical treatment cervical vertebra
The Chinese medicine composition of disease.
The preparation method of the Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides can effectively facilitate each original
Expect the abundant fusion of active ingredient, and specification scientific and reasonable with operating procedure, be easy to the advantages that standardization mass produces.Should
Method makes full use of the active ingredient in Chinese medicine material of the present invention, retains effective component, removes the toxic substance of each Chinese medicine material
Matter, excitant and side effect, effectively strengthen drug effect, relax the property of medicine, the Chinese medicine composition of present invention treatment cervical spondylopathy is prepared,
Preparation method is easy, workable, product good effect.
Preferably, embodiment of the present invention provides a kind of preparation method of the Chinese medicine composition of above-mentioned treatment cervical spondylopathy, bag
Include following steps：
(a) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:8；
(b) with after each Chinese medicine material 24h of the ginger juice immersion formula ratio of step (a), each Chinese medicine material is placed in and steams appearance
In device, Steam by water bath 4h, then dry, and repeat to steam and shine repeatedly, five, which steam five, shines；
(c) it is 100 mesh that each Chinese medicine material after being dried in step (b), which crushes, mixes packaging, obtain medical treatment cervical spondylopathy
Chinese medicine composition.
According to the third aspect of the present invention, embodiment of the present invention provides a kind of Chinese traditional medicine composition of above-mentioned treatment cervical spondylopathy
Application of the thing in the medicine for preparing treatment cervical spondylopathy.
The Chinese medicine composition for the treatment cervical spondylopathy that embodiment of the present invention provides has promoting blood circulation and removing blood stasis, relaxing muscles and tendons qi-regulating, wind-dispelling
The effect of dredging collateral, invigorating striae of the skin and damp-clearing pain-relieving, the effect to the fast and effective analgesic of cervical vertebra can be realized, effectively treats neck
Vertebra disease, it is quick, good effect, have no toxic side effect.
Alternatively, Chinese medicine moxibustion bag can be made in the Chinese medicine composition of present invention treatment cervical spondylopathy, and specification is typical but unrestricted
Property is 15cm × 7cm × 3cm.In use, after affected part is cleaned up, it is directly that Chinese medicine moxibustion is coated behind affected part, 6-12h
Cervical spondylopathy can be alleviated, once a day, being used continuously 15-30 times can effectively alleviate or cure cervical spondylopathy, without the secondary work of any poison
With, and recurrence rate is low.
The present invention is elaborated with reference to specific embodiment and comparative example.
Embodiment 1
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
10 parts of Radix Angelicae Sinensis, 10 parts of Ligusticum wallichii, 10 parts of cassia twig, 10 parts of monkshood, 18 parts of safflower, 10 parts of reticulate millettia, 12 parts of the root of Dahurain angelica, bush
15 parts, 9 parts of hairyvein agrimony, 8 parts of ginger.
The preparation method of the Chinese medicine composition of above-mentioned treatment cervical spondylopathy, comprises the following steps：
(1) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:8；
(2) with after each Chinese medicine material 24h of the ginger juice immersion formula ratio of step (1), each Chinese medicine material is placed in and steams appearance
In device, Steam by water bath 4h, then dry, and repeat to steam and shine repeatedly, five, which steam five, shines；
(3) it is 100 mesh that each Chinese medicine material after being dried in step (2), which crushes, mixes packaging, obtain medical treatment cervical spondylopathy
Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
5 parts of Radix Angelicae Sinensis, 14 parts of Ligusticum wallichii, 6 parts of cassia twig, 13 parts of monkshood, 12 parts of safflower, 5 parts of reticulate millettia, 16 parts of the root of Dahurain angelica, bush 10
Part, 6 parts of hairyvein agrimony, 5 parts of ginger.
