CN110075245A - A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy - Google Patents
A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy Download PDFInfo
- Publication number
- CN110075245A CN110075245A CN201910409802.0A CN201910409802A CN110075245A CN 110075245 A CN110075245 A CN 110075245A CN 201910409802 A CN201910409802 A CN 201910409802A CN 110075245 A CN110075245 A CN 110075245A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- water
- corydalis tuber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Animal Husbandry (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to processing technique of Chinese herbs fields, and in particular to a kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy.The Chinese medicine composition includes 20~40 parts of corydalis tuber, 12~19 parts of geranium wilfordii, 10~15 parts of Stephania epigaea, 3~9 parts of Maackia amurensis Rupr et Maxim plum, 1~10 part of water wax gourd root skin, 3~15 parts of adiantum cpilus-veneris, 7~21 parts of sargentodoxa cuneata, 1~8 part of trigone, 5~12 parts of curcuma zedoary, 1~9 part of ground bettle；Water extracts after by corydalis tuber vinegar system, and corydalis tuber medicinal extract is made, then after the fresh and alive ground bettle processing that will grow up, mixes with other raw materials and carry out water extraction, ground bettle medicinal extract is made；Corydalis tuber medicinal extract is uniformly mixed with ground bettle medicinal extract finally, is processed into tablet, electuary, capsule or injection；Finished product Chinese medicine composition is while eliminating and relieving pain, also will not influence patient, other feel normal, such as feel touching, the sense of hearing, vision, smell and physiology consciousness, it can also mitigate the emotional reactions such as the fear as caused by pain, anxiety, anxious, it is alternative or ban and various patient is allowed to generate the analgesics relied on.
Description
Technical field
The present invention relates to processing technique of Chinese herbs fields, and in particular to a kind of Chinese medicine composition with no addiction analgesic efficacy and
Preparation method.
Background technique
Antalgesic is to mainly act on central nervous system, selectively elimination and medicine for relieving pain.It is widely used in
As severe trauma, war wound, burn, surgical operation, it is pernicious it is swollen caused by severe pain caused by pain, myocardial infarction；Gastrointestinal tract and liver
Dull pain caused by gallbladder systemic disease, headache, toothache, arthralgia, bone or myalgia, dysmenorrhea, childbirth analgesic etc..
The antalgesic that countries in the world use at present has: morphine, codeine, meperidine, dihydroetorphine, fentanyl, U.S. are husky
Ketone, anadol, strong pain etc., this kind of antalgesic can make patient be easy to be resistant to and generate different degrees of floaty euphoria to pain.It is glad
Pleasant sensation can lure that patient thirsts for medication again into, and medication is so that at answering repeatedly.After habituation, once being discontinued, there is interruption disease in patient
Shape, show as have the fidgets, it is apathetic, shed tears, have a running nose, trembling, perspiring, vomitting, diarrhea, even collapse, aboulia
Deng.Drug addicts are the pain for pursuing the glad caused bring interruption symptom that is discontinued with escape of bring of the above drug, often
It often goes to obtain drug by fair means or foul, it is very harmful.Therefore, the antalgesic of these easy habituation, it is necessary to press " administration of narcotic drug item
Example " strict control control use.
Summary of the invention
To solve the above-mentioned problems, change existing antalgesic and be easy the status for allowing patient to eat medicine habituation, and reach help and suffer from
Person solves the purpose of pain, and researcher of the invention passes through the clinical research of many decades, successfully develops one kind with no addiction
Chinese medicine composition of analgesic efficacy and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition with no addiction analgesic efficacy, comprising:
20~40 parts of corydalis tuber, 12~19 parts of geranium wilfordii, 10~15 parts of Stephania epigaea, 3~9 parts of Maackia amurensis Rupr et Maxim plum, water wax gourd 1~10
Part, 3~15 parts of adiantum cpilus-veneris, 7~21 parts of sargentodoxa cuneata, 1~8 part of trigone, 5~12 parts of curcuma zedoary, 1~9 part of ground bettle.
