CN110101089A - A kind of diet fiber composition with hypoglycemic and effect of weight reducing - Google Patents

A kind of diet fiber composition with hypoglycemic and effect of weight reducing Download PDF

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CN110101089A
CN110101089A CN201910312423.XA CN201910312423A CN110101089A CN 110101089 A CN110101089 A CN 110101089A CN 201910312423 A CN201910312423 A CN 201910312423A CN 110101089 A CN110101089 A CN 110101089A
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composition
weight
mouse
diet
fiber composition
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李超英
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Han Ji Biotechnology (wuhan) Co Ltd
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Han Ji Biotechnology (wuhan) Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733Fructosans, e.g. inulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of diet fiber composition, it is by following weight proportion at being grouped as: highland barley flour 30-83%, inulin 10-30%, konjaku flour 5-20%, odd Asia seed powder 2-20%.Animal test results show that the diet fiber composition has effects that weight-reducing and hypoglycemic, will not cause again after edible the excess weight of mouse reduce with it is faint.Human experiment the experimental results showed that, the present invention can be substantially reduced the BMI index of obese people, and after cutting out after half a year, and BMI index does not have a rebound phenomenon, therefore have preferable health-care effect.

Description

A kind of diet fiber composition with hypoglycemic and effect of weight reducing
Technical field
The invention belongs to field of health care food, and in particular to a kind of dietary fiber group with hypoglycemic and effect of weight reducing Close object.
Background technique
With the continuous improvement of Living consumption, metabolic disease such as hypertension, hyperglycemia (diabetes), hyperlipemia The disease incidence such as disease, high lithemia are higher and higher.Metabolic disease is mostly related with overnutrition, scientific investigations showed that, overnutrition draws The obesity and " four is high " symptom of hair are directly related.Therefore, excessive Nutrients Absorption is controlled or reduces gradually to be regarded as by people A kind of important health care mode.Low in calories, high satiety is a kind of diet mould for controlling excessive Nutrition intake for food and drink food Formula, wherein dietary fiber is due to that can provide high satiety while have both low in calories, moreover it is possible to beneficial work is played to beneficial bacteria of intestinal tract With the " the 7th be also therefore defined as by academia after protein, carbohydrate, fat, water, vitamin and mineral Kind nutrient ".Dietary fiber is the important component of various generation food and drink foods or health food on the market at present.
However, excessive intake dietary fiber might not be advantageous to human body, " Chinese residents dietary guidelines 2016 editions " is built View, the daily ingestion of dietary fiber of adult are advisable with 30g or so.Excessive intake dietary fiber, not only results in body pair The Replacement effect of absorption of nutrient ingredients reduces the control weight effect eaten for food and drink;Can also hinder body absorb carbohydrate, The microelements such as protein, fat and minerals, vitamin cause the shortage symptom of nutrient.Therefore, ensuring diet fibre On the basis of total intake of dimension, scientifically collocation is very crucial using dietary fiber.Have on the market largely about diet at present The report of fiber composition, but most of function of only focusing on Weight-reducing and lipid-lowering, and people should be matched by having ignored dietary fiber itself The absorbing structure of body nutrient, so as to cause following defect: (1) dosage of dietary fiber and collocation are unreasonable, stop after eating, Because the compensation of body is easy to the rebound for the physical signs such as weight body fat occur;(2) after long term consumer is edible due to The intake of the microelements such as carbohydrate, protein, fat and minerals, vitamin is affected, it may appear that physical strength, resistance Power decline, or even cause the diseases such as malnutrition.
Summary of the invention
The purpose of the present invention is aiming at the problem that most of dietary fibers on the market do not match human nutrition element absorbing structure, On the basis of receiving traditional medicine compatibility idea, in conjunction with the Advanced Idea of modern nutriology, experienced by zoopery and people The method of card provides a kind of more reasonable diet fiber composition type and its proportion of arranging in pairs or groups.The diet fiber composition is not It is only capable of providing satiety, while promoting the growth of intestine beneficial bacteria colony, and have and lose weight, alleviate hyperglycemia, hyperlipidemia, rouge The effect of fat liver and hypertension, high lithemia.Importantly, this diet fiber composition is eaten for a long time, weak nothing will not be caused Power;After stopping eats this diet fiber composition, the Diet lifestyle of health is maintained, indices in a long time will not Rebound.
