CN110006221A - Bulk pharmaceutical chemicals automatic discharge apparatus and its control method with isolator - Google Patents
Bulk pharmaceutical chemicals automatic discharge apparatus and its control method with isolator Download PDFInfo
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- CN110006221A CN110006221A CN201910291604.9A CN201910291604A CN110006221A CN 110006221 A CN110006221 A CN 110006221A CN 201910291604 A CN201910291604 A CN 201910291604A CN 110006221 A CN110006221 A CN 110006221A
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- Prior art keywords
- isolation cover
- suction gun
- sterilizing gas
- sterilizing
- cover
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- 239000000126 substance Substances 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims description 23
- 238000002955 isolation Methods 0.000 claims abstract description 145
- 230000001954 sterilising effect Effects 0.000 claims abstract description 110
- 239000007921 spray Substances 0.000 claims abstract description 35
- 238000007599 discharging Methods 0.000 claims abstract description 18
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 230000008676 import Effects 0.000 claims abstract description 3
- 230000005540 biological transmission Effects 0.000 claims description 21
- 238000004140 cleaning Methods 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 13
- 238000005406 washing Methods 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 230000033001 locomotion Effects 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 16
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 239000007789 gas Substances 0.000 description 50
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000005192 partition Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000002309 gasification Methods 0.000 description 3
- 238000003032 molecular docking Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000007602 hot air drying Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000012376 hot air sterilization Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/001—Handling, e.g. loading or unloading arrangements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The present invention discloses a kind of bulk pharmaceutical chemicals automatic discharge apparatus with isolator, including discharging unit and is environmentally isolated unit, and discharging unit includes frame body and suction gun；Being environmentally isolated unit includes isolation cover, sterilizing gas generating device and air flow system, isolation cover covers above the frame body, the suction gun is placed in the isolation cover, and isolation cover is equipped with spray gun inlet and outlet, air inlet and air outlet, and the spray gun import and export is equipped with sealing plate；Sterilizing gas generating device is sent into the isolation cover for generating sterilizing gas；Air flow system flows to the air-flow of the air outlet for being formed in isolation cover from the air inlet.Suction gun is isolated by isolation cover by the present invention, sterilizing gas is generated by sterilizing gas generating device again to be filled in isolation cover, killing bacterial action not only is played to the suction gun in isolation cover, also it sterilizes to environment in isolation cover, provides safe and reliable gnotobasis for the absorption of medicine block.
Description
Technical field
The invention belongs to food, medical packaging field of mechanical technique, and in particular to a kind of bulk pharmaceutical chemicals with isolator are automatic
Discharging device and its control method.
Background technique
Automatic feed/discharge equipment is the key ancillary equipment applied to lyophilized technique equipment, and major function is automatically will
The raw material that need to carry out lyophilized technique processing is automatically fed into or takes out, the function for reaching optimization input and output material effect, improving input and output material efficiency
Energy.General standard input and output material RGV trolley (Rail Guided Vehicle, rail Shuttling trolley), is for bottled preparation
Product discharges.
Bulk pharmaceutical chemicals are after handling by lyophilized technique, are condensed in the block stock product formed on freeze dryer plate layer, right
The discharging of block stock product, traditional mode of action is: manually block-like bulk pharmaceutical chemicals crushed and is collected, but it is such
Operation mode has the problem that
1, it need to consume that a large amount of physical strength, production efficiency is not high and product collecting effect is unstable；
If 2, bulk pharmaceutical chemicals have certain risk, operating cost relatively high to the protection level requirements of operator
It is bigger；
3, the washing and sterilizing of rewinding rifle is generally used offline mode, expends the time, complicated for operation；
4, rewinding environment cannot be monitored and is controlled during rewinding, for dangerous drug, such as mould
Element can not play the role of security isolation.
Application No. is 201610529039.1 patent documents to disclose a kind of aseptic freeze-dried isolator of use for laboratory drug
System, including hot air sterilizer system, freeze dryer system and Sterilized isolator system, hot air sterilizer system pass through hot air sterilization
Device is tightly connected Sterilized isolator system, and freeze dryer system is tightly connected system by freeze dryer and connects sterile isolation system.
Summary of the invention
The main object of the present invention is to provide a kind of bulk pharmaceutical chemicals automatic discharge apparatus with isolator, it is intended to solve existing
Bulk pharmaceutical chemicals discharge method production efficiency is not high, discharging process is easy also can not be anti-to operator's progress safety by environmental pollution
The problem of shield.