Preferably, the Chinese medicine composition includes following raw material composition:
26~35 parts of corydalis tuber, 12~15 parts of geranium wilfordii, 13~15 parts of Stephania epigaea, 5~9 parts of Maackia amurensis Rupr et Maxim plum, 3~5 parts of water wax gourd,
7~12 parts of adiantum cpilus-veneris, 12~17 parts of sargentodoxa cuneata, 4~7 parts of trigone, 8~12 parts of curcuma zedoary, 3~7 parts of ground bettle.
Preferably, the Chinese medicine composition includes following raw material composition:
32 parts of corydalis tuber, 15 parts of geranium wilfordii, 15 parts of Stephania epigaea, 8 parts of Maackia amurensis Rupr et Maxim plum, 4 parts of water wax gourd, 9 parts of adiantum cpilus-veneris, sargentodoxa cuneata 17
Part, 6 parts of trigone, 10 parts of curcuma zedoary, 5 parts of ground bettle.
Preferably, the water wax gourd is substantially the combination of the above water wax gourd root of triennial, skin, or both.
Preferably, the group of the water wax gourd root and skin is combined into the combination of dry water wax gourd root skin, and portfolio ratio is 2:3~5.
Preferably, the ground bettle can also be mixed into the Chinese medicine composition after Cortex Eucommiae, kernel, radix bupleuri compatibility.
Preferably, the proportion compatibility of the ground bettle and Cortex Eucommiae, kernel, radix bupleuri, Radix Glycyrrhizae is 35:2:4:1:1.
A kind of preparation method of the Chinese medicine composition with no addiction analgesic efficacy, comprising the following steps:
A, fresh corydalis tuber is taken, is cleaned up, light-coloured vinegar mixed liquor is added and is mixed thoroughly to corydalis tuber, mixture is totally submerged, is placed in
3~5h is impregnated in closed container；25~30min of ultrasonic oscillation after immersion, then at 50~65 DEG C of temperature, pressure 1~
Hot 20~25min of reflow treatment, is filtered while hot under conditions of 10Pa, take corydalis tuber be placed in clear water eluriate 2~3 times after drain surface layer
Moisture, dry sealed storage are spare；
B, fresh and alive adult ground bettle is taken, cleans to be placed in boiling water and floats soup to complete death, pull out and drain away the water, and it is clean
Net river sand is puddled uniformly to be placed in 75~85 DEG C of frying pans and be fried to golden yellow, separates river sand, and selection by winnowing, which completely removes to be dried to after river sand, to be contained
Water≤7%, dry sealed storage are spare；
C, it takes spare corydalis tuber to be put into hot reflux extracting-concentration machine, the deionized water of 5~25 times of quality is added, carries out hot reflux
Water extracts, and it is spare to be condensed into corydalis tuber medicinal extract；
Simultaneously take in spare ground beetle, after crushing with geranium wilfordii, Stephania epigaea, Maackia amurensis Rupr et Maxim plum, water wax gourd, adiantum cpilus-veneris, sargentodoxa cuneata, three
Rib, curcuma zedoary are put into hot reflux extracting-concentration machine, puddle uniformly, the deionized water of 5~25 times of quality is added, carries out hot recirculation water
It extracts, it is spare to be condensed into ground beetle medicinal extract；
D, it takes the spare corydalis tuber medicinal extract in part and ground beetle medicinal extract to puddle uniformly, is crushed after drying, electuary, tablet or capsule is made
Agent；
Or the spare corydalis tuber medicinal extract in part and ground beetle medicinal extract is taken to puddle uniformly, 1~2 times of water for injection is added, after mixing again
It is heated to slightly boiled, keeps slightly boiled 20~25min, stop heating, stand 18~for 24 hours, filtrate is filtered to take, filtrate is through 325 mesh screens
It is centrifuged after filtering, upper layer centrifugate is taken to be prepared into injection.
Further, the mature vinegar and 53~60 degree of white wine that the light-coloured vinegar mixed liquor is 6.4~6.7 by pH value are by 9:1~2
Volume ratio is prepared.
Further, before the spare ground bettle is used for circumfluence distillation, period of storage need≤72h.
