CN109999056A - A kind of compound pellet and preparation method thereof containing a variety of amino acid, vitamine minerals - Google Patents

A kind of compound pellet and preparation method thereof containing a variety of amino acid, vitamine minerals Download PDF

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Publication number
CN109999056A
CN109999056A CN201910250615.2A CN201910250615A CN109999056A CN 109999056 A CN109999056 A CN 109999056A CN 201910250615 A CN201910250615 A CN 201910250615A CN 109999056 A CN109999056 A CN 109999056A
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China
Prior art keywords
vitamin
amino acid
minerals
capsule core
variety
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Pending
Application number
CN201910250615.2A
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Chinese (zh)
Inventor
程天贵
汪大顺
丁杰
张红霞
覃遵武
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BAFENG PHARMACEUTICAL Co Ltd HUBEI PROV
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BAFENG PHARMACEUTICAL Co Ltd HUBEI PROV
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Priority to CN201910250615.2A priority Critical patent/CN109999056A/en
Publication of CN109999056A publication Critical patent/CN109999056A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
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    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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Abstract

The present invention provides a kind of compound pellets containing a variety of amino acid, vitamine minerals, including capsule core and the packet medicine clothing being wrapped in outside capsule core, separation layer is equipped between the capsule core and packet medicine clothing, the capsule core includes vitamin, minerals and auxiliary material, the packet medicine clothing is the amino acid of powder or suspension formation, and the amino acid includes leucine, isoleucine, valine, lysine, threonine, methionine, tryptophan, phenylalanine.The compound pellet converges in a variety of amino acid, multivitamin and several mineral materials three categories ingredient in pellet, form a complete entirety, ensure homogeneity, other ingredients such as amino acid and vitamin, minerals are separated by separation layer simultaneously, avoid the interaction between different constituents, improve the stability of preparation, it can be used for the adjuvant treatment of disease caused by amino acid, vitamin and mineral deficiency, and the nutrition and health care with sub-health population Health restoration after being ill, facilitate the immune function for enhancing human body.

Description

A kind of compound pellet and preparation method thereof containing a variety of amino acid, vitamine minerals
Technical field
The invention belongs to medicines and health protection food technology fields, and in particular to a kind of containing a variety of amino acid, vitamine minerals Compound pellet and preparation method thereof.
Background technique
Amino acid is the base substance of protein needed for constituting human nutrition, is that one kind contains basic amine group and acidic carboxypolymer Organic compound, the amino acid of constitutive protein matter is largely a-amino acid, is planted for 20.Amino acid is to constitute protein Basic unit is played a significant role by metabolism in human body, such as synthetic tissue protein, becomes acid, hormone, antibody, creatine Deng containing ammoniacal substance, it is changed into carbohydrate and fat, is oxidized to carbon dioxide and water and urea, generate energy etc.；It is different Some differences of its physiological action of amino acid, human body often take compound rear use when supplementing amino acid, at present amino acid oral one As be 18~20 kinds, include amino acid and nonessential amino acid needed by human.
Vitamin also known as vitamin, for popular, that is, the substance to sustain life is to maintain human life activity necessary one Type organic matter is also to maintain the important active substances of human health.The content of vitamin in vivo is seldom, but indispensable, This kind of compound cannot generally synthesize in vivo or synthetic quantity religion is few, cannot meet the needs, the needs of human body are mainly from natural Food.It is divided into fat-soluble and water-soluble two class according to the chemical property of vitamin, liposoluble vitamin is in addition to the content in food It influences outside supply amount, it is necessary to fat absorption, so fat food also influences fat soluble vitamin absorption；Water soluble vitamin Food supply is then relied primarily on, if eaten food vitamin content is very few, will appear hypovitaminosis, normal human is not to Demand with vitamin is different, and certain vitamin is required supplementation with when necessary.
