CN110075027A - A kind of sodium hyaluronate anti-acne moisturizing essence and preparation method thereof - Google Patents
A kind of sodium hyaluronate anti-acne moisturizing essence and preparation method thereof Download PDFInfo
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention discloses a kind of sodium hyaluronate anti-acne moisturizing essence and preparation method thereof.The sodium hyaluronate anti-acne moisturizing essence is made of the raw material of following percentages: sodium hyaluronate 5~15%, Rosa Damascana 1~6%, saualane 2~6%, fullerene nanoparticle 0.01~0.1%, moisturizer 10~25%, thickener 0.1~0.5%, grape pip extracting solution 0.1~0.5%, fiveleaf carpetweet herb extracting solution 0.1~0.5%, Radix Notoginseng extracting solution 0.1~0.5%, two split yeast tunning lysis object 0.2~0.8%, deionized water surplus.The Essence energy rapid osmotic flesh bottom has anti-inflammatory, sterilization, anti-acne, moisture-keeping function, has effects that peel off cutin, accelerated ageing corneocyte updates, to enable the skin to fully absorb functional component, so that the effect of functional component be made to give full play to.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of sodium hyaluronate anti-acne moisturizing essence and its preparation side
Method.
Background technique
Whelk, acne, dark sore are medically referred to as acne, are a kind of common sebaceous glands chronic diseases.Whelk
Generation is mostly caused by endocrine disorder, although conventional western medicines in treatment whelk can treat endocrine, generally medicine for oral administration,
Seldom external application, and treatment speed is slow, effect is general, can also develop drug resistance.Acne-eliminating cosmetic on the market is mostly chemical synthesis
Product, to skin spinosity, and effect is all unobvious, commonly there is poor permeability, is not easy the problems such as absorbing, anti-acne moistening effect is simultaneously
Inapparent status.
Summary of the invention
The purpose of the present invention is intended to provide a kind of sodium hyaluronate anti-acne moisturizing essence and preparation method thereof, to solve above-mentioned skill
Art problem.
To achieve the goals above, the technical solution of the present invention is as follows:
In a first aspect, a kind of sodium hyaluronate anti-acne moisturizing essence provided by the invention, by following percentages
Raw material is made: sodium hyaluronate 5~15%, Rosa Damascana 1~6%, saualane 2~6%, fullerene nanoparticle 0.01~0.1%,
Moisturizer 10~25%, thickener 0.1~0.5%, grape pip extracting solution 0.1~0.5%, fiveleaf carpetweet herb extracting solution 0.1~
0.5%, Radix Notoginseng extracting solution 0.1~0.5%, two splits yeast tunning lysis object 0.2~0.8%, deionized water surplus.
Preferably, the sodium hyaluronate is selected from one of oligomerization sodium hyaluronate, low molecule sodium hyaluronate, sub-Q or more
Kind, wherein the molecular weight of the oligomerization sodium hyaluronate is less than 10kDa, the molecular weight of the low molecule sodium hyaluronate be 10kDa~
The molecular weight of 1000kDa, the sub-Q are greater than 1000kDa.
It is further preferred that sodium hyaluronate choosing by weight ratio be 0.5~2:1~3:0.5~1 oligomerization sodium hyaluronate, it is low
Molecule sodium hyaluronate, sub-Q composition.
Preferably, the moisturizer is selected from glycerol, butanediol, 1,3~propylene glycol, polyglycereol~10, ethoxy urea, 1,2
~one or more of pentanediol and glycerol caprylate.
Preferably, the thickener is selected from xanthan gum.
Preferably, the sodium hyaluronate anti-acne moisturizing essence, is made: sodium hyaluronate of the raw material of following percentages
12%, Rosa Damascana 3%, saualane 4%, fullerene nanoparticle 0.05%, moisturizer 10%, thickener 0.3%, grape pip
Extracting solution 0.2%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng extracting solution 0.3%, two split yeast tunning lysis object 0.5%, go
Ion water surplus.