It is provided by the invention as follows with the application of no addiction analgesic Chinese medicine composition clinically:
One, the no addiction analgesia Chinese medicine composition can be used for various sharp pains, war wound, wound, burn, operation, advanced cancer
Caused severe pain, it is quick；With morphine, Sauteralgyl without obvious rejection, when patient uses morphine, Sauteralgyl invalid long
When, it uses the Chinese medicine composition instead and remains to generate good analgesic effect；
Two, the no addiction analgesia Chinese medicine composition can also be used in Chronic persistent dull pain, be suitable for intestines and stomach and liver and gallbladder system
Pain caused by disease of uniting, headache, toothache, arthralgia, courbature, ostalgia etc. after generality headache and cerebral concussion, to fetus with
It gives a birth without influence, thus it is ideal to point analgesic and cramp；
Three, the no addiction analgesia Chinese medicine composition can also be used in the dry dynamic uneasiness for releasing brain stupor early stage, enter its peace and quiet
Saliva can be used for intractable aypnia.
The beneficial effects of the present invention are:
1, compared with prior art, no addiction antalgesic provided by the invention is natural traditional Chinese medicine preparation, and each at present
The antalgesic that state uses is different, and while eliminating and relieving pain, also will not influence patient, other feel normal for it, such as feels
Touching, the sense of hearing, vision, smell etc. and physiology consciousness, moreover it is possible to it is anti-to mitigate the moods such as the fear as caused by pain, anxiety, anxious
Answer, it is alternative or ban it is various allow patient generate rely on analgesics, bring benefit to the mankind；
2, the product is pure Chinese herbal medicine preparation, proves that analgesic activity is unrelated with opiate receptor through many years clinic trial, without resistance to
By property, it is additive, have no toxic side effect, analgesia intensity is 45 times of morphine, and suddenly 8 times of society take orally and easily absorb, a few minutes hair
The effect of waving, blood drug concentration peaks after 1~2h, and about 4~6h can generate apparent analgesic activity, can make at patient
It in rest state, is easy to fall asleep, rather than can't fall asleep or depth lethargic sleep；
Specific embodiment
The present invention is further described in detail With reference to embodiment, but technical solution provided by the invention
It not only include the content showed in embodiment.
Embodiment 1
Present embodiments provide a kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy, the Chinese medicine group
Closing object includes following raw material component:
32 parts of corydalis tuber, 15 parts of geranium wilfordii, 15 parts of Stephania epigaea, 8 parts of Maackia amurensis Rupr et Maxim plum, 4 parts of water wax gourd, 9 parts of adiantum cpilus-veneris, sargentodoxa cuneata 17
Part, 6 parts of trigone, 10 parts of curcuma zedoary, 5 parts of ground bettle.
Wherein, the water wax gourd is substantially the combination of the above water wax gourd root of triennial, skin, or both, when selection water wax gourd root
The composition of skin is applied, and the group of the two is combined into the combination of dry water wax gourd root skin, portfolio ratio 2:5.
