CN106386786A - Freezing preservation container for low-temperature-sensitive biological sample - Google Patents
Freezing preservation container for low-temperature-sensitive biological sample Download PDFInfo
- Publication number
- CN106386786A CN106386786A CN201611077087.8A CN201611077087A CN106386786A CN 106386786 A CN106386786 A CN 106386786A CN 201611077087 A CN201611077087 A CN 201611077087A CN 106386786 A CN106386786 A CN 106386786A
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- CN
- China
- Prior art keywords
- container body
- temperature
- bracket
- sample
- low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
- A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
Abstract
The invention discloses a freezing preservation container for a low-temperature-sensitive biological sample. The freezing preservation container comprises a container body, a sealing cover capable of sealing the container body, a bracket and a sample preservation pipe. The bracket is in a disc shape, a plurality of sample preservation pipe bearing holes matched with the outer diameter of the sample preservation pipe are formed in the disc-shaped bracket, the sample preservation pipe is inserted into the sample preservation pipe bearing holes, and the outer circumference of the bracket extends upwards to be hung on an opening of the container body through an everted flange. The container body and the sealing cover are both made from high density polyethylene materials, the container body is of a sealed interlayer structure, a phase-change material is arranged in the interlayer, and STLN10 or SN12 is adopted as the phase-change material. Due to the fact that the phase-change material can release latent heat into the temperature-sensitive sample at low temperature, the temperature is prevented from being reduced too fast, rapid changes of the temperature-sensitive sample temperature is avoided, and freezing preservation of the low-temperature-sensitive biological sample can be achieved.
Description
Technical field
The present invention relates to a kind of Frozen Biological preservation container for low-temperature sensitive.
Background technology
Phase-change material（Refer to vary with temperature and change physical property and be provided that the material of latent heat.Phase-change material has
Change the ability of its physical state in certain temperature range., when being heated to fusion temperature, just produce taking solid-liquid phase change as a example
Raw phase transformation from solid-state to liquid, during fusing, phase-change material absorbs and stores substantial amounts of latent heat；When phase-change material cooling
When, the heat of storage, in environment to be dispersed within the scope of certain temperature, carries out the reverse transformation from liquid to solid-state.At this
In two kinds of phase transition process, stored or release energy is referred to as latent heat of phase change.When physical state changes, the temperature of material itself
Degree almost remains unchanged before phase transformation completes, and forms a wide temperature platform although temperature-resistant, but absorb or release latent
Heat is but quite big, is widely used to space flight, building and clothes.
Sample is mainly freezed by the method being presently used for extending patient's cell in biological specimen and the hospital in laboratory
It is stored in -80 °C of refrigerators, but during frost, because temperature significantly declines suddenly, form substantial amounts of ice crystal, can bring
The a series of physiology of sample, the change of environment and function, causes the frostbite of sample.
Therefore develop a kind of what biological sample being avoided that low-temperature sensitive damaged freezing Support Equipment significant.
Content of the invention
The invention provides a kind of Frozen Biological preservation container for low-temperature sensitive, it is using phase-change material to reach
Preserve to the Frozen Biological to low-temperature sensitive, because phase-change material can discharge latent heat to temperature sensitivity sample in low temperature
In, stop temperature drop too fast, it is to avoid the drastically change of temperature sensitivity sample temperature, to reach the biological sample to low-temperature sensitive
Freezen protective, it is to avoid it sustains damage.
In order to solve the above problems, the technical solution adopted in the present invention is such, a kind of life for low-temperature sensitive
Thing sample freezing container is it is characterised in that include a container body, the closure of resealable container main body, setting appearance
For the bracket accepting sample storage tube and the multiple independent sample storage tube being positioned on bracket in device main body, described support
Frame is discoid, offers multiple sample storage tube receiving holes matching with sample storage tube external diameter on discoid bracket,
Described sample storage tube insertion sample storage tube accepts in the hole, and described bracket excircle extends upward through the flange turning up
Hang at the opening of container body, described container body and closure are made by high-density polyethylene material, described container
Main body is the sandwich of sealing, is provided with phase-change material in this interlayer, STLN10 or SN12 selected by described phase-change material.
Wherein, STLN10 or SN12 is the phase-change material of commercialization, and phase transition temperature is divided into -11 °C and -12 °C
Preferably, described sample storage tube receiving hole is in equidistantly circular distribution along discoid bracket circumference.
Described container body and closure are threaded connection.
Beneficial effect：
1st, because phase-change material can discharge latent heat in low temperature in temperature sensitivity sample, stop the too fast reduction of temperature, it is to avoid
The drastically change of temperature sensitivity sample temperature, preserves it is adaptable to haemocyte, blood to reach to the Frozen Biological of low-temperature sensitive
Slurry, plant, zooblast etc. preserve.
2nd, the present invention is simple, easy-to-use, using the phase-change material filled in advance come keeping temperature fall off rate, when it is set to
When -80 DEG C of deep freezers or liquid nitrogen container, its interior temperature sensitivity sample can be kept with reduction of speed at a temperature of more mitigation
Rate is declined, in addition, when it is taken out and be put in room temperature from -80 DEG C of deep freezers or liquid nitrogen container, can keep its interior temperature
The temperature that the sensitive sample of degree is maintained in several hours, without being connected to power supply or other machinery device.
3rd, the present invention includes multiple independent sample storage tube, and separates each other, can prevent the mutual of sample
Pollution, avoids phase-change material to sample contamination simultaneously.
4th, described container body and closure are made by high-density polyethylene material, preferably play mitigation temperature drastically
The effect of change.
Brief description
Fig. 1 is present configuration schematic diagram.
