CN110101804A - A kind of epilepsy drugs combination of the extract containing cannabidiol and preparation method thereof - Google Patents
A kind of epilepsy drugs combination of the extract containing cannabidiol and preparation method thereof Download PDFInfo
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- CN110101804A CN110101804A CN201910460070.8A CN201910460070A CN110101804A CN 110101804 A CN110101804 A CN 110101804A CN 201910460070 A CN201910460070 A CN 201910460070A CN 110101804 A CN110101804 A CN 110101804A
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Abstract
A kind of epilepsy drugs combination of the extract containing cannabidiol and preparation method thereof, each component in combination formula, it according to the weight ratio include cannabidiol extract, Chinese medicine (ginseng, Rhizoma Gastrodiae, the larva of a silkworm with batrytis, uncaria, sheep epilepsy grass, mother-of-pearl, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Glycyrrhizae, peppermint, the leaf of bamboo, bulbus fritillariae cirrhosae；Arisaema cum bile, scorpio, cinnabar, walnut kernel and cucumber stem) and adhesive.Cannabidiol extract is added in the present invention, CBD can help to control the consumption of GABA neurotransmitter, inhibit brain excitement, to reduce epileptic attack, may also help in the curative effect for improving other antiepileptics；It is added to kinds of traditional Chinese medicines ingredient, from regulating qi-flowing for eliminating phlegm, Inflammation Zhijing gradually switchs to improve spleen kidney, based on tonifying heart and spleen, improves the vital organs of the human body of patient, fundamentally treats epilepsy, therapeutic effect is good, Small side effects；Particle is made in pharmaceutical composition, it is convenient to take, it is good to absorb.
Description
Technical field
The present invention relates to the epilepsy drugs of disease treatment field more particularly to a kind of extract containing cannabidiol combination and its
Preparation method.
Background technique
Epilepsy is " epilepsy " or " epilepsy " being commonly called as, and is the electric discharge of cerebral neuron paroxysmal abnormality, causes of short duration
A kind of chronic disease of cerebral disorder.It is shown according to Chinese cri dernier cri disease data, the overall illness rate of domestic epilepsy is
7.0 ‰, annual morbidity is that have the activity epilepsy illness rate of breaking-out in 28.8/10 ten thousand, 1 year be 4.6 ‰.Estimation is Chinese about accordingly
There is 9,000,000 or so epileptic, wherein 500~6,000,000 be movable Patients with Epilepsy, while newly increasing epileptic about every year
400000, have become the second largest common disease that neurology department is only second to headache in Chinese epilepsy.
Epilepsy therapy mostly uses Western medicine, and therapeutic effect is good, but side effect is big, spend it is higher, pure Chinese medicine treatment then curative effect compared with
Slowly, spend the time long.
To solve the above problems, proposing the epilepsy drugs combination and its preparation of a kind of extract containing cannabidiol in the application
Method.
Summary of the invention
(1) goal of the invention
To solve technical problem present in background technique, the present invention proposes a kind of epilepsy medicine of extract containing cannabidiol
Object combination and preparation method thereof, the present invention is added to cannabidiol extract, and CBD can help to control disappearing for GABA neurotransmitter
Consumption inhibits brain excitement, to reduce epileptic attack, may also help in the curative effect for improving other antiepileptics；It is added to
Kinds of traditional Chinese medicines ingredient, from regulating qi-flowing for eliminating phlegm, Inflammation Zhijing gradually switchs to improve spleen kidney, based on tonifying heart and spleen, to the five internal organs six of patient
Internal organs is improved, and fundamentally treats epilepsy, therapeutic effect is good, Small side effects.
(2) technical solution
To solve the above problems, combination is matched the present invention provides a kind of combination of the epilepsy drugs of extract containing cannabidiol
Each component in side includes cannabidiol extract, Chinese medicine and adhesive according to the weight ratio；Wherein cannabidiol extract is
0.02-0.05 parts；Chinese medicine includes 7-10 parts of ginseng, 7-10 parts of Rhizoma Gastrodiae, 10-13 parts of the larva of a silkworm with batrytis, 15-18 parts of uncaria, sheep epilepsy grass
17-20 parts, 10-13 parts of mother-of-pearl, 15-18 parts of Radix Angelicae Sinensis, 20-23 parts of Radix Paeoniae Alba, 8-11 parts of Rhizoma Chuanxiong, 6-9 parts of Radix Glycyrrhizae, peppermint 7-10
Part, 10-13 parts of the leaf of bamboo, 15-18 parts of bulbus fritillariae cirrhosae；10-13 parts of arisaema cum bile, 12-15 parts of scorpio, 15-18 parts of cinnabar, walnut kernel 10-
13 parts and cucumber stem 17-20 parts；Adhesive is 20-30 parts.