In the present embodiment, the Chinese medicine composition with no addiction analgesic efficacy the preparation method is as follows:
A, fresh corydalis tuber is taken, is cleaned up, light-coloured vinegar mixed liquor is added and is mixed thoroughly to corydalis tuber, mixture is totally submerged, is placed in
5h is impregnated in closed container；Ultrasonic oscillation 25min after immersion, ultrasonic frequency 25KHz；Then at 62 DEG C of temperature or so,
Under conditions of pressure 30Pa or so heat reflux closed processes 20min, filter while hot, take corydalis tuber be placed in clear water eluriate 3 times after drip
Dry surface moisture, dry sealed storage are spare；The mature vinegar and 60 degree of white wine that the light-coloured vinegar mixed liquor is 6.4 by pH value are by 9:1's
Volume ratio is prepared；
B, fresh and alive adult ground bettle is taken, cleans to be placed in boiling water and floats soup to complete death, pull out and drain away the water, and it is clean
Net river sand is puddled uniformly to be placed in 85 DEG C of frying pans and be fried to golden yellow, separates river sand, selection by winnowing is dried to water content after completely removing river sand
Less than or equal to 7%, dry sealed storage is spare, in order to guarantee the drug effect of ground bettle, for the storage before circumfluence distillation
Time is 52h；
C, it takes spare corydalis tuber to be put into hot reflux extracting-concentration machine, the deionized water of 15 times of quality is added, carry out hot recirculation water
It extracts, it is spare to be condensed into corydalis tuber medicinal extract；
Simultaneously take in spare ground beetle, after crushing with geranium wilfordii, Stephania epigaea, Maackia amurensis Rupr et Maxim plum, water wax gourd, adiantum cpilus-veneris, sargentodoxa cuneata, three
Rib, curcuma zedoary are put into hot reflux extracting-concentration machine, puddle uniformly, the deionized water of 15 times of quality is added, carries out hot recirculation water and mentions
It takes, it is spare to be condensed into ground beetle medicinal extract；
D, take spare corydalis tuber medicinal extract and ground beetle medicinal extract puddled uniformly, crushed after drying, in feeding tablet press machine tabletting at tablet,
Every 5g, vacuum packaging, dry stored protected from light；
Embodiment 2
Present embodiments provide a kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy, the Chinese medicine group
Closing object includes following raw material component:
35 parts of corydalis tuber, 12 parts of geranium wilfordii, 15 parts of Stephania epigaea, 5 parts of Maackia amurensis Rupr et Maxim plum, 5 parts of water wax gourd, 7 parts of adiantum cpilus-veneris, sargentodoxa cuneata 17
Part, 4 parts of trigone, 12 parts of curcuma zedoary, 3 parts of ground bettle；
Wherein, the water wax gourd is substantially the above old root of water wax gourd of triennial.
In the present embodiment, the Chinese medicine composition with no addiction analgesic efficacy the preparation method is as follows:
A, fresh corydalis tuber is taken, is cleaned up, light-coloured vinegar mixed liquor is added and is mixed thoroughly to corydalis tuber, mixture is totally submerged, is placed in
3h is impregnated in closed container；Ultrasonic oscillation 30min after immersion, ultrasonic frequency 30KHz are then at 65 DEG C of temperature or so, pressure
Hot reflow treatment 25min, is filtered while hot under conditions of power 1Pa or so, is taken corydalis tuber to be placed in clear water and is drained superficial water after elutriation time
Point, dry sealed storage is spare；Mature vinegar and 53 degree of white wine that the light-coloured vinegar mixed liquor is 6.7 by pH value press the volume ratio system of 9:2
It is standby to form；
B, fresh and alive adult ground bettle is taken, cleans to be placed in boiling water and floats soup to complete death, pull out and drain away the water, and it is clean
Net river sand is puddled uniformly to be placed in 75 DEG C of frying pans and be fried to golden yellow, separates river sand, selection by winnowing is dried to water content after completely removing river sand
It is 5%, dry sealed storage is spare, in order to guarantee the drug effect of ground bettle, is being for the period of storage before circumfluence distillation
36h；
C, it takes spare corydalis tuber to be put into hot reflux extracting-concentration machine, the deionized water of 5 times of quality is added, carry out hot recirculation water and mention
It takes, it is spare to be condensed into corydalis tuber medicinal extract；
Simultaneously take in spare ground beetle, after crushing with geranium wilfordii, Stephania epigaea, Maackia amurensis Rupr et Maxim plum, water wax gourd, adiantum cpilus-veneris, sargentodoxa cuneata, three
Rib, curcuma zedoary are put into hot reflux extracting-concentration machine, puddle uniformly, the deionized water of 25 times of quality is added, carries out hot recirculation water and mentions
It takes, it is spare to be condensed into ground beetle medicinal extract；
D, it takes spare corydalis tuber medicinal extract and ground beetle medicinal extract to puddle uniformly, is crushed after drying, be sent into pelletizer and graininess is made,
It is reprocessed into capsule；
Embodiment 3
Present embodiments provide a kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy, the Chinese medicine group
Closing object includes following raw material component:
20 parts of corydalis tuber, 19 parts of geranium wilfordii, 10 parts of Stephania epigaea, 9 parts of Maackia amurensis Rupr et Maxim plum, 1~part of water wax gourd, 15 parts of adiantum cpilus-veneris, big blood
7 parts of rattan, 1 part of trigone, 5 parts of curcuma zedoary, 1 part of ground bettle；
Wherein, the water wax gourd bark from old tress that the water wax gourd is 3 years raw or more.