Fig. 2 is the structural representation of bracket.
Specific embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment and accompanying drawing, the invention will be further described, should
Embodiment is only used for explaining the present invention, does not constitute limiting the scope of the present invention.
Referring to Fig. 1 and Fig. 2, a kind of freezing container, including cylindrical container body 1, a resealable container master
For accepting the bracket 3 of sample storage tube and being positioned over multiple independent on bracket in the closure 2 of body, setting container body
Sample storage tube 4, sample storage tube 4 inserts the connection realizing sample storage tube 4 and bracket 3 in sample storage tube receiving hole 6；Tool
Body ground, described bracket 3 is discoid, offers multiple samples matching with sample storage tube external diameter on discoid bracket
Preserve pipe receiving hole 6, this sample storage tube receiving hole 6 is in equidistantly circular distribution along discoid bracket 3 circumference, bracket 3
Excircle extends upward through the flange turning up and hangs at the opening of container body 1.
Described container body and closure are threaded connection, and described container body 1 is the sandwich of sealing, should
It is provided with phase-change material 5, STLN10 or SN12 selected by described phase-change material in interlayer.
In order to get the effect of insulation, described container body 1 and closure 2 are made by high-density polyethylene material.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.
Claims (4)
1. a kind of Frozen Biological preservation container for low-temperature sensitive it is characterised in that include container body, can be close
For accepting the bracket of sample storage tube and being positioned over multiple on bracket in the closure of envelope container body, setting container body
Independent sample storage tube, described bracket is discoid, offers multiple and sample storage tube external diameter on discoid bracket
The sample storage tube receiving hole matching, described sample storage tube insertion sample storage tube accepts in the hole, outside described bracket
Circumference extends upward through the flange turning up and hangs at the opening of container body, and described container body and closure are by high density
Polythene material is made, and described container body is the sandwich of sealing, is provided with phase-change material in this interlayer, described phase
Become material selection STLN10 or SN12.
2. a kind of Frozen Biological preservation container for low-temperature sensitive according to claim 1 is it is characterised in that institute
The sample storage tube receiving hole stated is in equidistantly circular distribution along discoid bracket circumference.
3. a kind of Frozen Biological preservation container for low-temperature sensitive according to claim 1 is it is characterised in that institute
The container body stated and closure are threaded connection.
4. a kind of Frozen Biological preservation container for low-temperature sensitive according to claim 1 is it is characterised in that institute
The container body stated is cylinder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611077087.8A CN106386786A (en) | 2016-11-30 | 2016-11-30 | Freezing preservation container for low-temperature-sensitive biological sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611077087.8A CN106386786A (en) | 2016-11-30 | 2016-11-30 | Freezing preservation container for low-temperature-sensitive biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106386786A true CN106386786A (en) | 2017-02-15 |
Family
ID=58084891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611077087.8A Withdrawn CN106386786A (en) | 2016-11-30 | 2016-11-30 | Freezing preservation container for low-temperature-sensitive biological sample |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106386786A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107136052A (en) * | 2017-07-03 | 2017-09-08 | 上海理工大学 | A kind of medical speed governing heat sink |
| CN107318827A (en) * | 2017-07-03 | 2017-11-07 | 上海理工大学 | A kind of medical speed governing heat sink with communication function |
| CN110024776A (en) * | 2019-05-16 | 2019-07-19 | 刘文静 | A kind of dedicated embryo's storage device of vitrifying freeze thawing |
| US11352262B2 (en) | 2017-12-18 | 2022-06-07 | Praxair Technology, Inc. | Methods for automatic filling, charging and dispensing carbon dioxide snow block |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105627A (en) * | 1990-04-20 | 1992-04-21 | Nihon Freezer Co., Ltd. | Cryopreservation container of animal cell |
| TW443980B (en) * | 1998-09-29 | 2001-07-01 | Life Science Holdings Inc | Portable apparatus for storing and/or transporting biological samples, tissues and/or organs |
| CN101473179A (en) * | 2006-07-13 | 2009-07-01 | B·西克斯特 | Transport container for maintaining the temperature of frozen goods |
-
2016
- 2016-11-30 CN CN201611077087.8A patent/CN106386786A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105627A (en) * | 1990-04-20 | 1992-04-21 | Nihon Freezer Co., Ltd. | Cryopreservation container of animal cell |
| TW443980B (en) * | 1998-09-29 | 2001-07-01 | Life Science Holdings Inc | Portable apparatus for storing and/or transporting biological samples, tissues and/or organs |
| CN101473179A (en) * | 2006-07-13 | 2009-07-01 | B·西克斯特 | Transport container for maintaining the temperature of frozen goods |
Non-Patent Citations (1)
| Title |
|---|
| 杨武 等: "《改变世界的信息材料》", 31 January 2012, 甘肃科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107136052A (en) * | 2017-07-03 | 2017-09-08 | 上海理工大学 | A kind of medical speed governing heat sink |
| CN107318827A (en) * | 2017-07-03 | 2017-11-07 | 上海理工大学 | A kind of medical speed governing heat sink with communication function |
| CN107136052B (en) * | 2017-07-03 | 2020-11-03 | 上海理工大学 | Medical speed-regulating and temperature-reducing device |
| US11352262B2 (en) | 2017-12-18 | 2022-06-07 | Praxair Technology, Inc. | Methods for automatic filling, charging and dispensing carbon dioxide snow block |
| CN110024776A (en) * | 2019-05-16 | 2019-07-19 | 刘文静 | A kind of dedicated embryo's storage device of vitrifying freeze thawing |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170215 |
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| WW01 | Invention patent application withdrawn after publication |