CN110024776A - A kind of dedicated embryo's storage device of vitrifying freeze thawing - Google Patents
A kind of dedicated embryo's storage device of vitrifying freeze thawing Download PDFInfo
- Publication number
- CN110024776A CN110024776A CN201910408623.5A CN201910408623A CN110024776A CN 110024776 A CN110024776 A CN 110024776A CN 201910408623 A CN201910408623 A CN 201910408623A CN 110024776 A CN110024776 A CN 110024776A
- Authority
- CN
- China
- Prior art keywords
- freeze thawing
- liquid nitrogen
- bottom plate
- storage device
- tank body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
Abstract
The invention discloses a kind of dedicated embryo's storage devices of vitrifying freeze thawing, it is specifically a kind of to avoid contact of the liquid nitrogen with ambient atmosphere, the freeze thawing equipment leaked, the intracorporal liquid nitrogen of tank is extracted out by the pump housing, to realize the isolation of liquid nitrogen and ambient atmosphere, prevent to leak, overcome and input liquid nitrogen in the way of toppling in the prior art, there are problems that leakage.One upper side of bottom plate is fixedly installed with mounting plate, one upper side fixing sleeve hoop of mounting plate, the tank body being equipped with for storing liquid nitrogen is sat in cuff, the pump housing of the mounting plate other side installation for extracting the liquid nitrogen in tank body out, freeze thawing case is fixed on bottom plate, it is connected between freeze thawing case and tank body by conduit and the pump housing, and upper layer is provided with sealing plate inside freeze thawing case, sealing plate edge is fixed with sealing joint strip, sealing joint strip and freeze thawing chamber interior wall are interference fitted, and are provided on sealing plate multiple for placing the cavity of medical vessels.
Description
Technical field
The present invention relates to a kind of Medical Devices, specifically a kind of dedicated embryo's storage device of vitrifying freeze thawing.
Background technique
Vitrifying freeze-thaw technology is-kind of the method for being rapidly frozen cell or tissue, can avoid intracellular ice in frozen-thaw process
Brilliant formation, reduces cellular damage to greatest extent, mankind's gamete, embryo freezen protective in achieve many progress.Closely
For over ten years, vitrifying freeze-thaw technology has been successfully applied to each of mature oocyte, immature oocyte, sperm and embryo
The freezen protective of a developmental stage and the successively report of unsoundness baby due.The technical operation is simple, faster, just gradually
As one of application technology important in Issues of Human Assisted Reproductive Technologies.
However need to store human embryos during the freeze thawing of vitrifying at present, most important refrigerant is exactly liquid
Nitrogen, since liquid nitrogen temperature is extremely low, when use, needs significant care, but is required to manually be operated, and gives whole operation process
The certain danger of bring, secondly because the presence of liquid nitrogen makes that a large amount of fog can be generated in storage device, it is difficult to which resolution is deposited
Embryo's information of storage also gives the unnecessary trouble of medical personnel's bring.
Chinese patent discloses a kind of dedicated embryo's storage device of vitrifying freeze thawing, and application No. is 201420121119.X's
Device, but there are a fairly obvious drawbacks for the device, since liquid nitrogen being poured into cabinet by way of toppling over, such as
It is a the technical issues of being not easily overcome that, which avoids liquid nitrogen from contacting with ambient atmosphere, is necessarily brought greatly to medical staff's operation
It is required that using the danger that can also have leakage.
Summary of the invention
The purpose of the present invention is to provide a kind of dedicated embryo's storage devices of vitrifying freeze thawing, to solve above-mentioned background technique
The problem of middle proposition.
To achieve the above object, the invention provides the following technical scheme:
A kind of dedicated embryo's storage device of vitrifying freeze thawing including bottom plate, stores the tank body of liquid nitrogen and for placing vessel
Freeze thawing case;One upper side of bottom plate is fixedly installed with mounting plate, and one upper side fixing sleeve hoop of mounting plate, the interior seat of cuff, which is equipped with, to be used for
The tank body of liquid nitrogen is stored, the mounting plate other side is installed the pump housing for extracting the liquid nitrogen in tank body out, is fixed on bottom plate
Freeze thawing case is connected between freeze thawing case and tank body by conduit and the pump housing, and upper layer is provided with sealing plate, sealing plate inside freeze thawing case
Edge is fixed with sealing joint strip, and sealing joint strip and freeze thawing chamber interior wall are interference fitted, and is provided on sealing plate multiple for placing doctor
Treat the cavity of vessel.