The preparation method of the Chinese medicine composition of above-mentioned treatment cervical spondylopathy, comprises the following steps：
(1) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:5；
(2) with after each Chinese medicine material 20h of the ginger juice immersion formula ratio of step (1), each Chinese medicine material is placed in and steams appearance
In device, Steam by water bath 2h, then dry, and repeat to steam and shine repeatedly, six, which steam six, shines；
(3) it is 80 mesh that each Chinese medicine material after being dried in step (2), which crushes, mixes packaging, obtain medical treatment cervical spondylopathy
Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
15 parts of Radix Angelicae Sinensis, 5 parts of Ligusticum wallichii, 14 parts of cassia twig, 5 parts of monkshood, 25 parts of safflower, 15 parts of reticulate millettia, 8 parts of the root of Dahurain angelica, bush 20
Part, 15 parts of hairyvein agrimony, 10 parts of ginger.
The preparation method of the Chinese medicine composition of above-mentioned treatment cervical spondylopathy, comprises the following steps：
(1) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:10；
(2) with after each Chinese medicine material 30h of the ginger juice immersion formula ratio of step (1), each Chinese medicine material is placed in and steams appearance
In device, Steam by water bath 6h, then dry, and repeat to steam and shine repeatedly, four, which steam four, shines；
(3) it is 200 mesh that each Chinese medicine material after being dried in step (2), which crushes, mixes packaging, obtain medical treatment cervical spondylopathy
Chinese medicine composition.
Embodiment 4
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
8 parts of Radix Angelicae Sinensis, 12 parts of Ligusticum wallichii, 15 parts of cassia twig, 8 parts of monkshood, 21 parts of safflower, 12 parts of reticulate millettia, 14 parts of the root of Dahurain angelica, bush 14
Part, 8 parts of hairyvein agrimony, 6 parts of ginger.
The preparation method of the Chinese medicine composition of the treatment cervical spondylopathy is the same as embodiment 1.
Embodiment 5
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
13 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, 6 parts of cassia twig, 7 parts of monkshood, 13 parts of safflower, 14 parts of reticulate millettia, 13 parts of the root of Dahurain angelica, bush 19
Part, 11 parts of hairyvein agrimony, 9 parts of ginger.
The preparation method of the Chinese medicine composition of the treatment cervical spondylopathy is the same as embodiment 1.
Embodiment 6
A kind of Chinese medicine composition for treating cervical spondylopathy, according to mass fraction meter, mainly it is made up of following raw material：
9 parts of Radix Angelicae Sinensis, 11 parts of Ligusticum wallichii, 7 parts of cassia twig, 13 parts of monkshood, 17 parts of safflower, 6 parts of reticulate millettia, 9 parts of the root of Dahurain angelica, bush 17
Part, 12 parts of hairyvein agrimony, 7 parts of ginger.
The preparation method of the Chinese medicine composition of the treatment cervical spondylopathy is the same as embodiment 1.
Comparative example
A kind of Chinese medicine preparation of existing treatment cervical spondylopathy, is made up of following raw material：Cassia twig 15g, stir-baked RADIX PAEONIAE ALBA 30g, the root of kudzu vine
30g, bark of ash 15g, root of Chinese clematis 15g, reticulate millettia 30g, notopterygium root 10g, Ligusticum wallichii 15g, honey-fried licorice root 6g, 3, ginger, 6 pieces of jujube, raw material
Blending water routinely decocts, daily 1 dose, oral with the yellow rice wine 50ml warmed after supper.
Test example
First, irritation test：
Healthy rabbits 30 are selected, are divided into 6 groups, 1-6 groups applied to detection 1-6 of the embodiment of the present invention respectively to preparing
Treatment cervical spondylopathy Chinese medicine composition excitant.
The processing of rabbit：Fur on the outside of hindlimb joints before rabbit in each group is cut, exposes skin 5cm × 5cm, then
In the Chinese medicine composition 12h of the fixed present invention treatment cervical spondylopathy for applying equivalent of front left limb, front right limb and rear left limb, rear right limb
Any material is not applied, as control position, 24h is then normally raised, observes the change of skin at coating.
Observation index：
Skin severe reaction, produce blister or discharge secretion；
Skin mild reaction, there is erythema or erythema；
Dermoanergy, skin color are normal.
Observe the change of skin of each group rabbit, the results showed that, experiment area skin is reactionless, of the invention real so as to illustrate
The Chinese medicine composition of the obtained treatment cervical spondylopathys of a 1-6 is applied to no skin irritation, being capable of safe and secure use.
