CN1100551C - Instant particles 'Xinnaotong' for treating heart and brain diseases - Google Patents
Instant particles 'Xinnaotong' for treating heart and brain diseases Download PDFInfo
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- CN1100551C CN1100551C CN00112475A CN00112475A CN1100551C CN 1100551 C CN1100551 C CN 1100551C CN 00112475 A CN00112475 A CN 00112475A CN 00112475 A CN00112475 A CN 00112475A CN 1100551 C CN1100551 C CN 1100551C
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Abstract
The present invention provides a ' Xinnaotong' granule which relates to a preparation of pure Chinese herbs and is especially suitable for treating and preventing cardiovascular and cerebrovascular diseases. The present invention is characterized in that the present invention is formed by preparing raw material such as astragalus roots of pure Chinese herbs, red peony roots or white peony roots, angelica, peach kernels, safflowers, earthworms, spatholobus stems, honeysuckle stems, leeches and hemlock parsley. The present invention has the raw material ingredients with the proportioning range of 15 to 35% of astragalus roots, 3.7 to 4.7% of red peony roots or white peony roots, 2.3 to 7.2% of angelica, 2.3 to 9.2% of peach kernels, 2.3 to 7.2% of safflowers, 6 to 14% of earthworms, 9 to 21% of spatholobus stems, 10 to 20% of honeysuckle stems, 2.3 to 7.2% of leeches and 3 to 8% of hemlock parsley by weight.
Description
Technical field
What a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease of the present invention related to is a kind of pure Chinese herbal and crude drugs preparations, is the medicine of treatment cardiovascular and cerebrovascular disease, is specially adapted to the treatment and the control of cardiovascular and cerebrovascular disease.
Background technology
At present, the optimal Therapeutic Method of cerebral infarction is a thrombolytic, conventional urokinase 50～3,000,000 units add normal saline or 5% glucose 250ml intravenous drip, can be owing to the time window of treatment only in 3～6 hours, and most of patient is at the appointed time with the interior thromboembolism treatment that do not obtain, the more important thing is thromboembolism treatment after the intracranial hemorrhage rate very high, should be as conventional therapy, so at present in conceptual phase, and traditional treatment by Chinese herbs is limited to the branch of middle internal organs apoplex involving the channels and collaterals.In view of now change medical science to the understanding of cerebral infarction from the pathomorphism graphical analysis, the influence of disposition aminoacid and free radical proves that fully traditional theory also has weak point.
Summary of the invention
The objective of the invention is provides a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease at above-mentioned weak point, have haemolysis blood stasis dispelling, tonifying QI to promote blood circulation, blood stasis dispelling blood, the meridian dredging, make blood capable unimpeded, passages through which vital energy circulates communicates, can blood vessel dilating, reduce blood viscosity and platelet aggregation, thrombus.
A kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease of the present invention takes following scheme to realize: a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease is that preparation of raw material forms by pure Chinese medicine astragalus, Radix Paeoniae Rubra or the Radix Paeoniae Alba, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Pheretima, Caulis Spatholobi, Caulis Lonicerae, Hirudo, Rhizoma Chuanxiong.
Material composition weight percent ratio range is:
The Radix Astragali 15～35%
The Radix Paeoniae Rubra or the Radix Paeoniae Alba 3.7～14.7%
Radix Angelicae Sinensis 2.3～7.2%
Semen Persicae 2.3～9.2%
Flos Carthami 2.3～7.2%
Pheretima 6～14%
Caulis Spatholobi 9～21%
Caulis Lonicerae 10～20%
Hirudo 2.3～7.2%
Rhizoma Chuanxiong 3～8%
Process for making:
1, take by weighing Hirudo, Pheretima by above proportioning and add that water is an amount of to decoct twice, 2～3 hours for the first time, decocted 1.5～2 hours for the second time, decocting liquid merges, the static liquid of crossing, inclining, it is standby to get supernatant concentration;
2, by above proportioning take by weighing the Chinese crude drug Radix Astragali, Radix Paeoniae Rubra or the Radix Paeoniae Alba, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Caulis Spatholobi, Caulis Lonicerae, Rhizoma Chuanxiong decocts with water 2～3 hours, decocted 1.5～2 hours for the second time, decocting liquid merges, the static liquid of crossing inclines and gets supernatant concentration, adds equivalent 95% ethanol, fully stir evenly, cold storage 24 hours filters and discards precipitate, filtrate recycling ethanol;
3, above-mentioned two liquid are merged, continue to be concentrated into the accent paste, add appropriate amount of auxiliary materials, adjuvant can adopt dextrin etc., makes soft material, makes granule or bulk, and dry packing promptly gets a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease.
