CN110037053B - Efficient antibacterial liquid and preparation method thereof - Google Patents
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Abstract
The invention relates to a high-efficiency antibacterial liquid and a preparation method thereof, belonging to the technical field of antibiosis. The antibacterial liquid takes nano silver particles as an antibacterial active substance, and is matched with a modified alumina sol dispersion process to stabilize the chemical state and antibacterial activity of the silver particles, so that the use amount of silver is reduced to the greatest extent, the antibacterial activity of the silver particles is stabilized, and the antibacterial effect is sustained. The antibacterial liquid provided by the invention is simple in preparation and use method, free of irritation and toxicity to human bodies and strong in practicability, and can be coated on the surfaces of indoor facilities in various ways such as coating and spraying, so that a high-efficiency antibacterial effect is achieved. Test tests show that the antibacterial liquid provided by the invention can enable the antibacterial rate of a target base material to reach more than 90% in 30 days, and effectively reduce the infection risk in hospitals.
Description
Technical Field
The invention relates to a high-efficiency antibacterial liquid and a preparation method thereof, belonging to the technical field of antibiosis.
Background
Nosocomial infections are a global public health problem and are one of the major and difficult points of hospital administration. With the development of hospital modernization and the wide application of invasive diagnosis and treatment means, hormones, chemical methods, radiotherapy and antibiotics in medical measures, the incidence of infection in hospitals at home and abroad is obviously increased. Relevant reports show that in the united states, more than 200 million patients develop nosocomial infections each year, costing as much as $ 45 million for medical use. The occurrence of nosocomial infection not only can bring extra pain to patients, but also prolongs hospitalization time, increases the workload of medical care, and often causes the diseases suffered by the patients to fail to achieve the expected curative effect, even to cause death. Therefore, the prevention of nosocomial infection is particularly important, and the incidence rate is listed as one of indexes of the classification operation of hospitals in China. Hospital disinfection and sterilization are one of the important means for preventing and controlling hospital infection, preventing the spread of infectious diseases, maintaining medical quality and ensuring the safety of patients and medical care personnel.
The common disinfection and sterilization methods in hospitals at present comprise high temperature and high pressure, ultraviolet rays and antibacterial agent sterilization. The high temperature and high pressure method is only suitable for specific medical appliances and cannot be widely applied in the hospital environment; ultraviolet sterilization depends on an ultraviolet lamp, has limited irradiation range and higher energy consumption, and can also damage human cells, so the ultraviolet sterilization can only be applied in a specific closed environment; the sterilization of antibacterial agents is a method for in-hospital sterilization which is commonly applied at present, common antibacterial agents include peracetic acid, sodium hypochlorite, hydrogen peroxide and the like, but the antibacterial agents are extremely irritant and toxic to human bodies, and can bring certain damage to patients and medical care personnel when being widely used in hospitals, and the antibacterial agents are unstable in chemical structure, easy to decompose and incapable of lasting sterilization effect.
Silver, as a classical antimicrobial agent, has been widely used in ancient times. The silver ions can absorb sulfydryl on the protease in the bacterial body and quickly combine with the sulfydryl, so that the protease loses activity, and the bacteria die. After the bacteria are killed, silver ions are dissociated from the bacterial corpses and then contact with other bacterial colonies, and the sterilization process is carried out repeatedly. The silver ion has extremely high bactericidal capacity, and trace silver is harmless to human bodies, so that the silver ion is suitable for being used as an antibacterial disinfectant in hospitals. However, silver, as a noble metal, is too costly to use directly as an antimicrobial. Therefore, there is a need for a systematic development of silver antibacterial agents that can maintain their high antibacterial activity while reducing the amount used and maintain the antibacterial effect for the longest time.
Disclosure of Invention
The invention aims to provide a high-efficiency antibacterial liquid and a preparation method thereof, aiming at the defects of strong irritation, certain toxicity and short lasting effect of the existing antibacterial agent used in hospitals.
According to the technical scheme, the antibacterial liquid takes nano silver particles as an antibacterial active substance, and is matched with a modified aluminum sol dispersion process to stabilize the chemical state and antibacterial activity of the silver particles. The antibacterial liquid can be coated on the surfaces of various hospital internal facilities such as table boards, handrails, ventilation pipelines and the like in a smearing or spraying manner, and has a long-term antibacterial effect.