2nd, analgesic effect is tested
A hot plate methods
150 female mices are selected, 20~24g of body weight, are individually placed on the hot plate pain threshold detector of 55 ± 0.5 DEG C of temperature, from
The mouse rear foot touches time of the hot plate untill metapedes is added as pain indicator.In determining the threshold of pain on hot plate pain threshold detector before experiment
Value, then selects mouse of the pain threshold in 5~30s 80, stochastic averagina is divided into 8 groups, and the 1st~6 group is correspondingly given the present invention
The Chinese medicine composition of the obtained treatment cervical spondylopathy of embodiment 1~6, the 7th group of Chinese medicine preparation for correspondingly taking comparative example, the 8th group is
Blank control group, not to any medicine.Repetition measure twice normal pain threshold as the group be administered before basic threshold.Before experiment
24h takes the Chinese medicine composition of corresponding treatment cervical spondylopathy to fix and spread on using mouse web portion shaving about 3cm × 3cm as topical application of drug area
The topical application of drug area of mouse web portion, dose all same, by daily single, and for three days on end, the 7th group of Chinese medicine system for correspondingly taking comparative example
Agent.Each group determines the pain threshold of mouse after 1h is administered in last time, compares the front and rear pain threshold of mouse administration, and united
Meter analysis, as a result as shown in table 1.
The hot plate method result of the test of table 1
From the result in table 1, compared with blank control group and comparative example, the embodiment of the present invention 1~6 is obtained to treat
The Chinese medicine composition of cervical spondylopathy can significantly improve tolerance degree (p of the mouse to pain<0.05), wherein made from embodiment 1
The effect for treating the Chinese medicine composition of cervical spondylopathy is best.As a result showing the Chinese medicine composition of present invention treatment cervical spondylopathy has preferably
Alleviation cervical vertebra ache effect.
B acetic acid writhing tests
80 mouse of selection, male and female half and half, 20~24g of body weight, stochastic averagina are divided into 8 groups, and the 1st~6 group is correspondingly given this
The Chinese medicine composition of the obtained treatment cervical spondylopathy of inventive embodiments 1~6, the 7th group of Chinese medicine preparation for correspondingly using comparative example, the 8th
Group is blank control group, not to any medicine.24h before experiment, using mouse web portion shaving about 3cm × 3cm as topical application of drug area, take phase
The Chinese medicine composition for the treatment cervical spondylopathy answered fixes the topical application of drug area for spreading on mouse web portion, dose all same, by daily single, connects
It is continuous 3 days, the 7th group of Chinese medicine preparation for correspondingly taking comparative example.Each group is in the vinegar of last time administration 1h pneumoretroperitoneums injection 0.6%
Acid solution 0.2mL/ only, and records the writhing number of mouse in 30min, carries out statistical analysis, as a result as shown in table 2.
The acetic acid twisting result of the test of table 2
| Group | Medicament sources | Writhing number |
| 1 | Embodiment 1 | 31.3±4.2 |
| 2 | Embodiment 2 | 32.5±5.1 |
| 3 | Embodiment 3 | 32.0±3.7 |
| 4 | Embodiment 4 | 32.7±4.8 |
| 5 | Embodiment 5 | 33.1±5.0 |
| 6 | Embodiment 6 | 32.9±4.2 |
| 7 | Comparative example | 50.1±4.1 |
| 8 | Blank control group | 61.5±4.4 |
From the result in table 2, compared with blank control group and comparative example, the embodiment of the present invention 1~6 is obtained to treat
The Chinese medicine composition of cervical spondylopathy can significantly improve tolerance degree (p of the mouse to pain<0.05), wherein made from embodiment 1
The effect for treating the Chinese medicine composition of cervical spondylopathy is best.As a result showing the Chinese medicine composition of present invention treatment cervical spondylopathy has well
Alleviation cervical vertebra ache effect.
3rd, clinical test
Clinical test is carried out to 280 patient with cervical Spondylopathy, wherein the people of male patient 136, the people of female patient 144, age 30-58
Year, average age 41 years old.7 groups are divided into, wherein 1-6 groups are corresponding to use the obtained treatment cervical vertebras of 1-6 of the embodiment of the present invention
The Chinese medicine composition of disease, the Chinese medicine composition that patient's every night treats the present invention cervical spondylopathy spread on affected part, the next morning
Remove, according to the difference of the respective state of an illness, be used continuously 20 days.The 7th group of Chinese medicine preparation for taking comparative example, continuously takes 20 days.