Preferably, the sodium hyaluronate anti-acne moisturizing essence, is made: sodium hyaluronate of the raw material of following percentages
10%, Rosa Damascana 5%, saualane 2.5%, fullerene nanoparticle 0.025%, moisturizer 6%, thickener 0.3%, grape
Seed extracting solution 0.3%, fiveleaf carpetweet herb extracting solution 0.3%, Radix Notoginseng extracting solution 0.3%, two split yeast tunning lysis object 0.6%,
Deionized water surplus.
Preferably, the sodium hyaluronate anti-acne moisturizing essence, is made: sodium hyaluronate of the raw material of following percentages
12%, Rosa Damascana 3.5%, saualane 5%, fullerene nanoparticle 0.06%, moisturizer 8%, thickener 0.2%, grape
Seed extracting solution 0.4%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng extracting solution 0.2%, two split yeast tunning lysis object 0.6%,
Deionized water surplus.
Second aspect, a kind of preparation side of sodium hyaluronate anti-acne moisturizing essence as described in relation to the first aspect provided by the invention
Method includes the following steps:
(1) moisturizer, thickener, grape pip extracting solution, fiveleaf carpetweet herb extracting solution, Radix Notoginseng extracting solution, two are split into yeast fermentation
Product lysis object and deionized water mixing, are heated with stirring to 70~80 DEG C, and 5~15min of insulated and stirred, obtain mixture A；
(2) fullerene nanoparticle is added in saualane, obtains suspension after sonicated, by rose under ultrasound
Rare essential oil is added drop-wise in suspension, continues 20~40min of ultrasonic treatment, obtains mixture B；
(3) mixture B is added in mixing A, after mixing evenly, obtains sodium hyaluronate anti-acne moisturizing essence.
Compared with prior art, the beneficial effects of the present invention are:
(1) sodium hyaluronate anti-acne moisturizing essence energy rapid osmotic flesh provided by the invention bottom, sodium hyaluronate and grape pip extract
Liquid, fiveleaf carpetweet herb extracting solution, Radix Notoginseng extracting solution synergistic effect, it is reasonably combined, anti-inflammatory, the sterilization, anti-acne of Essence can be effectively improved
Effect, improves itself moisturizing and water lock ability from flesh bottom, promotes to do caused by the proliferation and differentiation, reduction water shortage of epidermal cell
Line, microgroove, and can prevent and repair skin injury, restore gloss elasticity；
(2) present invention is by fullerene nanoparticle being dispersed in spiny dogfish alkane solvents, shape using saualane as solvent
At suspension, then Rosa Damascana is instilled, incorporates fullerene nanoparticle in Rosa Damascana, make fullerene nanoparticle in essence
It is uniformly dispersed in liquid, prevents nanoparticle aggregation, increase fullerene nanoparticle and enter the probability of keratoderma, to mention
High Essence removes the ability of free radical；
(3) of the invention two, which split yeast tunning lysis, can peel off cutin effect, and accelerated ageing corneocyte updates
It regenerates, to enable the skin to fully absorb other functional components, so that the effect of other functional components be made to give full play to.
Detailed description of the invention
Fig. 1 is the moisturizing effect picture of the Essence of each embodiment and comparative example.
Specific embodiment
Specific embodiments of the present invention will be further explained with reference to the accompanying drawing.It should be noted that for
The explanation of these embodiments is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, disclosed below
The each embodiment of the present invention involved in technical characteristic can be combined with each other as long as they do not conflict with each other.
Embodiment 1
A kind of preparation method of sodium hyaluronate anti-acne moisturizing essence provided in this embodiment, includes the following steps:
(1) raw material for weighing following percentages is made: sodium hyaluronate 12%, Rosa Damascana 3%, saualane 4%,
Fullerene nanoparticle 0.05%, glycerol 8%, butanediol 1%, 1,3~propylene glycol 1%, xanthan gum 0.3%, grape pip extract
Liquid 0.2%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng extracting solution 0.3%, two split yeast tunning lysis object 0.5%, deionization
Water surplus, wherein the sodium hyaluronate choosing is 0.5~2:1~3:0.5~1 oligomerization sodium hyaluronate, low molecule glass urine by weight ratio
Acid, sub-Q composition, the molecular weight of the oligomerization sodium hyaluronate are less than 10kDa, the molecular weight of the low molecule sodium hyaluronate
Molecular weight for 10kDa~1000kDa, the sub-Q is greater than 1000kDa；
(2) glycerol, butanediol, 1,3~propylene glycol, xanthan gum, grape pip extracting solution, fiveleaf carpetweet herb extracting solution, Radix Notoginseng are mentioned
It takes liquid, two to split yeast tunning lysis object and deionized water mixing, is heated with stirring to 75 ± 2 DEG C, and insulated and stirred 10min,
Obtain mixture A；
(3) fullerene nanoparticle is added in saualane, obtains suspension after sonicated, with 10 under ultrasound
Rosa Damascana is added drop-wise in suspension by drop/min drop speed, is continued to be ultrasonically treated 30min, is obtained mixture B；
(4) mixture B is added in mixing A, after mixing evenly, obtains sodium hyaluronate anti-acne moisturizing essence.