As a further solution of the present invention: the sealing plate down either side is respectively and fixedly provided with telescopic rod, and telescopic rod lower part is close
The cylinder that is slidably connected is sealed, cylinder passes through freeze thawing bottom portion and bottom plate, and seals and fix with the two, and place position is connected with freeze thawing case in conduit
In the lower section of sealing plate.
As further scheme of the invention: two sides are fixed with bracket above the sealing plate, and pedestal upper end rotation connects
Idler wheel is connect, idler wheel upper end is bonded cover board, and cover board is articulated with freeze thawing box outer wall, and by multiple between cover board outer rim and freeze thawing box outer wall
The connection of position mechanism.
As further scheme of the invention: the bottom plate has been respectively arranged below directive wheel and traveling wheel, wherein leads
The lower part of wheel carrier is rotatably installed in wheel and traveling wheel, the wheel carrier upper end for being equipped with directive wheel is connect with bottom plate by bearing,
The wheel carrier upper end for being equipped with traveling wheel is fixedly connected with bottom plate.
As further scheme of the invention: the bottom plate upper side is fixed with push rod.
As further scheme of the invention: the resetting-mechanism includes sleeve, motion bar and spring, wherein activity
Bar top is hinged on cover board outer rim, and motion bar lower part is socketed in sleeve, and sleeve lower end is hinged on the outer wall of freeze thawing case, and sleeve
Spring is inside installed, the upper end of spring abuts the lower end of motion bar, and lower spring end abuts sleeve bottom, and spring is in compression always
State.
As the present invention further scheme: the cylinder be connected to air pump, air pump and the equal wire connecting power of the pump housing and
Controller.
As further scheme of the invention: the conduit is provided with close to tank body side for controlling liquid nitrogen flow
Stopcock.
As the present invention further scheme: have on the controller first switch of control pump housing work respectively and
Control the second switch of air pump work.
Compared with prior art, the beneficial effects of the present invention are: the device is extracted out the intracorporal liquid nitrogen of tank by the pump housing, from
And realize the isolation of liquid nitrogen and ambient atmosphere, prevent to leak, overcomes and input liquid in the way of toppling in the prior art
There is leakage in nitrogen, and the device does not need the tilt angle of adjustment tank body, operation is more when carrying out liquid nitrogen input
It is convenient, in addition, the lifting structure that the device is also provided with convenient for picking and placing, while also having the function of upper cover automatic open-close, it keeps the temperature
Better effect, freeze thawing speed is faster.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the dedicated embryo's storage device of vitrifying freeze thawing.
Fig. 2 is the enlarged drawing of resetting-mechanism in a kind of dedicated embryo's storage device of vitrifying freeze thawing.
Fig. 3 is the structural schematic diagram of resetting-mechanism in a kind of dedicated embryo's storage device of vitrifying freeze thawing.
In figure: 1- bottom plate;2- tank body;3- freeze thawing case;4- mounting plate;5- cuff;The 6- pump housing;7- stopcock;8- conduit;9- row
Walk wheel;10- directive wheel;11- sealing plate;12- sealing joint strip;13- cavity;14- cylinder;15- telescopic rod;16- bracket;17- rolling
Wheel;18- cover board;19- resetting-mechanism;20- push rod;191- sleeve;192- motion bar;193- spring.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Please refer to Fig. 1~3, in the embodiment of the present invention, a kind of dedicated embryo's storage device of vitrifying freeze thawing, including bottom plate 1,
Store the tank body 2 of liquid nitrogen and the freeze thawing case 3 for placing vessel;1 one upper side of bottom plate is fixedly installed with mounting plate 4, peace
4 one upper side fixing sleeve hoop 5 of loading board, cuff 5 is interior to sit the tank body 2 being equipped with for storing liquid nitrogen, and the installation of 4 other side of mounting plate is used
In by the pump housing 6 of the liquid nitrogen extraction in tank body 2, the stability of tank body 2 is improved by cuff 5, it will be in tank body 2 using the pump housing 6
Liquid nitrogen extraction, to realize the isolation of liquid nitrogen and ambient atmosphere, prevents to leak;It is fixed with freeze thawing case 3 on the bottom plate 1,
It is connected between freeze thawing case 3 and tank body 2 by conduit 8 and the pump housing 6, it should be noted that conduit 8 is provided with close to 2 side of tank body
For controlling the stopcock 7 of liquid nitrogen flow, and 3 inside upper layer of freeze thawing case is provided with sealing plate 11, and 11 edge of sealing plate is fixed with close
Seal strip 12, it should be noted that sealing joint strip 12 and 3 inner wall of freeze thawing case are interference fitted, and are provided with multiple use on sealing plate 11
In the cavity 13 for placing medical vessels, using 3 inner wall of sealing joint strip 12 and freeze thawing case of interference fit, so that freeze thawing case 3 is upper
Lower part is completely cut off by sealing plate 11, and sealing plate 11 can also slide simultaneously along 3 inner wall upper-lower seal of freeze thawing case, avoids being located at freeze thawing case 3
The liquid nitrogen of lower part is contacted with air, 6 wire connecting power of the pump housing and controller.