Diet fiber composition provided by the invention is by following weight proportion at being grouped as: highland barley flour 50-83%, chrysanthemum Powder 10-30%, konjaku flour 5-20%, odd Asia seed powder 2-20%.
Preferably, the weight proportion of the ingredient is: highland barley flour 70%, inulin 13%, konjaku flour 9%, odd Asia seed powder 8%.
Highland barley is also known as naked barley, is a kind of cereal of grass tree section Hordeum, is more common in the plateaus such as China Qinghai, Tibet Band.Non-starch polysaccharide beta glucan rich in highland barley, current study show that, β-glucan is that one kind can be by human body The dietary fiber being absorbed and utilized has cleaning enteron aisle, adjusts blood glucose, reduces cholesterol and improve the big function of immunity four.
Inulin is the deposit polysaccharide in a kind of plant, typically from jerusalem artichoke, witloof stem tuber in.Inulin is a kind of excellent The soluble dietary fiber of matter, and can effectively be utilized by intestinal flora.Currently, inulin has become a kind of important bifid bar Bacterium proliferation factor.
Konjaku flour is in Araeceae konjaku platymiscium, konjaku glucomannan ingredient rich in, in water Sticky jelly can be formed, promotes the wriggling of enteron aisle and satiety is provided, meanwhile, konjaku flour can also provide battalion for intestinal flora It supports, promote the generation of probiotics and synthesizes the substance beneficial to human body.
Odd Asia seed is a kind of food of South America state Mexico area specialty, also known as chia kind.Since it is abundant Nutritive value and good mouthfeel, have become the new resource food in China.Odd Asia seed is rich in dietary fiber, eats after immersion Control caloric intake, the effect of relax bowel and defecation can be played.
Dietary fiber is generally classified according to dissolubility, and soluble dietary fiber and insoluble dietary fiber two are divided into Major class, most diet fiber compositions are to carry out formula design according to this classification method on the market at present, however, this It can not be accurately reflected in the feature of people's body absorption metabolism according to the classification method that the physical property of dietary fiber carries out. Dietary fiber is divided into three categories according to dietary fiber in the intracorporal digestion and absorption situation of people by the present invention again: (1) can be by people The dietary fiber that body is absorbed and utilized, the dietary fiber that (2) can be utilized by intestinal flora fermentation, (3) completely anti-digestibility and utilization Dietary fiber.
In order to more preferably match the characteristics of human nutrition element absorbs, in diet fiber composition provided by the invention, highland barley institute The beta glucan class dietary fiber of offer is the dietary fiber that can be utilized by human body slow-absorbing, and inulin and konjaku flour are can The dietary fiber utilized by intestinal flora fermentation, the dietary fiber that odd Asia seed provides are the dietary fiber of completely anti-digestibility and utilization, The weight ratio of three classes dietary fiber is 50-83:15-50:2-20.
Animal test results show: (1) diet fiber composition provided by the invention can reduce the weight of obesity mice, long The phase edible excess weight that will not cause mouse again reduces and faint.(2) diet fiber composition can also reduce mouse Fasting blood-glucose, TG, TC, the LDL-C reduced in serum is horizontal, and it is horizontal to increase HDL-C, reduces liver coefficient and the total gallbladder of liver is solid Alcohol content illustrates that the present invention also has the function of hypoglycemic and improves fatty liver.
Human experiment is the results showed that the present invention can be substantially reduced the BMI index of obese people, and cut out After half a year, BMI value does not have a rebound phenomenon, therefore has better health-care effect.BMI (personal body mass index) is mesh The preceding fat or thin degree of common measurement human body in the world and whether Jian Kang a standard.Studies have shown that fat and insulin supports Resist it is closely related, insulin resistance be cause 2 patients with type Ⅰ DM one of key factor, insulin resistance simultaneously and hyperlipidemia, height The metabolic diseases such as uric acid, hypertension have close association.
It is significantly, because current is most that the BMI index of obese people, which reduces in weight-reducing class health food, Added dietary fiber can not only make subject different degrees of physical strength occur, resist after long-term consumption in number diet products Power decline, while being also easy to rebound after stopping eating, BMI index is even likely to be more than using before diet products.This Diet fiber composition can be continual and steady mitigation and maintain body weight, to the hyperglycemia of human body, hyperlipidemia, fatty liver, The decline of the indexs such as hypertension and high lithemia can also have a significant effect.