An efficient antibacterial liquid and a preparation method thereof, comprising the following steps:
(1) preparation of silver dispersion: dispersing a silver source in deionized water according to the mass content of 0.01-0.1% of silver, adding a pH regulator, regulating the pH of the system to 2-5, and stirring in a fume hood in a dark place for 6-12 hours to obtain a silver dispersion liquid;
(2) preparation of base dispersion: dispersing an aluminum source in deionized water according to the aluminum content of 1-5%, adding a pH regulator to regulate the pH of the system to 1-3, then placing the system in a water bath, and heating in a water bath at 50-80 ℃ for 3-6 h. Cooling the system to 20-30 ℃, adding a dispersing agent with the content of 0.1-0.5% relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 1-4 hours, wherein the ultrasonic frequency is 50-150 kHz, finally placing the system in a water bath kettle, and heating in a water bath at 70-90 ℃ for 4-8 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) in a dark environment at a rotating speed of 100-200 rpm by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at a dropping rate of 0.01-0.1 mL/s by using a peristaltic pump, controlling the final silver mass content of the system to be 0.01-0.1 per mill, and then continuously stirring for 2-4 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving a stabilizer in a mixed solution of deionized water and ethanol according to the mass fraction of 0.1-1% of the stabilizer to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 5-20%. And (3) placing the dispersion liquid prepared in the step (3) in a black light lamp environment, uniformly stirring at a rotating speed of 100-200 rpm, adding the stabilizer solution into the dispersion liquid at a dropping speed of 0.01-0.1 mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 1-5: 1. And after the dropwise addition is finished, continuously stirring for 4-8 hours to finish the preparation of the antibacterial liquid.
Further, the silver source in the step (1) is one or more of silver nitrate, silver oxide, silver acetate and silver carbonate; the pH regulator in the steps (1) and (2) is nitric acid, and the mass fraction of the nitric acid is 10-40%.
Further, the aluminum source in the step (2) is one or more of pseudo-boehmite, gibbsite and alumina; the dispersant is citric acid or tartaric acid.
Further, the stabilizing agent in the step (4) is one or more of glucose, maltose, xylose and mannose; the power of the black light lamp is 5-40W.
The invention has the beneficial effects that: the invention takes nano silver as an antibacterial active component, has high antibacterial performance and no irritation and harm to human bodies, reduces the consumption of silver to the maximum extent and plays a role in stabilizing the antibacterial activity of the silver particles by the high dispersion effect of the modified alumina sol on the silver particles, so that the antibacterial effect is sustained. Meanwhile, the antibacterial liquid provided by the invention is simple in preparation and use method and strong in practicability, can be coated on the surfaces of the facilities in the hospital in various ways such as coating and spraying, has a wide antibacterial effect, and reduces the infection risk in the hospital to the greatest extent.
Detailed Description
The present invention is described in detail below by way of examples, and it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention.
Example 1
A preparation method of high-efficiency antibacterial liquid comprises the following steps:
(1) preparation of silver dispersion: dispersing silver oxide into deionized water according to the mass content of silver of 0.01%, then adding 10% of nitric acid by mass fraction, controlling the pH of the system at 2.0, and stirring in a fume hood in a dark place for 6 hours to obtain silver dispersion liquid;
(2) preparation of base dispersion: dispersing boehmite in deionized water according to the aluminum content of 1%, adding 10% by mass of nitric acid to control the pH value of the system to be 3.0, then placing the system in a water bath kettle, and heating in a water bath at 50 ℃ for 3 h. Cooling the system to 20 ℃, adding citric acid with the content of 0.1 percent relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 1 hour, wherein the ultrasonic frequency is 50kHz, finally placing the system in a water bath kettle, and heating in a water bath at 70 ℃ for 4 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) in a dark environment at the rotating speed of 100rpm by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at the dropping speed of 0.01mL/s by using a peristaltic pump, controlling the final silver mass content of the system to be 0.01 per mill, and then continuously stirring for 2 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving xylose into a mixed solution of deionized water and ethanol according to the mass fraction of the xylose of 0.1 percent to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 5 percent. And (3) placing the dispersion liquid prepared in the step (3) in a 5W black light lamp environment, uniformly stirring at a rotating speed of 100rpm, adding the stabilizer solution into the dispersion liquid at a dropping speed of 0.01mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 1: 1. And after the dropwise addition is finished, stirring is continued for 4 hours to finish the preparation of the antibacterial liquid.