11 down either side of sealing plate is respectively and fixedly provided with telescopic rod 15, and 15 lower seal of telescopic rod is slidably connected cylinder 14,
Cylinder 14 passes through 3 bottom of freeze thawing case and bottom plate 1, and seals and fix with the two, it should be noted that conduit 7 and freeze thawing case 3 are connected
Place is located at the lower section of sealing plate 11, drives telescopic rod 15 is flexible to drive the up and down of sealing plate 11 by cylinder 14, from
And the cavity 13 for being placed with vessel is driven to move up and down, convenient for vessel are fetched from freeze thawing case 3;11 top two of sealing plate
Side is fixed with bracket 16, and 16 upper end of bracket is rotatablely connected idler wheel 17, and 17 upper end of idler wheel is bonded cover board 18, and cover board 18 is articulated with freeze thawing
3 outer wall of case, and connected between 3 outer wall of 18 outer rim of cover board and freeze thawing case by resetting-mechanism 19, when sealing plate 11 moves up driving device
Ware, which follows, to be moved up when carrying out pick-and-place vessel, and 18 rotating opening of cover board of two sides is driven using idler wheel 17, when sealing plate 11 moves down,
The cover board 18 of two sides is closed under the action of resetting-mechanism 19,3 top of freeze thawing case is kept the temperature, reduces by 3 top of freeze thawing case
With the Speed of diffusion of external environment;The cylinder 14 is connected to air pump, air pump wire connecting power and controller, further
Ground, on controller tool there are two control switch, respectively the control pump housing 6 work the second of first switch and control air pump work
Switch.
The bottom plate 1 has been respectively arranged below directive wheel 10 and traveling wheel 9, wherein directive wheel 10 and traveling wheel 9 rotate
It is mounted on the lower part of wheel carrier, the wheel carrier upper end for being equipped with directive wheel 10 is connect with bottom plate 1 by bearing, and traveling wheel 9 is equipped with
Wheel carrier upper end is fixedly connected with bottom plate 1, and 1 upper side of bottom plate is fixed with push rod 20, pushes push rod 20 that bottom plate 1 is driven to walk,
Cooperate push rod 20 to control direction of travel using directive wheel 10, realizes turning function.
Embodiment 2
In another embodiment of the present invention, a kind of dedicated embryo's storage device of vitrifying freeze thawing, including bottom plate 1, storage liquid nitrogen
Tank body 2 and freeze thawing case 3 for placing vessel;1 one upper side of bottom plate is fixedly installed with mounting plate 4,4 side of mounting plate
Cuff 5 is fixed in top, sits the tank body 2 being equipped with for storing liquid nitrogen in cuff 5, and the installation of 4 other side of mounting plate is for by tank body 2
In liquid nitrogen extraction the pump housing 6, by cuff 5 improve tank body 2 stability, using the pump housing 6 by tank body 2 liquid nitrogen extract out,
To realize the isolation of liquid nitrogen and ambient atmosphere, prevent to leak;Be fixed with freeze thawing case 3 on the bottom plate 1, freeze thawing case 3 with
It is connected to by conduit 8 with the pump housing 6 between tank body 2, it should be noted that conduit 8 is provided with close to 2 side of tank body for controlling liquid
The stopcock 7 of nitrogen flow, and 3 inside upper layer of freeze thawing case is provided with sealing plate 11,11 edge of sealing plate is fixed with sealing joint strip 12, needs
It is noted that sealing joint strip 12 and 3 inner wall of freeze thawing case are interference fitted, it is provided on sealing plate 11 multiple for placing Medical treatment device
The cavity 13 of ware, using 3 inner wall of sealing joint strip 12 and freeze thawing case of interference fit, so that the top and the bottom of freeze thawing case 3 are by sealing plate
11 isolations, sealing plate 11 can also slide simultaneously along 3 inner wall upper-lower seal of freeze thawing case, avoid the liquid nitrogen for being located at 3 lower part of freeze thawing case and
Air contact, 6 wire connecting power of the pump housing and controller.