Specific embodiment
The present invention is described in detail below by embodiment.
Embodiment 1
Highland barley flour, inulin, konjaku flour and Qi Ya seed powder are divided into three classes dietary fiber: the beta glucan being rich in highland barley flour It is that one kind can be by the dietary fiber (hereinafter referred to as 1 class dietary fiber) of human body slow-absorbing, inulin and konjaku flour are a kind of energy Enough dietary fibers (hereinafter referred to as 2 class dietary fibers) utilized by intestinal flora fermentation, the dietary fiber that odd Asia seed provides is energy The dietary fiber (hereinafter referred to as 3 class dietary fibers) of enough completely anti-digestibility and utilizations.According to this mode classification, eight groups of differences are designed The diet fiber composition of proportion is shown in Table in detail described in 1.
The tested diet fiber composition of table 1 matches (g)
Each crushing material is crossed into 60-100 mesh;Ultraviolet sterilization is carried out after mixing.According to " health food is examined and evaluation skill Art specification 2003 editions ", designing animal swimming with a load attached to the body experiment, verify after edible 1 month diet fiber composition to the weight of animals and The influence of swimming time.
120 males, 6 week old kunming mice is selected, is classified as 10 groups, every group 12.Experimental group uses MD12033 first High glucose and high fat feed (offer of Jiangsu Mei Disen biological medicine Co., Ltd) is fed 3 months, and the weight gain of each group mouse weight is measured Situation.Mouse of 105 weight more than Normal group weight 20% is wherein picked out altogether as model group mouse.Feed 3 After month, Normal group 10.4 ± 0.3g of weight gain, model group 20.1 ± 0.4g of weight gain, model group weight gain is Normal group 193%, have statistical significance (P < 0.05), according to the requirement in " health food examine with assessment technique specification 2003 editions ", Illustrate this obese model modeling success.
After modeling success, the diet fiber composition described in table 1, continuous gavage are raised 1 month respectively daily, stomach-filling (according to " Chinese residents dietary guidelines 2016 editions ", diet that adult daily intakes is fine for the human normal amount recommended for amount Dimension amount be 30g/d, adult human body weight by 60Kg calculate) convert 1 multiple dose (being equal to human body dosage).Normal group is used Chow diet is fed, and model control group uses always high glucose and high fat diet.Each group of every 10 days records after beginning stomach-filling The average weight (the results are shown in Table 2) of mouse carries out mouse forced swimming test according to classical method after stomach-filling 1 month.
Mice weights are first weighed before forced swim test, and 5% weight sheet lead of mouse tail load is placed in swimming trunk middle reaches Swimming, the depth of water are no less than 30cm, and 25 DEG C ± 1.0 DEG C of water temperature, record mouse swimming started to dead time, i.e. mice burden swimming Time (the results are shown in Table 3).
2 each group average mice body weight (g) of table
0 day 10 days 20 days 30 days
Composition 1 37.6±0.2 35.2±0.2 34.3±0.2 33.1±0.3
Composition 2 37.4±0.3 33.3±0.4 30.4±0.3 27.2±0.2
Composition 3 36.5±0.1 32.1±0.6 28.2±0.2 27.1±0.3
Composition 4 33.7±0.2 30.2±0.7 27.5±0.1 26.3±0.1
Composition 5 37.1±0.5 33.5±0.3 28.7±0.5 26.6±0.2
Composition 6 35.8±0.4 31.7±0.4 26.4±0.4 22.9±0.5*
Composition 7 34.2±0.2 30.2±0.1 24.5±0.1 22.2±0.3*
Composition 8 35.1±0.6 27.5±0.2 23.2±0.3 20.3±0.2*
Model comparison 37.8±0.2 38.4±0.3 38.8±0.2 39.5±0.1
Normal control 24.1±0.3 25.2±0.1 26.1±0.3 26.3±0.6
* there is statistical difference, P < 0.05 compared with normal control.Every group of n=10-11.
8 composition group mouse and model control group mouse are included in after high glucose and high fat diet 3 months (i.e. in table 2 0 day) it is that modeling is successfully small;Compared with model control group, all there is difference after 10 days in each group of stomach-filling dietary fiber The weight loss of degree.But compared with the mouse weight of Normal group, after stomach-filling dietary fiber 30 days, composition 6,7,8 The weight ratio Normal group mouse of three groups of mouse is lower, has statistical difference (P < 0.05), illustrates excessive 2 classes and 3 classes The excess weight that dietary fiber diet can cause mouse reduces and the data (being shown in Table 3) of mice burden swimming experiment combine It sees, excess weight reduction is unfavorable for mouse health.Contrast model control group weight, the mouse of composition 1 after continuous gavage 30 days Weight loss is unobvious (P > 0.05 does not have statistical difference), illustrates that very few 2 classes and 3 class dietary fibers cannot obviously drop Low mouse weight.2,3,4,5 four groups of mouse weight reducing effects of composition are preferable, both reduced weight (with model control group ratio Compared with, P < 0.05, there is statistical difference), but do not occur phenomenon that weight drops too low (compared with Normal group, P > 0.05, do not have statistical difference).