The gas of Radix Astragali invigorating the heart and spleen in a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) composition of raw materials for the treatment of cardiovascular and cerebrovascular disease, the Radix Paeoniae Rubra or the Radix Paeoniae Alba, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami blood circulation and promoting silt, Pheretima, Hirudo removing blood stasis, Caulis Spatholobi, Caulis Lonicerae are enriched blood and are invigorated blood circulation, and there is the effect of blood circulation and promoting silt full side, the merit that benefiting QI and nourishing blood is arranged again, be suitable for the apoplexy card and belong to blood stagnancy due to deficiency of QI, card is seen hemiplegia, hemianesthesia, the mouth eye is nibbled tiltedly, speech is stuttering puckery, complexion white, shortness of breath and fatigue, the mouth sialorrhea, from sweating, cardiopalmus loose stool, brothers' swelling, the dark white and thin fur of light red tongue, the deep-thready pulse person.
Cerebral infarction (apoplexy) also belongs to network ens morbi category, nearly assumed name cures Zhang Xichun and has recognized that apoplexy takes place due to the meridians generation pathological changes of brains all: basis of its disease is the Liver and kidney imbalance of YIN and YANG, the dysfunction of the spleen, disease be designated as the wind-phlegm blood stasis, it is deficient that its morbidity mostly is internal injury, eating and drinking without temperance, factors such as disorder of emotion are relevant, and clinical manifestation has expectorant stasis of blood junction type, liver-Yang sthenia type, blood stagnancy due to deficiency of QI types etc. are dissimilar, but sick position is at brain, and basic pathogenesis is to stop in the blood stasis, blood stagnant in cerebral venation syndrome, gods are lost and are supported, and therefore blood stasis is through disease important pathological product all the time,, a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) of cardiovascular and cerebrovascular disease for the treatment of is with blood circulation promoting and blood stasis dispelling, tonifying QI to promote blood circulation is a fundamentum, so help blood capable with Radix Astragali QI invigorating, amount is energetically specially to scheme high benefit, Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Hirudo blood circulation promoting and blood stasis dispelling, with blood stasis dispelling blood, the meridian dredging works freely blood, and passages through which vital energy circulates communicates, the prescription uniqueness, with modern pharmacological research energy blood vessel dilating, reduce viscosity of blood and platelet aggregation, thrombolytic function matches.In the treatment of cardiovascular and cerebrovascular disease, take the course of its own.
The specific embodiment
Embodiment 1
1, takes by weighing raw material of Chinese medicine Radix Astragali 15kg (weight proportion 15%), Radix Paeoniae Rubra 14.7kg (weight proportion 14.7%), Radix Angelicae Sinensis 7.2kg (weight proportion 7.2%), Semen Persicae 9.2kg (weight proportion 9.2%), Flos Carthami 7.2kg (weight proportion 7.2%), Pheretima 14kg (weight proportion 14%), Caulis Spatholobi 17.4kg (weight proportion 17.4%), Caulis Lonicerae 10kg (weight proportion 10%), Hirudo 2.3kg (weight proportion 2.3%), Rhizoma Chuanxiong 3kg (weight proportion 3%) by proportioning.
2, get above-mentioned Hirudo by the proportioning weighing, Pheretima and add that water is an amount of to be decocted 2 hours, 1.5 hours for the second time, decocting liquid merged, the static liquid of crossing, and inclining, it is standby to get supernatant concentration;
3, getting the above-mentioned Chinese crude drug Radix Astragali, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Caulis Spatholobi, Caulis Lonicerae, Rhizoma Chuanxiong by the proportioning weighing decocts with water twice, decocted 2 hours for the first time, decocted 1.5 hours for the second time, decocting liquid merges, the static liquid of crossing, incline and get supernatant concentration, add equivalent 95% ethanol, fully stir evenly cold storage 24 hours, filtration discards precipitate, filtrate recycling ethanol;
3, above-mentioned two liquid are merged, continue to be concentrated into the thick paste shape, add an amount of dextrin, make soft material, make granule or bulk, dry packing promptly gets a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease.