Criterion of therapeutical effect：It is effective：Cervical vertebra ache disappears, and does not recur；Effectively, pain disappears substantially, and does not recur；Minor effect：
The different degrees of alleviation of pain, occasionally there is recurrence；It is invalid：Pain is without alleviation.
Corresponding therapeutic effect is counted, as a result as shown in table 3.
The statistical result of the therapeutic effect of table 3
| Group | Medicament sources | Effective number | Efficiently individual quantity | Minor effect number | Invalid number |
| 1 | Embodiment 1 | 37 | 2 | 1 | 0 |
| 2 | Embodiment 2 | 33 | 4 | 2 | 1 |
| 3 | Embodiment 3 | 35 | 3 | 1 | 1 |
| 4 | Embodiment 4 | 34 | 4 | 1 | 1 |
| 5 | Embodiment 5 | 36 | 2 | 1 | 1 |
| 6 | Embodiment 6 | 35 | 3 | 1 | 1 |
| 7 | Comparative example | 5 | 16 | 12 | 7 |
As shown in Table 3, the Chinese medicine composition of the obtained treatment cervical spondylopathys of 1-6 of the embodiment of the present invention has well
The effect of cervical spondylopathy is treated, the effective and effective total accounting of number is up to 97.5%.According to clinical effectiveness, the embodiment of the present invention 1 is made
Treatment cervical spondylopathy Chinese medicine composition effect it is best, it is most short just effectively to cure cervical spondylopathy using 15 days, good effect, take effect
It hurry up, recurrence rate is low, has no toxic side effect.Check only has 0.5% recurrence rate, and pain during recurrence in 3 months to 1 year after recovery from illness
Light compared with before treatment, secondary consolidate after use is no longer recurred during recurrence.
The pharmacological research of above-mentioned clinical test results proves that the Chinese medicine composition of present invention treatment cervical spondylopathy stops with promoting blood circulation
Bitterly, relaxing muscles and tendons qi-regulating, dispelling wind and removing obstruction in the meridians, invigorating striae of the skin, clearing dampization are become silted up, and the effect of detumescence and drawing out poison, can reach good treatment cervical vertebra
The effect of disease, it is quick, efficacy stability, have no toxic side effect, it is safe and convenient to use；Directly apply in affected part, can ensure that medicine has
The through lesions position of composition is imitated, rapid recovery cervical vertebra ache, nonirritant or anaphylaxis, percutaneous absorbability is good, evident in efficacy.
Typical case：
1st, Mrs Li, 37 years old, General Office Clerk's work is engaged in, bows for a long time and handles official business and cause to suffer from cervical spondylopathy, neck is frequent
Pain, it is often accompanied by dizziness.After Chinese medicine composition 1 time using present invention treatment cervical spondylopathy, shoulder cervical pain substantially delays
Solution, dizzy phenomenon disappear, persistently using being cured completely after 15 times, so far without recurrence.
2nd, Mr. Zhao, 42 years old, worked middle injury the year before, and cervical vertebra joint congestion and swelling pain is violent, it is difficult to out-of-bed activity, influences
Normal walking.Substantially being mitigated using pain after the Chinese medicine composition 3 times of present invention treatment cervical spondylopathy, the walking that can leave the bed is worked,
30 healings completely later of continuous use, can normally do physical labor, so far without recurrence.
3rd, Mrs Wang, 31 years old, certain editorial office of periodical publisher employee, cervical spondylopathy is suffered from because of long-term work of bowing, through normal after sitting
Easy neck stiffness, headache is dizzy, and face is numb.Use cervical vertebra ache after the Chinese medicine composition 1 time of present invention treatment cervical spondylopathy
Phenomenon is obviously improved, and dizziness headache and face pain and numbness are disappeared, and cervical spondylopathys are cured completely after being used continuously 15 times, so far without
Recurrence.