Preferably, adhesive be starch, it is Icing Sugar, lactose, dextrin, in any one in mannitol or a variety of.
Preferably, the purity of cannabidiol extract is 80%-90%.
Preferably, cannabidiol extract the preparation method comprises the following steps: first to the leaf of hemp and flower pre-process, handle
Mode includes cleaning, drying and smashes, and obtains hemp powder；Hemp powder is handled using supercritical carbon dioxide extraction method, is obtained
Obtain extract liquor；Extract liquor is handled using resin isolation technics, isolates cannabidiol primary extract；Using membrane filtration technique to hemp
Diphenol primary extract is filtered, and obtains cannabidiol extract.
Preferably, cannabidiol extract needs to disinfect before use；Sterilization method are as follows: by cannabidiol extract
Flow through UV sterilizer；Exposure dose is 200-220J/m2, irradiation time 60-100s.
It is combined by a kind of epilepsy drugs of above-mentioned extract containing cannabidiol, proposes a kind of extract containing cannabidiol
The preparation method of epilepsy drugs combination, method and step include:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is
30 DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
Preferably, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；Extracted
It stirs within every 20 minutes in journey primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is
50% traditional Chinese medicinal ointment.
Preferably, adhesive needs that suitable water dissolution is added before use.
Preferably, every packet drug granule weight is 5g.
Preferably, instructions of taking are as follows: take daily twice, each taking a packet, 30 days as one therapeutic course.
Above-mentioned technical proposal of the invention has following beneficial technical effect:
One, it is added to cannabidiol extract in the present invention, since the GABA neurotransmitter in human brain has calm effect
Fruit can inhibit the excitability of brain centres, and CBD can help to control the consumption of GABA neurotransmitter, inhibit brain emerging
It puts forth energy, to reduce epileptic attack, may also help in the curative effect for improving other antiepileptics；Furthermore CBD can help endogenous
Cannboid maintain one it is reasonable horizontal, allow patient body to feel good, be pleasant, but will not as THC habituation.
Two, it is added to kinds of traditional Chinese medicines ingredient in the present invention, from regulating qi-flowing for eliminating phlegm, Inflammation Zhijing gradually switchs to improve spleen kidney, mends
Based on heart-spleen boosting, the vital organs of the human body of patient are improved, fundamentally treat epilepsy, therapeutic effect is good, Small side effects.
Three, particle is made in pharmaceutical composition in the present invention, it is convenient to take, it is good to absorb.
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, With reference to embodiment, to this
Invention is further described.It should be understood that these descriptions are merely illustrative, and it is not intended to limit the scope of the invention.This
Outside, in the following description, descriptions of well-known structures and technologies are omitted, so as not to unnecessarily obscure the concept of the present invention.
Embodiment 1
A kind of epilepsy drugs of extract containing cannabidiol proposed by the present invention combines, each component in combination formula, according to
Weight proportion includes cannabidiol extract, Chinese medicine and adhesive；Wherein cannabidiol extract is 0.02 part；Chinese medicine packet
Include 7 parts of ginseng, 7 parts of Rhizoma Gastrodiae, 10 parts of the larva of a silkworm with batrytis, 15 parts of uncaria, sheep epilepsy careless 17 parts, 10 parts of mother-of-pearl, 15 parts of Radix Angelicae Sinensis, Radix Paeoniae Alba 20
Part, 8 parts of Rhizoma Chuanxiong, 6 parts of Radix Glycyrrhizae, 7 parts of peppermint, 10 parts of the leaf of bamboo, 15 parts of bulbus fritillariae cirrhosae；10 parts of arisaema cum bile, 12 parts of scorpio, 15 parts of cinnabar,
10 parts and 17 parts of cucumber stem of walnut kernel；Adhesive is 20 parts.
In an alternative embodiment, adhesive be starch, Icing Sugar, lactose, dextrin, in any one in mannitol or
It is a variety of.
In an alternative embodiment, the purity of cannabidiol extract is 80%-90%.
In an alternative embodiment, cannabidiol extract the preparation method comprises the following steps: first to the leaf of hemp and flower
It is pre-processed, processing mode includes cleaning, drying and smashes, and obtains hemp powder；Using supercritical carbon dioxide extraction method
Hemp powder is handled, extract liquor is obtained；Extract liquor is handled using resin isolation technics, isolates cannabidiol primary extract；Using
Membrane filtration technique is filtered cannabidiol primary extract, obtains cannabidiol extract.