To achieve the above object, the present invention proposes a kind of bulk pharmaceutical chemicals automatic discharge apparatus with isolator, comprising:
Discharging unit, including can along the frame body that transmission track moves, be movably disposed on the frame body
Suction gun；
It is environmentally isolated unit, comprising:
Isolation cover covers above the frame body, and the suction gun is placed in the isolation cover, the isolation cover
It is equipped with spray gun inlet and outlet, air inlet and air outlet, the spray gun import and export is equipped with sealing plate；
Sterilizing gas generating device is disposed on the bulk pharmaceutical chemicals automatic discharge apparatus, is sent into for generating sterilizing gas
In the isolation cover；
Air flow system, for forming the air-flow for flowing to the air outlet from the air inlet in isolation cover.
It is preferably, described to be environmentally isolated unit further include:
Heating group is set in the isolation cover；
Detection system, for detecting the temperature in isolation cover, humidity, pressure and sterilizing gas concentration；
Control system is connect with the detection system, sterilizing gas generating device and air flow system.
Preferably, the bulk pharmaceutical chemicals automatic discharge apparatus with isolator further includes cleaning unit, and the cleaning unit is used
In being passed through cleansing medium into the suction gun.
Preferably, the air flow system includes:
The first cover chamber, the second cover chamber and the third cover chamber being formed in the isolation cover from the bottom to top, the suction gun hold
It is placed in first cover chamber；
Blower is set in second cover chamber, is connected between second cover chamber and the first cover chamber by the blower；
Intake stack is set in the third cover chamber, the intake stack connection air inlet, on the intake stack
Equipped with first filter and air inlet valve；
Exhaust duct, one end is connect with the air outlet, the other end protrudes into the third cover chamber, the exhaust duct
The one end for protruding into third cover chamber be equipped with the second filter, exhaust valve and by-passing valve.
Preferably, the transmission track includes set on the main orbit of the chassis body bottom and from track, for driving
The chassis body longitudinal movement, the discharging unit further include:
Pulverizer is set on frame body and is located in the isolation cover, the discharging of the pulverizer and the suction gun
Mouth connection；
Traversing axis is set to the chassis body bottom, for driving the chassis body transverse shifting；
Position detecting device, for detecting the position of the chassis body；
Spray gun transmission shaft, for driving the suction gun transversal stretching mobile；
Lifting shaft, for driving the suction gun lifting moving；
Safety door is set on the isolation cover, and the safety door is equipped with isolation gloves.
The present invention also proposes a kind of control method of bulk pharmaceutical chemicals automatic discharge apparatus with isolator, comprising:
S1, washing and sterilizing step,
The spray gun inlet and outlet for opening isolation cover, make suction gun stretch out isolation cover and dock with cleaning unit, in suction gun
It is passed through cleansing medium, cleansing medium is made to circulate in suction gun, after the completion of to the suction gun washing and sterilizing, suction gun is received
It returns in isolation cover, and closes spray gun inlet and outlet；
S2 is environmentally isolated sterilization steps,
Suction gun is isolated using isolation cover,
Make to be filled with sterilizing gas in isolation cover by sterilizing gas generating device, suction gun carried out to be environmentally isolated sterilizing,
After a period of time, sterilizing gas generating device is closed,
Air flow system is opened, the pressure for forming constant flow in isolation cover is made to be higher than the air-flow of external air pressure,
By the sterilizing gas discharge in isolation cover；
S3, raw material rewinding step,
Spray gun inlet and outlet are opened, pressure remained steady in isolation cover is made by air flow system, control suction gun to original
Expect that medicine carries out rewinding.
Preferably, the S1, washing and sterilizing step include:
It is passed through clean water into suction gun, suction gun is cleaned,
After the completion of cleaning, hot wind is passed through into suction gun and is dried,
Steam is passed through into suction gun, to carrying out steam sterilizing in suction gun,
After the completion of sterilizing, it is passed through hot wind again into suction gun and is dried, completes washing and sterilizing.
Preferably, the S2, is environmentally isolated sterilization steps, further includes:
Before being passed through sterilizing gas and carrying out being environmentally isolated sterilizing to isolation cover, heating group is opened, while opening sterilizing air
Body generating device makes to be passed through sterilizing gas in isolation cover,
When detecting that isolation case temperature reaches preset temperature, the sterilizing gas generating device is closed,
By the changing value size of the pressure in detection isolation cover whithin a period of time, to progress air-tightness inspection in isolation cover
It looks into, if passed examination, enters next step if inspection is unqualified and carry out warning note.
Preferably, it in the S2, is environmentally isolated in sterilization steps:
The pressure in isolation cover is adjusted by air flow system, passes through the gasification speed of sterilizing gas generating device
The sterilizing gas concentration in isolation cover is adjusted, the temperature in isolation cover is adjusted by heating group, passes through isolation internal mask pressure, sterilizing
Humidity in the size comprehensive adjustment isolation cover of gas concentration and temperature,
When pressure, sterilizing gas concentration, the temperature and humidity in isolation cover all reach preset value, start to carry out sterilometer
When；
After closing sterilizing gas generating device, opening air flow system, pass through the sterilizing air in detection isolation cover
Whether bulk concentration and humidity, the sterilizing gas in detection and isolation cover empty.