Human elementary (minerals) refers to the chemical element of group adult body, the natural environment background phase of it and life location It adapts to, generallys include three classes: macroelement, microelement and age element.Wherein microelement is the various element of group adult body In account for the element of human total weight's a ten thousandth, they are total to account for the 0.05% of human total weight, and microelement has iron, zinc, copper More than 40 clocks such as cobalt, molybdenum, violent, chromium, selenium, silicon, fluorine, vanadium, iodine, strontium, bromine, boron, barium, arsenic, lithium, nickel, tin；According to body to microelement Need situation to be divided into essential trace element and Non-necessary Trace Elements again.Maintain the indispensable member of human normal vital movement It is called usually as essential trace element, the essential trace element that majority generally acknowledge at present has: iron (Fe), copper (Cu), zinc (Zn), cobalt (Co), molybdenum (Mo), selenium (Se), iodine (I), manganese (Mn), silicon (Si), vanadium (V), tin (Sn), fluorine (F), 13 kinds of nickel (Ni)；Macroelement The element that human total weight's a ten thousandth or more is accounted for for content, as human body is oxygen-containing 65%, carbon 18%, hydrogen 10%, nitrogen 3%, calcium 1.5%, phosphorus 1%, potassium 0.35%, sulphur 0.25%, sodium 0.15%, chlorine 0.15%, magnesium 0.05%, they are referred to as human body constant member Element.Whether microelement or macroelement maintain metabolism to the trophism that all has of human body, or even maintain life Life has vital effect.
And in the prior art and have no by a variety of amino acid, multivitamin and a variety of human elementaries (minerals) by be suitable for The report of the compound pellet of formula composition.Domestic patent CN100364528C be related to be amino acid and vitamin composition pellet Capsule, preparation method are that various pellets are respectively prepared in amino acid and vitamin, remix filling capsule；This production method can not Amino acid and vitamin are converged in the same pellet, cannot ensure the homogeneity of each ingredient in final preparation completely.
Summary of the invention
The purpose of the present invention is overcoming contained nutritional ingredient in existing compound pellet few, and the nutrition such as amino acid, vitamin Ingredient separates pill, and the problem of cannot ensure each compositional uniformity in final preparation.
For this purpose, the present invention provides a kind of compound pellet containing a variety of amino acid, vitamine minerals, including capsule core and packet The packet medicine clothing being rolled in outside capsule core, between the capsule core and packet medicine clothing be equipped with separation layer, the capsule core include vitamin, minerals and Auxiliary material, the packet medicine clothing are the amino acid of powder or suspension formation, and the amino acid includes leucine, isoleucine, figured silk fabrics ammonia Acid, lysine, threonine, methionine, tryptophan, phenylalanine.
Further, the vitamin includes vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, dimension Raw element B6, vitamin B7, Vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, in choline at least 12 kinds.
Further, the minerals include zinc, calcium, iron, selenium, magnesium, at least five kinds of human elementaries in manganese.
Further, the auxiliary material includes starch, microcrystalline cellulose, lactose.
Further, the amino acid further includes histidine, arginine, alanine, asparatate, cysteine, paddy At least one of propylhomoserin, proline, tyrosine, glycine, serine, asparagine, glutamine.
Further, the separation layer is made of hydroxypropyl methyl cellulose or stomach dissolution type coating powder, solid content 5 ~10%.
Further, one layer of exterior coating is also enclosed with outside the packet medicine clothing, the exterior coating uses hydroxypropyl methyl Cellulose, hydroxypropyl cellulose, ethyl cellulose or coating powder are made.
In addition, the present invention also provides the preparation method of the above-mentioned compound pellet containing a variety of amino acid, vitamine minerals, Include the following steps:
1) vitamin, minerals are weighed by recipe quantity, is uniformly mixed after pulverizing and sieving with auxiliary material, added water or containing adhesive Softwood is made in aqueous solution mixing, and by extrusion-method for rolling circle, capsule core is made, spare；
2) a variety of amino acid are weighed by recipe quantity, is micronized using airslide disintegrating mill, add water or add sticky auxiliary material Amino acid capsule core annex solution is prepared in homogeneous mixing, spare；
3) insolated layer materials are added water and stirred and is configured to the barrier gown liquid that solid content is 8%, it is spare；
4) capsule core for obtaining step 1) is after fluidized bed drying, using the barrier gown liquid of step 3) in capsule core outer surface It is coated, forms one layer of separation layer；
5) the amino acid capsule core annex solution that step 2) obtains is sprayed the capsule core that feeding to step 4) obtains with atomised form On, one layer of packet medicine clothing containing amino acid is formed to get compound pellet.