Influence of the different diet fiber compositions of table 3 to the mice burden swimming time
Group Swimming time (min)
Composition 1 5.5±0.5
Composition 2 4.9±0.4
Composition 3 5.4±0.5
Composition 4 5.1±0.4
Composition 5 5.0±0.4
Composition 6 3.7±0.3*
Composition 7 3.5±0.2*
Composition 8 2.1±0.2*
Model comparison 4.5±0.5
Normal control 5.2±0.4
* there is statistical difference, P < 0.05 compared with normal control.Every group of n=10-11.
It compares as can be seen from the above results with Normal group, the composition 1-5 group mice burden swimming time does not have Significant changes (P > 0.05 does not have statistical difference), illustrate that mouse ate this five groups of dietary fibers after 30 days, do not occur The phenomenon that weak and physically-draining.And the walking weight load of tri- groups of mouse of composition 6-8 occurs being substantially reduced (P < 0.05, there is statistical difference), illustrate that excessive 2,3 class dietary fiber accountings can not only be such that mouse weight excessively reduces, and And it can also cause the faint of mouse.
The experimental result of consolidated statement 2 and table 3: the mouse weight decline of edible composition 1 is unobvious, composition 6,7,8 For mouse because excess weight decline has caused faint phenomenon, the mouse of composition 2,3,4,5 can either be substantially reduced body Weight, and be not in faint phenomenon.Diet fiber composition provided by the invention: highland barley flour 70%, inulin 13%, evil spirit Taro powder 9%, odd Asia seed powder 8% (composition 3) can either be effectively reduced the weight of obesity mice, will not draw again after one month edible Rise mouse excess weight reduce and it is faint, have optimal Weight-reducing health effect.
Embodiment 2
Select 110 males, 6 week old kunming mice, 10 are normal control, are fed with chow diet, and 100 with high in fat High sugar feed is fed.It is injected intraperitoneally after 7d 2% streptozotocin (STZ), 0.1g/kg weight, restores diet after injecting 1h, build Vertical diabetes B model (the method is common diabetic mouse model).The fasting blood-glucose after fasting 5h is measured after modeling, It takes mouse of the fasting blood sugar higher than 16.7mol/L to be tested, shares 90 mouse and meet the requirements, select modeling successful 90 mouse add 10 Normal group mouse, are grouped as follows:
Diet fiber composition nursing group: totally 8 groups of diet fiber composition in table 1, every kind composition 10, totally 80;
Model control group: modeling successful subsequent continues feeding high lipid food, and 10;
Normal group: feeding chow diet always, 10.
During experiment, drinking-water is freely eaten in mouse.
1. fasting plasma glucose
It after every group of mouse is deprived of food but not water 12h, cuts caudal vein and takes blood, measure fasting blood-glucose, every 10d measurement with blood glucose meter Once, 30d is observed altogether, the results are shown in Table 4.
4 experiment mice of table is averaged fasting blood-glucose (mmol/L)
The fasting blood sugar of model control group is all larger than equal to 11.1mmol/L, illustrates Glycemia Decline success.And model Control is compared, and the mouse fasting blood-glucose for taking diet fiber composition decreased significantly.Wherein composition 2,3,4,5 after 30d Group mouse fasting blood-glucose decline situation is preferable.
2. serum lipid assay
It feeds mouse until the last day, mouse is deprived of food but not water 12h posterior orbit and takes blood, is then centrifuged for isolated supernatant Liquid, every group of sample measure total triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL- according to kit method C), the content (HDL-C) of high-density lipoprotein.
5 experiment mice items serum lipids index (mmol/L) of table
TG TC LDL-C HDL-C
Composition 1 2.26 3.43 0.64 2.32
Composition 2 2.13 3.06 0.51 2.89
Composition 3 1.95 3.05 0.54 2.91
Composition 4 2.02 3.05 0.53 2.92
Composition 5 2.03 3.04 0.56 2.82
Composition 6 2.21 3.24 0.64 2.42
Composition 7 2.12 3.33 0.62 2.41
Composition 8 2.15 3.11 0.55 2.78
Model comparison 2.62 3.51 0.68 2.29
Normal control 1.83 3.01 0.55 2.94
It is compared with Normal group, TG, TC, LDL-C of model control group are improved, and HDL-C decreases.And mould Type control is compared, and mouse TG, TC, the LDL-C for taking diet fiber composition have different degrees of reduction, and HDL-C is mentioned Height illustrates that diet fiber composition has the blood lipids index of diabetic mice different degrees of improvement.
5. liver coefficient and liver total cholesterol measure