Preferably, the S3, raw material rewinding step, comprising:
S31 longitudinally moves to corresponding freeze-drying by bulk pharmaceutical chemicals automatic discharge apparatus described in main orbit and secondary orbits controlling
Before machine；
It is laterally adjacent to the freeze dryer to control the bulk pharmaceutical chemicals automatic discharge apparatus by traversing axis by S32；
S33 controls corresponding plate layer in the suction gun lifting moving to freeze dryer by lifting shaft；
S34 controls the suction gun by spray gun transmission shaft and protrudes into freeze dryer；
S35 opens suction gun, and the position of protruding into of suction gun is adjusted by spray gun transmission shaft, completes ply rewinding；
The position of next plate layer after the completion of ply rewinding, is adjusted to, repetition step corresponding with suction gun position by S36
S34 and S35 completes the rewinding of next plate layer.
Compared with prior art, technical solution of the present invention the utility model has the advantages that
One, the bulk pharmaceutical chemicals automatic discharge apparatus proposed by the present invention with isolator, discharging unit can pass through transmission track
Transmission be moved to position corresponding with freeze dryer, then suction is carried out to medicine block by the movement of suction gun, realizes automation
Control suction, reduce the participation of operating personnel, reduce human cost, standardized work but also operating efficiency improve,
Improve the stability and reliability of suction.Suction gun is isolated by isolation cover, then passes through sterilizing gas generating device
It generates sterilizing gas to be filled in isolation cover, killing bacterial action not only is played to the suction gun in isolation cover, also in isolation cover
Environment sterilizes, and provides safe and reliable gnotobasis for the absorption of medicine block.Isolation cover can not only prevent operation process
The middle possible powder flying chip occurred, which leaks, pollutes production environment, moreover it is possible to play security isolation to risk bulk pharmaceutical chemicals medicine block
Effect, prevents from damaging the health of operating personnel.
Two, the control method of the bulk pharmaceutical chemicals automatic discharge apparatus proposed by the present invention with isolator first carries out suction gun
Cleaning carries out air tightness test to isolation cover, opens sterilizing gas generating device after air-tightness is qualified and carries out in isolation cover
Isolation sterilizing, sterilizing reach setting time heel row it is residual, finally open again spray gun inlet and outlet control suction gun carry out suction, by every
Safe and reliable gnotobasis is provided for the discharging of medicine block from cover, realizes the whole aseptic controlling of draw operation, is also behaviour
The health for making personnel provides security protection.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
The structure shown according to these attached drawings obtains other attached drawings.
Fig. 1 is the internal structure chart for the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that one embodiment of the invention proposes；
Fig. 2 is that the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that Fig. 1 is proposed is installed on the structure chart on transmission track；
Fig. 3 is enlarged drawing at the A of Fig. 2；
Fig. 4 is the connection signal of suction gun and pulverizer in the bulk pharmaceutical chemicals automatic discharge apparatus with isolator of Fig. 1 proposition
Figure；
Fig. 5 is the vertical view view of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that Fig. 1 is proposed saved after roof trim plate
Corner structure figure；
Fig. 6 is the main view of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that Fig. 1 is proposed saved after roof trim plate；
Fig. 7 is that saving for the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that Fig. 1 is proposed looks up view after roof trim plate
Corner structure figure.
Drawing reference numeral explanation of the invention:
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute is only used in the embodiment of the present invention
In explaining in relative positional relationship, the motion conditions etc. under a certain particular pose (as shown in the picture) between each component, if should
When particular pose changes, then directionality instruction also correspondingly changes correspondingly.
In addition, the description for being such as related to " first ", " second " in the present invention is used for description purposes only, and should not be understood as
Its relative importance of indication or suggestion or the quantity for implicitly indicating indicated technical characteristic.Define as a result, " first ",
The feature of " second " can explicitly or implicitly include at least one of the features.In the description of the present invention, " multiple " contain
Justice is at least two, such as two, three etc., unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " connection ", " fixation " etc. shall be understood in a broad sense,
For example, " fixation " may be a fixed connection, it may be a detachable connection, or integral；It can be mechanical connection, be also possible to
Electrical connection；It can be directly connected, the connection inside two elements or two can also be can be indirectly connected through an intermediary
The interaction relationship of a element, unless otherwise restricted clearly.It for the ordinary skill in the art, can basis
Concrete condition understands the concrete meaning of above-mentioned term in the present invention.