Further, the preparation method of above-mentioned compound pellet further includes step 6), in the packet medicine clothing of step 5) compound pellet One layer of exterior coating of outer package.
Further, separation layer weight gain 10~20% in the step 4), exterior coating weight gain 0~10% in step 6).
Compared with prior art, beneficial effects of the present invention:
(1) this compound pellet containing a variety of amino acid, vitamine minerals provided by the invention is by a variety of amino acid, more Kind vitamin and a variety of human elementaries (minerals) three categories ingredient converge in pellet, form a complete entirety, it is ensured that One property, while being separated the coating containing amino acid and vitamin, mineral composition by separation layer, avoid different constituents Between interaction, improve the stability of its preparation.
(2) this compound pellet good appearance provided by the invention, and good fluidity need to only be processed just through simple formulations Granule, capsule, tablet can be made, it is not necessary that glidant is added, so that it may directly be loaded in hollow softgel shell, capsule is made Agent；Granule is made with auxiliary materials such as sweetener, suspending agents；With the preferable auxiliary material of mobility, mixes direct tablet compressing and be obtained with Tablet has good market application prospect.
(3) this compound pellet provided by the invention can be used for amino acid, vitamin and human elementary (minerals) shortage The adjuvant treatment of caused disease, and the nutrition and health care with sub-health population Health restoration after being ill help to enhance human body Immune function.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field Art personnel all other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.
It present embodiments provides a kind of compound pellet containing a variety of amino acid, vitamine minerals, including capsule core and is wrapped in Packet medicine clothing outside capsule core, is equipped with separation layer between the capsule core and packet medicine clothing, the capsule core includes vitamin, minerals and auxiliary Material, the packet medicine clothing are the amino acid of powder or suspension formation, the amino acid include leucine, isoleucine, valine, Lysine, threonine, methionine, tryptophan, phenylalanine.Wherein, separation layer is mainly used for amino acid and other compositions Isolation, avoids interacting, and improves the stability of the compound pellet preparations, and main material uses hydroxypropyl methyl fiber Element or the stomach dissolution type coating powder for directly buying such as Ka Lekang.
Specifically, the amino acid further includes histidine, arginine, alanine, asparatate, cysteine, paddy ammonia At least one of acid, proline, tyrosine, glycine, serine, asparagine, glutamine.The characteristic and work of each amino acid With as shown in table 1.The vitamin includes vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, Vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, at least 12 in choline Kind, the characteristic of each vitamin and effect are as shown in table 2.The minerals include zinc, calcium, iron, selenium, magnesium, at least five kinds of people in manganese Element of volume, the carrier of each element are to have listed the various carriers used, and each element common carrier and effect are as shown in table 3.Institute Stating auxiliary material includes starch, microcrystalline cellulose, lactose.
A kind of embodiment of optimization, the packet medicine clothing are also enclosed with one layer of exterior coating outside, which is common The coating that water not readily dissolves, main function are pellet short time (3~5min) non-breakable dissolutions in water, are not only improved anti- Tide, when being also beneficial to form suspension in water with granule made of the pellet, ingredient is not easy to dissolve out, and has to mouthfeel is improved Important function；Its material is using hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethyl cellulose or directly buys commercially available coating Powder, such as reinforce damp-proof and be coated pre- pulvis, HPC aqueous dispersion, EC aqueous dispersion.
Table 1: aminoacids characteristic and effect
Table 2: vitamin characteristic and effect
Table 3: human elementary common carrier and effect
Illustrate the prescription and preparation method thereof of this compound pellet of the present invention below by specific embodiment.