4th, Mr. Zheng, 35 years old, IT industries are engaged in for many years, programmer, are ached for a long time with computer work, frequent shoulder neck, collare
Portion is stiff, suffers from cervical spondylopathy through hospital diagnosis.1 back porch neck of Chinese medicine composition using present invention treatment cervical spondylopathy is ached disappearance,
Wry Neck situation improves afterwards, and cervical vertebra disease symptoms disappear after continuous use three times, cures completely, and so far without recurrence.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from the present invention's
In the case of spirit and scope, many other change and modification can be made.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of Chinese medicine composition for treating cervical spondylopathy, it is characterised in that according to mass fraction meter, mainly by following Chinese medicine material
It is made：
Radix Angelicae Sinensis 5-15 parts, Ligusticum wallichii 5-15 parts, cassia twig 5-15 parts, monkshood 5-15 parts, safflower 12-25 parts, reticulate millettia 5-15 parts, the root of Dahurain angelica
8-16 parts, bush 10-20 parts, hairyvein agrimony 5-15 parts.
2. the Chinese medicine composition for the treatment of cervical spondylopathy according to claim 1, it is characterised in that main according to mass fraction meter
To be made up of following Chinese medicine material：
Radix Angelicae Sinensis 6-14 parts, Ligusticum wallichii 7-14 parts, cassia twig 6-14 parts, monkshood 6-14 parts, safflower 15-24 parts, reticulate millettia 6-14 parts, the root of Dahurain angelica
9-15 parts, bush 12-18 parts, hairyvein agrimony 6-14 parts.
3. the Chinese medicine composition for the treatment of cervical spondylopathy according to claim 2, it is characterised in that main according to mass fraction meter
To be made up of following Chinese medicine material：
Radix Angelicae Sinensis 7-12 parts, Ligusticum wallichii 8-12 parts, cassia twig 8-12 parts, monkshood 7-12 parts, safflower 16-20 parts, reticulate millettia 7-12 parts, the root of Dahurain angelica
10-14 parts, bush 13-16 parts, hairyvein agrimony 7-12 parts.
4. the Chinese medicine composition of the treatment cervical spondylopathy according to claim any one of 1-3, it is characterised in that according to mass parts
Number meter, in addition to ginger 5-10 parts.
5. the preparation method of the Chinese medicine composition of the treatment cervical spondylopathy described in a kind of claim 4, it is characterised in that including as follows
Step：Each Chinese medicine material soaked with ginger juice repeatedly steam and shone, is then crushed, the Chinese traditional medicine composition for the cervical spondylopathy that obtains medical treatment
Thing.
6. preparation method according to claim 5, it is characterised in that the preparation process of ginger juice is：By the ginger of formula ratio
Clear water is added after crushing and stirs evenly into ginger juice, the mass ratio of ginger and clear water is 1：(5-10)；
Preferably, the time that ginger juice soaks each Chinese medicine material is 20-30h.
7. preparation method according to claim 5, it is characterised in that carried out to each Chinese medicine material soaked with ginger juice more
It is secondary to steam concretely comprising the following steps for solarization：Each Chinese medicine material that ginger juice was soaked, which is placed in, to be steamed in container, Steam by water bath 2-6h, is then shone
It is dry, and repeat to steam and shine repeatedly.
8. preparation method according to claim 5, it is characterised in that crushing mesh number is 80-200 mesh.
9. the preparation method of the Chinese medicine composition of cervical spondylopathy is treated described in a kind of claim 5, it is characterised in that including following step
Suddenly：
(a) will formula ratio ginger crush after add clear water and stir evenly into ginger juice, the mass ratio of ginger and clear water is 1:(5-10)；
(b) with after each Chinese medicine material 20-30h of the ginger juice immersion formula ratio of step (a), each Chinese medicine material is placed in and steams container
It is interior, Steam by water bath 2-6h, then dry, and repeat to steam and shine repeatedly；
(c) it is 80-200 mesh that each Chinese medicine material after being dried in step (b), which crushes, mixes packaging, obtain medical treatment cervical spondylopathy
Chinese medicine composition.
10. the Chinese medicine composition of the treatment cervical spondylopathy described in claim any one of 1-4 is in the medicine for preparing treatment cervical spondylopathy
Application.
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Application publication date: 20171117 |