It in addition, the technical solution between each embodiment of the present invention can be combined with each other, but must be general with this field
Based on logical technical staff can be realized, it will be understood that when the combination of technical solution appearance is conflicting or cannot achieve this
The combination of technical solution is not present, also not the present invention claims protection scope within.
Embodiment one
The present embodiment one proposes a kind of bulk pharmaceutical chemicals automatic discharge apparatus with isolator.
Fig. 1 to Fig. 7 is please referred to, the bulk pharmaceutical chemicals automatic discharge apparatus with isolator, including discharging unit and it is environmentally isolated list
Member.In the following description, upper and lower, left and right all directions are based on the direction of Fig. 1.
Discharging unit includes frame body 11 and suction gun 12.Frame body 11 is located on transmission track, can be along transmission rail
Road is moved to position corresponding with freeze dryer.Suction gun 12 is mounted on frame body 11, and the material sucking port direction of suction gun 12 is frozen
Dry machine can draw the bulk pharmaceutical chemicals medicine block on freeze dryer inner panel layer after suction gun 12 is mobile to be protruded into freeze dryer.
Being environmentally isolated unit includes isolation cover 21, sterilizing gas generating device 22 and air flow system.21 bottom of isolation cover
Portion's opening, is located above frame body 11, suction gun 12 is isolated, and the left and right sides of isolation cover 21 is provided with spray gun disengaging
Mouth 211, suction gun 12 pass through spray gun inlet and outlet 211 and stretch out or withdraw out of isolation cover 21, and spray gun is imported and exported at 211 equipped with close
Sealing plate 212, for being sealed to isolation cover 21.Sterilizing gas generating device 22 is for generating sterilizing gas, specifically in this reality
It applies in mode, sterilizing gas is hydrogen peroxide, and sterilizing gas generating device 22 includes the peroxidating set on 11 bottom of frame body
Hydrogen bottle, hydrogen peroxide bottle are connected with soft air pipe, and soft air pipe accesses in isolation cover 21, and evaporating pan is equipped in isolation cover 21 and is used for mistake
Hydrogen oxide is heated, and so that hydrogen peroxide vaporization is generated hydrogen peroxide steam and is filled in isolation cover, has good bactericidal effect.
It is environmentally isolated unit and is additionally provided with air flow system, persistently circulation has the air-flow of flowing for making in isolation cover 21.
Specifically in the present embodiment, there are two suction gun 12 is set, and the telescopic direction of two suction guns 12 is on the contrary, be used for
Absorption collection is carried out to the medicine block in two freeze dryers, therefore has a spray gun disengaging in the left and right sides of isolation cover 21
Mouthfuls 211, and it is to be appreciated that in some other embodiment, when suction gun quantity only one when, can also be on isolation cover
One spray gun of corresponding only setting is imported and exported, and is not limited thereto.
So that first, discharging unit can be moved to position corresponding with freeze dryer by the transmission of transmission track,
Suction is carried out to medicine block by the movement of suction gun 12 again, automation control suction is realized, reduces the participation of operating personnel,
Human cost is reduced, standardized work also improves the stability and reliability of suction but also operating efficiency raising.The
Two, suction gun is isolated by isolation cover 21, then sterilizing gas is generated by sterilizing gas generating device 22 and is filled with isolation
In cover 21, killing bacterial action not only is played to the suction gun in isolation cover 21, also sterilizes to environment in isolation cover 21, is
The absorption of medicine block provides safe and reliable gnotobasis.Third, isolation cover 21 can not only prevent may hair in operation process
Raw powder flying chip, which leaks, pollutes production environment, moreover it is possible to play the role of security isolation to risk bulk pharmaceutical chemicals medicine block, prevent
Only the health of operating personnel is damaged.
Further, described to be environmentally isolated unit further include: heating group, detection system and control system.Heating group is located at
In isolation cover 21, for being heated in isolation cover 21.Detection system is also provided in isolation cover 21, for detecting isolation cover 21
Interior temperature, humidity, pressure and sterilizing gas concentration, specifically in the present embodiment, detection system can be using individually temperature
Sensor, humidity sensor, concentration sensor and pressure sensor are spent, it can also be using with temperature, humidity and Concentration Testing
Function three-in-one Temperature Humidity Sensor and pressure sensor, detection system are connect with control system, the temperature that will test, wet
Degree, pressure and sterilizing gas concentration signal are transmitted to control system.Control system also with heating group 23, sterilizing gas generating device 22
It is connected with air flow system, for adjusting heating according to temperature, humidity, pressure and the sterilizing gas concentration in isolation cover 21
The heating power of group 23 and opening and closing adjust gasification speed and the opening and closing of sterilizing gas generating device 22, adjust air flowing
The speed air flow of system and opening and closing.