After experiment, the liver of simultaneously separating mouse is dissected, is dried after being cleaned with physiological saline with filter paper, weighing calculates liver Dirty coefficient (liver coefficient=liver weight/mouse total weight).Each group of liver takes supernatant to carry out liver after homogenized Dirty total cholesterol level measurement.Liver coefficient reflects the content of liver fat indirectly;Total cholesterol of liver reflects in liver The formation of blood lipid health status and hyperlipidemia, atherosclerosis have relationship.
6 experiment mice of table is averaged liver coefficient and total cholesterol of liver
Liver coefficient (%) Total cholesterol of liver (mmol/L)
Composition 1 3.92 0.22
Composition 2 3.62 0.17
Composition 3 3.59 0.15
Composition 4 3.54 0.12
Composition 5 3.65 0.14
Composition 6 3.77 0.16
Composition 7 3.72 0.15
Composition 8 3.76 0.21
Model comparison 4.43 0.25
Normal control 3.53 0.09
It is compared with Normal group, the average liver coefficient of model control group is higher with total cholesterol of liver, illustrates mould Type control group mice hepatic fat content is higher;It is compared with model comparison, the mouse for taking diet fiber composition is averaged liver Coefficient and total cholesterol of liver have different degrees of reduction, illustrate that liver fat amount decreases, hyperlipidaemic conditions are changed It is kind.
Consolidated statement 4, table 5, the content of table 6, composition 1 is to the fasting blood-glucose of mouse, serum lipids, liver coefficient and liver Total cholesterol improves less obvious;Although composition 6,7,8 also can blood lipid to mouse, liver index have improvement, tie Embodiment 1 is closed, the mouse of composition 6,7,8 is because excess weight decline has caused faint phenomenon.Composition 2,3,4,5 Mouse both improved blood glucose, blood lipid and liver index, and be again not in faint while being substantially reduced weight The phenomenon that.In conclusion diet fiber composition provided by the invention can either improve blood glucose, blood lipid and liver index, it is long Phase is edible and mouse will not be made faint situation occur while weight significantly reduces, and has better Weight-reducing health effect Fruit.
Embodiment 3
The present embodiment investigates diet fiber composition of the present invention to personal body mass index (BMI) by human experiment experiment Influence, and then reflect diet fiber composition to the hyperlipidemia of volunteer, hyperglycemia, hypertension, high lithemia and fatty liver Etc. indexs decline whether have the effect of it is certain.
It is fat (BMI > 28) 40 (each 20 of men and women) to choose weight, age bracket is 30-55 years old, the every Tiangeng of these volunteers According to itself age, height, weight, daily activity, set according to the heat Calculation formula in " Chinese residents dietary guidelines 2016 " Count recommending recipes, thermal range 2100-2700kcal/d.It is designed in recipe and takes a packet (20g) dietary fiber composition every night Object (composition 3 in table 1: highland barley flour 70%, inulin 13%, konjaku flour 9%, odd Asia seed powder 8%), and deducted in master menu The corresponding heat of diet fiber composition.It is taken after diet fiber composition is stirred evenly with 200-300mL warm water.Continuously take half Year, the every two moon records volunteer's weight, and monthly follow-up records subjectivity sense of the volunteer to own bodies situation By.After cutting out diet fiber composition, continue follow-up volunteer half a year, volunteer keeps above-mentioned " Chinese residents during this Dietary guidelines 2016 " in recommend healthy diet, weight of two months records, observe BMI whether have rebound.Because it is personal because Element, this observation midway are total to depigmentation volunteer 4 (male 1, women 3), final observation number 36.
Influence of 7 diet fiber composition of table to BMI
The above human experiment the experimental results showed that, persistently take diet fiber composition within 6 months, aspiration can be obviously improved The BMI of the weight of person, volunteer is reduced to from fat level close to normal level.Cutting out diet fiber composition Weight is observed in half a year, in the case where volunteer keeps the healthy diet recommended in " Chinese residents dietary guidelines 2016 ", will The phenomenon that BMI value of hope person is not changed significantly, is not had a rebound.Since this diet fiber composition can be continual and steady Mitigation and maintain volunteer BMI, to indexs such as the hyperlipidemia of volunteer, hyperglycemia, hypertension, high lithemia and fatty livers Decline should also have certain effect.Meanwhile being recognized by follow-up and keeping good spirit in volunteer 12 months There is not the digestion and absorptions problem such as abdominal pain, flatulence, constipation in situation, also without occur in default of carbohydrate, fat, The faint equal malnutritive problem of protein and dimension minerals initiation.