In an alternative embodiment, cannabidiol extract needs to disinfect before use；Sterilization method are as follows: will
Cannabidiol extract flows through UV sterilizer；Exposure dose is 200-220J/m2, irradiation time 60-100s.
It is combined by a kind of epilepsy drugs of above-mentioned extract containing cannabidiol, proposes a kind of extract containing cannabidiol
The preparation method of epilepsy drugs combination, method and step include:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is
30 DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
In an alternative embodiment, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；Extracted
It stirs within every 20 minutes in journey primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is
50% traditional Chinese medicinal ointment.
In an alternative embodiment, adhesive needs that suitable water dissolution is added before use.
In an alternative embodiment, every packet drug granule weight is 5g.
Embodiment 2
A kind of epilepsy drugs of extract containing cannabidiol proposed by the present invention combines, each component in combination formula, according to
Weight proportion includes cannabidiol extract, Chinese medicine and adhesive；Wherein cannabidiol extract is 0.05 part；Chinese medicine packet
Include 10 parts of ginseng, 10 parts of Rhizoma Gastrodiae, 13 parts of the larva of a silkworm with batrytis, 18 parts of uncaria, sheep epilepsy careless 20 parts, 13 parts of mother-of-pearl, 18 parts of Radix Angelicae Sinensis, Radix Paeoniae Alba 23
Part, 11 parts of Rhizoma Chuanxiong, 9 parts of Radix Glycyrrhizae, 10 parts of peppermint, 13 parts of the leaf of bamboo, 18 parts of bulbus fritillariae cirrhosae；13 parts of arisaema cum bile, 15 parts of scorpio, cinnabar 18
Part, 13 parts of walnut kernel and 20 parts of cucumber stem；Adhesive is 30 parts.
In an alternative embodiment, adhesive be starch, Icing Sugar, lactose, dextrin, in any one in mannitol or
It is a variety of.
In an alternative embodiment, the purity of cannabidiol extract is 80%-90%.
In an alternative embodiment, cannabidiol extract the preparation method comprises the following steps: first to the leaf of hemp and flower
It is pre-processed, processing mode includes cleaning, drying and smashes, and obtains hemp powder；Using supercritical carbon dioxide extraction method
Hemp powder is handled, extract liquor is obtained；Extract liquor is handled using resin isolation technics, isolates cannabidiol primary extract；Using
Membrane filtration technique is filtered cannabidiol primary extract, obtains cannabidiol extract.
In an alternative embodiment, cannabidiol extract needs to disinfect before use；Sterilization method are as follows: will
Cannabidiol extract flows through UV sterilizer；Exposure dose is 200-220J/m2, irradiation time 60-100s.
It is combined by a kind of epilepsy drugs of above-mentioned extract containing cannabidiol, proposes a kind of extract containing cannabidiol
The preparation method of epilepsy drugs combination, method and step include:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is
30 DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
In an alternative embodiment, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；Extracted
It stirs within every 20 minutes in journey primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is
50% traditional Chinese medicinal ointment.
In an alternative embodiment, adhesive needs that suitable water dissolution is added before use.
In an alternative embodiment, every packet drug granule weight is 5g.
Embodiment 3
A kind of epilepsy drugs of extract containing cannabidiol proposed by the present invention combines, each component in combination formula, according to
Weight proportion includes cannabidiol extract, Chinese medicine and adhesive；Wherein cannabidiol extract is 0.03 part；Chinese medicine packet
Include 8 parts of ginseng, 8 parts of Rhizoma Gastrodiae, 11 parts of the larva of a silkworm with batrytis, 18 parts of uncaria, sheep epilepsy careless 19 parts, 10 parts of mother-of-pearl, 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Alba 23
Part, 8 parts of Rhizoma Chuanxiong, 7 parts of Radix Glycyrrhizae, 10 parts of peppermint, 11 parts of the leaf of bamboo, 15 parts of bulbus fritillariae cirrhosae；11 parts of arisaema cum bile, 15 parts of scorpio, 16 parts of cinnabar,
10 parts and 19 parts of cucumber stem of walnut kernel；Adhesive is 22 parts.
In an alternative embodiment, adhesive be starch, Icing Sugar, lactose, dextrin, in any one in mannitol or
It is a variety of.