So that environment isolated location temperature, humidity, pressure and can go out in real-time monitoring isolation cover 21 in the present invention
The environmental parameters such as bacterium gas concentration realize automation sterilizing by control system, improve operating efficiency.
Further, the bulk pharmaceutical chemicals automatic discharge apparatus with isolator further includes cleaning unit, when in use, cleaning
Unit is connect with the material sucking port of suction gun 12, for being passed through cleansing medium into suction gun 12.Specifically in the present embodiment, clearly
It includes that water enters pipeline, steam enters pipeline and wind enters pipeline that medium, which is washed, including clean clear water and high-temperature steam, cleaning unit,
Water enters pipeline connection clear water source and is equipped with purge valve, and steam enters pipeline connection vapour source and is equipped with steam valve, and wind enters pipe
Hot air source is connected on road and is equipped with hot-blast valve.
So that suction gun 12 carries out isolation sterilizing in the sterilizing gas generated by sterilizing gas generating device 22
Before, it first to stretch out outer connect with cleaning unit of isolation cover 21 and carry out washing and sterilizing.When the material sucking port of suction gun 12 is passed through docking
When hose enters pipeline with water and connect, clear water enters in suction gun 12 from material sucking port to be discharged from the discharge port of suction gun 12 again, can
To progress clean water cleaning in suction gun 12；It, being capable of suction gun and suction gun when suction gun 12 being entered pipeline with wind connecting
The docking hose of connection and other connecting pipes carry out heated-air drying；When suction gun 12 being entered pipeline with steam connecting, steam
Vapour, which enters in suction gun 12, to carry out further steam sterilizing to suction gun 12.
Further, the first cover chamber 214, the second cover chamber 215 and third cover chamber are formed in isolation cover 21 from the bottom to top
216, the first cover chamber 214 and the second cover chamber 215 are two chambers of sealing, by the between the first cover chamber 214 and the second cover chamber 215
One partition 217 separates, and blower 31 is installed in the first partition 217, and the air supply direction of blower 31 is downward.Second cover chamber 215
It is second partition 218 between third cover chamber 216, is roof trim plate 219 above second partition, third cover chamber 216 is by second
Partition 218 and roof trim plate 219 enclose.
Air flow system includes blower 31, intake stack 32 and exhaust duct 33.The air inlet of isolation cover 21 is set to the
On two partitions 218.Intake stack 32 is connected to air inlet and is set in third cover chamber 216.The air outlet 213 of isolation cover 21 is set to
The front and back side of its bottom.Exhaust duct 33 connects with the multiple air outlets 213 for being located at front side and positioned at multiple air outlets 213 of rear side
It is logical.Specifically in the present embodiment, 21 front side of isolation cover and rear side are respectively equipped with three air outlets 213, three outlet air of every side
Mouth 213 is led to by two exhaust ducts 33 close to top, and wherein an exhaust duct 33 protrudes into third cover chamber 216.Into
Air piping 32 is equipped with first filter 321 and air inlet valve 322, and one end that exhaust duct 33 protrudes into third cover chamber 216 is equipped with
Second filter 331, exhaust valve 332 and by-passing valve 333.
So that when opening air inlet valve 322 and exhaust valve 332, while starting blower 31, air is through first filter
321 filter and sterilize, and clean air is sucked in the first cover chamber 214 by blower 31 from the second cover chamber 215, the air outlet from bottom
213 discharges, then be discharged into outside atmosphere by more exhaust ducts 33 by the second filter 331.Formed in isolation cover 21 from
Top air inlet to bottom air outlet 213 continual and steady air-flow, isolation cover 21 carried out isolation sterilizing after, to isolation
It is passed through the air-flow in cover 21, can not only be played the role of the sterilizing gas discharge in isolation cover 21, moreover, because blower 31
Effect, the pressure of the air-flow is greater than the pressure of outside air, thus can also open spray gun inlet and outlet 211, the shifting of suction gun 12
When carrying out suction operation out, guarantee clean air environment in isolation cover 21, to reduce during suction suction gun 12 by again
The risk of secondary pollution.
Further, specifically in the present embodiment, the second cover chamber 215 in being also provided with multiple ventilations on isolation cover 21
Mouthfuls 2151, which includes two positioned at 21 front side of isolation cover and two positioned at 21 rear side of isolation cover, and respectively
It is connected to exhaust duct 33.The setting of ventilation opening 2151 can make air flowing in isolation cover 21 more unobstructed.