In the present embodiment, the Chinese medicine composition with no addiction analgesic efficacy the preparation method is as follows:
A, fresh corydalis tuber is taken, is cleaned up, light-coloured vinegar mixed liquor is added and is mixed thoroughly to corydalis tuber, mixture is totally submerged, is placed in
4h is impregnated in closed container；Ultrasonic oscillation 30min after immersion, ultrasonic frequency 20KHz, then at temperature 50 C, pressure
Hot reflow treatment 25min, is filtered while hot under conditions of 8Pa or so, take corydalis tuber be placed in clear water eluriate 3 times after drain superficial water
Point, dry sealed storage is spare；Mature vinegar and 58 degree of white wine that the light-coloured vinegar mixed liquor is 6.5 by pH value press the volume ratio system of 9:1
It is standby to form；
B, fresh and alive adult ground bettle is taken, cleans to be placed in boiling water and floats soup to complete death, pull out and drain away the water, and it is clean
Net river sand is puddled uniformly to be placed in 80 DEG C of frying pans and be fried to golden yellow, separates river sand, selection by winnowing is dried to water content after completely removing river sand
It is 4%, dry sealed storage is spare, in order to guarantee the drug effect of ground bettle, is being for the period of storage before circumfluence distillation
18h；
C, it takes spare corydalis tuber to be put into hot reflux extracting-concentration machine, the deionized water of 8 times of quality is added, carry out hot recirculation water and mention
It takes, it is spare to be condensed into corydalis tuber medicinal extract；
Simultaneously take in spare ground beetle, after crushing with geranium wilfordii, Stephania epigaea, Maackia amurensis Rupr et Maxim plum, water wax gourd, adiantum cpilus-veneris, sargentodoxa cuneata, three
Rib, curcuma zedoary are put into hot reflux extracting-concentration machine, puddle uniformly, the deionized water of 18 times of quality is added, carries out hot recirculation water and mentions
It takes, it is spare to be condensed into ground beetle medicinal extract；
D, the spare corydalis tuber medicinal extract and ground beetle medicinal extract for taking 2/3 are puddled uniformly, crush after drying, electuary is made；
The spare corydalis tuber medicinal extract and ground beetle medicinal extract for taking residue 1/3 again are puddled uniformly, and 2 times of waters for injection are added, mix again
After be heated to slightly boiled, keep slightly boiled 25min, stop heating, stand for 24 hours, filter to take filtrate, filtrate is after 325 mesh net filtrations
Centrifugation, takes upper layer centrifugate to be prepared into injection.
The above described is only a preferred embodiment of the present invention, being not intended to limit the present invention in any form, appoint
What without departing from technical solution of the present invention content, according to the technical essence of the invention any modification to the above embodiments, etc.
With variation and modification, all of which are still within the scope of the technical scheme of the invention.
Clinical case
Case 1
Mr. Wang, female, 46 years old, people from Kweiyang treated 2 years in vain in tumour hospital because breast cancer causes chest to have an intense pain, in
Go to our hospital's clinical treatment on August 29th, 2012, daily Chinese medicine composition 3 times of the preparation of embodiment 1,4 tablets once, continuously
It fully recovers after taking 3 months, or else chest can have an intense pain.Eye track does not find undesirable condition so far.
Case 2
Chen, female, 28 years old, breast cancer caused double newborn swelling, and enlargement of lymph nodes is in great pain, and multiple hospitals treatment is invalid,
Analgesic can not all solve.In on September 12nd, 2012 to the just analgesic completely in two days of our hospital's clinical treatment, band medicine went home to take, often
Chinese medicine composition 3 times for taking the preparation of embodiment 2 day, 5 tablets each time, fully recover, so far without pain after two wheat harvesting periods, also multiple without the state of an illness
Hair.