Embodiment 2
1, takes by weighing raw material of Chinese medicine Radix Astragali 27kg (weight proportion 27%), Radix Paeoniae Alba 3.7kg (weight proportion 3.7%), Radix Angelicae Sinensis 2.3kg (weight proportion 2.3%), Semen Persicae 2.5kg (weight proportion 2.5%), Flos Carthami 2.3kg (weight proportion 2.3%), Pheretima 6kg (weight proportion 6%), Caulis Spatholobi 21kg (weight proportion 21%), Caulis Lonicerae 20kg (weight proportion 20%), Hirudo 7.2kg (weight proportion 7.2%), Rhizoma Chuanxiong 8kg (weight proportion 8%) by proportioning.
2, get above-mentioned Hirudo by the proportioning weighing, Pheretima and add that water is an amount of to be decocted 3 hours, 2 hours for the second time, decocting liquid merged, the static liquid of crossing, and inclining, it is standby to get supernatant concentration;
3, getting the above-mentioned Chinese crude drug Radix Astragali, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Caulis Spatholobi, Caulis Lonicerae, Rhizoma Chuanxiong by the proportioning weighing decocts with water twice, decocted 2.5 hours for the first time, decocted 2 hours for the second time, decocting liquid merges, the static liquid of crossing, incline and get supernatant concentration, add equivalent 95% ethanol, fully stir evenly cold storage 24 hours, filtration discards precipitate, filtrate recycling ethanol;
4, above-mentioned two liquid are merged, continue to be concentrated into the thick paste shape, add an amount of dextrin, make soft material, make granule or bulk, dry packing promptly gets a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease.
Embodiment 3
1, takes by weighing raw material of Chinese medicine Radix Astragali 35kg (weight proportion 35%), Radix Paeoniae Rubra 8kg (weight proportion 8%), Radix Angelicae Sinensis 4kg (weight proportion 4%), Semen Persicae 4kg (weight proportion 4%), Flos Carthami 3kg (weight proportion 3%), Pheretima 8kg (weight proportion 8%), Caulis Spatholobi 9kg (weight proportion 9%), Caulis Lonicerae 18kg (weight proportion 18%), Hirudo 5kg (weight proportion 5%), Rhizoma Chuanxiong 6kg (weight proportion 6%) by proportioning.
2, get above-mentioned Hirudo by the proportioning weighing, Pheretima and add that water is an amount of to be decocted 2 hours, 1.5 hours for the second time, decocting liquid merged, the static liquid of crossing, and inclining, it is standby to get supernatant concentration;
3, getting the above-mentioned Chinese crude drug Radix Astragali, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Caulis Spatholobi, Caulis Lonicerae, Rhizoma Chuanxiong by the proportioning weighing decocts with water twice, decocted 2 hours for the first time, decocted 1.5 hours for the second time, decocting liquid merges, the static liquid of crossing, incline and get supernatant concentration, add equivalent 95% ethanol, fully stir evenly cold storage 24 hours, filtration discards precipitate, filtrate recycling ethanol;
4, above-mentioned two liquid are merged, continue to be concentrated into the thick paste shape, add an amount of dextrin, make soft material, make granule or bulk, dry packing promptly gets a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease.
A kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) treatment cerebral infarction observation of curative effect for the treatment of cardiovascular and cerebrovascular disease
A kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease is a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease, have haemolysis blood stasis dispelling, tonifying QI to promote blood circulation, blood stasis dispelling blood, the meridian dredging, make blood capable unimpeded, passages through which vital energy circulates communicates, can blood vessel dilating, reduce blood viscosity and platelet aggregation, the function of thrombus, through clinic trial treatment cerebral infarction 150 routine patients, receive satisfied curative effect, situation is as follows:
1, clinical data
Case is selected:
Include standard in: Cerebral Infarction Patients one example that a variety of causes causes, its limb activity is malfunctioning, and head CT is unenhanced all sees the low-density kitchen range that reaches the position in various degree, can't take care of oneself.
Exclusion standard: the complication that causes after congenital disease and the operation.
Differential diagnosis in tcm: the hot stasis of blood junction type of expectorant (acute period of cerebral infarction), liver-Yang sthenia type (cerebral infarction subacute stage) blood stagnancy due to deficiency of QI type (cerebral infarction at restoration stage).
Observation of curative effect: 150 examples all hitch the patient of institute, are divided into two groups at random, treatment group instant particles ' Xinnaotong ' for treating heart and brain diseases oral liquid, matched group troxerutin.
Pharmaceutical formulation and specification: heart and brain lead to granule.
Usage: once a day, every day 150ml, sleep before half an hour take, 21 days is a course of treatment.
2, criterion of therapeutical effect:
Recovery from illness: limbs recover fully, can be engaged in physical work.
Produce effects: the limbs muscular strength recovers fully, can carry out light physical labor.