Further, the transmission track of 11 bottom of frame body includes main orbit 141 and from track 142, for driving
State the longitudinal movement of chassis body 11.Discharging unit 1 further include: pulverizer 13, traversing axis 15, position detecting device 16, spray gun pass
Moving axis 17, lifting shaft 18, the front and back side of isolation cover 21 are equipped with safety door 24, and safety door 24 is equipped with isolation gloves 241.Pulverizer
13 are connected between the discharge port of suction gun 12 and the discharge pipe of discharging unit 1, can crush to the medicine block just collected,
To make this bulk pharmaceutical chemicals automatic discharge apparatus for the crushing of medicine block and collect unified combine once again, improving crushing and collecting production
The efficiency of product, also perfect entire rewinding process.Traversing axis 15 is located at 11 bottom of chassis body, horizontal for driver framework main body 11
To movement.Position detecting device 16 is used for the position of detection framework main body 11；Spray gun transmission shaft 17 is for driving suction gun 12 horizontal
To telescopic moving；Lifting shaft 18 is for driving 12 lifting moving of suction gun.
Embodiment two
Below based on the bulk pharmaceutical chemicals automatic discharge apparatus with isolator that embodiment one proposes, the band is further specifically described
The control method of the bulk pharmaceutical chemicals automatic discharge apparatus of isolator.
A kind of control method of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator, comprising:
S1, washing and sterilizing step, comprising:
S11, spray gun dock step, comprising:
The spray gun inlet and outlet 211 for opening isolation cover 21, make suction gun 12 stretch out the isolation cover 21, make the suction of suction gun 12
Material mouth is connect with cleaning unit by docking hose；
S12, clean water cleaning step, comprising:
Making the material sucking port of suction gun 12 enter pipeline with water to be connected, clear water circulates from clear water source into suction gun 12, and one section
After time, closes water and enter pipeline；
S13, the first hot air drying step, comprising:
Make suction gun 12 enter pipeline with wind to be connected, hot wind circulates from hot air source into suction gun 12, after a period of time, closes
It closes wind and enters pipeline；
S14, steam sterilizing step, comprising:
Make suction gun 12 enter pipeline with steam to be connected, water vapour circulates from vapour source into suction gun 12, a period of time
Afterwards, steam off enters pipeline；
S15, the second hot air drying step, comprising:
Make suction gun 12 enter pipeline with wind to be connected, hot wind circulates from hot air source into suction gun 12, after a period of time, closes
It closes wind and enters pipeline；
S16, spray gun withdraw step, comprising:
Each pipeline for closing cleaning unit withdraws suction gun 12 in isolation cover 21, and closes spray gun inlet and outlet 211.
S2 is environmentally isolated sterilization steps, comprising:
S21, airtight test step, comprising:
Air inlet valve 322, exhaust valve 332, by-passing valve 333 and the safety door 24 of air flow system are closed, heating group is opened
23, while sterilizing gas generating device 22 is opened, make to be passed through sterilizing gas in isolation cover 21.When detecting temperature in isolation cover 21
When reaching preset temperature, sterilizing gas generating device 22 is closed.Detect the variation of pressure whithin a period of time in isolation cover 21
It is worth size, to leakage test is carried out in isolation cover 21, if judgement is qualified, enters next step and carried out if judgement is unqualified
Warning note.
S22, sterilizing gas sterilization steps, comprising:
Air inlet valve 322 and exhaust valve 332 are closed, sterilizing gas generating device 22 and by-passing valve 333 are opened.Pass through side
The opening size of port valve 333 adjusts the pressure in isolation cover 21, passes through the gasification speed tune of sterilizing gas generating device 22
The sterilizing gas concentration in isolation cover 21 is saved, the temperature in isolation cover 21 is adjusted by heating group 23, passes through 21 internal pressure of isolation cover
Humidity in the size comprehensive adjustment isolation cover 21 of power, sterilizing gas concentration and temperature.When the pressure in isolation cover 21, sterilizing air
When bulk concentration, temperature and humidity all reach preset value, when starting to carry out sterilometer.After a period of time, sterilizing gas is closed
Device 22.
S23, environment arrange residual step, comprising:
Sterilizing gas generating device 22 is closed, air inlet valve 322, exhaust valve 332 and by-passing valve 333 is opened, makes to be isolated
Constant flow has air-flow in cover 21, and the pressure of the air-flow is higher than external air pressure.Pass through the sterilizing in detection isolation cover 21
Gas concentration and humidity judge whether the row of sterilizing gas is residual up to standard.