Case 3
Liu, male, 36 years old, head caused by being heavily hit because of brain had an intense pain, in great pain in the morning, afternoon and evening, through multiple hospitals
Treatment is invalid, and takes " headache powder " for long periods of time, causes " headache powder " medication addicted.Receive to examine to our hospital at the beginning of 3 months 2016
Disconnected treatment, the Chinese medicine composition electuary prepared with embodiment 3 go home to take, 3 times a day, daily 20g, boiled water rush it is even after take,
It continuously takes 2 months occiput pain to be treated completely, does not feel again to have a headache, and break taking for " headache powder ".Tracking
The state of an illness so far, no bad phenomenon.
Case 4
Lee, male, 29 years old, because large area burn caused by burn surface area it is in great pain, take that other hospitals give only
After pain medicine, burn surface area pain, itch are still felt, especially want to grab sore place with hand；Or sore place is spread on other herb medicinal paste for external application
Afterwards, after pain obtains part improvement, but medicine for external application drug effect disappears, pain is more violent, and patient thirsts for being applied in burn site in real time
Drug.After its Chinese medicine composition tablet for taking the preparation of embodiment 1, feeling of pain is weakened significantly, and daily 3 times, every time 3
Piece, warm water are taken, and no longer feel pain substantially after continuously taking 75 days, will not thirst for obtaining controlling for other drugs again
It treats；After taking 3 months, state of an illness recovery from illness.Track the state of an illness so far, no bad phenomenon.
Case 5
The ten multidigit women such as Lee, Lyu, Zhang, Liu, because abdominal pain unbearably, tosss and turns caused by dysmenorrhea
Feel, takes after a variety of dysmenorrhea drugs that still gnawing pains take no rest.After taking Chinese medicinal composition capsules agent prepared with embodiment 3, feeling of pain is obtained
To significantly weak, taken in the morning and evening during dysmenorrhea, 3 tablets each time, warm water is taken, after taking the same day substantially will not again by
Abdominal pain sense, life are no different with ordinary times.
The clinical cure case for the Chinese medicine composition with no addiction analgesic efficacy that the present patent application provides further includes thousands of
Examples up to ten thousand, the above only particular therein.
In conclusion no addiction analgesia Chinese medicine composition provided by the invention can effective for various sharp pains, war wound, wound,
Severe pain caused by burn, operation, advanced cancer, it is quick；Apply also for pain caused by intestines and stomach and hepatobiliary system disease
Bitterly, headache, toothache, arthralgia, courbature, bone are bitterly etc., no tolerance, additive, nontoxic after general headache and cerebral concussion
Side effect.
Claims (10)
1. a kind of Chinese medicine composition with no addiction analgesic efficacy characterized by comprising
20~40 parts of corydalis tuber, 12~19 parts of geranium wilfordii, 10~15 parts of Stephania epigaea, 3~9 parts of Maackia amurensis Rupr et Maxim plum, 1~10 part of water wax gourd, pig
3~15 parts of hair on the neck grass, 7~21 parts of sargentodoxa cuneata, 1~8 part of trigone, 5~12 parts of curcuma zedoary, 1~9 part of ground bettle.
2. a kind of Chinese medicine composition with no addiction analgesic efficacy according to claim 1 characterized by comprising
26~35 parts of corydalis tuber, 12~15 parts of geranium wilfordii, 13~15 parts of Stephania epigaea, 5~9 parts of Maackia amurensis Rupr et Maxim plum, 3~5 parts of water wax gourd, bristles
Careless 7~12 parts, 12~17 parts of sargentodoxa cuneata, 4~7 parts of trigone, 8~12 parts of curcuma zedoary, 3~7 parts of ground bettle.
3. a kind of Chinese medicine composition with no addiction analgesic efficacy according to claim 1 characterized by comprising
32 parts of corydalis tuber, 15 parts of geranium wilfordii, 15 parts of Stephania epigaea, 8 parts of Maackia amurensis Rupr et Maxim plum, 4 parts of water wax gourd, 9 parts of adiantum cpilus-veneris, 17 parts of sargentodoxa cuneata,
6 parts of trigone, 10 parts of curcuma zedoary, 5 parts of ground bettle.