In an alternative embodiment, the purity of cannabidiol extract is 80%-90%.
In an alternative embodiment, cannabidiol extract the preparation method comprises the following steps: first to the leaf of hemp and flower
It is pre-processed, processing mode includes cleaning, drying and smashes, and obtains hemp powder；Using supercritical carbon dioxide extraction method
Hemp powder is handled, extract liquor is obtained；Extract liquor is handled using resin isolation technics, isolates cannabidiol primary extract；Using
Membrane filtration technique is filtered cannabidiol primary extract, obtains cannabidiol extract.
In an alternative embodiment, cannabidiol extract needs to disinfect before use；Sterilization method are as follows: will
Cannabidiol extract flows through UV sterilizer；Exposure dose is 200-220J/m2, irradiation time 60-100s.
It is combined by a kind of epilepsy drugs of above-mentioned extract containing cannabidiol, proposes a kind of extract containing cannabidiol
The preparation method of epilepsy drugs combination, method and step include:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is
30 DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
In an alternative embodiment, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；Extracted
It stirs within every 20 minutes in journey primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is
50% traditional Chinese medicinal ointment.
In an alternative embodiment, adhesive needs that suitable water dissolution is added before use.
In an alternative embodiment, every packet drug granule weight is 5g.
Embodiment 4
A kind of epilepsy drugs of extract containing cannabidiol proposed by the present invention combines, each component in combination formula, according to
Weight proportion includes cannabidiol extract, Chinese medicine and adhesive；Wherein cannabidiol extract is 0.035 part；Chinese medicine
Including 8.5 parts of ginseng, 8.5 parts of Rhizoma Gastrodiae, 11.5 parts of the larva of a silkworm with batrytis, 16.5 parts of uncaria, 18.5 parts of sheep epilepsy grass, 11.5 parts of mother-of-pearl, when
Return 16.5 parts, 21.5 parts of Radix Paeoniae Alba, 9.5 parts of Rhizoma Chuanxiong, 7.5 parts of Radix Glycyrrhizae, 8.5 parts of peppermint, 11.5 parts of the leaf of bamboo, 16.5 parts of bulbus fritillariae cirrhosae；Gallbladder
11.5 parts of Southern Star, 13.5 parts of scorpio, 16.5 parts of cinnabar, 11.5 parts of walnut kernel and 18.5 parts of cucumber stem；Adhesive is 25 parts.
In an alternative embodiment, adhesive be starch, Icing Sugar, lactose, dextrin, in any one in mannitol or
It is a variety of.
In an alternative embodiment, the purity of cannabidiol extract is 80%-90%.
In an alternative embodiment, cannabidiol extract the preparation method comprises the following steps: first to the leaf of hemp and flower
It is pre-processed, processing mode includes cleaning, drying and smashes, and obtains hemp powder；Using supercritical carbon dioxide extraction method
Hemp powder is handled, extract liquor is obtained；Extract liquor is handled using resin isolation technics, isolates cannabidiol primary extract；Using
Membrane filtration technique is filtered cannabidiol primary extract, obtains cannabidiol extract.
In an alternative embodiment, cannabidiol extract needs to disinfect before use；Sterilization method are as follows: will
Cannabidiol extract flows through UV sterilizer；Exposure dose is 200-220J/m2, irradiation time 60-100s.
It is combined by a kind of epilepsy drugs of above-mentioned extract containing cannabidiol, proposes a kind of extract containing cannabidiol
The preparation method of epilepsy drugs combination, method and step include:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is
30 DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
In an alternative embodiment, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；Extracted
It stirs within every 20 minutes in journey primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is
50% traditional Chinese medicinal ointment.
In an alternative embodiment, adhesive needs that suitable water dissolution is added before use.
In an alternative embodiment, every packet drug granule weight is 5g.
A kind of epilepsy drugs of the extract containing cannabidiol proposed in the various embodiments described above combines, instructions of taking are as follows:
It takes daily twice, each taking a packet, 30 days as one therapeutic course.
It should be understood that above-mentioned specific embodiment of the invention is used only for exemplary illustration or explains of the invention
Principle, but not to limit the present invention.Therefore, that is done without departing from the spirit and scope of the present invention is any
Modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.In addition, appended claims purport of the present invention
Covering the whole variations fallen into attached claim scope and boundary or this range and the equivalent form on boundary and is repairing
Change example.