S3, raw material rewinding step,
When sterilizing gas concentration and humidity are reduced to preset value in isolation cover 21, spray gun inlet and outlet 211 are opened, and pass through
The opening size for adjusting by-passing valve 333 stablizes pressure in isolation cover 21, then carries out raw material rewinding, comprising:
S31 controls bulk pharmaceutical chemicals automatic discharge apparatus by main orbit 141 and secondary track 142 and longitudinally moves to corresponding jelly
Before dry machine；
It is laterally adjacent to the freeze dryer to control bulk pharmaceutical chemicals automatic discharge apparatus by traversing axis 15 by S32；
S33 controls corresponding plate layer in 12 lifting moving to freeze dryer of rewinding rifle by lifting shaft 16；
S34 controls the rewinding rifle 12 by spray gun transmission shaft 17 and protrudes into freeze dryer；
S35 opens rewinding rifle 12, and the position of protruding into of rewinding rifle 12 is adjusted by spray gun transmission shaft 17, completes ply
Rewinding；
After the completion of ply rewinding, the upper and lower position of rewinding rifle 12 is adjusted by lifting shaft 18, moves rewinding rifle 12 by S36
It moves to corresponding with next plate layer, repeats step S34 and S35, complete the rewinding of next plate layer.
The control method of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator in present embodiment first carries out suction gun clear
Wash, air tightness test carried out to isolation cover, opened after air-tightness is qualified sterilizing gas generating device to carried out in isolation cover every
From sterilizing, sterilizing arrival setting time heel row is residual, finally opens spray gun inlet and outlet control suction gun again and carries out suction, passes through isolation
Cover provides safe and reliable gnotobasis for the discharging of medicine block, realizes the whole aseptic controlling of draw operation, is also operation
The health of personnel provides security protection.
The above description is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, all at this
Under the inventive concept of invention, using equivalent structure transformation made by description of the invention and accompanying drawing content, or directly/use indirectly
It is included in other related technical areas in scope of patent protection of the invention.
Claims (10)
1. a kind of bulk pharmaceutical chemicals automatic discharge apparatus with isolator characterized by comprising
Discharging unit, including can along the frame body (11) that transmission track moves, be movably disposed in the frame body (11)
On suction gun (12)；
It is environmentally isolated unit, comprising:
Isolation cover (21) covers at the frame body (11) above, and the suction gun (12) is placed in the isolation cover (31)
Interior, the isolation cover (21) is equipped with spray gun inlet and outlet (211), air inlet and air outlet (213), the spray gun inlet and outlet
(211) sealing plate (212) are equipped at；
Sterilizing gas generating device (22) is disposed on the bulk pharmaceutical chemicals automatic discharge apparatus, is sent into for generating sterilizing gas
In the isolation cover (21)；
Air flow system, for forming the air-flow for flowing to the air outlet (213) from the air inlet in isolation cover (21).
2. the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as described in claim 1, which is characterized in that described to be environmentally isolated list
Member further include:
Heating group (23) is set in the isolation cover (21)；
Detection system, for detecting temperature, humidity, pressure and sterilizing gas concentration in isolation cover (21)；
Control system is connect with the detection system, sterilizing gas generating device (22) and air flow system.
3. the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as described in claim 1, which is characterized in that further include that cleaning is single
Member, the cleaning unit are used to be passed through cleansing medium into the suction gun (12).
4. the bulk pharmaceutical chemicals automatic discharge apparatus as described in any one of claims 1 to 3 with isolator, which is characterized in that described
Air flow system includes:
The first cover chamber (214), the second cover chamber (215) and the third cover chamber being formed in the isolation cover (21) from the bottom to top
(216), the suction gun (12) is placed in first cover chamber (214)；
Blower (31) is set in second cover chamber (215), passes through between second cover chamber (215) and the first cover chamber (214)
Blower (31) connection；
Intake stack (32) is set in the third cover chamber (216), and the intake stack (32) connects the air inlet, described
Intake stack (32) is equipped with first filter (321) and air inlet valve (322)；
Exhaust duct (33), one end is connect with the air outlet (213), the other end protrudes into the third cover chamber (216), institute
The one end for protruding into third cover chamber (216) for stating exhaust duct (33) is equipped with the second filter (331), exhaust valve (332) and bypass
Valve (333).
5. the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as described in claim 1, which is characterized in that the transmission track packet
It includes set on the main orbit (141) of the chassis body (11) bottom and from track (142), for driving the chassis body (11)
Longitudinal movement, the discharging unit (1) further include:
Pulverizer (13), be set to frame body (11) on and be located at the isolation cover (31) in, the pulverizer (13) with it is described
The discharge port of suction gun (12) connects；
Traversing axis (15) is set to the chassis body (11) bottom, for driving the chassis body (11) transverse shifting；
Position detecting device (16), for detecting the position of the chassis body (11)；
Spray gun transmission shaft (17), for driving the suction gun (12) transversal stretching mobile；
Lifting shaft (18), for driving the suction gun (12) lifting moving；
Safety door (24) is set on the isolation cover (21), and the safety door is equipped with isolation gloves (241).