Example 2
A preparation method of high-efficiency antibacterial liquid comprises the following steps:
(1) preparation of silver dispersion: dispersing silver acetate in deionized water according to the mass content of silver of 0.03%, then adding nitric acid with the mass fraction of 40%, controlling the pH value of the system at 5.0, and stirring in a fume hood in a dark place for 12 hours to obtain a silver dispersion liquid;
(2) preparation of base dispersion: dispersing gibbsite in deionized water according to the aluminum content of 5%, adding nitric acid with the mass fraction of 40% to control the pH value of the system to be 1.0, then placing the system in a water bath kettle, and heating in a water bath at 80 ℃ for 6 h. Cooling the system to 30 ℃, adding tartaric acid with the content of 0.5 percent relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 4 hours, wherein the ultrasonic frequency is 150kHz, finally placing the system in a water bath kettle, and heating in a water bath at 90 ℃ for 8 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) in a light-proof environment at the rotating speed of 200rpm by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at the dropping speed of 0.1mL/s by using a peristaltic pump, controlling the final silver mass content of the system to be 0.03 per thousand, and then continuously stirring for 4 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving mannose into a mixed solution of deionized water and ethanol according to the mass fraction of 1% of mannose to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 20%. And (3) placing the dispersion liquid prepared in the step (3) in a 40W black light lamp environment, uniformly stirring at a rotating speed of 200rpm, adding the stabilizer solution into the dispersion liquid at a dropping speed of 0.1mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 5: 1. And after the dropwise addition is finished, stirring is continued for 8 hours to finish the preparation of the antibacterial liquid.
Example 3
A preparation method of high-efficiency antibacterial liquid comprises the following steps:
(1) preparation of silver dispersion: dispersing silver carbonate into deionized water according to the mass content of silver of 0.05%, then adding 20% of nitric acid by mass fraction, controlling the pH of the system at 3.0, and stirring in a fume hood in a dark place for 8 hours to obtain silver dispersion liquid;
(2) preparation of base dispersion: dispersing aluminum oxide in deionized water according to the aluminum content of 3%, adding 20% by mass of nitric acid to control the pH value of the system to be 2.0, then placing the system in a water bath, and heating in a water bath at 60 ℃ for 4 h. Cooling the system to 25 ℃, adding citric acid with the content of 0.3 percent relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 3 hours, wherein the ultrasonic frequency is 100kHz, finally placing the system in a water bath kettle, and heating in a water bath at 80 ℃ for 6 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) in a light-proof environment at the rotating speed of 150rpm by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at the dropping speed of 0.05mL/s by using a peristaltic pump, controlling the final mass content of silver in the system to be 0.05 per mill, and then continuously stirring for 3 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving maltose into a mixed solution of deionized water and ethanol according to the mass fraction of 0.5% of the maltose to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 10%. And (3) placing the dispersion liquid prepared in the step (3) in a 20W black light lamp environment, uniformly stirring at a rotating speed of 150rpm, adding the stabilizer solution into the dispersion liquid at a dropping speed of 0.05mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 2: 1. And after the dropwise addition is finished, stirring is continued for 6 hours to finish the preparation of the antibacterial liquid.
Example 4
A preparation method of high-efficiency antibacterial liquid comprises the following steps:
(1) preparation of silver dispersion: dispersing silver nitrate into deionized water according to the mass content of silver of 0.08%, then adding nitric acid with the mass fraction of 30%, controlling the pH of the system at 2.5, and stirring in a fume hood in a dark place for 10 hours to obtain a silver dispersion liquid;
(2) preparation of base dispersion: according to the aluminum content of 4%, the pseudoboehmite is dispersed in deionized water, the pH value of the system is controlled to be 2.5 by adding 10% of nitric acid by mass fraction, and then the system is placed in a water bath and heated in a water bath at 70 ℃ for 5 hours. Cooling the system to 25 ℃, adding tartaric acid with the content of 0.4 percent relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 2 hours, wherein the ultrasonic frequency is 120kHz, finally placing the system in a water bath, and heating in a water bath at 80 ℃ for 8 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) at a rotating speed of 160rpm in a light-proof environment by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at a dropping speed of 0.06mL/s by using a peristaltic pump, controlling the final silver mass content of the system to be 0.08 per mill, and then continuously stirring for 4 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving glucose into a mixed solution of deionized water and ethanol according to the mass fraction of the glucose of 0.8% to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 15%. And (3) placing the dispersion liquid prepared in the step (3) in a 30W black light lamp environment, uniformly stirring at the rotating speed of 160rpm, adding the stabilizer solution into the dispersion liquid at the dropping speed of 0.08mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 3: 1. And after the dropwise addition is finished, stirring is continued for 4 hours to finish the preparation of the antibacterial liquid.