4. a kind of Chinese medicine composition with no addiction analgesic efficacy, feature described in any one exist according to claim 1~4
In the water wax gourd is substantially the combination of the above water wax gourd root of triennial, skin, or both.
5. a kind of Chinese medicine composition with no addiction analgesic efficacy according to claim 4, which is characterized in that the water winter
The group of melon root and skin is combined into the combination of dry water wax gourd root skin, and portfolio ratio is 2:3~5.
6. a kind of Chinese medicine composition with no addiction analgesic efficacy, feature described in any one exist according to claim 1~4
In, the ground bettle can also be mixed into the Chinese medicine composition after Cortex Eucommiae, kernel, radix bupleuri compatibility.
7. a kind of Chinese medicine composition with no addiction analgesic efficacy according to claim 6, which is characterized in that the ground beetle
The proportion compatibility of worm and Cortex Eucommiae, kernel, radix bupleuri, Radix Glycyrrhizae is 35:2:4:1:1.
8. a kind of preparation method of the Chinese medicine composition with no addiction analgesic efficacy, which comprises the following steps:
A, fresh corydalis tuber is taken, is cleaned up, light-coloured vinegar mixed liquor is added and is mixed thoroughly to corydalis tuber, mixture is totally submerged, is placed in closed
3~5h is impregnated in container；25~30min of ultrasonic oscillation after immersion, then at 50~65 DEG C of temperature, 1~10Pa of pressure
Under the conditions of hot 20~25min of reflow treatment, filter while hot, take corydalis tuber be placed in clear water eluriate 2~3 times after drain surface moisture,
Dry sealed storage is spare；
B, fresh and alive adult ground bettle is taken, cleans to be placed in boiling water and floats soup to complete death, pull out and drain away the water, with clean river
Sand is puddled uniformly to be placed in 75~85 DEG C of frying pans and be fried to golden yellow, separates river sand, selection by winnowing is dried to water content after completely removing river sand
≤ 7%, dry sealed storage is spare；
C, it takes spare corydalis tuber to be put into hot reflux extracting-concentration machine, the deionized water of 5~25 times of quality is added, carries out hot recirculation water and mentions
It takes, it is spare to be condensed into corydalis tuber medicinal extract；
Simultaneously take in spare ground beetle, after crushing with geranium wilfordii, Stephania epigaea, Maackia amurensis Rupr et Maxim plum, water wax gourd, adiantum cpilus-veneris, sargentodoxa cuneata, trigone,
Curcuma zedoary is put into hot reflux extracting-concentration machine, puddles uniformly, the deionized water of 5~25 times of quality is added, carries out hot recirculation water and mentions
It takes, it is spare to be condensed into ground beetle medicinal extract；
D, it takes the spare corydalis tuber medicinal extract in part and ground beetle medicinal extract to puddle uniformly, is crushed after drying, electuary, tablet or capsule is made；
Or the spare corydalis tuber medicinal extract in part and ground beetle medicinal extract is taken to puddle uniformly, 1~2 times of water for injection is added, is heated after mixing again
It is extremely slightly boiled, slightly boiled 20~25min is kept, stops heating, standing 18~for 24 hours, filtrate is filtered to take, filtrate is through 325 mesh net filtrations
After be centrifuged, take upper layer centrifugate to be prepared into injection.
9. a kind of preparation method of Chinese medicine composition with no addiction analgesic efficacy according to claim 8, feature exist
Prepare in the volume ratio that the mature vinegar that, the light-coloured vinegar mixed liquor is 6.4~6.7 by pH value presses 9:1~2 with 53~60 degree white wine and
At.