Effectively: the limbs Myodynamia recovery, it is unable to be engaged in the physical work sense.
Invalid: no change before and after the treatment.
3, therapeutic outcome sees Table.
The curative effect of treatment group and matched group
4. discuss: therapeutic outcome shows in this table, recovery from illness of treatment group and produce effects case, and apparently higher than matched group, invalid pathology is starkly lower than matched group, and it is evident in efficacy to illustrate that a kind of Chinese patent medicine (instant particles ' Xinnaotong ' for treating heart and brain diseases) for the treatment of cardiovascular and cerebrovascular disease of the present invention is treated cerebral infarction.
Claims (1)
1, a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that by the pure Chinese patent medicine Radix Astragali, Radix Paeoniae Rubra or the Radix Paeoniae Alba, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Pheretima, Caulis Spatholobi, Caulis Lonicerae, Hirudo, Rhizoma Chuanxiong being that preparation of raw material forms;
Material composition weight percent ratio range is:
The Radix Astragali 15～35%
The Radix Paeoniae Rubra or the Radix Paeoniae Alba 3.7～14.7%
Radix Angelicae Sinensis 2.3～7.2%
Semen Persicae 2.3～9.2%
Flos Carthami 2.3～7.2%
Pheretima 6～14%
Caulis Spatholobi 9～21%
Caulis Lonicerae 10～20%
Hirudo 2.3～7.2%
Rhizoma Chuanxiong 3～8%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00112475A CN1100551C (en) | 2000-08-23 | 2000-08-23 | Instant particles 'Xinnaotong' for treating heart and brain diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00112475A CN1100551C (en) | 2000-08-23 | 2000-08-23 | Instant particles 'Xinnaotong' for treating heart and brain diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1283485A CN1283485A (en) | 2001-02-14 |
| CN1100551C true CN1100551C (en) | 2003-02-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00112475A Expired - Fee Related CN1100551C (en) | 2000-08-23 | 2000-08-23 | Instant particles 'Xinnaotong' for treating heart and brain diseases |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298346C (en) * | 2003-04-18 | 2007-02-07 | 侯增光 | Dynamic medicine for channels and collaterals and blood vessel |
| CN1293900C (en) * | 2003-08-07 | 2007-01-10 | 南京中医药大学 | Medicine for treating cerebral infarction and preparation method |
| AU2007100239A4 (en) * | 2007-03-20 | 2007-05-03 | Andrew H. Kyriacou | Angelica: for correction of liver anomalies and reduction of blood pressure |
| CN101310737B (en) * | 2007-08-10 | 2011-08-31 | 赵玉英 | Medicine for treating ischemic stroke and its preparation method |
| CN102178758A (en) * | 2011-04-29 | 2011-09-14 | 薛红云 | Medicament for treating peripheral nerve of diabetes |
| CN104367737A (en) * | 2013-11-18 | 2015-02-25 | 王斯宣 | Traditional Chinese medicine composition for treatment of cardio cerebrovascular obstruction |
| CN104324135A (en) * | 2014-11-04 | 2015-02-04 | 湖南中医药大学 | Traditional Chinese medicine composition for treating ischemic stroke and preparation method and application of traditional Chinese medicine composition |
| CN105213969A (en) * | 2015-10-14 | 2016-01-06 | 许绍典 | A kind of Chinese medicine composition curing mainly apoplexy cerebral infarction |
| CN106563040A (en) * | 2016-10-30 | 2017-04-19 | 李昌铀 | Traditional Chinese medicine formula for treating facial paralysis caused by stroke |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081888A (en) * | 1993-01-01 | 1994-02-16 | 河南省中药研究所 | Treatment commonly encountered diseases of internal department, the apoplexy of frequently-occurring disease and the Chinese patent medicine tablet of sequela |
| CN1110153A (en) * | 1994-04-04 | 1995-10-18 | 赵步长 | Drug composition and medicated cap containing said drug composition for curing cerebrovascular disease and angiocardiopathy |
-
2000
- 2000-08-23 CN CN00112475A patent/CN1100551C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081888A (en) * | 1993-01-01 | 1994-02-16 | 河南省中药研究所 | Treatment commonly encountered diseases of internal department, the apoplexy of frequently-occurring disease and the Chinese patent medicine tablet of sequela |
| CN1110153A (en) * | 1994-04-04 | 1995-10-18 | 赵步长 | Drug composition and medicated cap containing said drug composition for curing cerebrovascular disease and angiocardiopathy |
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| CN1283485A (en) | 2001-02-14 |
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