Embodiment 2
Sodium hyaluronate anti-acne moisturizing essence, the present embodiment is made using preparation method similar to Example 1 in the present embodiment
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by the present embodiment, by weight percentage, comprising:
Sodium hyaluronate 10%, Rosa Damascana 5%, saualane 2.5%, fullerene nanoparticle 0.025%, glycerol 2%, butanediol 2%, 1,
3~propylene glycol 2%, xanthan gum 0.3%, grape pip extracting solution 0.3%, fiveleaf carpetweet herb extracting solution 0.3%, Radix Notoginseng extracting solution 0.3%,
Two split yeast tunning lysis object 0.6%, deionized water surplus, wherein the sodium hyaluronate choosing is 0.5~2:1 by weight ratio
Oligomerization sodium hyaluronate, low molecule sodium hyaluronate, the sub-Q composition of~3:0.5~1, the molecular weight of the oligomerization sodium hyaluronate are small
It is 10kDa~1000kDa in the molecular weight of 10kDa, the low molecule sodium hyaluronate, the molecular weight of the sub-Q is greater than
1000kDa。
Embodiment 3
Sodium hyaluronate anti-acne moisturizing essence, the present embodiment is made using preparation method similar to Example 1 in the present embodiment
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by the present embodiment, by weight percentage, comprising:
Sodium hyaluronate 12%, Rosa Damascana 3.5%, saualane 5%, fullerene nanoparticle 0.06%, glycerol 5%, butanediol 1%, 1,3
~propylene glycol 2%, xanthan gum 0.2%, grape pip extracting solution 0.4%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng extracting solution 0.2%,
Two split yeast tunning lysis object 0.6%, deionized water surplus, wherein the sodium hyaluronate choosing is 0.5~2:1 by weight ratio
Oligomerization sodium hyaluronate, low molecule sodium hyaluronate, the sub-Q composition of~3:0.5~1, the molecular weight of the oligomerization sodium hyaluronate are small
It is 10kDa~1000kDa in the molecular weight of 10kDa, the low molecule sodium hyaluronate, the molecular weight of the sub-Q is greater than
1000kDa。
Embodiment 4
Sodium hyaluronate anti-acne moisturizing essence, the present embodiment is made using preparation method similar to Example 1 in the present embodiment
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by the present embodiment, by weight percentage, comprising:
Sodium hyaluronate 15%, Rosa Damascana 6%, saualane 6%, fullerene nanoparticle 0.1%, glycerol 6%, butanediol 2%, 1,3~
Propylene glycol 2%, xanthan gum 0.5%, grape pip extracting solution 0.5%, fiveleaf carpetweet herb extracting solution 0.5%, Radix Notoginseng extracting solution 0.5%, two
Split yeast tunning lysis object 0.2%, decoyl hydroximic acid 0.5%, deionized water surplus.
Embodiment 5
Sodium hyaluronate anti-acne moisturizing essence, the present embodiment is made using preparation method similar to Example 1 in the present embodiment
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by the present embodiment, by weight percentage, comprising:
Sodium hyaluronate 5%, Rosa Damascana 1%, saualane 2%, fullerene nanoparticle 0.01%, glycerol 15%, butanediol 5%, 1,3~
Propylene glycol 5%, xanthan gum 0.1%, grape pip extracting solution 0.1%, fiveleaf carpetweet herb extracting solution 0.1%, Radix Notoginseng extracting solution 0.1%, two
Split yeast tunning lysis object 0.8%, decoyl hydroximic acid 0.1%, deionized water surplus.