Example 5
A preparation method of high-efficiency antibacterial liquid comprises the following steps:
(1) preparation of silver dispersion: dispersing silver nitrate into deionized water according to the mass content of silver of 0.1%, then adding nitric acid with the mass fraction of 20%, controlling the pH of the system at 2.0, and stirring in a fume hood in a dark place for 12 hours to obtain a silver dispersion liquid;
(2) preparation of base dispersion: the pseudo-boehmite is dispersed in deionized water according to the aluminum content of 3 percent, nitric acid with the mass fraction of 10 percent is added to control the pH value of the system to be 2.0, and then the system is placed in a water bath and heated in a water bath at the temperature of 80 ℃ for 6 hours. Cooling the system to 20 ℃, adding citric acid with the content of 0.4 percent relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 4 hours, wherein the ultrasonic frequency is 80kHz, finally placing the system in a water bath kettle, and heating in a water bath at 90 ℃ for 6 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) at a rotating speed of 150rpm in a light-proof environment by using a stirrer, then adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at a dropping speed of 0.02mL/s by using a peristaltic pump, controlling the final mass content of silver in the system to be 0.1 per mill, and then continuously stirring for 4 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving glucose into a mixed solution of deionized water and ethanol according to the mass fraction of 1% of the glucose to form a stabilizer solution, wherein the mass fraction of the ethanol in the mixed solution is 10%. And (3) placing the dispersion liquid prepared in the step (3) in a 30W black light lamp environment, uniformly stirring at a rotating speed of 140rpm, adding the stabilizer solution into the dispersion liquid at a dropping speed of 0.02mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to the silver in the dispersion liquid to be 3: 1. And after the dropwise addition is finished, stirring is continued for 4 hours to finish the preparation of the antibacterial liquid.
Application examples antimicrobial Performance test
The test selects fiber boards and stainless steel boards which are widely used in the table board and the pipeline in the hospital as the antibacterial base materials. The above test substrates were cut into 50 × 50mm sizes (thickness: about 5mm), and the antibacterial liquids prepared in examples 1 to 5 were uniformly applied to the above fiber boards and stainless steel boards, respectively, with the application amount of the antibacterial liquid on each board controlled to 25 ± 1 g.
After the antibacterial liquid coated on the board is naturally dried, the antibacterial performance test is carried out according to the national standard GB/T21510 'method for testing antibacterial performance of nano inorganic materials', and the strains for testing are Staphylococcus aureus (Staphylococcus aureus) and Escherichia coli (Escherichia coli).
In order to investigate the stability of the antibacterial system, the fiber plate and the stainless steel plate which are partially coated with the antibacterial liquid are naturally placed at room temperature for 7-30 days, and then an antibacterial performance test is carried out. The final antibacterial performance test results are shown in tables 1-4.