10. a kind of preparation method of Chinese medicine composition with no addiction analgesic efficacy according to claim 8, feature exist
In, before the spare ground bettle is used for circumfluence distillation, period of storage need≤72h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910409802.0A CN110075245A (en) | 2019-05-17 | 2019-05-17 | A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910409802.0A CN110075245A (en) | 2019-05-17 | 2019-05-17 | A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110075245A true CN110075245A (en) | 2019-08-02 |
Family
ID=67420614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910409802.0A Pending CN110075245A (en) | 2019-05-17 | 2019-05-17 | A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110075245A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480183A (en) * | 2003-07-04 | 2004-03-10 | 刘育才 | Prepared Chinese internal medicine for promoting blood circulation to stop pain |
| CN101785840A (en) * | 2009-01-22 | 2010-07-28 | 漳州片仔癀药业股份有限公司 | Medicine combination for traumatic injury and rheumatoid arthritis treatment |
| CN101822809A (en) * | 2009-09-26 | 2010-09-08 | 烟台大洋制药有限公司 | Pain-relieving and illness-eliminating granule and preparation method thereof |
-
2019
- 2019-05-17 CN CN201910409802.0A patent/CN110075245A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480183A (en) * | 2003-07-04 | 2004-03-10 | 刘育才 | Prepared Chinese internal medicine for promoting blood circulation to stop pain |
| CN101785840A (en) * | 2009-01-22 | 2010-07-28 | 漳州片仔癀药业股份有限公司 | Medicine combination for traumatic injury and rheumatoid arthritis treatment |
| CN101822809A (en) * | 2009-09-26 | 2010-09-08 | 烟台大洋制药有限公司 | Pain-relieving and illness-eliminating granule and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张祖芳: "止痛化症胶囊治疗子宫内膜异位症36例观察", 《时珍国医国药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1596914A (en) | Medicine for treating eye disease caused by visceral disease | |
| CN104288701A (en) | Traditional Chinese medicine composition for treating cholecystitis | |
| CN101912527A (en) | Medicinal preparation for curing wind chill blockage disease and preparation method thereof | |
| CN104274754A (en) | Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition | |
| CN105535127A (en) | Foot bath powder containing folium artemisiae argyi dregs and achieving sleep improvement function and preparation method thereof | |
| CN101601794B (en) | Traditional Chinese medicine preparation for reducing glucose and removing thirst | |
| CN110075245A (en) | A kind of Chinese medicine composition and preparation method thereof with no addiction analgesic efficacy | |
| CN109602832A (en) | A kind of Chinese medicine bathing antibacterial liquid/particle improving obstruction of the circulation of vital energy constitution and preparation and application method | |
| CN109674704A (en) | A kind of Chinese medicine bathing antibacterial liquid/particle improving damp-heat constitution and preparation and application method | |
| CN104524215B (en) | Treat capsule of stomach trouble and preparation method thereof | |
| CN103798472B (en) | A kind of health protection tea and health care's preparation | |
| CN104001057B (en) | For treating the heart schizoid medicine of kidney disorder type and preparation method thereof | |
| CN104013897B (en) | It is a kind of to treat Chinese medicine composition of dysmenorrhoea and preparation method thereof | |
| CN105535587A (en) | Traditional Chinese medicinal preparation for treating heart and kidney disharmony type palpitation and insomnia and preparation method of traditional Chinese medicinal preparation | |
| CN104027397B (en) | A kind of preparation method of integration of edible and medicinal herbs plant extract anti-sensitizer and application | |
| CN101406641B (en) | Compound medicament for treating vitiligo | |
| CN104784495A (en) | Traditional Chinese medicine preparation for treating infantile convulsion and preparation method | |
| CN103961627A (en) | Traditional Chinese medicine sober up paste with dendrobium officinale | |
| CN110787253A (en) | Formula and preparation method of traditional Chinese medicine hot compress medicine bag for relieving dysmenorrhea | |
| CN109646483A (en) | A kind of Chinese medicine bathing antibacterial liquid/particle improving blood stasis constitution and preparation and application method | |
| CN103768111B (en) | A kind of treat Chinese patent medicine that bee venom stings and preparation method thereof | |
| CN104068283B (en) | For preventing and treating the feed of sheep pox, Chinese medicine composition, preparation method and application | |
| CN101380388B (en) | Traditional Chinese medicine preparation for treating vascular headache | |
| CN106421113A (en) | Traditional Chinese medicinal composition for prevention and external treatment of insomnia and using method of traditional Chinese medicinal composition | |
| CN1216634C (en) | Medicinal composition for treating pain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190802 |
|
| RJ01 | Rejection of invention patent application after publication |