11 down either side of sealing plate is respectively and fixedly provided with telescopic rod 15, and 15 lower seal of telescopic rod is slidably connected cylinder 14,
Cylinder 14 passes through 3 bottom of freeze thawing case and bottom plate 1, and seals and fix with the two, it should be noted that conduit 7 and freeze thawing case 3 are connected
Place is located at the lower section of sealing plate 11, drives telescopic rod 15 is flexible to drive the up and down of sealing plate 11 by cylinder 14, from
And the cavity 13 for being placed with vessel is driven to move up and down, convenient for vessel are fetched from freeze thawing case 3;11 top two of sealing plate
Side is fixed with bracket 16, and 16 upper end of bracket is rotatablely connected idler wheel 17, and 17 upper end of idler wheel is bonded cover board 18, and cover board 18 is articulated with freeze thawing
3 outer wall of case, and connected between 3 outer wall of 18 outer rim of cover board and freeze thawing case by resetting-mechanism 19, when sealing plate 11 moves up driving device
Ware, which follows, to be moved up when carrying out pick-and-place vessel, and 18 rotating opening of cover board of two sides is driven using idler wheel 17, when sealing plate 11 moves down,
The cover board 18 of two sides is closed under the action of resetting-mechanism 19,3 top of freeze thawing case is kept the temperature, reduces by 3 top of freeze thawing case
With the Speed of diffusion of external environment;The cylinder 14 is connected to air pump, air pump wire connecting power and controller, further
Ground, on controller tool there are two control switch, respectively the control pump housing 6 work the second of first switch and control air pump work
Switch.
The bottom plate 1 has been respectively arranged below directive wheel 10 and traveling wheel 9, wherein directive wheel 10 and traveling wheel 9 rotate
It is mounted on the lower part of wheel carrier, the wheel carrier upper end for being equipped with directive wheel 10 is connect with bottom plate 1 by bearing, and traveling wheel 9 is equipped with
Wheel carrier upper end is fixedly connected with bottom plate 1, and 1 upper side of bottom plate is fixed with push rod 20, pushes push rod 20 that bottom plate 1 is driven to walk,
Cooperate push rod 20 to control direction of travel using directive wheel 10, realizes turning function.
The resetting-mechanism 19 includes sleeve 191, motion bar 192 and spring 193, wherein 192 top of motion bar is hinged on
18 outer rim of cover board, 192 lower part of motion bar are socketed in sleeve 191, and 191 lower end of sleeve is hinged on the outer wall of freeze thawing case 3, and sleeve
Spring 193 is installed, the upper end of spring 193 abuts the lower end of motion bar 192, and 193 lower end of spring abuts 191 bottom of sleeve in 191
Portion, spring 193 are in compressive state always, and in 18 rotating opening of cover board, motion bar 192 is further seated in sleeve 191, will
Spring 193 further compresses, and when idler wheel 17 moves down, drives motion bar 192 to stretch out cover board by the elastic force of spring 193
18 rotations are closed, and realize the function of automatic shutter cover board 18.