TABLE 1 results of the antibiotic property test of Staphylococcus aureus on fiberboard-expressed as antibiotic rate
| Days of storage/d | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| 0 | 95.1％ | 96.6％ | 98.5％ | 100％ | 100％ |
| 7 | 94.6％ | 96.2％ | 98.4％ | 99.7％ | 100％ |
| 14 | 94.5％ | 95.9％ | 98.2％ | 99.3％ | 99.8％ |
| 21 | 94.4％ | 95.8％ | 97.8％ | 99.2％ | 99.6％ |
| 30 | 94.0％ | 95.5％ | 97.5％ | 98.9％ | 99.1％ |
TABLE 2 antibacterial property test results of fiberboard E.coli expressed as antibacterial ratio
TABLE 3 test results of antibacterial property of Staphylococcus aureus of stainless steel plates, expressed as antibacterial rate
| Days of storage/d | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| 0 | 95.7％ | 97.0％ | 98.8％ | 99.9％ | 100％ |
| 7 | 95.6％ | 96.7％ | 98.3％ | 99.6％ | 100％ |
| 14 | 95.6％ | 96.6％ | 98.2％ | 99.5％ | 100％ |
| 21 | 95.2％ | 96.5％ | 98.2％ | 99.2％ | 99.8％ |
| 30 | 95.1％ | 96.5％ | 97.8％ | 99.0％ | 99.3％ |
TABLE 4 stainless steel plate results of the E.coli antibacterial property test, expressed as antibacterial ratio
| Days of storage/d | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| 0 | 96.4％ | 97.7％ | 99.0％ | 100％ | 100％ |
| 7 | 96.3％ | 97.6％ | 99.0％ | 99.9％ | 100％ |
| 14 | 96.3％ | 97.5％ | 98.3％ | 99.9％ | 100％ |
| 21 | 96.2％ | 97.5％ | 98.3％ | 99.2％ | 99.3％ |
| 30 | 96.1％ | 97.2％ | 98.2％ | 99.0％ | 98.8％ |
The results in the table show that the antibacterial liquid provided by the invention has high-efficiency antibacterial effect, and when the antibacterial liquid is applied to fiber boards and stainless steel plate base materials, the antibacterial rate of the antibacterial liquid within 30 days is more than 90%, so that the problem of nosocomial infection can be effectively solved.
Claims (8)
1. The preparation method of the high-efficiency antibacterial liquid is characterized by comprising the following steps: spraying the high-efficiency antibacterial liquid on a fiber board and a stainless steel plate substrate; the preparation steps are as follows:
(1) preparation of silver dispersion: dispersing a silver source in deionized water according to the mass content of 0.01-0.1% of silver, then adding a pH regulator, regulating the pH of the system to 2-5, and stirring for 6-12 h in a dark place to obtain a silver dispersion liquid;
(2) preparation of base dispersion: dispersing an aluminum source into deionized water according to the aluminum content of 1-5%, adding a pH regulator to regulate the pH of the system to 1-3, then placing the system into a water bath, and heating in a water bath at 50-80 ℃ for 3-6 h; cooling the system to 20-30 ℃, adding a dispersing agent with the content of 0.1-0.5% relative to the aluminum content, then placing the system in an ultrasonic environment for ultrasonic dispersion for 1-4 hours, wherein the ultrasonic frequency is 50-150 kHz, finally placing the system in a water bath kettle, and heating in a water bath at 70-90 ℃ for 4-8 hours to prepare a substrate dispersion liquid;
(3) and (3) system dispersion: uniformly stirring the substrate dispersion liquid prepared in the step (2) in a dark environment at a rotating speed of 100-200 rpm, adding the silver dispersion liquid prepared in the step (1) into the substrate dispersion liquid at a dropping speed of 0.01-0.1 mL/s, controlling the final mass content of silver in the system to be 0.01-0.1 per mill, and then continuously stirring for 2-4 hours to complete dispersion;
(4) the antibacterial system is stable: dissolving a stabilizer in a mixed solution of deionized water and ethanol according to the mass fraction of the stabilizer of 0.1-1% to form a stabilizer solution, wherein the mass fraction of ethanol in the mixed solution is 5-20%;
placing the dispersion liquid prepared in the step (3) in a black light lamp environment, uniformly stirring at a rotating speed of 100-200 rpm, adding a stabilizer solution into the dispersion liquid at a dropping speed of 0.01-0.1 mL/s through a peristaltic pump, and controlling the molar weight ratio of the stabilizer to silver in the dispersion liquid to be 1-5: 1; and after the dropwise addition is finished, continuously stirring for 4-8 hours to finish the preparation of the antibacterial liquid.
2. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the silver source in the step (1) is one or more of silver nitrate, silver oxide, silver acetate and silver carbonate.
3. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the pH regulator is a nitric acid solution with the mass fraction of 10% -40%.
4. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the aluminum source in the step (2) is one or more of pseudo-boehmite, gibbsite and alumina.
5. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the dispersant in the step (2) is citric acid or tartaric acid.
6. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the stabilizer in the step (4) is one or more of glucose, maltose, xylose and mannose.
7. The method for preparing highly efficient antibacterial liquid according to claim 1, wherein: the power of the black light lamp is 5-40W.
8. The high-efficiency antibacterial liquid prepared by the method of claim 1, which is characterized in that: nano silver particles are used as an antibacterial active substance, and a modified alumina sol dispersion process is matched to stabilize the chemical state and antibacterial activity of the silver particles.
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