Embodiment 1:
A kind of compound pellet containing a variety of amino acid, vitamine minerals is present embodiments provided, prescription is as follows:
L-Leu 42mg, l-Isoleucine 30mg, Valine 30mg, l-Lysine hydrochloride 45mg, L-threonine 21mg, l-methionine 39mg, L-Trp 10.5mg, L-phenylalanine 40mg, L- histidine monohydrochloride 30mg, L-arginine 32mg, l-Alanine 24mg, ASPARTIC ACID 16mg, L- cysteine hydrochloride 4.5mg, Pidolidone 14mg, L-PROLINE 7mg, l-tyrosine 2mg, glycine 22mg, Serine 5mg, asparagine 12mg, glutamine 14mg；
Vitamin A (beta carotene) 625IU, thiamine hydrochloride (vitamin B1) 7.5mg, riboflavin (vitamin B2) 7.5mg, niacinamide (vitamin B3) 15mg, calcium pantothenate (vitamin B5) 10mg, puridoxine hydrochloride (vitamin B6) 7.5mg, life Object element (vitamin B7) 0.5mg, folic acid (Vitamin B9) 100mg, Mecobalamin (vitamin B12) 40mcg, Calcium Ascorbate (dimension Raw element C) 30mg, Vitamin D3 (vitamine D3) 65IU, d- alpha-tocofecol succinic acid ester (vitamin E) 50IU, vitamin K 30mcg, lipotropin (choline) 4mg；
Calcium citrate (calcium) 200mg, Magnesium Asparticum (magnesium) 150mg, ferrous fumarate (iron) 7.5mg, zinc citrate 45 μ g of (zinc) 6mg, L- selenomethionine (selenium), grape acid manganese (manganese) 8mg.
This compound pellet of the present embodiment the preparation method is as follows:
1. weighing various vitamins and human elementary carrier (minerals) by above-mentioned recipe quantity, it crushed 60~80 meshes, It is uniformly mixed again with supplementary product starch, microcrystalline cellulose, lactose, adds 5%PVPK30Appropriate aqueous solution, softwood processed.
2. above-mentioned softwood is extruded into the bar of 1~3cm using 20 mesh screens through extruder；Bar is placed in rolling In circular knitting machine, engine speed is adjusted in 800~1000rpm, throws and justifies 5~8min, after uniform capsule core to be formed, discharging is set It is spare in drying in fluidized bed.
3. preparing barrier gown liquid, the stomach dissolution type coating powder of Ka Lekang is added into water, the barrier gown of solid content 8% is prepared in stirring Liquid is coated the capsule core of above-mentioned drying in fluidized bed, after pellet weight gain 20%, stops coating, thus outside capsule core Form one layer of separation layer.
4. weighing various amino acid by above-mentioned recipe quantity, through airslide disintegrating mill, amino acid micronizing materials are crushed to obtain, with 5%PVPK30Appropriate aqueous solution is configured to amino acid capsule core annex solution, through peristaltic pump, to above-mentioned spacer layer coating in fluidized bed Capsule core afterwards carries out spraying feeding, up to amino acid capsule core annex solution whole feeding to capsule core surface.
5. preparing exterior coating liquid, the pre- pulvis of damp-proof coating will be reinforced and add water, the outer coatings of solid content 8% are prepared in stirring Layer liquid, is coated above-mentioned capsule core in fluidized bed, after pellet weight gain 10%, stops coating, dry discharging, thus in ball One layer of exterior coating is formed outside core.
6. being packed after taking above-mentioned pellet to carry out intermediate inspection to obtain the final product.
7. when necessary, as needed, processing through simple formulations technique, which is made the mouths such as granule or capsule, tablet Formulation.