Comparative example 1
Sodium hyaluronate anti-acne moisturizing essence, this comparative example is made using preparation method similar to Example 1 in this comparative example
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by this comparative example, by weight percentage, comprising:
Sodium hyaluronate 12%, Rosa Damascana 3%, saualane 4%, fullerene nanoparticle 0.05%, glycerol 8%, butanediol 1%, 1,3~
Propylene glycol 1%, xanthan gum 0.3%, two split yeast tunning lysis object 0.5%, deionized water surplus.
Comparative example 2
Sodium hyaluronate anti-acne moisturizing essence, this comparative example is made using preparation method similar to Example 1 in this comparative example
It is only that the dosage of raw material is different from the difference of embodiment 1, raw material used by this comparative example, by weight percentage, comprising:
Sodium hyaluronate 12%, Rosa Damascana 3%, saualane 4%, fullerene nanoparticle 0.05%, glycerol 8%, butanediol 1%, 1,3~
Propylene glycol 1%, grape pip extracting solution 0.2%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng extracting solution 0.3%, is gone xanthan gum 0.3%
Ion water surplus.
Comparative example 3
Sodium hyaluronate anti-acne moisturizing essence, this comparative example is made using preparation method similar to Example 1 in this comparative example
Be only that step (3) are different from the difference of embodiment 1, (3) are specific as follows the step of this comparative example: by fullerene nanoparticle plus
Enter into saualane, obtain suspension after sonicated, hanging drop is added to by rose with 10 drops/min drop speed under ultrasound
In rare essential oil, continues to be ultrasonically treated 30min, obtain mixture B.
Effect example 1
Beneficial effect in order to further illustrate the present invention, the moisturizing to the Essence of Examples 1 to 5 and comparative example 1~3
Moisturizing effect is tested, and is randomly selected the volunteer that 90 ages are 20~50 years old, men and women each 45, is randomly divided into nine groups,
Respectively with the Essence of Examples 1 to 5 and comparative example 1~3.The testing procedure using step and moisturizing moisturizing effect of Essence
Specifically: after morning and evening face cleaning, left face smears the Essence of preparation of the embodiment of the present invention, and as test group, right face smears deionization
Water is as blank group, after continuing 2 axis, with the moisture of skin of moisture of skin tester test volunteer left face and right face same location
Content calculates skin moisture content increment rate, and calculation formula is as follows: skin moisture content increment rate=(test group moisture of skin
Content-blank group skin moisture content)/blank group skin moisture content × 100%, test result Fig. 1.
Effect example 2
20-45 years old age and without the trier of skin allergy history 400 is selected, is women, face there are apparent acne
And small pox is randomly divided into 8 groups as test crowd of the invention, tries out the embodiment of the present invention 1~5 and comparative example 1~3 respectively
Provided Essence, test method are as follows: after morning and evening face cleaning, according to the basic cosmetics nursing skin usually used, by essence
Liquid is used for after toner, before face cream, after continuous use 7 days, counts the feedback result of trier, concrete outcome is referring to table
1。
The using effect of 1 Essence of table counts
In conjunction with attached drawing, the embodiments of the present invention are described in detail above, but the present invention is not limited to described implementations
Mode.For a person skilled in the art, in the case where not departing from the principle of the invention and spirit, to these embodiments
A variety of change, modification, replacement and modification are carried out, are still fallen in protection scope of the present invention.
Claims (9)
1. a kind of sodium hyaluronate anti-acne moisturizing essence, which is characterized in that be made of the raw material of following percentages: glass urine
Acid 5~15%, Rosa Damascana 1~6%, saualane 2~6%, fullerene nanoparticle 0.01~0.1%, moisturizer 10~
25%, thickener 0.1~0.5%, grape pip extracting solution 0.1~0.5%, fiveleaf carpetweet herb extracting solution 0.1~0.5%, Radix Notoginseng are extracted
Liquid 0.1~0.5%, two splits yeast tunning lysis object 0.2~0.8%, deionized water surplus.
2. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the sodium hyaluronate is selected from oligomerization glass
One of uric acid, low molecule sodium hyaluronate, sub-Q are a variety of, wherein the molecular weight of the oligomerization sodium hyaluronate is less than
The molecular weight of 10kDa, the low molecule sodium hyaluronate are 10kDa~1000kDa, and the molecular weight of the sub-Q is greater than
1000kDa。
3. sodium hyaluronate anti-acne moisturizing essence according to claim 2, which is characterized in that the sodium hyaluronate is by weight ratio
The oligomerization of 0.5~2:1~3:0.5~1 sodium hyaluronate, low molecule sodium hyaluronate, sub-Q composition.
4. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the moisturizer be selected from glycerol,
One of butanediol, 1,3~propylene glycol, polyglycereol~10, ethoxy urea, 1,2~pentanediol and glycerol caprylate are more
Kind.
5. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the thickener is raw selected from the Chinese
Glue.
6. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the sodium hyaluronate anti-acne moisturizing essence
Magnificent liquid is made of the raw material of following percentages: sodium hyaluronate 12%, Rosa Damascana 3%, saualane 4%, fullerene are received
Rice corpuscles 0.05%, moisturizer 10%, thickener 0.3%, grape pip extracting solution 0.2%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng
Extracting solution 0.3%, two splits yeast tunning lysis object 0.5%, deionized water surplus.
7. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the sodium hyaluronate anti-acne moisturizing essence
Magnificent liquid is made of the raw material of following percentages: sodium hyaluronate 10%, Rosa Damascana 5%, saualane 2.5%, fullerene
Nanoparticle 0.025%, moisturizer 6%, thickener 0.3%, grape pip extracting solution 0.3%, fiveleaf carpetweet herb extracting solution 0.3%, three
Seven extracting solutions 0.3%, two split yeast tunning lysis object 0.6%, deionized water surplus.
8. sodium hyaluronate anti-acne moisturizing essence according to claim 1, which is characterized in that the sodium hyaluronate anti-acne moisturizing essence
Magnificent liquid is made of the raw material of following percentages: sodium hyaluronate 12%, Rosa Damascana 3.5%, saualane 5%, fullerene
Nanoparticle 0.06%, moisturizer 8%, thickener 0.2%, grape pip extracting solution 0.4%, fiveleaf carpetweet herb extracting solution 0.2%, Radix Notoginseng
Extracting solution 0.2%, two splits yeast tunning lysis object 0.6%, deionized water surplus.
9. a kind of preparation method of such as sodium hyaluronate anti-acne moisturizing essence according to any one of claims 1 to 8, including it is as follows
Step:
(1) moisturizer, thickener, grape pip extracting solution, fiveleaf carpetweet herb extracting solution, Radix Notoginseng extracting solution, two are split into yeast tunning
Lysis object and deionized water mixing, are heated with stirring to 70~80 DEG C, and 5~15min of insulated and stirred, obtain mixture A；
(2) fullerene nanoparticle is added in saualane, obtains suspension after sonicated, by rhodamine toner under ultrasound
Oil droplet is added in suspension, continues 20~40min of ultrasonic treatment, obtains mixture B；
(3) mixture B is added in mixing A, after mixing evenly, obtains sodium hyaluronate anti-acne moisturizing essence.
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| CN115068353A (en) * | 2022-05-06 | 2022-09-20 | 北京福纳康生物技术有限公司 | Fullerene composition, preparation method and application thereof |
| CN113925798B (en) * | 2021-11-16 | 2023-09-05 | 成都岚湖生物科技有限公司 | Hyaluronic acid acne-removing moisturizing essence preparation equipment and hyaluronic acid acne-removing moisturizing essence preparation method |
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2019
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294749A (en) * | 2020-11-12 | 2021-02-02 | 珂蓝(重庆)化妆品有限公司 | Composition for circularly moisturizing and oxygenating skin and application thereof |
| CN113925798B (en) * | 2021-11-16 | 2023-09-05 | 成都岚湖生物科技有限公司 | Hyaluronic acid acne-removing moisturizing essence preparation equipment and hyaluronic acid acne-removing moisturizing essence preparation method |
| CN115068353A (en) * | 2022-05-06 | 2022-09-20 | 北京福纳康生物技术有限公司 | Fullerene composition, preparation method and application thereof |
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