Claims (2)

1. a kind of diet fiber composition with hypoglycemic and effect of weight reducing, it is characterised in that by following weight proportion at It is grouped as: highland barley flour 50-83%, inulin 10-30%, konjaku flour 5-20%, odd Asia seed powder 2-20%.
2. diet fiber composition as described in claim 1, it is characterised in that by following weight proportion at being grouped as: highland barley Powder 70%, inulin 13%, konjaku flour 9%, odd Asia seed powder 8%.
CN201910312423.XA 2019-04-18 2019-04-18 A kind of diet fiber composition with hypoglycemic and effect of weight reducing Pending CN110101089A (en)

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CN110801026A (en) * 2019-10-25 2020-02-18 运鸿集团股份有限公司 Dietary fiber compound nutrient with weight-losing and lipid-lowering effects and preparation method thereof
CN110810694A (en) * 2019-11-14 2020-02-21 王艳辉 Special blood sugar reducing solid beverage for diabetic patients and preparation and use methods thereof
CN112806512A (en) * 2020-08-21 2021-05-18 湖南汇富康达健康管理研究院(有限合伙) Dietary fiber solid beverage capable of relaxing bowels and preparation method thereof
CN115624565A (en) * 2022-11-10 2023-01-20 上海交通大学 Highland barley tender leaf water-extraction polysaccharide with weight-losing and lipid-lowering effects and application thereof

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CN106901367A (en) * 2017-03-14 2017-06-30 张勇 The composition and preparation method and purposes of a kind of balance blood sugar
CN108260811A (en) * 2016-12-30 2018-07-10 西藏天麦力健康品有限公司 It is a kind of that there is the health food and its processing method lost weight and improve function of intestinal canal

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CN108260811A (en) * 2016-12-30 2018-07-10 西藏天麦力健康品有限公司 It is a kind of that there is the health food and its processing method lost weight and improve function of intestinal canal
CN106901367A (en) * 2017-03-14 2017-06-30 张勇 The composition and preparation method and purposes of a kind of balance blood sugar

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110801026A (en) * 2019-10-25 2020-02-18 运鸿集团股份有限公司 Dietary fiber compound nutrient with weight-losing and lipid-lowering effects and preparation method thereof
CN110810694A (en) * 2019-11-14 2020-02-21 王艳辉 Special blood sugar reducing solid beverage for diabetic patients and preparation and use methods thereof
CN112806512A (en) * 2020-08-21 2021-05-18 湖南汇富康达健康管理研究院(有限合伙) Dietary fiber solid beverage capable of relaxing bowels and preparation method thereof
CN115624565A (en) * 2022-11-10 2023-01-20 上海交通大学 Highland barley tender leaf water-extraction polysaccharide with weight-losing and lipid-lowering effects and application thereof
CN115624565B (en) * 2022-11-10 2024-03-26 上海交通大学 Highland barley tender leaf water-extracted polysaccharide with weight-losing and lipid-lowering effects and application thereof

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Application publication date: 20190809