Embodiment 2:
A kind of compound pellet containing a variety of amino acid, vitamine minerals is present embodiments provided, prescription is as follows:
L-Leu 42mg, l-Isoleucine 30mg, Valine 30mg, l-Lysine hydrochloride 45mg, L-threonine 21mg, l-methionine 39mg, L-Trp 10.5mg, L-phenylalanine 40mg, L- histidine monohydrochloride 30mg, L-arginine 32mg, l-Alanine 24mg, ASPARTIC ACID 16mg, L- cysteine hydrochloride 4.5mg, Pidolidone 14mg, L-PROLINE 7mg, l-tyrosine 2mg, glycine 22mg, Serine 5mg, asparagine 12mg, glutamine 14mg；
Vitamin A (beta carotene) 625IU, thiamine hydrochloride (vitamin B1) 7.5mg, riboflavin (vitamin B2) 7.5mg, niacinamide (vitamin B3) 15mg, calcium pantothenate (vitamin B5) 10mg, puridoxine hydrochloride (vitamin B6) 7.5mg, life Object element (vitamin B7) 0.5mg, folic acid (Vitamin B9) 100mg, Mecobalamin (vitamin B12) 40mcg, Calcium Ascorbate (dimension Raw element C) 30mg, Vitamin D3 (vitamine D3) 65IU, d- alpha-tocofecol succinic acid ester (vitamin E) 50IU；
Calcium citrate (calcium) 200mg, Magnesium Asparticum (magnesium) 150mg, ferrous fumarate (iron) 7.5mg, zinc citrate 45 μ g of (zinc) 6mg, L- selenomethionine (selenium).
The preparation method of this compound pellet of the present embodiment with above-described embodiment 1, the difference is that, separation layer is consolidated Content is 5%, and separation layer weight gain 20% is free of exterior coating.
Embodiment 3:
A kind of compound pellet containing a variety of amino acid, vitamine minerals is present embodiments provided, prescription is as follows:
L-Leu 42mg, l-Isoleucine 30mg, Valine 30mg, l-Lysine hydrochloride 45mg, L-threonine 21mg, l-methionine 39mg, L-Trp 10.5mg, L-phenylalanine 40mg, L- histidine monohydrochloride 30mg, L-arginine 32mg, l-Alanine 24mg, ASPARTIC ACID 16mg, L- cysteine hydrochloride 4.5mg, Pidolidone 14mg, L-PROLINE 7mg, l-tyrosine 2mg, glycine 22mg, Serine 5mg；
Vitamin A (beta carotene) 625IU, thiamine hydrochloride (vitamin B1) 7.5mg, riboflavin (vitamin B2) 7.5mg, niacinamide (vitamin B3) 15mg, calcium pantothenate (vitamin B5) 10mg, puridoxine hydrochloride (vitamin B6) 7.5mg, life Object element (vitamin B7) 0.5mg, folic acid (Vitamin B9) 100mg, Mecobalamin (vitamin B12) 40mcg, Calcium Ascorbate (dimension Raw element C) 30mg, Vitamin D3 (vitamine D3) 65IU, d- alpha-tocofecol succinic acid ester (vitamin E) 50IU；
Calcium citrate (calcium) 200mg, Magnesium Asparticum (magnesium) 150mg, ferrous fumarate (iron) 7.5mg, zinc citrate 45 μ g of (zinc) 6mg, L- selenomethionine (selenium).
The preparation method of this compound pellet of the present embodiment with above-described embodiment 1, the difference is that, separation layer is consolidated Content is 10%, separation layer weight gain 100%, exterior coating weight gain 5%.
Embodiment 4:
A kind of compound pellet containing a variety of amino acid, vitamine minerals is present embodiments provided, prescription is as follows:
L-Leu 42mg, l-Isoleucine 30mg, Valine 30mg, l-Lysine hydrochloride 45mg, L-threonine 21mg, l-methionine 39mg, L-Trp 10.5mg, L-phenylalanine 40mg, L- histidine monohydrochloride 30mg, L-arginine 32mg, l-Alanine 24mg, ASPARTIC ACID 16mg, L- cysteine hydrochloride 4.5mg, Pidolidone 14mg, L-PROLINE 7mg, l-tyrosine 2mg, glycine 22mg, Serine 5mg；
Vitamin A (beta carotene) 625IU, thiamine hydrochloride (vitamin B1) 7.5mg, riboflavin (vitamin B2) 7.5mg, niacinamide (vitamin B3) 15mg, calcium pantothenate (vitamin B5) 10mg, puridoxine hydrochloride (vitamin B6) 7.5mg, life Object element (vitamin B7) 0.5mg, folic acid (Vitamin B9) 100mg, Mecobalamin (vitamin B12) 40mcg, Calcium Ascorbate (dimension Raw element C) 30mg, Vitamin D3 (vitamine D3) 65IU, d- alpha-tocofecol succinic acid ester (vitamin E) 50IU, vitamin K 30mcg, lipotropin (choline) 4mg；
Calcium citrate (calcium) 200mg, Magnesium Asparticum (magnesium) 150mg, ferrous fumarate (iron) 7.5mg, zinc citrate 45 μ g of (zinc) 6mg, L- selenomethionine (selenium), grape acid manganese (manganese) 8mg.