Claims (10)
1. a kind of epilepsy drugs of extract containing cannabidiol combines, which is characterized in that each component in combination formula, according to weight
Proportion includes cannabidiol extract, Chinese medicine and adhesive；
Wherein cannabidiol extract is 0.02-0.05 parts；
Chinese medicine include 7-10 parts of ginseng, 7-10 parts of Rhizoma Gastrodiae, 10-13 parts of the larva of a silkworm with batrytis, 15-18 parts of uncaria, 17-20 parts of sheep epilepsy grass,
10-13 parts of mother-of-pearl, 15-18 parts of Radix Angelicae Sinensis, 20-23 parts of Radix Paeoniae Alba, 8-11 parts of Rhizoma Chuanxiong, 6-9 parts of Radix Glycyrrhizae, 7-10 parts of peppermint, leaf of bamboo 10-
13 parts, 15-18 parts of bulbus fritillariae cirrhosae；10-13 parts of arisaema cum bile, 12-15 parts of scorpio, 15-18 parts of cinnabar, 10-13 parts of walnut kernel and cucumber
17-20 parts of rattan；
Adhesive is 20-30 parts.
2. a kind of epilepsy drugs of extract containing cannabidiol according to claim 1 combines, which is characterized in that adhesive
It is in any one in starch, Icing Sugar, lactose, dextrin, mannitol or a variety of.
3. a kind of epilepsy drugs of extract containing cannabidiol according to claim 1 combines, which is characterized in that hemp two
The purity of phenol extraction object is 80%-90%.
4. a kind of epilepsy drugs of extract containing cannabidiol according to claim 3 combines, which is characterized in that hemp two
Phenol extraction object the preparation method comprises the following steps: being pre-processed first to the leaf of hemp and flower, processing mode includes cleaning, dry and powder
Essence obtains hemp powder；Hemp powder is handled using supercritical carbon dioxide extraction method, obtains extract liquor；It is separated using resin
Technical treatment extract liquor isolates cannabidiol primary extract；Cannabidiol primary extract is filtered using membrane filtration technique, is obtained
To cannabidiol extract.
5. a kind of epilepsy drugs of extract containing cannabidiol according to claim 1 combines, which is characterized in that hemp two
Phenol extraction object needs to disinfect before use；Sterilization method are as follows: cannabidiol extract is flowed through into disinfection by ultraviolet light and is set
It is standby；Exposure dose is 200-220J/m2, irradiation time 60-100s.
6. a kind of epilepsy drugs of extract containing cannabidiol according to claim 1 combines, which is characterized in that the drug
Combined preparation method includes:
S1, Chinese medicine is prepared；
S2, cannabidiol extract and adhesive are added into Chinese medicine, heating stirring handles 0.5-1h；Heating temperature is 30
DEG C -40 DEG C, mixing speed 80-100r/min obtains semi-finished product；
S3, semi-finished product are pressed into thick piece；
S4, by thick piece pulverization process, obtain drug granule；
S5, drug granule is dried under reduced pressure；Drying temperature is 20 DEG C -30 DEG C, and vacuum degree is set as 3-4kpa；
S6, packaging, storage preservation are sealed to drug granule.
7. the preparation method that a kind of epilepsy drugs of extract containing cannabidiol according to claim 6 combines, feature
Be, Chinese medicine the preparation method comprises the following steps:
A1, pulverization process is carried out to each taste Chinese medicine, and successively crosses the mesh screen of 100-120 mesh, obtain herb powder；
A2, according to the weight ratio, takes each taste herb powder, and the pure water of 2-3 times of volume is added into mixed-powder；
A3, the mixture in A2 is heated to boiling, then extracts 0.5-1h under conditions of 50 DEG C -60 DEG C；In leaching process
It stirs within every 20 minutes primary；
A4, leaching liquor is taken, using ultra centrifugation techniques and ultrafiltration impurity removing technology, leaching liquor is filtered for multiple times, obtains filtrate；
A5, concentration, vacuum degree 1.3-1.5kpa are carried out to filtrate, temperature is 35 DEG C -45 DEG C, and obtaining water content is 50%
Traditional Chinese medicinal ointment.
8. according to a kind of preparation method of the epilepsy drugs combination of the extract containing cannabidiol as claimed in claim 7, feature exists
In adhesive needs that suitable water dissolution is added before use.
9. a kind of epilepsy drugs of extract containing cannabidiol according to claim 1-8 combines, feature exists
In every packet drug granule weight is 5g.
10. a kind of epilepsy drugs of extract containing cannabidiol according to claim 9 combines, which is characterized in that take
Method are as follows: take daily twice, each taking a packet, 30 days as one therapeutic course.
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