The working principle of the invention is: the stability of tank body 2 is improved by cuff 5, using the pump housing 6 by the liquid in tank body 2
Nitrogen extraction, to realize the isolation of liquid nitrogen and ambient atmosphere, prevents to leak, and utilizes the sealing joint strip 12 and jelly of interference fit
Melt 3 inner wall of case, so that the top and the bottom of freeze thawing case 3 are completely cut off by sealing plate 11, sealing plate 11 simultaneously can also be above and below 3 inner wall of freeze thawing case
Sealing sliding avoids the liquid nitrogen positioned at 3 lower part of freeze thawing case from contacting with air, drives the flexible band of telescopic rod 15 by cylinder 14
Dynamic sealing plate 11 it is up and down, moved up and down to drive and be placed with the cavitys 13 of vessel, convenient for by vessel from freeze thawing case 3
Fetch, when sealing plate 11 move up drive vessel follow move up carry out pick-and-place vessel when, utilize idler wheel 17 drive two sides cover board 18
Rotating opening closes the cover board 18 of two sides under the action of resetting-mechanism 19, when sealing plate 11 is moved down on freeze thawing case 3
Portion is kept the temperature, and the Speed of diffusion on freeze thawing case 3 top and external environment is reduced, and pushes push rod 20 that bottom plate 1 is driven to walk, and is utilized
Directive wheel 10 cooperates push rod 20 to control direction of travel, realizes turning function, in 18 rotating opening of cover board, motion bar
192 are further seated in sleeve 191, and spring 193 is further compressed, and when idler wheel 17 moves down, pass through the bullet of spring 193
Power drives motion bar 192 to stretch out and cover board 18 is rotated closing, realizes the function of automatic shutter cover board 18.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (9)
1. a kind of dedicated embryo's storage device of vitrifying freeze thawing including bottom plate (1), stores the tank body (2) of liquid nitrogen and for placing
The freeze thawing case (3) of vessel;(1) one upper side of bottom plate is fixedly installed with mounting plate (4), (4) one upper side fixing sleeve hoop of mounting plate
(5), the tank body (2) being equipped with for storing liquid nitrogen is sat in cuff (5), which is characterized in that mounting plate (4) other side installation is used
It is fixed with freeze thawing case (3) on the pump housing (6) for extracting the liquid nitrogen in tank body (2) out, bottom plate (1), freeze thawing case (3) and tank body (2)
Between be connected to the pump housing (6) by conduit (8), and upper layer is provided with sealing plate (11) inside freeze thawing case (3), sealing plate (11) side
Edge is fixed with sealing joint strip (12), and sealing joint strip (12) and freeze thawing case (3) inner wall are interference fitted, and is provided on sealing plate (11) more
A cavity (13) for being used to place medical vessels.
2. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 1, which is characterized in that the sealing plate
(11) down either side is respectively and fixedly provided with telescopic rod (15), and telescopic rod (15) lower seal is slidably connected cylinder (14), and cylinder (14) is worn
Freeze thawing case (3) bottom and bottom plate (1) are crossed, and seals and fixes with the two, sealing plate is located at conduit (7) and freeze thawing case (3) conducting
(11) lower section.
3. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 2, which is characterized in that the sealing plate
(11) top two sides are fixed with bracket (16), and bracket (16) upper end is rotatablely connected idler wheel (17), and idler wheel (17) upper end is bonded cover board
(18), cover board (18) is articulated with freeze thawing case (3) outer wall, and passes through reset machine between cover board (18) outer rim and freeze thawing case (3) outer wall
Structure (19) connection.
4. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 1, which is characterized in that the bottom plate
(1) directive wheel (10) and traveling wheel (9) have been respectively arranged below, wherein directive wheel (10) and traveling wheel (9) are rotatably installed in
The lower part of wheel carrier, the wheel carrier upper end for being equipped with directive wheel (10) are connect with bottom plate (1) by bearing, and traveling wheel (9) is equipped with
Wheel carrier upper end is fixedly connected with bottom plate (1).
5. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 4, which is characterized in that the bottom plate
(1) upper side is fixed with push rod (20).
6. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 3, which is characterized in that the reset machine
Structure (19) includes sleeve (191), motion bar (192) and spring (193), wherein motion bar (192) top is hinged on cover board (18)
Outer rim, motion bar (192) lower part are socketed in sleeve (191), and sleeve (191) lower end is hinged on the outer wall of freeze thawing case (3), and covers
It is equipped with spring (193) in cylinder (191), the upper end of spring (193) abuts the lower end of motion bar (192), and spring (193) lower end is supported
Female connector cylinder (191) bottom, spring (193) are in compressive state always.
7. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 2, which is characterized in that the cylinder
(14) air pump, air pump and the pump housing (6) wire connecting power and controller are connected to.
8. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 1, which is characterized in that the conduit
(8) tank body (2) side is provided with the stopcock (7) for controlling liquid nitrogen flow.
9. the dedicated embryo's storage device of a kind of vitrifying freeze thawing according to claim 7, which is characterized in that the controller
The upper second switch with the first switch of the control pump housing (6) work respectively and control air pump work.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113812399A (en) * | 2021-10-27 | 2021-12-21 | 昆明医科大学第二附属医院 | Embryo and ovum vitrification freezing carrier device in auxiliary reproductive technology |
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Application publication date: 20190719 |