6. such as the control method of the bulk pharmaceutical chemicals automatic discharge apparatus described in any one of claim 1 to 5 with isolator, feature
It is, comprising:
S1, washing and sterilizing step,
Open isolation cover (21) spray gun import and export (211), make suction gun (12) stretch out isolation cover (21) and with cleaning unit pair
It connects, is passed through cleansing medium in suction gun (12), make cleansing medium circulation in suction gun (12), when to the suction gun (12)
After the completion of washing and sterilizing, suction gun (12) are withdrawn in isolation cover (21), and close spray gun inlet and outlet (211)；
S2 is environmentally isolated sterilization steps,
Suction gun (12) is isolated using isolation cover (21),
Make to be filled with sterilizing gas in isolation cover (21) by sterilizing gas generating device (22), to suction gun (12) carry out environment every
From sterilizing,
After a period of time, close sterilizing gas generating device (22),
Air flow system is opened, the pressure for forming constant flow in isolation cover (21) is made to be higher than the air-flow of external air pressure,
By the sterilizing gas discharge in isolation cover (21)；
S3, raw material rewinding step,
Spray gun inlet and outlet (211) are opened, isolation cover (21) interior pressure remained steady is made by air flow system, controls suction gun
(12) rewinding is carried out to bulk pharmaceutical chemicals.
7. the control method of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as claimed in claim 6, which is characterized in that described
S1, washing and sterilizing step include:
It is passed through clean water into suction gun (12), suction gun (12) is cleaned,
After the completion of cleaning, hot wind is passed through into suction gun (12) and is dried,
It is passed through steam into suction gun (12), it is interior to suction gun (12) to carry out steam sterilizing,
After the completion of sterilizing, it is passed through hot wind again into suction gun (12) and is dried, completes washing and sterilizing.
8. the control method of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as claimed in claim 6, which is characterized in that described
S2 is environmentally isolated sterilization steps, further includes:
It before being passed through sterilizing gas and carrying out being environmentally isolated sterilizing to isolation cover (21), opens heating group (23), while opening and going out
Bacterium gas generating unit (22) makes to be passed through sterilizing gas in isolation cover (21),
When detecting that isolation cover (21) interior temperature reaches preset temperature, the sterilizing gas generating device (22) is closed,
It is airtight to being carried out in isolation cover (21) by the changing value size of the pressure in detection isolation cover (21) whithin a period of time
Property inspection enter next step if passed examination and if inspection is unqualified carry out warning note.
9. such as the control method of the described in any item bulk pharmaceutical chemicals automatic discharge apparatus with isolator of claim 6 to 8, feature
It is, in the S2, is environmentally isolated in sterilization steps:
The pressure in isolation cover (21) is adjusted by air flow system, is occurred by the gas of sterilizing gas generating device (22)
Speed adjusts the sterilizing gas concentration in isolation cover (21), adjusts the temperature in isolation cover (21) by heating group (23), passes through
Humidity in the size comprehensive adjustment isolation cover (21) of the interior pressure of isolation cover (21), sterilizing gas concentration and temperature,
When pressure, sterilizing gas concentration, the temperature and humidity in isolation cover (21) all reach preset value, start to carry out sterilometer
When；
After closing sterilizing gas generating device (22), opening air flow system, pass through going out in detection isolation cover (21)
Whether bacterium gas concentration and humidity, the sterilizing gas in detection and isolation cover (21) empty.
10. the control method of the bulk pharmaceutical chemicals automatic discharge apparatus with isolator as claimed in claim 6, which is characterized in that institute
State S3, raw material rewinding step, comprising:
S31 controls the bulk pharmaceutical chemicals automatic discharge apparatus by main orbit (141) and secondary track (142) and longitudinally moves to correspondence
Freeze dryer before；
It is laterally adjacent to the freeze dryer to control the bulk pharmaceutical chemicals automatic discharge apparatus by traversing axis (15) by S32；
S33 controls corresponding plate layer in suction gun (12) lifting moving to freeze dryer by lifting shaft (18)；
S34 controls the suction gun (12) by spray gun transmission shaft (17) and protrudes into freeze dryer；
S35 is opened suction gun (12), and the position of protruding into of suction gun (12) is adjusted by spray gun transmission shaft (17), completes veneer
Layer rewinding；
The position of next plate layer after the completion of ply rewinding, is adjusted to, repetition step corresponding with suction gun (12) position by S36
S34 and S35 completes the rewinding of next plate layer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910291604.9A CN110006221A (en) | 2019-04-12 | 2019-04-12 | Bulk pharmaceutical chemicals automatic discharge apparatus and its control method with isolator |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910291604.9A CN110006221A (en) | 2019-04-12 | 2019-04-12 | Bulk pharmaceutical chemicals automatic discharge apparatus and its control method with isolator |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4227623A1 (en) * | 2022-02-14 | 2023-08-16 | Martin Christ Gefriertrocknungsanlagen GmbH | Pilot freezer containment and method of loading and / or unloading a pilot freezer dryer |
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