The preparation method of this compound pellet of the present embodiment is the same as above-described embodiment 1.
The foregoing examples are only illustrative of the present invention, does not constitute the limitation to protection scope of the present invention, all It is within being all belonged to the scope of protection of the present invention with the same or similar design of the present invention.

Claims (10)

1. a kind of compound pellet containing a variety of amino acid, vitamine minerals, it is characterised in that: including capsule core and be wrapped in capsule core Outer packet medicine clothing is equipped with separation layer between the capsule core and packet medicine clothing, the capsule core includes vitamin, minerals and auxiliary material, institute The amino acid that packet medicine clothing is powder or suspension formation is stated, the amino acid includes leucine, isoleucine, valine, relies ammonia Acid, threonine, methionine, tryptophan, phenylalanine.
2. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the dimension life Element include vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, Vitamin B9, Vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, at least 12 kinds in choline.
3. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the mineral Matter includes zinc, calcium, iron, selenium, magnesium, at least five kinds of human elementaries in manganese.
4. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the auxiliary material Including starch, microcrystalline cellulose, lactose.
5. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the amino Acid further include histidine, arginine, alanine, asparatate, cysteine, glutamic acid, proline, tyrosine, glycine, At least one of serine, asparagine, glutamine.
6. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the isolation Layer is made of hydroxypropyl methyl cellulose or stomach dissolution type coating powder, and solid content is 5~10%.
7. the compound pellet as described in claim 1 containing a variety of amino acid, vitamine minerals, it is characterised in that: the packet medicine One layer of exterior coating is also enclosed with outside clothing, the exterior coating is fine using hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethyl Dimension element or coating powder are made.
8. the preparation method of compound pellet as described in any one of claims 1 to 7, characterized by the following steps:
1) vitamin, minerals are weighed by recipe quantity, is uniformly mixed after pulverizing and sieving with auxiliary material, added water or water-soluble containing adhesive Softwood is made in liquid mixing, and by extrusion-method for rolling circle, capsule core is made, spare；
2) a variety of amino acid are weighed by recipe quantity, is micronized using airslide disintegrating mill, add water or add sticky auxiliary material homogeneous Amino acid capsule core annex solution is prepared in mixing, spare；
3) insolated layer materials are added water and stirred and is configured to the barrier gown liquid that solid content is 8%, it is spare；
4) capsule core for obtaining step 1) is carried out using the barrier gown liquid of step 3) in capsule core outer surface after fluidized bed drying Cladding, forms one layer of separation layer；
5) the amino acid capsule core annex solution that step 2) obtains is sprayed in the capsule core that feeding to step 4) obtains with atomised form, shape At one layer of packet medicine clothing containing amino acid to get compound pellet.
9. the preparation method of compound pellet as claimed in claim 8, it is characterised in that: it further include step 6), it is multiple in step 5) One layer of exterior coating is wrapped up outside the packet medicine clothing of square pellet.
10. the preparation method of compound pellet as claimed in claim 9, it is characterised in that: separation layer increases weight in the step 4) 10~20%, exterior coating weight gain 0~10% in step 6).
CN201910250615.2A 2019-03-29 2019-03-29 A kind of compound pellet and preparation method thereof containing a variety of amino acid, vitamine minerals Pending CN109999056A (en)

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Application publication date: 20190712